The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    ReevePreserved by Arabic mathematicians and canonized by Christian scholars, Aristotle's works have shaped Western thought, science, and religion for nearly two thousand years. Richard McKeon's The Basic Works of Aristotle--constituted out of the definitive Oxford translation and in print as a Random House hardcover for sixty years--has long been considered the best available one-volume Aristotle. Appearing in paperback at long last, this edition includes selections from the Organon, On the Heavens, The Short Physical Treatises, Rhetoric, among others, and On the Soul, On Generation and Corruption, Physics, Metaphysics, Nicomachean Ethics, Politics, and Poetics in their entirety.

    For the past two millennia, the ability to produce it in ever more efficient ways has supported the proliferation of literacy, media, religion, education, commerce, and art; it has formed the foundation of civilizations, promoting revolutions and restoring stability. One has only to look at history’s greatest press run, which produced 6.5 billion copies of Máo zhuxí yulu, Quotations from Chairman Mao Tse-tung (Zedong)—which doesn’t include editions in 37 foreign languages and in braille—to appreciate the range and influence of a single publication, in paper. Or take the fact that one of history’s most revered artists, Leonardo da Vinci, left behind only 15 paintings but 4,000 works on paper. And though the colonies were at the time calling for a boycott of all British goods, the one exception they made speaks to the essentiality of the material; they penned the Declaration of Independence on British paper.Now, amid discussion of “going paperless”—and as speculation about the effects of a digitally dependent society grows rampant—we’ve come to a world-historic juncture. Thousands of years ago, Socrates and Plato warned that written language would be the end of “true knowledge,” replacing the need to exercise memory and think through complex questions. Similar arguments were made about the switch from handwritten to printed books, and today about the role of computer technology. By tracing paper’s evolution from antiquity to the present, with an emphasis on the contributions made in Asia and the Middle East, Mark Kurlansky challenges common assumptions about technology’s influence, affirming that paper is here to stay. Paper will be the commodity history that guides us forward in the twenty-first century and illuminates our times.

    During the summer before the United States entered World War I, when ocean swimming was just becoming popular and luxurious Jersey Shore resorts were thriving as a chic playland for an opulent yet still innocent era's new leisure class, Americans were abruptly introduced to the terror of sharks. In July 1916 a lone Great White left its usual deep-ocean habitat and headed in the direction of the New Jersey shoreline. There, near the towns of Beach Haven and Spring Lake-and, incredibly, a farming community eleven miles inland-the most ferocious and unpredictable of predators began a deadly rampage: the first shark attacks on swimmers in U.S. history. For Americans celebrating an astoundingly prosperous epoch much like our own, fueled by the wizardry of revolutionary inventions, the arrival of this violent predator symbolized the limits of mankind's power against nature.Interweaving a vivid portrait of the era and meticulously drawn characters with chilling accounts of the shark's five attacks and the frenzied hunt that ensued, Michael Capuzzo has created a nonfiction historical thriller with the texture of Ragtime and the tension of Jaws. From the unnerving inevitability of the first attack on the esteemed son of a prosperous Philadelphia physician to the spine-tingling moment when a farm boy swimming in Matawan Creek feels the sandpaper-like skin of the passing shark, Close to Shore is an undeniably gripping saga.Heightening the drama are stories of the resulting panic in the citizenry, press and politicians, and of colorful personalities such as Herman Oelrichs, a flamboyant millionaire who made a bet that a shark was no match for a man (and set out to prove it); Museum of Natural History ichthyologist John Treadwell Nichols, faced with the challenge of stopping a mythic sea creature about which little was known; and, most memorable, the rogue Great White itself moving through a world that couldn't conceive of either its destructive power or its moral right to destroy.Scrupulously researched and superbly written, Close to Shore brings to life a breathtaking, pivotal moment in American history. Masterfully written and suffused with fascinating period detail and insights into the science and behavior of sharks, Close to Shore recounts a breathtaking, pivotal moment in American history with startling immediacy.

    The new edition maintains the authors' innovative solutions to two central problems of the course: first, the text continues to focus on about 80 sites, giving students less encyclopedic detail but essential coverage of the discoveries that have produced the major insights into prehistory; second, it continues to be organized into essays on sites and concepts, allowing professors complete flexibility in organizing their courses.

    In many countries, supplies of food and water are inadequate to support the population, so the world falls deeper and deeper into what economists call the "Malthusian trap."Here, Malthus examines the tendency of human numbers to outstrip their resources, and argues that poverty, disease, and starvation are necessary to keep societies from moving beyond their means of subsistence.Public Domain (P)2013 Audible Ltd

    Beginning millions of years ago with ancient “ant odometers” and moving through time to our modern-day quest for new dimensions, it covers 250 milestones in mathematical history. Among the numerous delights readers will learn about as they dip into this inviting anthology: cicada-generated prime numbers, magic squares from centuries ago, the discovery of pi and calculus, and the butterfly effect. Each topic gets a lavishly illustrated spread with stunning color art, along with formulas and concepts, fascinating facts about scientists’ lives, and real-world applications of the theorems.

