With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    In today's world, women have more power, legal recognition, and professional success than ever before. Alongside the evident progress of the women's movement, however, writer and journalist Naomi Wolf is troubled by a different kind of social control, which, she argues, may prove just as restrictive as the traditional image of homemaker and wife. It's the beauty myth, an obsession with physical perfection that traps the modern woman in an endless spiral of hope, self-consciousness, and self-hatred as she tries to fulfill society's impossible definition of "the flawless beauty."

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    After gaining admission to Oxford, and moving to the United States to become a journalist, through several love affairs, then marriage and family, Mead read and reread Middlemarch. The novel, which Virginia Woolf famously described as "one of the few English novels written for grown-up people," offered Mead something that modern life and literature did not.In this wise and revealing work of biography, reporting, and memoir, Rebecca Mead leads us into the life that the book made for her, as well as the many lives the novel has led since it was written. Employing a structure that deftly mirrors that of the novel, My Life in Middlemarch takes the themes of Eliot's masterpiece--the complexity of love, the meaning of marriage, the foundations of morality, and the drama of aspiration and failure--and brings them into our world. Offering both a fascinating reading of Eliot's biography and an exploration of the way aspects of Mead's life uncannily echo that of Eliot herself.

    From the United States Memory Championship to deep within the author's own mind, this is an electrifying work of journalism that reminds us that, in every way that matters, we are the sum of our memories.

    Every essay is crafted with the same scathing wit and poignant candor thousands of loyal readers have come to expect from visiting her notoriously hilarious blog.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    O'Connell addresses the pervasive imposter syndrome that comes with unplanned pregnancy, the second adolescence of a changing postpartum body, the problem of sex post-baby, the weird push to make "mom friends," and the fascinating strangeness of stepping into a new, not-yet-comfortable identity. O'Connell brings us into the delivery room rendering childbirth in all its feverish gore and glory, and shattering the fantasies of a "magical" or "natural" experience that warp our expectations and erode maternal self-esteem.And Now We Have Everything is an unflinchingly frank, funny, and intimate motherhood story for our times, about needing to have a baby in order to stop being one yourself.

    A cultural history of Wonder Woman traces the character's creation and enduring popularity, drawing on interviews and archival research to reveal the pivotal role of feminism in shaping her seven-decade story.Examines the life of Wonder Woman creator William Moulton Marston and his polyamorous relationship with wife Elizabeth Holloway and mistress Olive Byrne, both of whom inspired and influenced the comic book character's creation and development.-Abstract from WorldCat

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    And yet, very few of its readers know that the subject of the novel was inspired by a real-life case: the 1948 abduction of eleven-year-old Sally Horner.Weaving together suspenseful crime narrative, cultural and social history, and literary investigation, The Real Lolita tells Sally Horner’s full story for the very first time. Drawing upon extensive investigations, legal documents, public records, and interviews with remaining relatives, Sarah Weinman uncovers how much Nabokov knew of the Sally Horner case and the efforts he took to disguise that knowledge during the process of writing and publishing Lolita.Sally Horner’s story echoes the stories of countless girls and women who never had the chance to speak for themselves. By diving deeper in the publication history of Lolita and restoring Sally to her rightful place in the lore of the novel’s creation, The Real Lolita casts a new light on the dark inspiration for a modern classic.

    Based on more than two hundred personal interviews with both current and former Scientologists--both famous and less well known--and years of archival research, Lawrence Wright uses his extraordinary investigative skills to uncover for us the inner workings of the Church of Scientology: its origins in the imagination of science-fiction writer L. Ron Hubbard; its struggles to find acceptance as a legitimate (and legally acknowledged) religion; its vast, secret campaign to infiltrate the U.S. government; and its dramatic efforts to grow and prevail after the death of Hubbard.At the book's center, two men whom Wright brings vividly to life, showing how they have made Scientology what it is today: The darkly brilliant L. Ron Hubbard--whose restless, expansive mind invented a new religion tailor-made to prosper in the spiritually troubled post-World War II era. And his successor, David Miscavige--tough and driven, with the unenviable task of preserving the church in the face of ongoing scandals and continual legal assaults.We learn about Scientology's esoteric cosmology; about the auditing process that determines an inductee's state of being; about the Bridge to Total Freedom, through which members gain eternal life. We see the ways in which the church pursues celebrities, such as Tom Cruise and John Travolta, and how young idealists who joined the Sea Org, the church's clergy, whose members often enter as children, signing up with a billion-year contract and working with little pay in poor conditions. We meet men and women "disconnected" from friends and family by the church's policy of shunning critical voices. And we discover, through many firsthand stories, the violence that has long permeated the inner sanctum of the church.In Going Clear, Wright examines what fundamentally makes a religion a religion, and whether Scientology is, in fact, deserving of the constitutional protections achieved in its victory over the IRS. Employing all his exceptional journalistic skills of observations, understanding, and synthesis, and his ability to shape a story into a compelling narrative, Lawrence Wright has given us an evenhanded yet keenly incisive book that goes far beyond an immediate exposé and uncovers the very essence of what makes Scientology the institution it is.

    Linda Tirado, in her signature brutally honest yet personable voice, takes all of these preconceived notions and smashes them to bits. She articulates not only what it is to be working poor in America (yes, you can be poor and live in a house and have a job, even two), but what poverty is truly like—on all levels. Frankly and boldly, Tirado discusses openly how she went from lower-middle class, to sometimes middle class, to poor and everything in between, and in doing so reveals why “poor people don’t always behave the way middle-class America thinks they should.”

    Teenage girls are taking courses of testosterone and disfiguring their bodies. Parents are undermined; experts are over-relied upon; dissenters in science and medicine are intimidated; free speech truckles under renewed attack; socialized medicine bears hidden consequences; and an intersectional era has arisen in which the desire to escape a dominant identity encourages individuals to take cover in victim groups. Every person who has ever had a skeptical thought about the sudden rush toward a non-binary future but been afraid to express it—this book is for you.

    He has confronted, interviewed and researched dozens of serial killers and assassins, including Charles Manson, Richard Speck, John Wayne Gacy, and James Earl Ray - for a landmark study to understand their motives. To get inside their minds. He is Special Agent John Douglas, the model for law enforcement legend Jack Crawford in Thomas Harris's thrillers Red Dragon and The Silence of the Lambs, and the man who ushered in a new age in behavorial science and criminal profiling. Recently retired after twenty-five years of service, John Douglas can finally tell his unique and compelling story.