To Hogshire, pills are the quintessence of Western culture, embodying our desires, fears, ambivalence about life and death, health and freedom -- as well as our faith in the quick fix.Hogshire muses on pill naming and marketing, presents up-to-the-minute pill news, and discusses celebrities and their pills of choice. Along the way, he provides histories of drug manufacturers and examines how pills are the product of decades of scientific exploration and the result of billions of dollars in research.

    Left untouched were many of the things known to cause cancer, including tobacco, the workplace, radiation, or the global environment. Proof of how the world in which we live and work affects whether we get cancer was either overlooked or suppressed. This has been no accident. The War on Cancer was run by leaders of industries that made cancer-causing products, and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies-a legacy that persists to this day. This is the gripping story of a major public health effort diverted and distorted for private gain. A portion of the profits from this book will go to support research on cancer prevention.

    It will inspire the necessary and difficult conversations we all need to have with loved ones as it illuminates a path to a better way of death.Like so many of us, award-winning writer Katy Butler always assumed her aging parents would experience healthy, active retire­ments before dying peacefully at home. Then her father suffered a stroke that left him incapable of easily finishing a sentence or showering without assistance. Her mother was thrust into full-time caregiving, and Katy became one of the 24 mil­lion Americans who help care for aging parents. In an effort to correct a minor and non–life threatening heart arrhythmia, doctors outfitted her father with a pacemaker. The device kept his heart beating but did nothing to prevent his slide into dementia, incontinence, near-muteness, and misery. After several years, he asked his wife for help, telling her, "I am living too long." Mother and daughter faced a series of wrench­ing moral questions: When does death cease being a curse and become a blessing? Where is the line between saving life and prolonging a dying? When is the right time to say to a doctor, "Let my loved one go"? When doctors refused to disable the pace­maker, sentencing her father to a protracted and agonizing death, Katy set out to understand why. Her quest had barely begun when her mother faced her own illness, rebelled against her doctors, refused open-heart surgery, and instead met death head-on. Knocking on Heaven's Door, a revolution­ary blend of memoir and investigative reporting, is the fruit of the Butler family's journey. With a reporter's skill, a poet's eye, and a daughter's love, Butler explores what happens when our terror of death collides with the tech­nological imperatives of modern medicine. Her provocative thesis is that advanced medicine, in its single-minded pursuit of maximum longevity, often creates more suffering than it prevents. Butler lays bare the tangled web of technology, medicine, and commerce that modern dying has become and chronicles the rise of Slow Medicine - a growing movement that promotes care over cure. Knocking on Heaven's Door is a visionary map through the labyrinth of a broken and morally adrift medical system. It will inspire the necessary and difficult conversations we all need to have with loved ones as it illuminates a path to a better way of death.

    Now in book form for the first time, their simple method will teach you how to use basic design tools to create a life that will work for you.Using real-life stories and proven techniques like reframing, prototyping and mind-mapping, you will learn how to build your way forwards, step-by-positive-step, to a life that’s better by a design of your own making.Because a well-designed life means a life well-lived.

    Now in its Tenth Edition, this definitive guide has been completely revised and updated to again make it the most current and comprehensive introduction to the pharmacology of drugs that affect the mind and behavior.

    And through CODE, we see how this ingenuity and our very human compulsion to communicate have driven the technological innovations of the past two centuries. Using everyday objects and familiar language systems such as Braille and Morse code, author Charles Petzold weaves an illuminating narrative for anyone who’s ever wondered about the secret inner life of computers and other smart machines. It’s a cleverly illustrated and eminently comprehensible story—and along the way, you’ll discover you’ve gained a real context for understanding today’s world of PCs, digital media, and the Internet. No matter what your level of technical savvy, CODE will charm you—and perhaps even awaken the technophile within.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health--and in ways that matter for educational and economic success in our current society.In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society.Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of a society where everyone thrives, regardless of how one fares in the genetic lottery.

