But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    He’s taken sf to places it’s never been (Snow Crash, Anathem). He’s reinvented the historical novel (The Baroque Cycle), the international thriller (Reamde), and both at the same time (Cryptonomicon).Now he treats his legion of fans to Some Remarks, an enthralling collection of essays—Stephenson’s first nonfiction work since his long essay on technology, In the Beginning…Was the Command Line, more than a decade ago—as well as new and previously published short writings both fiction and non.Some Remarks is a magnificent showcase of a brilliantly inventive mind and talent, as he discourses on everything from Sir Isaac Newton to Star Wars.

    Using the latest genetic and anthropological data, Spencer Wells demonstrates that although humankind's decision to control our own food supply is what propelled us into the modern world, it had many downsides that we're just now beginning to recognize.

    The Structure of Scientific Revolutions is that kind of book. When it was first published in 1962, it was a landmark event in the history and philosophy of science. Fifty years later, it still has many lessons to teach. With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age. This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context.  Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science.

    It has found adherents in Silicon Valley billionaires Ray Kurzweil and Peter Diamandis. Google has entered the picture, establishing a bio-tech subsidiary aimed at solving the problem of aging.In To Be a Machine, journalist Mark O'Connell takes a headlong dive into this burgeoning movement. He travels to the laboratories, conferences, and basements of today's foremost transhumanists, where he's presented with the staggering possibilities and moral quandaries of new technologies like mind uploading, artificial superintelligence, cryonics, and device implants.A contributor to Slate, The New Yorker, and The New York Times Magazine, O'Connell serves as a sharp and lively guide to the outer limits of technology in the twenty first century. In investigating what it means to be a machine, he offers a surprising, singular meditation on what it means to be human."

    Neuroscience can now begin to unlock the key to the self. Our knowledge of the brain has progressed so rapidly that it will change the way we think of ourselves as human beings. It will change our notion of understanding. This is a revolution which will have impact on all our lives. Neuroscientists are gathering new empirical evidence about consciousness and human nature; they are picking up where the great earlier thinkers like Freud, Darwin, Charcot and others began. This evidence begins to give substance to some of the grand statements and intuitive leaps made in the nineteenth and early twentieth century about the nature of the self.

    "Wired" magazine sent him to Singapore to report on one of the world's most buttoned-up states. "The New York Times Magazine" asked him to describe what was wrong with the Internet. Rolling Stone published his essay on the ways our lives are all "soundtracked" by the music and the culture around us. And in a speech at the 2010 Book Expo, he memorably described the interactive relationship between writer and reader.These essays and articles have never been collected-until now. Some have never appeared in print at all. In addition, "Distrust That Particular Flavor" includes journalism from small publishers, online sources, and magazines no longer in existence. This volume will be essential reading for any lover of William Gibson's novels. "Distrust That Particular Flavor" offers readers a privileged view into the mind of a writer whose thinking has shaped not only a generation of writers but our entire culture.

    Optimism, courage, joy and spirituality were central to Leary's final days and his death. Design for Dying -- Leary's last book -- shows us how we too can make dying the high point of life. Irreverent, thought-provoking and hilarious, Leary's parting shot pioneers new ways to die and new ways for the living to think about death. Urging us to take control of our deaths (and even to determine when and how we will die), Leary relates his own plan for "directed dying," a death we plan and orchestrate to reflect our own lives and values.And the psychedelic prophet flings open a whole new range of beyond-death possibilites for the wired generation. From downloading consciousness onto the Net -- so that our souls can outlive our bodies -- to the way technology can enhance the final days of the dying to the far-out promises of cryogenics, Leary provides fascinating insights into how technology may eventually help us improve, and even sidestep, death. A thorough guide to death and dying resources and to online tools and further reading lists completes this surprising, funny and totally original look at the new frontiers of death.Speaking to everyone who has ever wondered if there's more to death - -if there's life beyond the final frontier, if death really means the end, if dirges and hearses and funeral flowers are really how we want to be remembered -- Leary's flamboyant final statement rteveals revolutionary ways to die and redefines, with Leary's trademark creativity and joy, how the living can think about death.

    Asimov takes the reader on a rousing mental trip into the world of mathematics, physics, chemistry, biology, and astronomy.

    The conversion of energy on Earth ranges from terra-forming forces of plate tectonics to cumulative erosive effects of raindrops. Life on Earth depends on the photosynthetic conversion of solar energy into plant biomass. Humans have come to rely on many more energy flows—ranging from fossil fuels to photovoltaic generation of electricity—for their civilized existence. In this monumental history, Vaclav Smil provides a comprehensive account of how energy has shaped society, from pre-agricultural foraging societies through today's fossil fuel–driven civilization.Humans are the only species that can systematically harness energies outside their bodies, using the power of their intellect and an enormous variety of artifacts—from the simplest tools to internal combustion engines and nuclear reactors. The epochal transition to fossil fuels affected everything: agriculture, industry, transportation, weapons, communication, economics, urbanization, quality of life, politics, and the environment. Smil describes humanity's energy eras in panoramic and interdisciplinary fashion, offering readers a magisterial overview. This book is an extensively updated and expanded version of Smil's Energy in World History (1994). Smil has incorporated an enormous amount of new material, reflecting the dramatic developments in energy studies over the last two decades and his own research over that time.

