But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    This book covers all the dials, menus, and controls, showing you how to use each one. It explains how to change and use various lenses and offers advice on exposure, focus, printing, using flash, sharing photos online, and much more, all with plenty of full-color examples to show what you can achieve.Canon's popular T3i/600D offers a vast array of options for the new dSLR photographer; this book guides you through all the settings, dials, and menusExplains how to use Live View mode and record, edit, and play back videoProvides tips and advice on working with exposure, manipulating focus and color, switching from auto to manual controls, and using lighting creativelyShows how to get photos from the camera to the computer, then edit and manage them using different software packagesIllustrated with full-color photos from the author, showing what you can achieveThis fun and friendly book helps you to quickly and confidently take advantage of the many creative possibilities offered by your new Canon camera.

    How to approach complex normal and abnormal behaviors through biology. How to integrate disciplines including sociobiology, ethology, neuroscience, and endocrinology to examine behaviors such as aggression, sexual behavior, language use, and mental illness.36 hours lectures

    The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank.Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world.Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children.What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.From the Hardcover edition.

    Contemplation of time and the discoveries of modern science lead to the assertion that the mind is paramount and limitless.

    Too often, overwhelmed by anatomical detail, students miss out on the functional beauty of the nervous system and its relevance to clinical practice.

    The nature of football continually changes, which means its analysis must also keep pace. This book is for students, thinkers, and theorists of the game.'Ted Hopkins - Carlton premiership player, author, and co-founder of Champion Data. Australian Rules football has been described as the most data-rich sport on Earth. Every time and everywhere an AFL side takes to the field, it is shadowed by an army of statisticians and number crunchers. The information they gather has become the sport's new language and currency. ABC journalist James Coventry, author of the acclaimed Time and Space, has joined forces with a group of razor-sharp analysts to decipher the data, and to use it to question some of football's long-held truisms. Do umpires really favour the home side? Has goal kicking accuracy deteriorated? Is Geelong the true master of the draft? Are blonds unfairly favoured in Brownlow medal voting? And are Victorians the most passionate fans? Through a blend of entertaining storytelling and expert analysis, this book will answer more questions about footy than you ever thought to ask. Praise for Time and Space:'Brilliant, masterful' - The Guardian'Arguably one of the most important books yet written on Australian Rules football.' - Inside History'Should find its way into the hands of every coach.' - AFL Record

    of Maryland School of Medicine), offers case histories of the health problems of a dozen long-dead famous figures diagnosed from modern medical perspectives. Illustrations depict patients including the odd-looking Pharaoh Akhenaten, C

    He was eager to begin his first practice, but it turned out to be more than he bargained for. In just two years, in September, 1918, the entire village was sickened in rapid succession in the flu pandemic that killed quickly and indiscriminately throughout the world. It was wartime, and Nixon was unable to find help., This story is an up close and personal account of what it was like to be sick with the HINI type virus in 1918. It is a tale of a dedicated doctor whose selflessness, compassion and courage helped the villagers survive in the pandemic that killed more people in a year than the Black Death killed in a century...

    Now revised and updated to include expanded coverage of monetary policy, this volume traces the history of macroeconomics and the evolution of macroeconomic thought and the resulting theory and policy.

    Purchasers are entitled to a free trial membership in the General Books Club where they can select from more than a million books without charge. Subjects: Astronomy; History / General; Juvenile Nonfiction / Science

    - Book Review Editor of the journal "Modern Pathology," the official journal of the United States-Canadian Academy of Pathology and prestigious best-selling author. This is the 5th edition of a book that has already established itself as the classic pathology textbook in India. This new edition has been updated, and improved to meet the highest standards of quality and information now required by pathology courses around the world. Editorially this new edition carries particular emphasis on molecular pathology and genetics in the pathogenesis of various diseases, and the pathological discussions of each organ or system is preceded with a short description of its structure and function. The material is integrated with extensive page cross references between chapters and the whole book has been thoroughly re-edited, with new images, illustrations and line drawings. The book is accompanied by the free student revision aid "Pathology - Quick Review and MCQs" and therefore, together as a package, "Textbook of Pathology, 5E" will be a major contribution to the required reading of undergraduate medical students worldwide.

    One island, two unique societies (Norse and Inuit). Only one of these societies would succeed--the other would fail. But how? With his trademark accessibility and comprehensiveness, Diamond documents how environmental damage, climate change, loss of friendly contacts and the rise of hostile ones, and the unique political, economic, and social settings of prehistoric Greenland combine to demonstrate exactly why and how societies choose to fail or succeed. Jared Diamond's latest book, "The World Until Yesterday: What Can We Learn from Traditional Societies?," is available from Viking.

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    The culprit--so necessary and yet the source of such upheaval--is the X chromosome, and this is its story. An enlightening and entertaining tour of the cultural and natural history of this intriguing member of the genome, "The X in Sex" traces the journey toward our current understanding of the nature of X. From its chance discovery in the nineteenth century to the promise and implications of ongoing research, David Bainbridge shows how the X evolved and where it and its counterpart Y are going, how it helps assign developing human babies their sex--and maybe even their sexuality--and how it affects our lives in infinitely complex and subtle ways. X offers cures for disease, challenges our cultural, ethical, and scientific assumptions about maleness and femaleness, and has even reshaped our views of human evolution and human nature.