The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern tobacco plantations to the dense immigrant neighborhoods of northern cities to far-flung villages on the edges of the nascent American empire. In Pox, award-winning historian Michael Willrich offers a gripping chronicle of how the nation's continentwide fight against smallpox launched one of the most important civil liberties struggles of the twentieth century.At the dawn of the activist Progressive era and during a moment of great optimism about modern medicine, the government responded to the deadly epidemic by calling for universal compulsory vaccination. To enforce the law, public health authorities relied on quarantines, pesthouses, and "virus squads"-corps of doctors and club-wielding police. Though these measures eventually contained the disease, they also sparked a wave of popular resistance among Americans who perceived them as a threat to their health and to their rights.At the time, anti-vaccinationists were often dismissed as misguided cranks, but Willrich argues that they belonged to a wider legacy of American dissent that attended the rise of an increasingly powerful government. While a well-organized anti-vaccination movement sprang up during these years, many Americans resisted in subtler ways-by concealing sick family members or forging immunization certificates. Pox introduces us to memorable characters on both sides of the debate, from Henning Jacobson, a Swedish Lutheran minister whose battle against vaccination went all the way to the Supreme Court, to C. P. Wertenbaker, a federal surgeon who saw himself as a medical missionary combating a deadly-and preventable-disease.As Willrich suggests, many of the questions first raised by the Progressive-era antivaccination movement are still with us: How far should the government go to protect us from peril? What happens when the interests of public health collide with religious beliefs and personal conscience? In Pox, Willrich delivers a riveting tale about the clash of modern medicine, civil liberties, and government power at the turn of the last century that resonates powerfully today.

    Ernst Gräfenberg was among the most sought-after gynecologists in pre-World War II Germany. The creator of the first IUD, known as the Gräfenberg ring, he was posthumously credited with identifying the eponymous "Gräfenberg spot" or G-spot. He was also a Jew in Nazi Germany, and by 1938 he had been stripped of his practice, his possessions, and his freedom and was languishing in a Nazi prison. After being allegedly ransomed from confinement by Planned Parenthood founder Margaret Sanger, Gräfenberg fled to America, where he eventually became the only male doctor at Sanger's birth control clinic.In this bracing essay, Rebecca Tuhus-Dubrow rescues from near obscurity the pioneering inventor of a contraceptive device that unleashed decades of controversy. And as we see efforts to roll back reproductive rights, it is also a cautionary tale as relevant today as it was nearly a century ago.RUNNING TIME ➼ 1hr. and 9mins.©2020 Rebecca Tuhus-Dubrow (P)2019 Brilliance, Publishing, Inc., all rights reserved.

    Now comes a gripping account of the doctors and scientists fighting to protect us, an urgent wake-up call about the future of emerging viruses—from the #1 bestselling author of The Hot Zone, soon to be a National Geographic original miniseries.This time, Ebola started with a two-year-old child who likely had contact with a wild creature and whose entire family quickly fell ill and died. The ensuing global drama activated health professionals in North America, Europe, and Africa in a desperate race against time to contain the viral wildfire. By the end—as the virus mutated into its deadliest form, and spread farther and faster than ever before—30,000 people would be infected, and the dead would be spread across eight countries on three continents.In this taut and suspenseful medical drama, Richard Preston deeply chronicles the outbreak, in which we saw for the first time the specter of Ebola jumping continents, crossing the Atlantic, and infecting people in America. Rich in characters and conflict—physical, emotional, and ethical—Crisis in the Red Zone is an immersion in one of the great public health calamities of our time.Preston writes of doctors and nurses in the field putting their own lives on the line, of government bureaucrats and NGO administrators moving, often fitfully, to try to contain the outbreak, and of pharmaceutical companies racing to develop drugs to combat the virus. He also explores the charged ethical dilemma over who should and did receive the rare doses of an experimental treatment when they became available at the peak of the disaster. Crisis in the Red Zone makes clear that the outbreak of 2013–2014 is a harbinger of further, more severe outbreaks, and of emerging viruses heretofore unimagined—in any country, on any continent. In our ever more interconnected world, with roads and towns cut deep into the jungles of equatorial Africa, viruses both familiar and undiscovered are being unleashed into more densely populated areas than ever before.The more we discover about the virosphere, the more we realize its deadly potential. Crisis in the Red Zone is an exquisitely timely book, a stark warning of viral outbreaks to come.

