Fundamentals of Biostatistics with CD-Rom.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Marieb and Katja Hoehn have produced the most accessible, comprehensive, up-to-date, and visually stunning anatomy & physiology textbook on the market. Marieb draws on her career as an A&P professor and her experience as a part-time nursing student, while Hoehn relies on her medical education and classroom experience to explain concepts and processes in a meaningful and memorable way. The most significant revision to date, the Eighth Edition makes it easier for you to learn key concepts in A&P. The new edition features a whole new art program that is not only more visually dynamic and vibrant than in previous editions but is also much more pedagogically effective for today's students, including new Focus figures, which guide you through the toughest concepts in A&P. The text has been edited to make it easier than ever to study from and navigate, with integrated objectives, new concept check questions, and a new design program.

    Now Schaum's is better than ever-with a new look, a new format with hundreds of practice problems, and completely updated information to conform to the latest developments in every field of study.Fully compatible with your classroom text, Schaum's highlights all the important facts you need to know. Use Schaum's to shorten your study time-and get your best test scores!Schaum's Outlines-Problem Solved.

    KEY TOPICS: A Preview of the Cell, The Chemistry of the Cell, The Macromolecules of the Cell, Cells and Organelles, Bioenergetics: The Flow of Energy in the Cell, Enzymes: The Catalysts of Life, Membranes: Their Structure, Function, and Chemistry, Transport Across Membranes: Overcoming the Permeability Barrier, Chemotrophic Energy Metabolism: Glycolysis and Fermentation, Chemotrophic Energy Metabolism: Aerobic Respiration, Phototrophic Energy Metabolism: Photosynthesis, The Endomembrane System and Peroxisomes, Signal Transduction Mechanisms: I. Electrical and Synaptic Signaling in Neurons, Signal Transduction Mechanisms: II. Messengers and Receptors, Cytoskeletal Systems, Cellular Movement: Motility and Contractility, Beyond the Cell: Cell Adhesion, Cell Junctions, and Extracellular Structures, The Structural Basis of Cellular Information: DNA, Chromosomes, and the Nucleus, The Cell Cycle, DNA Replication, and Mitosis, Sexual Reproduction, Meiosis, and Genetic Recombination, Gene Expression: I. The Genetic Code and Transcription, Gene Expression: II. Protein Synthesis and Sorting, The Regulation of Gene Expression, Cancer Cells, Principles and Techniques of Microscopy. MARKET: For all readers interested in molecular biology.

    The more than 1,200 color photographs and two dozen line drawings include numerous exceptionally striking images. The giant silk moths, tiger moths, and many other species covered include forest pests, common garden guests, economically important species, and of course, the Mescal Worm and Mexican Jumping Bean caterpillars. Full-page species accounts cover almost 400 species, with up to six images per species including an image of the adult plus succinct text with information on distribution, seasonal activity, foodplants, and life history. These accounts are generously complemented with additional images of earlier instars, closely related species, noteworthy behaviors, and other intriguing aspects of caterpillar biology.Many caterpillars are illustrated here for the first time. Dozens of new foodplant records are presented and erroneous records are corrected. The book provides considerable information on the distribution, biology, and taxonomy of caterpillars beyond that available in other popular works on Eastern butterflies and moths. The introductory chapter covers caterpillar structure, life cycles, rearing, natural enemies, photography, and conservation. The section titled Caterpillar Projects will be of special interest to educators.Given the dearth of accessible guides on the identification and natural history of caterpillars, Caterpillars of Eastern North America is a must for entomologists and museum curators, forest managers, conservation biologists and others who seek a compact, easy-to-use guide to the caterpillars of this vast region. A compact guide to nearly 700 caterpillars east of the Mississippi, from forest pests to garden guests and economically important species 1,200 color photos and 24 line drawings enable easy identification Full-page species accounts with image of adult insect for almost 400 species, plus succinct text on distribution and other vital information Many caterpillars illustrated here for the first time Current information on distribution, biology, and taxonomy not found in other popular works A section geared toward educators, Caterpillar Projects An indispensable resource for all who seek an easy-to-use guide to the caterpillars of this vast region

    Describes how fractals were discovered, explains their unique properties, and discusses the mathematical foundation of fractals.

    Gould explores recapitulation as an idea that intrigued politicians and theologians as well as scientists. He shows that Haeckel's hypothesis--that human fetuses with gill slits are, literally, tiny fish, exact replicas of their water-breathing ancestors--had an influence that extended beyond biology into education, criminology, psychoanalysis (Freud and Jung were devout recapitulationists), and racism. The theory of recapitulation, Gould argues, finally collapsed not from the weight of contrary data, but because the rise of Mendelian genetics rendered it untenable.Turning to modern concepts, Gould demonstrates that, even though the whole subject of parallels between ontogeny and phylogeny fell into disrepute, it is still one of the great themes of evolutionary biology. Heterochrony--changes in developmental timing, producing parallels between ontogeny and phylogeny--is shown to be crucial to an understanding of gene regulation, the key to any rapprochement between molecular and evolutionary biology. Gould argues that the primary evolutionary value of heterochrony may lie in immediate ecological advantages for slow or rapid maturation, rather than in long-term changes of form, as all previous theories proclaimed.Neoteny--the opposite of recapitulation--is shown to be the most important determinant of human evolution. We have evolved by retaining the juvenile characters of our ancestors and have achieved both behavioral flexibility and our characteristic morphology thereby (large brains by prolonged retention of rapid fetal growth rates, for example).Gould concludes that "there may be nothing new under the sun, but permutation of the old within complex systems can do wonders. As biologists, we deal directly with the kind of material complexity that confers an unbounded potential upon simple, continuous changes in underlying processes. This is the chief joy of our science."