    With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most—drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

    scientific community has long led the world in research on such areas as public health, environmental science, and issues affecting quality of life. Our scientists have produced landmark studies on the dangers of DDT, tobacco smoke, acid rain, and global warming. But at the same time, a small yet potent subset of this community leads the world in vehement denial of these dangers.Merchants of Doubt tells the story of how a loose-knit group of high-level scientists and scientific advisers, with deep connections in politics and industry, ran effective campaigns to mislead the public and deny well-established scientific knowledge over four decades. Remarkably, the same individuals surface repeatedly—some of the same figures who have claimed that the science of global warming is "not settled" denied the truth of studies linking smoking to lung cancer, coal smoke to acid rain, and CFCs to the ozone hole. "Doubt is our product," wrote one tobacco executive. These "experts" supplied it.Naomi Oreskes and Erik M. Conway, historians of science, roll back the rug on this dark corner of the American scientific community, showing how ideology and corporate interests, aided by a too-compliant media, have skewed public understanding of some of the most pressing issues of our era.

    It's what you have if you're a politician and you've strayed from your wife, and it's why five times as many Americans undergo plastic surgery and cosmetic procedures today than did just ten years ago. It's the value that parents teach their children with song lyrics like "I am special. Look at me," the skill teenagers and young adults obsessively hone on Facebook and MySpace, and the reason high school students physically beat classmates and then broadcast their violence on YouTube for all to see. It's the message preached by prosperity gospel and the vacuous ethos spread by celebrity newsmakers. And it's what's making people depressed, lonely, and buried under piles of debt.Jean M. Twenge's influential and controversial first book, Generation Me, generated a national debate with its trenchant depiction of the challenges twenty- and thirtysomethings face emotionally and professionally in today's world -- and the fallout these issues create for older generations as well as employers. Now, Dr. Twenge is on to a new incendiary topic that has repercussions for every age-group and class: the pernicious spread of narcissism in today's culture and its catastrophic effects. Dr. Twenge joins forces with W. Keith Campbell, Ph.D., a nationally recognized expert on narcissism, for The Narcissism Epidemic, their eye-opening exposition of the alarming rise of narcissism -- and they show how to stop it.Every day, you encounter the real costs of narcissism: in your relationships and family, in the workplace and the economy at large, in schools that fail to teach necessary skills, in culture, and in politics. Even the world economy has been damaged by risky, unrealistic overconfidence. Filled with arresting anecdotes that illustrate the hold narcissism has on us today -- from people hiring fake paparazzi in order to experience feeling famous to college students who won't leave a professor's office until their B+ becomes an A -- The Narcissism Epidemic is at once a riveting window into the consequences of narcissism, a probing analysis of the culture at large, and a prescription to combat the widespread problems caused by narcissism. As a society, we have a chance to slow the epidemic of narcissism once we learn to identify it, minimize the forces that sustain and transmit it, and treat it where we find it. Drawing on their own extensive research as well as decades of other experts' studies, Drs. Twenge and Campbell show us how.