    Diligently treating the drug addicts of Vancouver's notorious Downtown Eastside with sympathy in his heart and legislative reform in mind can't be easy. But Maté never judges. His book is a powerful call-to-arms, both for the decriminalization of drugs and for a more sympathetic and informed view of addiction. As Maté observes, "Those whom we dismiss as 'junkies' are not creatures from a different world, only men and women mired at the extreme end of a continuum on which, here or there, all of us might well locate ourselves." In the Realm of Hungry Ghosts begins by introducing us to many of Dr. Maté's most dire patients who steal, cheat, sell sex, and otherwise harm themselves for their next hit. Maté looks to the root causes of addiction, applying a clinical and psychological view to the physical manifestation and offering some enlightening answers for why people inflict such catastrophe on themselves.Finally, he takes aim at the hugely ineffectual, largely U.S.-led War on Drugs (and its worldwide followers), challenging the wisdom of fighting drugs instead of aiding the addicts, and showing how controversial measures such as safe injection sites are measurably more successful at reducing drug-related crime and the spread of disease than anything most major governments have going. It's not easy reading, but we ignore his arguments at our peril. When it comes to combating the drug trade and the ravages of addiction, society can use all the help it can get. --Kim Hughes

    Beginning with his family’s odyssey, In a Different Key tells the extraordinary story of this often misunderstood condition, and of the civil rights battles waged by the families of those who have it. Unfolding over decades, it is a beautifully rendered history of ordinary people determined to secure a place in the world for those with autism—by liberating children from dank institutions, campaigning for their right to go to school, challenging expert opinion on what it means to have autism, and persuading society to accept those who are different.  It is the story of women like Ruth Sullivan, who rebelled against a medical establishment that blamed cold and rejecting “refrigerator mothers” for causing autism; and of fathers who pushed scientists to dig harder for treatments. Many others played starring roles too: doctors like Leo Kanner, who pioneered our understanding of autism; lawyers like Tom Gilhool, who took the families’ battle for education to the courtroom; scientists who sparred over how to treat autism; and those with autism, like Temple Grandin, Alex Plank, and Ari Ne’eman, who explained their inner worlds and championed the philosophy of neurodiversity. This is also a story of fierce controversies—from the question of whether there is truly an autism “epidemic,” and whether vaccines played a part in it; to scandals involving “facilitated communication,” one of many treatments that have proved to be blind alleys; to stark disagreements about whether scientists should pursue a cure for autism. There are dark turns too: we learn about experimenters feeding LSD to children with autism, or shocking them with electricity to change their behavior; and the authors reveal compelling evidence that Hans Asperger, discoverer of the syndrome named after him, participated in the Nazi program that consigned disabled children to death.<

    He asked them to disclose something that, for scientific reasons, worries them—particularly scenarios that aren't on the popular radar yet. Encompassing neuroscience, economics, philosophy, physics, psychology, biology, and more—here are 150 ideas that will revolutionize your understanding of the world.Steven Pinker uncovers the real risk factors for war * Mihaly Csikszentmihalyi peers into the coming virtual abyss * Nobel laureate Frank Wilczek laments our squandered opportunities to prevent global catastrophe * Seth Lloyd calculates the threat of a financial black hole * Alison Gopnik on the loss of childhood * Nassim Nicholas Taleb explains why firefighters understand risk far better than economic "experts" * Matt Ridley on the alarming re-emergence of superstition * Daniel C. Dennett and george dyson ponder the impact of a major breakdown of the Internet * Jennifer Jacquet fears human-induced damage to the planet due to "the Anthropocebo Effect" * Douglas Rushkoff fears humanity is losing its soul * Nicholas Carr on the "patience deficit" * Tim O'Reilly foresees a coming new Dark Age * Scott Atran on the homogenization of human experience * Sherry Turkle explores what's lost when kids are constantly connected * Kevin Kelly outlines the looming "underpopulation bomb" * Helen Fisher on the fate of men * Lawrence Krauss dreads what we don't know about the universe * Susan Blackmore on the loss of manual skills * Kate Jeffery on the death of death * plus J. Craig Venter, Daniel Goleman, Virginia Heffernan, Sam Harris, Brian Eno, Martin Rees, and more