    In his political speeches especially and in his correspondence we see the excitement, tension and intrigue of politics and the part he played in the turmoil of the time. Of about 106 speeches, delivered before the Roman people or the Senate if they were political, before jurors if judicial, 58 survive (a few of them incompletely). In the fourteenth century Petrarch and other Italian humanists discovered manuscripts containing more than 900 letters of which more than 800 were written by Cicero and nearly 100 by others to him. These afford a revelation of the man all the more striking because most were not written for publication. Six rhetorical works survive and another in fragments. Philosophical works include seven extant major compositions and a number of others; and some lost. There is also poetry, some original, some as translations from the Greek. The Loeb Classical Library edition of Cicero is in twenty-nine volumes.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    She draws on conversations with hundreds of the world's top scientists and on her own work as a Pulitzer Prize-winning writer for the New York Times to create a thoroughly entertaining guide to scientific literacy. Angier's gifts are on full display in The Canon, an ebullient celebration of science that stands to become a classic. The Canon is vital reading for anyone who wants to understand the great issues of our time -- from stem cells and bird flu to evolution and global warming. And it's for every parent who has ever panicked when a child asked how the earth was formed or what electricity is. Angier's sparkling prose and memorable metaphors bring the science to life, reigniting our own childhood delight in discovering how the world works. "Of course you should know about science," writes Angier, "for the same reason Dr. Seuss counsels his readers to sing with a Ying or play Ring the Gack: These things are fun and fun is good." The Canon is a joyride through the major scientific disciplines: physics, chemistry, biology, geology, and astronomy. Along the way, we learn what is actually happening when our ice cream melts or our coffee gets cold, what our liver cells do when we eat a caramel, why the horse is an example of evolution at work, and how we're all really made of stardust. It's Lewis Carroll meets Lewis Thomas -- a book that will enrapture, inspire, and enlighten.

    Mile-by-mile road logs document every approach to the park and every interior road. Through charts and explanations, readers learn of Yellowstone's campgrounds and facilities, geyser basins and the frequency of the geyser eruptions, and out-of-the-way hikes. Updates include descriptions of new lodgings, scientific information reflecting recent research, 65 new color photos, and revised maps. A field guide to the animals and plants, a selected reading list, and a 21-page index round out this comprehensive guidebook.

    This guide divides the attractions into sections—the North Rim, South Rim, Colorado River, and Havasu Falls—with lodging, dining, and camping information given for each. Outfitters for hiking, backpacking, mule rides, and rafting adventures are listed, and carefully researched chapters about the park's history, geology, and wildlife encourage leisurely study of the area's unmatched natural beauty. This book is the winner of the Benjamin Franklin Award for best full-color travel guide and the Independent Publisher Award for best travel guide. About The Complete Guides:With a large number of beautiful, high-quality color photographs, these guides are as browsable as the best coffee table books but also supply travelers with maps, travel tips, and extensive listings for lodging, camping, and sightseeing.

    . . a book that enriches our understanding of how the struggle to think new thoughts is shared across time and space and people.”—The Sunday Telegraph (London)Christmas, 1859. Just one month after the publication of On the Origin of Species, Charles Darwin received an unsettling letter. He had expected criticism; in fact, letters were arriving daily, most expressing outrage and accusations of heresy. But this letter was different. It accused him of failing to acknowledge his predecessors, of taking credit for a theory that had already been discovered by others. Darwin realized that he had made an error in omitting from Origin of Species any mention of his intellectual forebears. Yet when he tried to trace all of the natural philosophers who had laid the groundwork for his theory, he found that history had already forgotten many of them.Darwin’s Ghosts tells the story of the collective discovery of evolution, from Aristotle, walking the shores of Lesbos with his pupils, to Al-Jahiz, an Arab writer in the first century, from Leonardo da Vinci, searching for fossils in the mine shafts of the Tuscan hills, to Denis Diderot in Paris, exploring the origins of species while under the surveillance of the secret police, and the brilliant naturalists of the Jardin de Plantes, finding evidence for evolutionary change in the natural history collections stolen during the Napoleonic wars. Evolution was not discovered single-handedly, Rebecca Stott argues, contrary to what has become standard lore, but is an idea that emerged over many centuries, advanced by daring individuals across the globe who had the imagination to speculate on nature’s extraordinary ways, and who had the courage to articulate such speculations at a time when to do so was often considered heresy.With each chapter focusing on an early evolutionary thinker, Darwin’s Ghosts is a fascinating account of a diverse group of individuals who, despite the very real dangers of challenging a system in which everything was presumed to have been created perfectly by God, felt compelled to understand where we came from. Ultimately, Stott demonstrates, ideas—including evolution itself—evolve just as animals and plants do, by intermingling, toppling weaker notions, and developing over stretches of time. Darwin’s Ghosts presents a groundbreaking new theory of an idea that has changed our very understanding of who we are.

    Humans have "subdued 75 per cent of the land surface, concocted a wizardry of industrial and medical marvels, strung lights all across the darkness." We now collect the DNA of vanishing species in a "frozen ark," equip orangutans with iPads, create wearable technologies and synthetic species that might one day outsmart us. With her distinctive gift for making scientific discovery intelligible to the layperson, Ackerman takes us on an exciting journey to understand this bewildering new reality, introducing us to many of the people and ideas now creating--perhaps saving--the future.The Human Ageis a surprising, optimistic engagement with the dramatic transformations that have shaped, and continue to alter, our world, our relationship with nature and our prospects for the future.

    He died in 1492 at the age of forty-three. He came to power in fifteenth-century Florence at the age of twenty. In the twenty-odd years of his rule, this banker, politician, international diplomat, free-wheeling poet and songwriter, and energetic revolutionary helped to give shape, tone, and tempo to that truly dazzling time of Western history, the Renaissance. This book, by award-winning author Charles L. Mee, Jr., recounts the remarkable life of Lorenzo de’ Medici and of the times in which he lived.