But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    As Moe came to terms with his own illness, he began to see similar patterns of behavior and coping mechanisms surfacing in conversations with others, including high-profile comedians who'd struggled with the disease. Moe saw that there was tremendous comfort and community in open dialogue about these shared experiences and that humor had a unique power. Thus was born the podcast The Hilarious World of Depression.Inspired by the immediate success of the podcast, Moe has written a remarkable investigation of the disease, part memoir of his own journey, part treasure trove of laugh-out-loud stories and insights drawn from years of interviews with some of the most brilliant minds facing similar challenges. Throughout the course of this powerful narrative, depression's universal themes come to light, among them, struggles with identity, lack of understanding of the symptoms, the challenges of work-life, self-medicating, the fallout of the disease in the lives of our loved ones, the tragedy of suicide, and the hereditary aspects of the disease.The Hilarious World of Depression illuminates depression in an entirely fresh and inspiring way.

    Their family farm in the Lake District hills was part of an ancient agricultural landscape: a patchwork of crops and meadows, of pastures grazed with livestock, and hedgerows teeming with wildlife. And yet, by the time James inherited the farm, it was barely recognizable. The men and women had vanished from the fields; the old stone barns had crumbled; the skies had emptied of birds and their wind-blown song.Pastoral Song is the story of an inheritance: one that affects us all. It tells of how rural landscapes around the world were brought close to collapse, and the age-old rhythms of work, weather, community and wild things were lost. And yet this elegy from the northern fells is also a song of hope: of how, guided by the past, one farmer began to salvage a tiny corner of England that was now his, doing his best to restore the life that had vanished and to leave a legacy for the future.This is a book about what it means to have love and pride in a place, and how, against all the odds, it may still be possible to build a new pastoral: not a utopia, but somewhere decent for us all.

    But do those of us who accept the reality of human-caused climate change truly believe it? If we did, surely we would be roused to act on what we know. Will future generations distinguish between those who didn’t believe in the science of global warming and those who said they accepted the science but failed to change their lives in response?In We Are the Weather, Jonathan Safran Foer explores the central global dilemma of our time in a surprising, deeply personal, and urgent new way. The task of saving the planet will involve a great reckoning with ourselves—with our all-too-human reluctance to sacrifice immediate comfort for the sake of the future. We have, he reveals, turned our planet into a farm for growing animal products, and the consequences are catastrophic. Only collective action will save our home and way of life. And it all starts with what we eat—and don’t eat—for breakfast.

    I order another bourbon, neat. This is the drink that will flip the switch. I don’t even know how I got here, to this place, to this point. Something is happening to me lately. I’m drinking too much. My sheets are soaking wet when I wake up from nightmares of decaying corpses. I order another drink and swig it, trying to forget about the latest case I can’t shake.Crime-solving for me is more complex than the challenge of the hunt, or the process of piecing together a scientific puzzle. The thought of good people suffering drives me, for better or worse, to the point of obsession.People always ask how I am able to detach from the horrors of my work. Part of it is an innate capacity to compartmentalize; the rest is experience and exposure, and I’ve had plenty of both. But I had always taken pride in the fact that I can keep my feelings locked up to get the job done. It’s only been recently that it feels like all that suppressed darkness is beginning to seep out.When I look back at my long career, there is a lot I am proud of. I have caught some of the most notorious killers of the twenty-first century and brought justice and closure for their victims and families. I want to tell you about a lifetime solving these cold cases, from Laci Peterson to Jaycee Dugard to the Pittsburg homicides to, yes, my twenty-year-long hunt for the Golden State Killer.But a deeper question eats at me as I ask myself, at what cost? I have sacrificed relationships, joy—even fatherhood—because the pursuit of evil always came first. Did I make the right choice? It’s something I grapple with every day. Yet as I stand in the spot where a young girl took her last breath, as I look into the eyes of her family, I know that, for me, there has never been a choice. “I don’t know if I can solve your case,” I whisper. “But I promise I will do my best.”It is a promise I know I can keep.“Paul Holes takes you on a fascinating and sometimes disturbing journey inside the mind of someone who hunts monsters for a living—and in order to live. And his insights on Michelle McNamara—whose loss I still feel every day—are incredible.”—Patton Oswalt"Paul Holes is a natural criminal profiler with a talent for describing how the process works. In his book, Unmasked, he marches the reader into the real world of criminal behavior and blends his forensic expertise with his unfiltered personal life experiences as he tackles both cold cases and modern crimes. This is a book you will not be able to put down.”—Dr. Ann Wolbert Burgess, author of A Killer by Design and co-author of Sexual Homicide

    Parenting is stressful, children are insane, and you’re only human. Carla Naumburg, PhD, a clinical social worker, was so at a loss with her daughters that she found herself Googling “how to stop yelling at my kids” during a particularly grueling evening. That moment led to this book—a short, empathic, insight-packed, and tip-filled program for how to manage your triggers, stop the meltdowns, and become a calmer, happier parent with calmer, happier kids.How to Stop Losing Your Sh*t with Your Kids not only explains why we explode at our children but also teaches us everything we need to know to decrease stress and increase patience, even in the most challenging family moments. Based on recent research and evidence-based practices, and written in the warm, funny, instantly relatable tone of a parent who’s been there, the book guides even the most harried parents toward a new way of engaging with their children. Readers will come away feeling less ashamed and more empowered to get their sh*t together, instead of losing it.