    What followed was a rigorous, pathbreaking, and enthralling exchange, which has been viewed millions of times since it was first posted on YouTube. This is intellectual inquiry at its best: exhilarating, funny, and unpredictable, sincere and probing, reminding us just how varied and colorful the threads of modern atheism are. Here is the transcript of that conversation, in print for the first time, augmented by material from the living participants: Dawkins, Harris, and Dennett. These new essays, introduced by Stephen Fry, mark the evolution of their thinking and highlight particularly resonant aspects of this epic exchange. Each man contends with the most fundamental questions of human existence while challenging the others to articulate their own stance on God and religion, cultural criticism, spirituality, debate with people of faith, and the components of a truly ethical life.

    Armstrong writes about her experience as one of only a few people to participate in an experimental treatment for depression involving ten rounds of a chemically induced coma approximating brain death.For years, Heather B. Armstrong has alluded to her struggle with depression on her website. But in 2016, Heather found herself in the depths of a depression she just couldn’t shake, an episode darker and longer than anything she had previously experienced. This book recalls the torturous eighteen months of suicidal depression she endured and the month-long experimental study in which doctors used propofol anesthesia to quiet all brain activity for a full fifteen minutes before bringing her back from a flatline. Ten times. The experience wasn’t easy. Not for Heather or her family. But a switch was flipped, and Heather hasn’t experienced a single moment of suicidal depression since. The Valedictorian of Being Dead brings to light a groundbreaking new treatment for depression.

    David Agus tackles these fundamental questions and dismantles misperceptions about what “health” really means. Presenting an eye-opening picture of the human body and all the ways it works—and fails—Dr. Agus shows us how a new perspective on our individual health will allow us to achieve a long, vigorous life. Offering insights and access to powerful new technologies that promise to transform medicine, Dr. Agus emphasizes his belief that there is no “right” answer, no master guide that is “one size fits all.” Each one of us must get to know our bodies in uniquely personal ways, and he shows us exactly how to do that. A bold call for all of us to become our own personal health advocates, The End of Illness is a moving departure from orthodox thinking.

    Together they spent a combined thirty years in prison before finally being exonerated in 2008. Meanwhile, the real killer remained free.The Cadaver King and the Country Dentist chronicles how the courts and Mississippi's death investigation system--a relic of the Jim Crow era--failed to deliver justice for its citizens and recounts the horrifying story of the two men who built successful careers on the back of this system. For nearly two decades, medical examiner Dr. Steven Hayne performed the vast majority of Mississippi's autopsies, while his friend Dr. Michael West, a local dentist, pitched himself as a forensic jack-of-all-trades. Together they became the go-to experts for prosecutors and helped put countless Mississippians in prison. But then some of those convictions began to fall apart. Radley Balko and Tucker Carrington argue that bad forensics, structural racism, and institutional failures are at fault, and raise sobering questions about our criminal justice system's ability to address them.

      Along the way, he reveals the untold story of Hans Asperger, the father of Asperger’s syndrome, whose “little professors” were targeted by the darkest social-engineering experiment in human history; exposes the covert campaign by child psychiatrist Leo Kanner to suppress knowledge of the autism spectrum for fifty years; and casts light on the growing movement of "neurodiversity" activists seeking respect, support, technological innovation, accommodations in the workplace and in education, and the right to self-determination for those with cognitive differences.

    Bitches are moody. To succeed in life, we are told, we must have it all under control. We have to tamp down our inherent shifts in favor of a more static way of being. But our bodies are wiser than we imagine. Moods are not an annoyance to be stuffed away. They are a finely-tuned feedback system that, if heeded, can tell us how best to manage our lives. Our changing moods let us know when our bodies are primed to tackle different challenges and when we should be alert to developing problems. They help us select the right tool for each of our many jobs. If we deny our emotionality, we deny the breadth of our talents. With the right care of our inherently dynamic bodies, we can master our moods to avail ourselves of this great natural strength.  Yet millions of American women are medicating away their emotions because our culture says that moodiness is a problem to be fixed. One in four of us takes a psychiatric drug. If you add sleeping pills to the mix, the statistics become considerably higher. Over-prescribed medications can have devastating consequences for women in many areas of our lives: sex, relationships, sleep, eating, focus, balance, and aging.  And even if we don’t pop a pill, women everywhere are numbing their emotions with food, alcohol, and a host of addictive behaviors that deny the wisdom of our bodies and keep us from addressing the real issues that we face. Dr. Julie Holland knows there is a better way. She’s been sharing her frank and funny wisdom with her patients for years, and in Moody Bitches Dr. Holland offers readers a guide to our bodies and our moodiness that includes insider information about the pros and cons of the drugs we’re being offered, the direct link between food and mood, an honest discussion about sex, practical exercise and sleep strategies, as well as some surprising and highly effective natural therapies that can help us press the reset button on our own bodies and minds. In the tradition of Our Bodies, Our Selves, this groundbreaking guide for women of all ages will forge a much needed new path in women’s health—and offer women invaluable information on how to live better, and be more balanced, at every stage of life.

