The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    Politicians and marketers present shoddy evidence for dubious claims all the time. But smart people make mistakes too, and when it comes to statistics, plenty of otherwise great scientists--yes, even those published in peer-reviewed journals--are doing statistics wrong."Statistics Done Wrong" comes to the rescue with cautionary tales of all-too-common statistical fallacies. It'll help you see where and why researchers often go wrong and teach you the best practices for avoiding their mistakes.In this book, you'll learn: - Why "statistically significant" doesn't necessarily imply practical significance- Ideas behind hypothesis testing and regression analysis, and common misinterpretations of those ideas- How and how not to ask questions, design experiments, and work with data- Why many studies have too little data to detect what they're looking for-and, surprisingly, why this means published results are often overestimates- Why false positives are much more common than "significant at the 5% level" would suggestBy walking through colorful examples of statistics gone awry, the book offers approachable lessons on proper methodology, and each chapter ends with pro tips for practicing scientists and statisticians. No matter what your level of experience, "Statistics Done Wrong" will teach you how to be a better analyst, data scientist, or researcher.

    With this guide, pioneering Go programmer Mark Summerfield shows how to write code that takes full advantage of Go's breakthrough features and idioms. Both a tutorial and a language reference, "Programming in Go" brings together all the knowledge you need to evaluate Go, think in Go, and write high-performance software with Go. Summerfield presents multiple idiom comparisons showing exactly how Go improves upon older languages, calling special attention to Go's key innovations. Along the way, he explains everything from the absolute basics through Go's lock-free channel-based concurrency and its flexible and unusual duck-typing type-safe approach to object-orientation. Throughout, Summerfield's approach is thoroughly practical. Each chapter offers multiple live code examples designed to encourage experimentation and help you quickly develop mastery. Wherever possible, complete programs and packages are presented to provide realistic use cases, as well as exercises. Coverage includes:-- Quickly getting and installing Go, and building and running Go programs -- Exploring Go's syntax, features, and extensive standard library -- Programming Boolean values, expressions, and numeric types -- Creating, comparing, indexing, slicing, and formatting strings -- Understanding Go's highly efficient built-in collection types: slices and maps -- Using Go as a procedural programming language -- Discovering Go's unusual and flexible approach to object orientation -- Mastering Go's unique, simple, and natural approach to fine-grained concurrency -- Reading and writing binary, text, JSON, and XML files -- Importing and using standard library packages, custom packages, and third-party packages -- Creating, documenting, unit testing, and benchmarking custom packages

    What is the meaning of life? What was Hitler's religion? What's the deal with the Flying Spaghetti Monster? And what was Mother Teresa's dark secret? This book is highly recommended for everyone curious about America's most misunderstood minority, as well as for those who wish to better understand their atheist friends, neighbors or coworkers.

    This methodology revealed distinct cyclical patterns that were used to provide the foundation for his forecasting. The wonderful advances in science add to the mix, but are tools to use, not answers that should automatically be accepted as we see with the climate agenda. The lesson in weather, in history, in anything, is that the foundation you stand on today is built from yesterday to reach for tomorrow. The book examines the clash between that philosophy and one that minimizes lessons of the past, or ignores them, and uses climate and weather to simply further an agenda that has very little to do with either. An uncurious media is a willing accomplice in advancing the missive to the population, The Climate Chronicles reveals that clash in an effort to get the reader to search beyond what they are told. As such its a must read for those seeking not an agenda driven answer, but the right answer, wherever it may lead them. Bastardi's goal is not to get you to blindly accept what he says, but to dig in and examine for yourself. The book shows, given the implications of not doing so, more is at stake than just tomorrows weather.

    Using graphics, checklists, and sample forms, this guide readies you for each step of the process, including selecting the committee, getting acclimated to academic writing, preparing for your oral defense, and publishing your research. New features include:A chapter on ethical considerations Expanded coverage of digital data collection and the Internet More detailed information on conducting the literature review A discussion of how to develop a theoretical or conceptual framework

    Fields Cookies... What backward messages on records are really trying to tell you... Frank Sinatra's real age... Why you can't counterfeit a lottery ticket... Barbra Streisand's blue movie... The other Boy Scout rituals... Ingmar Bergman's soap commercials... The formula for Play-Doh... and more.