    It's embedded in our DNA. Our diet has changed dramatically over the past ten thousand years, but our genetic blueprint has not -- our bodies are not designed to process the types of food we are fed today. It's like putting diesel fuel into a regular car -- it just won't work. And making matters worse is the fact that diets don't work either: less than 6 percent of weight-loss attempts succeed. The average person who goes on a diet actually gains five pounds. But a medical revolution is under way, finally showing us precisely how the powerful forces that keep weight on can actually be reprogrammed to automatically burn fat and keep weight off for good. The concept is simple. By learning how to work with our bodies instead of against them, we can ignite the natural fat-burning furnaces that lie dormant within us. For the first time ever, Dr. Mark Hyman makes this new science of weight loss available to the general public. This medical revolution is based on a groundbreaking concept called nutrigenomics -- the science of how food talks to our genes. This science is actually startlingly simple. Food contains information and instructions for our bodies -- eat the right foods and send instructions of weight loss and health; eat the wrong foods and send messages of weight gain and disease. After spending the last ten years conducting pioneering, hands-on research with over two thousand patients at Canyon Ranch, one of the world's leading health resorts, Dr. Hyman has discovered the seven fundamental causes of obesity. While fad diets have identified one or two of these causes, never before have they all been integrated into a single, simple plan for automatic weight loss -- this is the promise of "UltraMetabolism." "UltraMetabolism" is an easy-to-follow eight-week plan to help you lose weight based on your own unique genetic needs. Since each of our bodies is different and may require more or less of certain nutrients to awaken our fat-burning DNA, Dr. Hyman shows you exactly how to customize the program for your own particular needs. The program includes menus, recipes, and shopping lists, as well as recommendations for supplements and exercise and lifestyle treatments designed to create a healthy metabolism -- an "UltraMetabolism" -- permanent weight loss, and lifelong health.Ultrametabolism Testimonials..".I lost 50 pounds and have kept it off for 4 years.""The last five years have become the healthiest years of my life. Because of Dr. Hyman's program, I have an in-depth understanding of my physical condition and have tailored a weight loss program for my needs. Since following his plan, I've significantly reduced my cholesterol from 240 to 160. In addition, I lost 50 pounds and have kept it off for 4 years."-- Joseph Bernstein Milwaukee, WI"I've dropped 2 dress sizes (so far)...Dr. Hyman literally gave me my life back.""Over the past few years I had gained 70 lbs and felt progressively worse as I bounced from doctor to doctor without any real answers for my weight gain, my migraines, or my many other ailments. Dr. Hyman helped me understand how many of my health issues were due to food allergies. Lab tests showed I was allergic to 28 different foods! I started on the DeTox phase of Dr. Hymans program and within 3 weeks, I lost 11 pounds and my swollen wrists and puffy face went away. I used to wake up extremely exhausted, but now I wake up at 6 am and maintain a constant level of energy throughout the day. No other program gave me a means to discover the real source of my problems. Now I have the energy to play with my 8-year-old and 11-year-old children. My entire family is finally eating healthier, and I've dropped 2 dress sizes (so far!) Dr Hyman literally gave me my life back."-- Audrey Meyer Lampert North Granby, CT"The menu was easy to implement, in spite of my hectic lifestyle...""Through Dr. Hyman's program, I not only dropped my cholesterol from 335 to below 200, but I lost 20 lbs and have kept if off for the last 2 years through his instructions including a specific meal plan, exercise, and supplements. The menu was easy to implement, in spite of my hectic lifestyle and easy to adapt when I traveled to hotels and restaurants. Matter of fact, I went from a pant size of 38 to a 36 and needed to buy a lot of new clothes."-- Cavas Gobhai Cambridge, MA"It was easy! All I needed to do was follow his instructions; in the first 30 days I lost 21 pounds.""Substituting simple foods with other healthy foods that I love helped me lose the cravings for all the junk I used to eat. Dr. Hyman's weight loss program gave me a lot of information about my body. It was easy! All I needed to do was follow his instructions; in the first 30 days I lost 21 pounds. I feel better than I have in 10 years and can now walk up the stairs without losing my breath. I forgot how good I could I feel."-- Deede Dominick Phippsburg, Maine"I was ready for a change, and Dr. Hyman's program helped me prioritize my life.""After I quit smoking three years ago, I snacked a lot in order to forget about smoking. After doing that for 6 months, I gained almost 30 pounds. I was sick and tired of having no energy, and I wanted to feel good again. In addition, I love to shop, and I wanted to buy fancy clothes without having to shop at the big and tall store. I was ready for a change, and Dr. Hyman's program helped me prioritize my life. Since I started in 2003 I have lost over 60 pounds and have maintained the loss. In addition, I've gone from a size 18 to a size 10. When I look at old pictures, I realize that I feel and look better than I did 15 years ago."-- Margarida Glenhage Gothenburg Sweden..".I lost 30 lbs with no exercise.""As a single mother, I was tired of feeling sick all the time and decided to change my life so that I could become healthy for my 3%-year-old daughter. After relearning how to feed myself and my daughter, I lost 30 lbs with no exercise from June to December and I dropped my cholesterol 105 points."-- Nancy Grey DC Bronxville, NY"I lost 30 lbs, went back to a size 4, and no longer have migraines.""After going through an 8-month period of being very sick with hives, having extreme inflammation in my face, and gaining 30 pounds, I found Dr. Hyman's program. Because I went through his simple plan, I uncovered that I am allergic to gluten, the protein in wheat, which was the source of all my problems. After getting on his plan, I lost 30 lbs, went back to a size 4, and no longer have migraines. My husband even noticed the change and went on the program too; so far, he's lost 45 pounds."-- Debbie Gosney Charlotte, NC..".it's easy to jump back on when I occasionally fall off...""This program gave me the satisfaction of being in control of my body and life. I've maintained my 18-pound weight loss since 2002, reduced my glucose levels from 170 to 102, and taken control over my diabetes to the point where I no longer have any symptoms. Going on a program like this is like a religious conversion; it's easy to jump back on when I occasionally fall off and I have more energy than I've ever had. At the age of 71, I run 4 miles a day and feel great."