    For two decades, historian Alice Dreger has led a life of extraordinary engagement, combining activist service to victims of unethical medical research with defense of scientists whose work has outraged identity politics activists. With spirit and wit, Dreger offers in Galileo’s Middle Finger an unforgettable vision of the importance of rigorous truth seeking in today’s America, where both the free press and free scholarly inquiry struggle under dire economic and political threats.This illuminating chronicle begins with Dreger’s own research into the treatment of people born intersex (once called hermaphrodites). Realization of the shocking surgical and ethical abuses conducted in the name of “normalizing” intersex children’s gender identities moved Dreger to become an internationally recognized patient rights’ activist. But even as the intersex rights movement succeeded, Dreger began to realize how some fellow progressive activists were employing lies and personal attacks to silence scientists whose data revealed uncomfortable truths about humans. In researching one such case, Dreger suddenly became the target of just these kinds of attacks.Troubled, she decided to try to understand more—to travel the country to ferret out the truth behind various controversies, to obtain a global view of the nature and costs of these battles. Galileo’s Middle Finger describes Dreger’s long and harrowing journeys between the two camps for which she felt equal empathy: social justice activists determined to win and researchers determined to put hard truths before comfort. Ultimately what emerges is a lesson about the intertwining of justice and of truth—and a lesson of the importance of responsible scholars and journalists to our fragile democracy.

    With a brief history of the whole universe, you’ll be left scratching your head and gazing up in absolute wonder.Everything you thought you could never understand about the universe is explained in plain-old filthy English. Giving you a little taste of the glorious reality you inhabit by providing an introduction to some of the incredible stuff out there.Over 50 chapters on subjects including:What actually happened during the big bangblack holestime travelthe degenerate astronomer who drank all night and died from holding his bladder… and also lost his nose in a duel the things you take for granted until you really think about them; like matter – what the fuck is all this shit that we are?Space is Cool as Fuck features more than 100 wild artworks, photographs and illustrations from 40 international young artists curated by brilliant designer Cynthia Larenas. From hand-picked unknowns like Kate Kurucz and Adrian du P.B. through up-and-comers like Aida Azin, Waiton Fong and Cal Sinadinovic, to the more established Kareena Zerefos, Chrissie Abbot, Uno Moralez, Regan Tanamui (Ha Ha) and Marina Zumi, each artist brings their own aesthetic to the majesty and wonder of space giving the book its exquisitely eclectic style.For more information on Lost the Plot, visit ltpbooks.com

    But why are they on the rise?     Science writer Moises Velasquez-Manoff offers a new and controversial way of thinking about autoimmune disease—one that may foster a paradigm shift in the way we think about health and hygiene.     In the early twentieth century, the dawn of improved hygiene, water treatment, vaccines, and antibiotics saved countless lives, eradicating diseases that had plagued humanity for millennia. But in the wake of this triumph, a new threat arose: The human immune system began to malfunction.     A growing body of evidence suggests that the very steps we took to cure these maladies have also eradicated organisms that once kept our bodies in balance. To combat this “epidemic of absence,” a group of scientists has begun deliberately reintroducing parasitic worms—helminthes—to calm the immune system of their hosts. This book takes a close look at the scientists at the vanguard of “worm therapy,” which has been proven to not only preempt immune malfunction, but to send a number of disorders—from Crohn’s Disease to multiple sclerosis to asthma—into remission.     Exploring the greater context of rampant immune system dysfunction in the developed world, and its implications for developing countries, Velasquez-Manoff offers an eye-opening and elegant portrait of science’s new view of the human organism.