Dubbed the 'man in black', guitarist Ritchie Blackmore found fame with Seventies rock giants Deep Purple, then walked away from them to create Rainbow, only to abandon them and form another band in 1997 - Blackmore's Night.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Its effects on our view of life have been wide and deep. One of the most world-shaking books ever published, Charles Darwin's On the Origin of Species, first appeared in print over 130 years ago, and it touched off a debate that rages to this day.Every modern evolutionist turns to Darwin's work again and again. Current controversies in the life sciences very often have as their starting point some vagueness in Darwin's writings or some question Darwin was unable to answer owing to the insufficient biological knowledge available during his time. Despite the intense study of Darwin's life and work, however, many of us cannot explain his theories (he had several separate ones) and the evidence and reasoning behind them, nor do we appreciate the modifications of the Darwinian paradigm that have kept it viable throughout the twentieth century.Who could elucidate the subtleties of Darwin's thought and that of his contemporaries and intellectual heirs--A. R. Wallace, T. H. Huxley, August Weismann, Asa Gray--better than Ernst Mayr, a man considered by many to be the greatest evolutionist of the century? In this gem of historical scholarship, Mayr has achieved a remarkable distillation of Charles Darwin's scientific thought and his enormous legacy to twentieth-century biology. Here we have an accessible account of the revolutionary ideas that Darwin thrust upon the world. Describing his treatise as "one long argument," Darwin definitively refuted the belief in the divine creation of each individual species, establishing in its place the concept that all of life descended from a common ancestor. He proposed the idea that humans were not the special products of creation but evolved according to principles that operate everywhere else in the living world; he upset current notions of a perfectly designed, benign natural world and substituted in their place the concept of a struggle for survival; and he introduced probability, chance, and uniqueness into scientific discourse.This is an important book for students, biologists, and general readers interested in the history of ideas--especially ideas that have radically altered our worldview. Here is a book by a grand master that spells out in simple terms the historical issues and presents the controversies in a manner that makes them understandable from a modern perspective.

    But as Ocean Guardian founder William McKeever reveals, sharks are evolutionary marvels essential to maintaining a balanced ecosystem. We can learn much from sharks, he argues, and our knowledge about them continues to grow. The first book to reveal in full the hidden lives of sharks, Emperors of the Deep examines four species—Mako, Tiger, Hammerhead, and Great White—as never before, and includes fascinating details such as:Sharks are 50-million years older than trees;Sharks have survived five extinction level events, including the one that killed off the dinosaurs;Sharks have electroreception, a sixth-sense that lets them pick up on electric fields generated by living things;Sharks can dive 4,000 feet below the surface;Sharks account for only 6 human fatalities per year, while humans kill 100 million sharks per year.McKeever goes back through time to probe the shark’s pre-historic secrets and how it has become the world’s most feared and most misunderstood predator, and takes us on a pulse-pounding tour around the world and deep under the water’s surface, from the frigid waters of the Arctic Circle to the coral reefs of the tropical Central Pacific, to see sharks up close in their natural habitat. He also interviews ecologists, conservationists, and world-renowned shark experts, including the founders of Greenpeace’s Rainbow Warrior, the head of the Massachusetts Shark Research Program, and the self-professed “last great shark hunter.”At once a deep-dive into the misunderstood world of sharks and an urgent call to protect them, Emperors of the Deep celebrates this wild species that hold the key to unlocking the mysteries of the ocean—if we can prevent their extinction from climate change and human hunters.

    Describes how fractals were discovered, explains their unique properties, and discusses the mathematical foundation of fractals.

    Details from cell structure and genetics, to immunology and pathogenicity, to taxonomy and phylogeny are covered. Also, based on recent taxonomic advances in RNA analysis, a new organization also makes this the first text to be divided by the three cell domains--Bacteria, Archaea, and Eukaryotes.

    Illustrated with hundreds of photographs, this visual documentary of Michael Jackson presents all the facts and includes his records, concerts, videos and awards, his public appearances and performances, memorabilia and records you never knew existed.

    In this groundbreaking analysis, over thirty of the most popular treatments—acupuncture, homeopathy, aromatherapy, reflexology, chiropractic, and herbal medicines—are examined for their benefits and potential dangers. Questions answered include: What works and what doesn't? What are the secrets, and what are the lies? Who can you trust, and who is ripping you off? Can science decide what is best, or do the old wives' tales really tap into ancient, superior wisdom?In their scrutiny of alternative and complementary cures, authors Simon Singh and Edzard Ernst also strive to reassert the primacy of the scientific method as a means for determining public health practice and policy.

    Hundreds of thousands of pianos are bought and sold each year, yet most people buy a piano with only the vaguest idea of what to look for as they make this major purchase. The Piano Book evaluates and compares every brand and style of piano sold in the United States. There is information on piano moving and storage, inspecting individual new and used pianos, the special market for Steinways, and sales gimmicks to watch out for. An annual supplement, sold separately, lists current prices for more than 2,500 new piano models.

    It provides up to date information on structural properties, the processing of materials and their applications.

    A twentieth anniversary edition of Pauling's seminal work on the role of vitamins and minerals in preventing disease and achieving optimal health.

    Now in its Eleventh Edition, this classic atlas continues to provide students with accurate anatomical images presented in a pedagogically effective, clinically relevant manner. This new edition has been revised to include 100 additional four-color illustrations, additional orientation drawings, and updated terminology.This edition is packaged with a student version of Dynamic Human Anatomy, an interactive electronic supplement which includes 800 images from the Eleventh Edition of Grant's, 8 video clips from Acland's DVD Atlas of Human Anatomy, and 100 USMLE-style review questions in anatomy.

    Constable Wood was a disaster waiting to happen. He was the sort of cop who was happier helping little old ladies across the street (even when they were quite content where they were) than pursuing the perpetrators of dreadful deeds. But if he failed to strike fear into the hearts of the criminal underworld, his superiors had a real problem on their hands. Never before had they been forced to deal with such a well-meaning but accident-prone officer and they hoped, fervently, never to see his like again. From his early encounters with a less-than-impressed public, through the terrifying days of the Springbok Tour riots, to the gradual realisation that perhaps he wasn’t cut out for life on the beat, this is the hilarious story of a young cop who created a severe disturbance in the force.