The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Turn to any page, and you'll find essential point-of-care guidance on all the major conditions seen in clinical medicine. Completely updated to reflect all the major advances and new clinical developments, the new edition of the Manual is the most indispensable yet. It continues to focus on diagnosis and therapy with an emphasis on patient care and offers authoritative, high-yield coverage of: Etiology and epidemiology Clinically relevant pathophysiology Signs & Symptoms o Differential Diagnosis Physical and Laboratory Findings Therapeutics o Practice GuidelinesNEW FEATURESFull-color presentation for the first time!Full-color images of clinical conditions encountered in dermatology, cardiology, and eye diseases New chapters on end-of-life care, congenital heart disease in the adult patient, non-invasive cardiac examination, and metabolic syndromeLook for these other great Harrison's titles:Harrison's Principles of Internal Medicine, 17eHarrison's Online available through Accessmedicine.com

    This new edition continues its tradition of providing the most comprehensive and up-to-date content available today. New chapters on medical nutrition therapy for psychiatric disease and developmental disorders spotlight the advances made in these areas. Extensive appendices, tables, illustrations, figures, and clinical insight boxes give practical hands-on procedures and clinical tools with the most current information, including brand-new guidelines on food intake and physical activity, and highlight the inclusion of the new food guide pyramid, MyPyramid, to use in everyday practice.Edited by two leading experts in nutrition, L. Kathleen Mahan and Sylvia Escott-Stump, and written by nationally recognized contributors to ensure that all information is comprehensive and current.Hundreds of full-color illustrations bring nutrition therapy to life and provide a realistic representation of clinical practice.UNIQUE! Pathophysiology algorithms present the cause, pathophysiology, and the medical nutrition management for a variety of disorders and conditions, helping you better understand the illness process and provide optimum nutritional care.Clinical Insight, New Directions, and Focus On... boxes provide additional information and suggest further discussion, study, or research.Clinical Scenarios offer case studies that help you apply what you've learned to real-world situations.Relevant websites direct you to online resources for further information on specific chapter topics.Key Terms are defined at the beginning of each chapter and highlighted within the text to help you focus your study and test your mastery of the information.Evolve Student Resource contains WebLinks and more than 1,000 self-assessment study questions that provide instant feedback.Medical Nutrition Therapy for Psychiatric Conditions chapter explores recent research into the links between nutrition and mental disorders such as Alzheimer's disease, anxiety disorder, bipolar disorder, dementia, depression, and schizophrenia.Medical Nutrition Therapy for Developmental Disabilities chapter looks at the unique nutritional needs of individuals with ADHD, Downs syndrome, cerebral palsy, and muscular dystrophy and the role medical nutrition therapy plays in providing effective care.Information on energy, macronutrients, vitamins, and minerals is now summarized in easy-to-read, need-to-know tables and bulleted lists, providing a quick review of basic nutrition.Updated information on the Dietary Guidelines for Americans 2005 and MyPyramid presents information on the newest recommendations for nutrients and physical activity throughout the text, while integrating the customizable MyPyramid into plans of care.Sample Nutrition Diagnosis boxes in each chapter present a problem, its etiology, and its signs and symptoms before concluding with a sample nutrition diagnosis, providing you with real-life scenarios you may encounter in practice.Nutritional Facts in the appendices put the content of the chapter into a practical and convenient format that students and dietetics professionals can use in their education of the client on necessary nutritional care.Updated content is provided on the new Dietary Reference Intakes, the 2000 Dietary Guidelines and Healthy People 2010.New information is included on type 2 diabetes and prediabetes.The newest guidelines released by the National Institute of Health to assist with implementing the DASH diet for effective management of hypertension.The latest information is presented on dietary supplementation and integrative care, with cutting-edge evidence of how the nursing care process is changing to provide better care.

    This guide provides explanations of eigenvalues, eigenvectors, linear transformations, linear equations, vectors, and matrices.