    Assuming no prior science knowledge, this book supports main concepts with clinical applications, making them more relevant to students pursuing careers in the allied health field.

    Kauffman's At Home in the Universe, which The New York Times Book Review called "passionately written" and nature named "courageous," introduced pivotal ideas about order and evolution in complex life systems. In investigations, Kauffman builds on these theories and finds that classical science does not take into account that physical systems--such as people in a biosphere--effect their dynamic environments in addition to being affected by them. These systems act on their own behalf as autonomous agents, but what defines them as such? In other words, what is life? By defining and explaining autonomous agents and work in the contexts of thermodynamics and of information theory, Kauffman supplies a novel answer to this age-old question that goes beyond traditional scientific thinking. Much of Investigations unpacks the progressively surprising implications of his definition. Kauffman lays out a foundation for a new concept of organization, and explores the requirements for the emergence of a general biology that will transcend terrestrial biology to seek laws governing biospheres anywhere in the cosmos. Moreover, he presents four candidate laws to explain how autonomous agents co-create their biosphere and the startling idea of a "co-creating" cosmos. A showcase of Kauffman's most fundamental and significant ideas, Investigations presents a new way of thinking about the basics of general biology that will change the way we understand life itself--on this planet and anywhere else in the cosmos.

    Come with me--see what I have seen--and try to understand what global warming really means for us and for our children. Leave Washington and travel to the places I have visited..."--From the PrefaceA glacier disappears high in the Peruvian Andes. Floodwaters surge across the English countryside. Ten thousand Pacific Islanders begin to evacuate their homeland. A dust storm turns day into night across the Inner Mongolian plains. These events may seem unrelated, but they are not. Even as scientists and other experts debate the specifics, climate crisis is already affecting the lives of millions.In this ground-breaking book, Mark Lynas reveals the first evidence--collected during an epic three-year journey across five continents--about how global warming is hitting people's lives all around the world. From American hurricane chasers to Mongolian herders, from Alaskan Eskimos to South Sea islanders, Lynas's encounters and discoveries give us a stark warning about the even worse dangers that lie ahead if nothing is done.High Tide's message is urgent and its revelations are at once shocking and inspiring--shocking as so few of us yet realize the magnitude of what's happening, and inspiring as there is still time to avert much greater catastrophe. No one who reads this book will be able to look their children in the eyes and say "I didn't know."As global temperatures soar to record levels, Lynas bears witness to:- CRIPPLING DROUGHT: China's Yellow River no longer reaches the sea for half the year, and villages across the north of the country are disappearing under advancing sand dunes- BAKED ALASKA: Permafrost is melting, leaving houses, roads and whole forests sucked into the thawing ground. Winter is in retreat, leaving animals confused and Native Alaskan people without a livelihood- DISAPPEARING GLACIERS: Every glaciated mountain range on Earth is experiencing massive ice losses. Montana's Glacier National Park has lost 100 glaciers in the last century; only 50 remain. Water supplies to hundreds of millions of people--from Peru to Pakistan--are threatened- HIGH TIDES: Islanders on the tiny South Pacific nation of Tuvalu are already leaving their homeland as rising sea levels engulf their atolls. Today 70 percent of the world's sandy shorelines are retreating; up to 90 percent of the beaches on the Eastern U.S. seaboard are eroding fast- CATASTROPHIC FLOODS: English villagers now talk about a "wet season" rather than a winter. Heavier rainfall is now falling across the global mid-latitudes, from the continental U.S. to Russia, sparking devastating floods on an ever more frequent basis.

    65 full-color and 30 duotone photos.Contents:Foreword / Gilbert M. Grosvenor --A Message from Jane Goodall --The Beginning --The Chimpanzees --The Realization --The People --The Promise --The Jane Goodall Institute.

    A compelling and revolutionary work that calls for the immediate extension of our human rights to the great apes.The Great Ape Project looks forward to a new stage in the development of the community of equals, whereby the great apes-chimpanzees, gorillas, and orangutans-will actually receive many of the same protections and rights that are already accorded to humans.This profound collection of thirty-one essays by the world's most distinguished observers of free-living apes make up a uniquely satisfying whole, blending observation and interpretation in a highly persuasive case for a complete reassessment of the moral status of our closest kin.

    Hephaestus Books represents a new publishing paradigm, allowing disparate content sources to be curated into cohesive, relevant, and informative books. To date, this content has been curated from Wikipedia articles and images under Creative Commons licensing, although as Hephaestus Books continues to increase in scope and dimension, more licensed and public domain content is being added. We believe books such as this represent a new and exciting lexicon in the sharing of human knowledge. This particular book is a collaboration focused on Malazan Book of the Fallen.More info: The Malazan Book of the Fallen is an epic fantasy series written by Canadian author Steven Erikson, published in ten volumes beginning with the novel Gardens of the Moon. As of August 2009, nine novels in the series have been published leaving only the final volume forthcoming. Erikson's series is complex with a wide scope, and presents the narratives of a large cast of characters. In 2005, Esslemont began publishing his own series of five novels set in the same world, beginning with Night of Knives. Although Esslemont's books are published under a different series title - Novels of the Malazan Empire - Esslemont and Erikson collaborated on the storyline for the entire fifteen-book project and Esslemont's novels are considered as canonical and integral to the series as Erikson's own.

    The all-new Kaufman Field Guide to Advanced Birding takes a different approach, clarifying the basics and providing a framework for learning about each group. Overall principles of identification are explained in clear language, and ten chapters on specific groups of birds show how these principles can be applied in practice. Anyone with a keen interest in identifying birds will find that this book makes the learning process more effective and enjoyable, and that truly understanding what we see and hear can make birding more fun.