    But philosopher and cognitive scientist Andy Clark sees it differently. Cyborgs, he writes, are not something to be feared--we already are cyborgs. In Natural-Born Cyborgs, Clark argues that what makes humans so different from other species is our capacity to fully incorporate tools and supporting cultural practices into our existence. Technology as simple as writing on a sketchpad, as familiar as Google or a cellular phone, and as potentially revolutionary as mind-extending neural implants--all exploit our brains' astonishingly plastic nature. Our minds are primed to seek out and incorporate non-biological resources, so that we actually think and feel through our best technologies. Drawing on his expertise in cognitive science, Clark demonstrates that our sense of self and of physical presence can be expanded to a remarkable extent, placing the long-existing telephone and the emerging technology of telepresence on the same continuum. He explores ways in which we have adapted our lives to make use of technology (the measurement of time, for example, has wrought enormous changes in human existence), as well as ways in which increasingly fluid technologies can adapt to individual users during normal use. Bio-technological unions, Clark argues, are evolving with a speed never seen before in history. As we enter an age of wearable computers, sensory augmentation, wireless devices, intelligent environments, thought-controlled prosthetics, and rapid-fire information search and retrieval, the line between the user and her tools grows thinner day by day. This double whammy of plastic brains and increasingly responsive and well-fitted tools creates an unprecedented opportunity for ever-closer kinds of human-machine merger, he writes, arguing that such a merger is entirely natural. A stunning new look at the human brain and the human self, Natural Born Cyborgs reveals how our technology is indeed inseparable from who we are and how we think.

    The fundamental questions are answered, leaving only the details to be filled in. In this book, Dr Rupert Sheldrake, one of the world's most innovative scientists, shows that science is being constricted by assumptions that have hardened into dogmas. The 'scientific worldview' has become a belief system. All reality is material or physical. The world is a machine, made up of dead matter. Nature is purposeless. Consciousness is nothing but the physical activity of the brain. Free will is an illusion. God exists only as an idea in human minds, imprisoned within our skulls. Sheldrake examines these dogmas scientifically, and shows persuasively that science would be better off without them: freer, more interesting, and more fun.In The God Delusion Richard Dawkins used science to bash God, but here Rupert Sheldrake shows that Dawkins' understanding of what science can do is old-fashioned and itself a delusion.

    But in recent years, a startling new concept has evolved that places it more firmly than ever in a special position. Known as the Anthropic Cosmological Principle, this collection of ideas holds that the existence of intelligent observers determines the fundamental structure of the Universe. In its most radical version, the Anthropic Principle asserts that intelligent information-processing must come into existence in the Universe, and once it comes into existence, it will never die out. This wide-ranging and detailed book explores the many ramifications of the Anthropic Cosmological Principle, covering the whole spectrum of human inquiry from Aristotle to Z bosons. Bringing a unique combination of skills and knowledge to the subject, John D. Barrow and Frank J. Tipler--two of the world's leading cosmologists--cover the definition and nature of life, the search for extraterrestrial intelligence, and the interpretation of the quantum theory in relation to the existence of observers. The book will be of vital interest to philosophers, theologians, mathematicians, scientists, and historians, as well as to anyone concerned with the connection between the vastness of the universe of stars and galaxies and the existence of life within it on a small planet out in the suburbs of the Milky Way.

    Since then, Fisher has conducted pioneering brain research on lust, romantic love, and attachment; gathered data on more than 80,000 people to explain why you love who you love; and collected information on more than 30,000 men and women on sexting, hooking up, friends with benefits, and other current trends in courtship and marriage. And she presents a new, scientifically based and optimistic perspective on relationships in our digital age—what she calls “slow love.”This is a cutting-edge tour de force that traces human family life from its origins in Africa over 20 million years ago to the Internet dating sites and bedrooms of today. And it’s got it all: the copulatory gaze and other natural courting ploys; the who, when, where, and why of adultery; love addictions; her discovery of four broad chemically based personality styles and what each seeks in romance; the newest data on worldwide (biologically based) patterns of divorce; how and why men and women think differently; the real story of women, men, and power; the rise—and fall—of the sexual double standard; and what brain science tells us about how to make and keep a happy partnership.

    A compelling and revolutionary work that calls for the immediate extension of our human rights to the great apes.The Great Ape Project looks forward to a new stage in the development of the community of equals, whereby the great apes-chimpanzees, gorillas, and orangutans-will actually receive many of the same protections and rights that are already accorded to humans.This profound collection of thirty-one essays by the world's most distinguished observers of free-living apes make up a uniquely satisfying whole, blending observation and interpretation in a highly persuasive case for a complete reassessment of the moral status of our closest kin.