    It has dealt with issues of religious freedom, patriotism, terrorism, genetic engineering, and the ultimate science fiction question: what does it mean to be human? While the re-imagined BSG may not be packed with cool techie tools (the bad guys don't even have laser guns for frak's sake!), this book shows that the science in the series has a lot to say about the use of science and technology in our lives today.What are the principles behind artificial gravity and sublight propulsion? Are Cylons men or machines? How are humanoid Cylons able to interface with computers? By tackling these and other intriguing questions, The Science of Battlestar Galactica takes us billions of miles away from Earth so that we can turn around and see ourselves from a different perspective.Tackles fans' most pressing BSG questions, from how an FTL drive might work to how the 12 colonies of Kobol could co-exist to the principles behind Gaius Baltar's Cylon-detectorFeatures behind-the-scenes anecdotes, quotes from the BSG Series Bible, and over 60 photosIncludes a foreword by BSG co-executive producer, Jane Espenson, and an afterword by actor, Richard Hatch, who played Tom Zarek in the reimagined series and Captain Apollo in the classic seriesCo-written by BSG's scientific advisor and a Wired contributing editorPacked with must-know details and scientific background, this thought-provoking book will help you see Battlestar Galactica as never before.

    It's goal is the successful design and operation of chemical reactors. This text emphasizes qualitative arguments, simple design methods, graphical procedures, and frequent comparison of capabilities of the major reactor types. Simple ideas are treated first, and are then extended to the more complex.

    Things can exist in two places at once and travel backwards and forwards in time. Waves and particles are one and the same, and objects change their behaviour according to whether they are being watched. This is not some alternative universe but the realm of the very small, where quantum mechanics rules. In this weird world of atoms and their constituents, our common sense understanding of reality breaks down - yet quantum mechanics has never failed an experimental test. What does it all mean? For all its weirdness, quantum mechanics has given us many practical technologies including lasers and the transistors that underlie computers and all digital technology. In the future, it promises computers more powerful than any built before, the ability to communicate with absolute privacy, and even quantum teleportation. The Quantum World explores the past, present and future of quantum science, its applications and mind-bending implications. Discover how ideas from quantum mechanics are percolating out into the vast scale of the cosmos - perhaps, in the future, to reveal a new understanding of the big bang and the nature of space and time.ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

    This title is suitable for students preparing for careers in medicine, dentistry, nursing, and allied health, as well as research, teaching, and industry.

    In a self-contained manner it proceeds from mathematical and theoretical considerations to actual practical computer routines. With over 100 new routines bringing the total to well over 300, plus upgraded versions of the original routines, the new edition remains the most practical, comprehensive handbook of scientific computing available today.

    Polya, How to Solve It will show anyone in any field how to think straight. In lucid and appealing prose, Polya reveals how the mathematical method of demonstrating a proof or finding an unknown can be of help in attacking any problem that can be reasoned out--from building a bridge to winning a game of anagrams. Generations of readers have relished Polya's deft--indeed, brilliant--instructions on stripping away irrelevancies and going straight to the heart of the problem.

    Topics discussed include solid state physics, radioactivity, statistical physics, cosmology, astrophysics, the Schrodinger equation and more.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    This book applies the theory to the design of specialized audio spaces such as the home listening room, the control room, and the multi-track-recording studio.

    It covers topics ranging from personal responsibility and career development to architectural techniques for keeping your code flexible and easy to adapt and reuse. Read this book, and you'll learn how toFight software rot; Avoid the trap of duplicating knowledge; Write flexible, dynamic, and adaptable code; Avoid programming by coincidence; Bullet-proof your code with contracts, assertions, and exceptions; Capture real requirements; Test ruthlessly and effectively; Delight your users; Build teams of pragmatic programmers; and Make your developments more precise with automation. Written as a series of self-contained sections and filled with entertaining anecdotes, thoughtful examples, and interesting analogies, The Pragmatic Programmer illustrates the best practices and major pitfalls of many different aspects of software development. Whether you're a new coder, an experienced programmer, or a manager responsible for software projects, use these lessons daily, and you'll quickly see improvements in personal productivity, accuracy, and job satisfaction. You'll learn skills and develop habits and attitudes that form the foundation for long-term success in your career. You'll become a Pragmatic Programmer.

    No graduate student of quantum theory should leave it unread"--W.C Schieve, University of Texas