Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    The author argues for the preservation of the time and space in which to walk in an ever more car-dependent and accelerated world.

    Now this instant classic has been completely updated, outfitted with a whole new arsenal of indispensable knowledge on global affairs, popular culture, economic trends, scientific principles, and modern arts. Here's your chance to brush up on all those subjects you slept through in school, reacquaint yourself with all the facts you once knew (then promptly forgot), catch up on major developments in the world today, and become the Renaissance man or woman you always knew you could be! How do you tell the Balkans from the Caucasus? What's the difference between fission and fusion? Whigs and Tories? Shiites and Sunnis? Deduction and induction? Why aren't all Shakespearean comedies necessarily thigh-slappers? What are transcendental numbers and what are they good for? What really happened in Plato's cave? Is postmodernism dead or just having a bad hair day? And for extra credit, when should you use the adjective continual and when should you use continuous? An Incomplete Education answers these and thousands of other questions with incomparable wit, style, and clarity. American Studies, Art History, Economics, Film, Literature, Music, Philosophy, Political Science, Psychology, Religion, Science, and World History: Here's the bottom line on each of these major disciplines, distilled to its essence and served up with consummate flair.

    Dea Bala never expected the outpouring of responses that would follow. She was working as a lobbyist when the idea was born: she'd chat up respondents on the phone or at a coffee shop and let them tell her about their lives. Dea Bala soon had to quit her day job to make time for all of the Craigslist sessions. She took notes during each conversation and journaled about the emotional experience to expertly inhabit the voice of each subject. What emerges is a collection of narratives, all in first person, of anonymous people revealing their deepest, darkest secrets; or at least the most poignant moments of their lives. Infidelity, addiction, loss, corruption, the search for unconditional love—reading these carefully, empathetically crafted monologues reveals how suffering is something we all have in common. Each tragedy or triumph is unique, but the intensity of feeling is not.

    But as architect William McDonough and chemist Michael Braungart point out in this provocative, visionary book, such an approach only perpetuates the one-way, "cradle to grave" manufacturing model, dating to the Industrial Revolution, that creates such fantastic amounts of waste and pollution in the first place. Why not challenge the belief that human industry must damage the natural world? In fact, why not take nature itself as our model for making things? A tree produces thousands of blossoms in order to create another tree, yet we consider its abundance not wasteful but safe, beautiful, and highly effective.Waste equals food. Guided by this principle, McDonough and Braungart explain how products can be designed from the outset so that, after their useful lives, they will provide nourishment for something new. They can be conceived as "biological nutrients" that will easily reenter the water or soil without depositing synthetic materials and toxins. Or they can be "technical nutrients" that will continually circulate as pure and valuable materials within closed-loop industrial cycles, rather than being "recycled" -- really, downcycled -- into low-grade materials and uses. Drawing on their experience in (re)designing everything from carpeting to corporate campuses, McDonough and Braungart make an exciting and viable case for putting eco-effectiveness into practice, and show how anyone involved with making anything can begin to do as well.

    Its contributors—some of the most brilliant young scientists working today—provide not only an introduction to their cutting-edge research, but discuss the social, ethical, and philosophical ramifications of their work. With essays covering fields as diverse as astrophysics, paleoanthropology, climatology, and neuroscience, What's Next? is a lucid and informed guide to the new frontiers of science.

    Every person is wired for love differently, with different habits, needs, and reactions to conflict. The good news is that most people's minds work in predictable ways and respond well to security, attachment, and rituals, making it possible to actually neurologically prime the brain for greater love and fewer conflicts.Wired for Love is a complete insider’s guide to understanding your partner’s brain and enjoying a romantic relationship built on love and trust. Synthesizing research findings on how and why love lasts drawn from neuroscience, attachment theory, and emotion regulation, this book presents ten guiding principles that can improve any relationship.Strengthen your relationship by:Creating and maintaining a safe “couple bubble” Using morning and evening rituals to stay connected Learning to fight so that nobody loses Becoming the expert on what makes your partner feel loved By learning to use simple gestures and words, readers can learn to put out emotional fires and help their partners feel more safe and secure. The no-fault view of conflict in this book encourages readers to move past a "warring brain" mentality and toward a more cooperative "loving brain" understanding of the relationship. This book is essential reading for couples and others interested in understanding the complex dynamics at work behind love and trust in intimate relationships.While there’s no doubt that love is an inexact science, if you can discover how you and your partner are wired differently, you can overcome your differences to create a lasting intimate connection.

    Before humans ruled the earth, there were wolves. Once abundant in North America, these majestic creatures were hunted to near extinction in the lower 48 states by the 1920s. But in recent decades, conservationists have brought wolves back to the Rockies, igniting a battle over the very soul of the West.With novelistic detail, Nate Blakeslee tells the gripping story of one of these wolves, O-Six, a charismatic alpha female named for the year of her birth. Uncommonly powerful, with gray fur and faint black ovals around each eye, O-Six is a kind and merciful leader, a fiercely intelligent fighter, and a doting mother. She is beloved by wolf watchers, particularly renowned naturalist Rick McIntyre, and becomes something of a social media star, with followers around the world.But as she raises her pups and protects her pack, O-Six is challenged on all fronts: by hunters, who compete with wolves for the elk they both prize; by cattle ranchers who are losing livestock and have the ear of politicians; and by other Yellowstone wolves who are vying for control of the park’s stunningly beautiful Lamar Valley.These forces collide in American Wolf, a riveting multi-generational saga of hardship and triumph that tells a larger story about the ongoing cultural clash in the West—between those fighting for a vanishing way of life and those committed to restoring one of the country’s most iconic landscapes.

    Wars have been fought over it, revolutions have been triggered by it, national diets have been based on it, economies and livelihoods have depended on it. To the millions it has sustained, it has been a treasure more precious that gold. This book spans 1,000 years and four continents. From the Vikings to Clarence Birdseye, Mark Kurlansky introduces the explorers, merchants, writers, chefs and fisherman, whose lives have been interwoven with this prolific fish. He chronicles the cod wars of the 16th and 20th centuries. He blends in recipes and lore from the Middle Ages to the present. In a story that brings world history and human passions into captivating focus, he shows how the most profitable fish in history is today faced with extinction.

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.

    Along the way, you’ll encounter Boschean beasts, giant squid, guitar-playing sea slugs, and the great pioneers of neuroscience. Hana Roš and Matteo Farinella provide an insight into the most complex thing in the universe.