    Wilson has distilled sixty years of teaching into a book for students, young and old. Reflecting on his coming-of-age in the South as a Boy Scout and a lover of ants and butterflies, Wilson threads these twenty-one letters, each richly illustrated, with autobiographical anecdotes that illuminate his career--both his successes and his failures--and his motivations for becoming a biologist. At a time in human history when our survival is more than ever linked to our understanding of science, Wilson insists that success in the sciences does not depend on mathematical skill, but rather a passion for finding a problem and solving it. From the collapse of stars to the exploration of rain forests and the oceans' depths, Wilson instills a love of the innate creativity of science and a respect for the human being's modest place in the planet's ecosystem in his readers.

    We're going to exercise more and get in shape! Then five days a week at the gym turns into two... then becomes none. We hit the snooze button and skip the morning run. We really do want to be healthy and fit, but we're over whelmed and overextended—and exercise feels like another chore to complete. Is it any wonder we don't stick with it? Behavior expert Michelle Segar has devoted her career to the science of motivation. In No Sweat, she reveals that while "better health" or "weight loss" sound like strong incentives, human beings are hardwired to choose immediate gratification over delayed benefits. In other words, we're not going to exercise unless it makes us happy right now. So what's the solution? To achieve lasting fitness, we have to change our minds—before we can change our bodies. In No Sweat, Segar shows us how. Translating twenty years of research on exercise and motivation into a simple four-point program, she helps readers broaden their definition of exercise, find pleasure in physical activity, and discover realistic ways to fit it into their lives. Activities we enjoy, we repeat--making this evidence-based system more sustainable in the long run than a regimen of intense workouts. Even if we don't sweat, we really benefit. The success of the clients Segar has coached testifies to the power of her program. Their stories punctuate the book, entertaining and emboldening readers to break the cycle of exercise failure once and for all. Complete with worksheets, tips, and techniques, getting in shape has never been so easy—or so much fun.

    Dave Goulson has always been obsessed with wildlife, from his childhood menagerie of exotic pets and dabbling in experimental taxidermy to his groundbreaking research into the mysterious ways of the bumblebee and his mission to protect our rarest bees. Once commonly found in the marshes of Kent, the short-haired bumblebee now only exists in the wilds of New Zealand, the descendants of a few queen bees shipped over in the nineteenth century. Dave Goulson's passionate drive to reintroduce it to its native land is one of the highlights of a book that includes exclusive research into these curious creatures, history's relationship with the bumblebee and advice on how to protect it for all time. One of the UK's most respected conservationists and the founder of the Bumblebee Conservation Trust, Goulson combines Gerald Durrell-esque tales of a child's growing passion for nature with a deep insight into the crucial importance of the bumblebee. He details the minutiae of life in their nests, sharing fascinating research into the effects intensive farming has had on our bee populations and on the potential dangers if we are to continue down this path.

    At 11 she won her first international prize. She worked with many violins, waiting for the day she would play 'the one'. At 21 she found it: a rare 1696 Stradivarius, perfectly suited to her build and temperament. Her career soared. She recorded the Brahms concerto and a world tour was planned.Then, in a train station café, her violin was stolen. In an instant her world collapsed. She descended into a terrifying limbo land, unable to play another note.This is Min's extraordinary story - of a young woman staring into the void, wondering who she was, who she had been. It is a story of isolation and dependence, of love, loss and betrayal, and the intense, almost human bond that a musician has with their instrument. Above all it's a story of hope through a journey back to music.

    No one knows this better than author, naturalist, and adventurer Sy Montgomery. To research her books, Sy has traveled the world and encountered some of the planet's rarest and most beautiful animals. From tarantulas to tigers, Sy's life continually intersects with and is informed by the creatures she meets. This restorative memoir reflects on the personalities and quirks of thirteen animals--Sy's friends--and the truths revealed by their grace. It also explores vast themes: the otherness and sameness of people and animals; the various ways we learn to love and become empathetic; how we find our passion; how we create our families; coping with loss and despair; gratitude; forgiveness; and most of all, how to be a good creature in the world.

    Jen Gunter, the internet’s most fearless advocate for women’s health, brings you empowerment through knowledge by countering stubborn myths and misunderstandings about menopause with hard facts, real science, fascinating historical perspective, and expert advice.The only thing predictable about menopause is its unpredictability. Factor in widespread misinformation, a lack of research, and the culture of shame around women's bodies, and it's no wonder women are unsure what to expect during the menopause transition and beyond.Menopause is not a disease--it's a planned change, like puberty. And just like puberty, we should be educated on what's to come years in advance, rather than the current practice of leaving people on their own with bothersome symptoms and too much conflicting information. Knowing what is happening, why, and what to do about it is both empowering and reassuring.Frank and funny, Dr. Jen debunks misogynistic attitudes and challenges theover-mystification of menopause to reveal everything you really need to know about:- Perimenopause - Hot flashes - Sleep disruption - Sex and libido - Depression and mood changes - Skin and hair issues - Outdated therapies - Breast health - Weight and muscle mass - Health maintenance screening - And much more!Filled with practical, reassuring information, this essential guide will revolutionize how women experience menopause--including how their lives can be even better for it!

