But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

    Includes tables to compare different agents within a given class of drugs. For use as a review for Boards, self-testing, or reference. Previous edition: c1997.

    Paxil. Zoloft. Turn on your television and you are likely to see a commercial for one of the many selective serotonin reuptake inhibitors (SSRIs) on the market. We hear a lot about them, but do we really understand how these drugs work and what risks are involved for anyone who uses them?Let Them Eat Prozac explores the history of SSRIs from their early development to their latest marketing campaigns and the controversies that surround them. Initially, they seemed like wonder drugs for those with mild to moderate depression patients take just one daily dose, and unlike the tranquilizers that were popular in the 1960s, they supposedly did not lead to addiction. When Prozac was released in the late 1980s, David Healy was among the psychiatrists who prescribed it. But he soon observed that some of these patients became agitated and even attempted suicide. Studies were soon published, citing numerous cases in which patients became anxious and reported increased suicidal thoughts while taking Prozac. Could the new wonder drug actually be making patients worse?Healy draws on his own research and expertise to demonstrate the potential hazards associated with these drugs. He intersperses case histories with insider accounts of the research leading to the development and approval of SSRIs as a treatment for depression. Let Them Eat Prozac clearly demonstrates that the problems go much deeper than a disturbing side-effect of a particular drug. Current FDA regulations encourage drug companies to patent a specific compound and market it effectively to a large population on the basis of minimal effectiveness in a handful of trials.The pharmaceutical industry would like us to believe that SSRIs can safely treat depression, anxiety, and a host of other mental problems. But as Let Them Eat Prozac reveals, this "cure" may be worse than the disease.

    Today, mental disturbance is most commonly viewed through a medical lens, but societies have also sought to make sense of it through religion or the supernatural, or by constructing psychological or social explanations in an effort to tame the demons of unreason. Madness in Civilization traces the long and complex history of this affliction and our attempts to treat it.Beautifully illustrated throughout, Madness in Civilization takes readers from antiquity to today, painting a vivid and often harrowing portrait of the different ways that cultures around the world have interpreted and responded to the seemingly irrational, psychotic, and insane. From the Bible to Sigmund Freud, from exorcism to mesmerism, from Bedlam to Victorian asylums, from the theory of humors to modern pharmacology, the book explores the manifestations and meanings of madness, its challenges and consequences, and our varied responses to it. It also looks at how insanity has haunted the imaginations of artists and writers and describes the profound influence it has had on the arts, from drama, opera, and the novel to drawing, painting, and sculpture.Written by one of the world’s preeminent historians of psychiatry, Madness in Civilization is a panoramic history of the human encounter with unreason.

    But a recent groundbreaking discovery revealed them to be capable of terrifying Jekyll and Hyde behavior. When triggered--and anything that stirs up the immune system in the body can activate microglia--they can morph into destroyers, impacting a wide range of issues from memory problems and anxiety to depression and Alzheimer's. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to repair the brain in ways that help alleviate symptoms and hold the promise to one day prevent disease.A fascinating behind-the-scenes account of this cutting-edge science, The Angel and the Assassin also explores the medical implications of these game-changing discoveries. Award-winning journalist Donna Jackson Nakazawa began her investigation with a personal interest--when diagnosed with an autoimmune disorder years ago, she was convinced there was something physical going on in her brain as well as her body, though no doctor she consulted could explain how the two could be interacting in this way. With the compassion born of her own experience, she follows practitioners and patients on the front lines of treatments that help to "reboot" microglia--from neurofeedback and intermittent fasting to transcranial magnetic stimulation and gamma light flicker therapy. She witnesses patients finding significant relief from pressing symptoms--and at least one stunning recovery--offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.Proving once and for all the biological basis for the mind-body connection, the discovery of the true role of microglia stands to rewrite psychiatric and medical texts as we know them. Hailed as "riveting," "stunning," and "visionary," The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.

    Such a simple defect should be fixable, yet despite all of the resources that have been devoted to finding a pharmacological solution, depression remains stubbornly widespread. Why are we losing this fight?In this humane and illuminating challenge to defect models of depression, psychologist Jonathan Rottenberg argues that depression is a particularly severe outgrowth of our natural capacity for emotion. In other words, it is a low mood gone haywire. Drawing on recent developments in the science of mood—and his own harrowing depressive experience as a young adult—Rottenberg explains depression in evolutionary terms, showing how its dark pull arises from adaptations that evolved to help our ancestors ensure their survival. Moods, high and low, evolved to compel us to more efficiently pursue rewards. While this worked for our ancestors, our modern environment—in which daily survival is no longer a sole focus—makes it all too easy for low mood to slide into severe, long-lasting depression.Weaving together experimental and epidemiological research, clinical observations, and the voices of individuals who have struggled with depression, The Depths offers a bold new account of why depression endures—and makes a strong case for de-stigmatizing this increasingly common condition. In so doing, Rottenberg offers hope in the form of his own and other patients’ recovery, and points the way towards new paths for treatment.

    But until now, without compelling evidence, it has been impossible to say for sure that such a connection really exists and especially how it works.Now, that evidence has been discovered.A thrilling scientific detective story, The Balance Within tells how researchers finally uncovered the elusive mind-body connection and what it means for our health. In this beautifully written book, Dr. Esther Sternberg, whose discoveries were pivotal in helping to solve this mystery, provides first hand accounts of the breakthrough experiments that revealed the physical mechanisms - the nerves, cells, and hormones - used by the brain and immune system to communicate with each other. She describes just how stress can make us more susceptible to all types of illnesses, and how the immune system can alter our moods. Finally, she explains how our understanding of these connections in scientific terms is helping to answer such crucial questions as "Does stress make you sick?" "Is a positive outlook the key to better health?" and "How do our personal relationships, work, and other aspects of our lives affect our health?"A fascinating, elegantly written portrait of this rapidly emerging field with enormous potential for finding new ways to treat disease and cope with stress, The Balance Within is essential reading for anyone interested in making their body and mind whole again.