    In this fascinating book, Mario Livio tells the tale of a number at the heart of that mystery: phi, or 1.6180339887...This curious mathematical relationship, widely known as "The Golden Ratio," was discovered by Euclid more than two thousand years ago because of its crucial role in the construction of the pentagram, to which magical properties had been attributed. Since then it has shown a propensity to appear in the most astonishing variety of places, from mollusk shells, sunflower florets, and rose petals to the shape of the galaxy. Psychological studies have investigated whether the Golden Ratio is the most aesthetically pleasing proportion extant, and it has been asserted that the creators of the Pyramids and the Parthenon employed it. It is believed to feature in works of art from Leonardo da Vinci's Mona Lisa to Salvador Dali's The Sacrament of the Last Supper, and poets and composers have used it in their works. It has even been found to be connected to the behavior of the stock market!The Golden Ratio is a captivating journey through art and architecture, botany and biology, physics and mathematics. It tells the human story of numerous phi-fixated individuals, including the followers of Pythagoras who believed that this proportion revealed the hand of God; astronomer Johannes Kepler, who saw phi as the greatest treasure of geometry; such Renaissance thinkers as mathematician Leonardo Fibonacci of Pisa; and such masters of the modern world as Goethe, Cezanne, Bartok, and physicist Roger Penrose. Wherever his quest for the meaning of phi takes him, Mario Livio reveals the world as a place where order, beauty, and eternal mystery will always coexist.From the Hardcover edition.

    trace the Black Hand's coalescence into an organisation whose insidious influence reached across the Atlantic and into a presidential administration. And they go behind the headlines to reveal with chilling clarity the true extent of the Mafia's influence today.

    It presents in a unified manner an introduction to the mathematical theory underlying computer graphic applications. It covers topics of keen interest to students in engineering and computer science: transformations, projections, 2-D and 3-D curve definition schemes, and surface definitions. It also includes techniques, such as B-splines, which are incorporated as part of the software in advanced engineering workstations. A basic knowledge of vector and matrix algebra and calculus is required.

    Pure Substances, The First And Second Laws, Gases, Psychrometrics, The Vapor, Gas And Refrigeration Cycles, Heat Transfer, Compressible Flow, Chemical Reactions, Fuels, And More Are Presented In Detail And Enhanced With Practical Applications. This Version Presents The Material Using SI Units And Has Ample Material On SI Conversion, Steam Tables, And A Mollier Diagram. A CD-ROM, Included With The Print Version Of The Text, Includes A Fully Functional Version Of Quickfield (Widely Used In Industry), As Well As Numerous Demonstrations And Simulations With MATLAB, And Other Third Party Software.

    Fully stocked with solved problemsN950 of themNit shows you how to solve problems that may not have been fully explained in class. Plus you ge"

    It's goal is the successful design and operation of chemical reactors. This text emphasizes qualitative arguments, simple design methods, graphical procedures, and frequent comparison of capabilities of the major reactor types. Simple ideas are treated first, and are then extended to the more complex.

    The book begins with the basic concepts of logic and set theory, to familiarize students with the language of mathematics and how it is interpreted. These concepts are used as the basis for a step-by-step breakdown of the most important techniques used in constructing proofs. To help students construct their own proofs, this new edition contains over 200 new exercises, selected solutions, and an introduction to Proof Designer software. No background beyond standard high school mathematics is assumed. Previous Edition Hb (1994) 0-521-44116-1 Previous Edition Pb (1994) 0-521-44663-5

    This completely updated bestseller was also written with photographers in mind. Author Martin Evening describes features in Lightroom 4 in detail from a photographer’s perspective. As an established commercial and fashion photographer, Martin knows firsthand what photographers need for an efficient workflow. He has also been working with Lightroom from the beginning, monitoring the product’s development and providing valued feedback to Adobe. As a result, Martin knows the software inside and out, from image selection to image editing to image management. In this book you’ll learn how to:• Work efficiently with images shot in the raw or JPEG format • Import photographs with ease and sort them according to your workflow• Create and manage a personal image library• Apply tonal adjustments to multiple images quickly• Integrate Lightroom with Adobe Photoshop• Export images for print or Web as digital contact sheets or personal portfolios• Make the most of new features in Lightroom 4, such as the Camera Raw Process 2012 Basic panel tone controlsPhotographers will find Lightroom 4–and The Adobe Photoshop Lightroom 4 Book–indispensable tools in their digital darkrooms.This book’s companion site, www.thelightroombook.com, offers video tutorials, articles, sample images, and updates from author Martin Evening.“With Martin’s expert guidance, you’ll soon find that you have precisely the tools you need to turn your concentration back where it belongs–on making better pictures!”–George Jardine, digital photography consultant “As a photographer himself, Martin Evening knows what tools photographers need to realize their creative vision. In this book, he shows not only how Adobe Photoshop Lightroom works but also why it will become an essential part of any photographer’s workflow.”–Greg Gorman, photographer