    Now a world-renowned expert gives us a substantially updated and augmented edition of her classic work: drawing on an additional fifteen years of cutting-edge research, offering new information on all aspects of dyslexia and reading problems, and providing the tools that parents, teachers, and all dyslexic individuals need. This new edition also offers:- New material on the challenges faced by dyslexic individuals across all ages - Rich information on ongoing advances in digital technology that have dramatically increased dyslexics' ability to help themselves - New chapters on diagnosing dyslexia, choosing schools and colleges for dyslexic students, the co-implications of anxiety, ADHD, and dyslexia, and dyslexia in post-menopausal women - Extensively updated information on helping both dyslexic children and adults become better readers, with a detailed home program to enhance reading - Evidence-based universal screening for dyslexia as early as kindergarten and first grade - why and how - New information on how to identify dyslexia in all age ranges - Exercises to help children strengthen the brain areas that control reading - Ways to raise a child's self-esteem and reveal her strengths - Stories of successful men, women, and young adults who are dyslexic

    Childhood Interrupted also explains how to cope with these emotional traumas and even heal from them.Your biography becomes your biology. The emotional trauma we suffer as children not only shapes our emotional lives as adults, it also affects our physical health, longevity, and overall well-being. Scientists now know on a bio-chemical level exactly how parents, chronic fights, divorce, death in the family, being bullied or hazed, and growing up with a hypercritical, alcoholic, or mentally ill parent can leave permanent, physical fingerprints on our brains.When we as children encounter sudden or chronic adversity, excessive stress hormones cause powerful changes in the body, altering our body chemistry. The developing immune system and brain react to this chemical barrage by permanently re-setting our stress response to high, which in turn can have a devastating impact on our mental and physical health.Donna Jackson Nakazawa shares stories from people who have recognized and overcome their adverse experiences, shows why some children are more immune to stress than others, and explains why women are at particular risk. Groundbreaking in its research, inspiring in its clarity, Childhood Interrupted explains how you can reset your biology and help your loved ones find ways to heal.

    Metaphor, the authors explain, is a fundamental mechanism of mind, one that allows us to use what we know about our physical and social experience to provide understanding of countless other subjects. Because such metaphors structure our most basic understandings of our experience, they are "metaphors we live by", metaphors that can shape our perceptions and actions without our ever noticing them.In this updated edition of Lakoff and Johnson's influential book, the authors supply an afterword surveying how their theory of metaphor has developed within the cognitive sciences to become central to the contemporary understanding of how we think and how we express our thoughts in language.