    It was inside, inside my head, where all had become so wretchedly different. I had the night before been incontrovertibly a man of stable mood, of calm, of good cheer and unforced bonhomie. Now I had become changed, with dreadful suddenness, into another being altogether.”Simon Winchester has never shied away from big, even enormous, topics—as evidenced by his bestselling biography of the Atlantic Ocean, his account of the Krakatoa volcanic eruption, and his wildly popular “The Professor and the Madman,” about the making of the Oxford English Dictionary. In his Byliner Original “The Man with the Electrified Brain,” he takes on arguably his most daunting subject yet: his own flirtation with madness, and one of nature’s greatest and most enduring mysteries, the human brain. As a geology student in his second year at Oxford, Winchester was known as a young man of even temper and keen intellect, until one June morning when he woke to find himself “changed with dreadful suddenness into another being altogether,” his normal life “slumped into chasm” and “folded in the dirt.” For a period of nine days, he lived in immobilizing fear. Everyday items—familiar paintings, a pile of books, his own robe hanging from a hook—became objects of horror; the world lost color, purpose, all sense and safety. When the episode finally passed, he returned to normal, presuming that what had happened to him was a fluke. It wasn’t. The episode repeated itself at unpredictable and dangerous intervals for four years—always lasting for nine days—and very nearly caused the author’s death while he was on an expedition in the Arctic. What was wrong with him? Where could he find help? Would he spend the rest of his life anticipating the return of these mental blackouts? With the urgency of a whodunit, Winchester describes the coming and going of these terrifying dissociative states and the chance encounter that led to the controversial treatment of electroconvulsive therapy, which may or may not have cured him once and for all. Written by a consummate storyteller, “The Man with the Electrified Brain” locates that finest of lines between sanity and insanity and is Winchester’s most riveting and deeply personal work yet.

    From miraculous pregnancies to dirty protests, and from violent attacks on prisoners to heartbreaking acts of self-harm, she has witnessed it all. In this memoir, Amanda reveals the stories, the patients and the cases that have shaped a career helping those most of us would rather forget.

    Rahul Jandial is on the cutting edge of the latest advancements in neuroscience. This fascinating book draws on Dr. Jandial’s broad-spectrum expertise and brings together the best of various fields-–surgery, science, brain structure, the conscious mind–-all to explain the bigger picture of brain health and rejuvenation. It is a journey into his operating room, around the world on his surgical missions, inside his laboratory, and to the outer edges of neuroscience to reveal the latest brain breakthroughs that are turning science fiction into reality, translating their implications for everyday life. Busting myths along the way, Jandial helps readers get wired for success at work and school, perform better when the pressure is on, boost memory, control stress and emotions, minimize pain, stick to a healthy eating plan, unleash creativity, raise smarter kids, and stay sharp as they age. Combining the treatment guidelines he gives his patients, the most promising concepts from frontier science, and the smartest super-achiever hacks, he provides practical takeaways for optimizing brain function and leading a healthier, happier, more productive life.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Written especially for exercise science and physical education students, this text provides a solid foundation in theory illuminated by application and performance models to increase understanding and to help students apply what they've learned in the classroom and beyond.

    Teresi introduces us to brain-death experts, hospice workers, undertakers, coma specialists and those who have recovered from coma, organ transplant surgeons and organ procurers, anesthesiologists who study pain in legally dead patients, doctors who have saved living patients from organ harvests, nurses who care for beating-heart cadavers, ICU doctors who feel subtly pressured to declare patients dead rather than save them, and many others. Much of what they have to say is shocking. Teresi also provides a brief history of how death has been determined from the times of the ancient Egyptians and the Incas through the twenty-first century. And he draws on the writings and theories of celebrated scientists, doctors, and researchers—Jacques-Bénigne Winslow, Sherwin Nuland, Harvey Cushing, and Lynn Margulis, among others—to reveal how theories about dying and death have changed. With The Undead, Teresi makes us think twice about how the medical community decides when someone is dead.

    In You Are the Placebo, Dr. Joe Dispenza shares numerous documented cases of those who reversed cancer, heart disease, depression, crippling arthritis, and even the tremors of Parkinson’s disease by believing in a placebo. Similarly, Dr. Joe tells of how others have gotten sick and even died the victims of a hex or voodoo curse—or after being misdiagnosed with a fatal illness. Belief can be so strong that pharmaceutical companies use double- and triple-blind randomized studies to try to exclude the power of the mind over the body when evaluating new drugs.     Dr. Joe does more than simply explore the history and the physiology of the placebo effect. He asks the question: “Is it possible to teach the principles of the placebo, and without relying on any external substance, produce the same internal changes in a person’s health and ultimately in his or her life?” Then he shares scientific evidence (including color brain scans) of amazing healings from his workshops, in which participants learn his model of personal transformation, based on practical applications of the so-called placebo effect. The book ends with a “how-to” meditation for changing beliefs and perceptions that hold us back—the first step in healing.     You Are the Placebo combines the latest research in neuroscience, biology, psychology, hypnosis, behavioral conditioning, and quantum physics to demystify the workings of the placebo effect . . . and show how the seemingly impossible can become possible.