With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Full of extraordinary facts and astonishing stories, The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological make up.A wonderful successor to A Short History of Nearly Everything, this book will have you marvelling at the form you occupy, and celebrating the genius of your existence, time and time again.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    They have presided over multinational feminist organizations and written much of what we consider the feminist canon, espousing sexual liberation and satisfaction, LGBTQ inclusion, and racial solidarity, all while branding the language of the movement itself in whiteness and speaking over Black and Brown women in an effort to uphold privilege and perceived cultural superiority. An American Muslim woman, attorney, and political philosopher, Rafia Zakaria champions a reconstruction of feminism in Against White Feminism, centering women of color in this transformative overview and counter-manifesto to white feminism’s global, long-standing affinity with colonial, patriarchal, and white supremacist ideals.Covering such ground as the legacy of the British feminist imperialist savior complex and “the colonial thesis that all reform comes from the West” to the condescension of the white feminist–led “aid industrial complex” and the conflation of sexual liberation as the “sum total of empowerment,” Zakaria follows in the tradition of intersectional feminist forebears Kimberlé Crenshaw, Adrienne Rich, and Audre Lorde. Zakaria ultimately refutes and reimagines the apolitical aspirations of white feminist empowerment in this staggering, radical critique, with Black and Brown feminist thought at the forefront.

    A bacha posh (literally translated from Dari as "dressed up like a boy") is a third kind of child – a girl temporarily raised as a boy and presented as such to the outside world. Jenny Nordberg, the reporter who broke the story of this phenomenon for the New York Times, constructs a powerful and moving account of those secretly living on the other side of a deeply segregated society where women have almost no rights and little freedom. The Underground Girls of Kabul is anchored by vivid characters who bring this remarkable story to life: Azita, a female parliamentarian who sees no other choice but to turn her fourth daughter Mehran into a boy; Zahra, the tomboy teenager who struggles with puberty and refuses her parents' attempts to turn her back into a girl; Shukria, now a married mother of three after living for twenty years as a man; and Nader, who prays with Shahed, the undercover female police officer, as they both remain in male disguise as adults. At the heart of this emotional narrative is a new perspective on the extreme sacrifices of Afghan women and girls against the violent backdrop of America's longest war. Divided into four parts, the book follows those born as the unwanted sex in Afghanistan, but who live as the socially favored gender through childhood and puberty, only to later be forced into marriage and childbirth. The Underground Girls of Kabul charts their dramatic life cycles, while examining our own history and the parallels to subversive actions of people who live under oppression everywhere.

    In Will My Cat Eat My Eyeballs?, best-selling author and mortician Caitlin Doughty answers the most intriguing questions she’s ever received about what happens to our bodies when we die. In a brisk, informative, and morbidly funny style, Doughty explores everything from ancient Egyptian death rituals and the science of skeletons to flesh-eating insects and the proper depth at which to bury your pet if you want Fluffy to become a mummy. Now featuring an interview with a clinical expert on discussing these issues with young people—the source of some of our most revealing questions about death—Will My Cat Eat My Eyeballs? confronts our common fear of dying with candid, honest, and hilarious facts about what awaits the body we leave behind.

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    Twenty-Three Leading Feminist Writers on Protest and SolidarityWhen 53 percent of white women voted for Donald Trump and 94 percent of black women voted for Hillary Clinton, how can women unite in Trump's America? Nasty Women includes inspiring essays from a diverse group of talented women writers who seek to provide a broad look at how we got here and what we need to do to move forward.Featuring essays by REBECCA SOLNIT on Trump and his "misogyny army," CHERYL STRAYED on grappling with the aftermath of Hillary Clinton's loss, SARAH HEPOLA on resisting the urge to drink after the election, NICOLE CHUNG on family and friends who support Trump, KATHA POLLITT on the state of reproductive rights and what we do next, JILL FILIPOVIC on Trump's policies and the life of a young woman in West Africa, SAMANTHA IRBY on racism and living as a queer black woman in rural America, RANDA JARRAR on traveling across the country as a queer Muslim American, SARAH HOLLENBECK on Trump's cruelty toward the disabled, MEREDITH TALUSAN on feminism and the transgender community, and SARAH JAFFE on the labor movement and active and effective resistance, among others.

    Some disabilities are visible, others less apparent—but all are underrepresented in media and popular culture. Now, just in time for the thirtieth anniversary of the Americans with Disabilities Act, activist Alice Wong brings together this urgent, galvanizing collection of contemporary essays by disabled people.From Harriet McBryde Johnson’s account of her debate with Peter Singer over her own personhood to original pieces by authors like Keah Brown and Haben Girma; from blog posts, manifestos, and eulogies to Congressional testimonies, and beyond: this anthology gives a glimpse into the rich complexity of the disabled experience, highlighting the passions, talents, and everyday lives of this community. It invites readers to question their own understandings. It celebrates and documents disability culture in the now. It looks to the future and the past with hope and love.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    The Geek Feminist Revolution also features several entirely new essays written specifically for this volume.Unapologetically outspoken, Hurley has contributed essays to The Atlantic, Locus, Tor.com, and elsewhere on the rise of women in genre, her passion for science fiction and fantasy, and the diversification of publishing.