    Mapped by John Smith in 1608, settled during the American Revolution, the tiny sliver of mud is home to 470 hardy people who live an isolated and challenging existence, with one foot in the 21st century and another in times long passed. They are separated from their countrymen by the nation’s largest estuary, and a twelve-mile boat trip across often tempestuous water—the same water that for generations has made Tangier’s fleet of small fishing boats a chief source for the rightly prized Chesapeake Bay blue crab, and has lent the island its claim to fame as the softshell crab capital of the world.Yet for all of its long history, and despite its tenacity, Tangier is disappearing. The very water that has long sustained it is erasing the island day by day, wave by wave. It has lost two-thirds of its land since 1850, and still its shoreline retreats by fifteen feet a year—meaning this storied place will likely succumb first among U.S. towns to the effects of climate change. Experts reckon that, barring heroic intervention by the federal government, islanders could be forced to abandon their home within twenty-five years. Meanwhile, the graves of their forebears are being sprung open by encroaching tides, and the conservative and deeply religious Tangiermen ponder the end times.Chesapeake Requiem is an intimate look at the island’s past, present and tenuous future, by an acclaimed journalist who spent much of the past two years living among Tangier’s people, crabbing and oystering with its watermen, and observing its long traditions and odd ways. What emerges is the poignant tale of a world that has, quite nearly, gone by—and a leading-edge report on the coming fate of countless coastal communities.

    Our Big Bang, our distant future, parallel worlds, the sub-atomic and intergalactic - none of them are what they seem. But there is a way to understand this immense strangeness - mathematics. Seeking an answer to the fundamental puzzle of why our universe seems so mathematical, Tegmark proposes a radical idea: that our physical world not only is described by mathematics, but that it is mathematics. This may offer answers to our deepest questions: How large is reality? What is everything made of? Why is our universe the way it is?Table of ContentsPreface 1 What Is Reality? Not What It Seems • What’s the Ultimate Question? • The Journey Begins Part One: Zooming Out 2 Our Place in Space Cosmic Questions • How Big Is Space? • The Size of Earth • Distance to the Moon • Distance to the Sun and the Planets • Distance to the Stars • Distance to the Galaxies • What Is Space? 3 Our Place in TimeWhere Did Our Solar System Come From? • Where Did theGalaxies Come From? • Where Did the Mysterious MicrowavesCome From? • Where Did the Atoms Come From? 4 Our Universe by NumbersWanted: Precision Cosmology • Precision Microwave-Background Fluctuations • Precision Galaxy Clustering • The Ultimate Map of Our Universe • Where Did Our Big Bang Come From? 5 Our Cosmic Origins What’s Wrong with Our Big Bang? • How Inflation Works • The Gift That Keeps on Giving • Eternal Inflation 6 Welcome to the Multiverse The Level I Multiverse • The Level II Multiverse • Multiverse Halftime Roundup Part Two: Zooming In 7 Cosmic Legos Atomic Legos • Nuclear Legos • Particle-Physics Legos • Mathematical Legos • Photon Legos • Above the Law? • Quanta and Rainbows • Making Waves • Quantum Weirdness • The Collapse of Consensus • The Weirdness Can’t Be Confined • Quantum Confusion 8 The Level III Multiverse The Level III Multiverse • The Illusion of Randomness • Quantum Censorship • The Joys of Getting Scooped • Why Your Brain Isn’t a Quantum Computer • Subject, Object and Environment • Quantum Suicide • Quantum Immortality? • Multiverses Unified • Shifting Views: Many Worlds or Many Words? Part Three: Stepping Back 9 Internal Reality, External Reality and Consensus Reality External Reality and Internal Reality • The Truth, the Whole Truth and Nothing but the Truth • Consensus Reality • Physics: Linking External to Consensus Reality 10 Physical Reality and Mathematical Reality Math, Math Everywhere! • The Mathematical Universe Hypothesis • What Is a Mathematical Structure? 11 Is Time an Illusion? How Can Physical Reality Be Mathematical? • What Are You? • Where Are You? (And What Do You Perceive?) • When Are You? 12 The Level IV Multiverse Why I Believe in the Level IV Multiverse • Exploring the Level IV Multiverse: What’s Out There? • Implications of the Level IV Multiverse • Are We Living in a Simulation? • Relation Between the MUH, the Level IV Multiverse and Other Hypotheses •Testing the Level IV Multiverse 13 Life, Our Universe and Everything How Big Is Our Physical Reality? • The Future of Physics • The Future of Our Universe—How Will It End? • The Future of Life •The Future of You—Are You Insignificant? Acknowledgments Suggestions for Further Reading Index

    It was first published in 1789 by his brother Benjamin. It has been continuously in print since then, with nearly 300 editions up to 2007