    However, the iconic women of the 1990s—such as Hillary Clinton, Courtney Love, Roseanne Barr, Marcia Clark, and Anita Hill—earned their places in history not as trailblazers, but as whipping girls of the media. During this decade, American society grew increasingly hostile to women who dared to speak up, challenge power, or defy rigid expectations for female behavior.Deeply researched yet thoroughly engaging, 90s Bitch untangles the complex history of women in the 1990s, exploring how they were maligned by the media, vilified by popular culture, and objectified in the marketplace. In an age where even a presidential nominee can be derided as a “nasty woman,” it’s clear that the epidemic of casting women as bitches persists. To understand why we must take a long, hard look back at the 1990s—a decade in which female empowerment was twisted into bitchification and exploitation.Yarrow’s thoughtful, clear-eyed, and timely examination is a must-read for anyone seeking to understand gender politics and how we might end the “bitch epidemic” for the next generation.

    of California, Irvine) explores the historical development of prothin, antifat ideologies deployed in support of Western, patriarchal white supremacy. Beginning in the aesthetic ideals circulated by Renaissance thinkers and artists and bringing her narrative up into the 1990s, Strings charts how white Europeans and Anglo-Americans developed ideals of race and beauty that both explicitly and figuratively juxtaposed slim, desirable white women against corpulent, seemingly monstrous black women. The work is divided into three sections. The two chapters in the first part consider how Renaissance white women and women of color were depicted as plump and feminine, separated by class, yet belonging to the same gender. The second part of the work charts the rise of modern racial ideologies that yoked feminine beauty to Protestant, Anglo-Saxon whiteness. Later chapters and the epilogue consider how Americans normalized the "scientific management" of white women's bodies for the purpose of racial uplift, a project that continued to situate black women as the embodied Other. The author does not address fat from the angle of health or previous attitudes white Europeans held towards corpulence.

    Many women are repeat callers: on average, they will go back to an abusive partner eight times before leaving for good.‘You must get so frustrated when you think a woman’s ready to leave and then she decides to go back,’ I say.‘No,’ replies one phone counsellor, pointedly. ‘I’m frustrated that even though he promised to stop, he chose to abuse her again.’Women are abused or killed by their partners at astonishing rates: in Australia, almost 17 per cent of women over the age of fifteen – one in six – have been abused by an intimate partner.In this confronting and deeply researched account, journalist Jess Hill uncovers the ways in which abusers exert control in the darkest – and most intimate – ways imaginable. She asks: What do we know about perpetrators? Why is it so hard to leave? What does successful intervention look like?What emerges is not only a searing investigation of the violence so many women experience, but a dissection of how that violence can be enabled and reinforced by the judicial system we trust to protect us.Combining exhaustive research with riveting storytelling, See What You Made Me Do dismantles the flawed logic of victim-blaming and challenges everything you thought you knew about domestic and family violence.

    But as Jane Mayer shows in this powerful, meticulously reported history, a network of exceedingly wealthy people with extreme libertarian views bankrolled a systematic, step-by-step plan to fundamentally alter the American political system.The network has brought together some of the richest people on the planet. Their core beliefs—that taxes are a form of tyranny; that government oversight of business is an assault on freedom—are sincerely held. But these beliefs also advance their personal and corporate interests: Many of their companies have run afoul of federal pollution, worker safety, securities, and tax laws.The chief figures in the network are Charles and David Koch, whose father made his fortune in part by building oil refineries in Stalin’s Russia and Hitler’s Germany. The patriarch later was a founding member of the John Birch Society, whose politics were so radical it believed Dwight Eisenhower was a communist. The brothers were schooled in a political philosophy that asserted the only role of government is to provide security and to enforce property rights.When libertarian ideas proved decidedly unpopular with voters, the Koch brothers and their allies chose another path. If they pooled their vast resources, they could fund an interlocking array of organizations that could work in tandem to influence and ultimately control academic institutions, think tanks, the courts, statehouses, Congress, and, they hoped, the presidency. Richard Mellon Scaife, the mercurial heir to banking and oil fortunes, had the brilliant insight that most of their political activities could be written off as tax-deductible “philanthropy.”These organizations were given innocuous names such as Americans for Prosperity. Funding sources were hidden whenever possible. This process reached its apotheosis with the allegedly populist Tea Party movement, abetted mightily by the Citizens United decision—a case conceived of by legal advocates funded by the network.The political operatives the network employs are disciplined, smart, and at times ruthless. Mayer documents instances in which people affiliated with these groups hired private detectives to impugn whistle-blowers, journalists, and even government investigators. And their efforts have been remarkably successful. Libertarian views on taxes and regulation, once far outside the mainstream and still rejected by most Americans, are ascendant in the majority of state governments, the Supreme Court, and Congress. Meaningful environmental, labor, finance, and tax reforms have been stymied.Jane Mayer spent five years conducting hundreds of interviews-including with several sources within the network-and scoured public records, private papers, and court proceedings in reporting this book. In a taut and utterly convincing narrative, she traces the byzantine trail of the billions of dollars spent by the network and provides vivid portraits of the colorful figures behind the new American oligarchy.Dark Money is a book that must be read by anyone who cares about the future of American democracy.