Diligently treating the drug addicts of Vancouver's notorious Downtown Eastside with sympathy in his heart and legislative reform in mind can't be easy. But Maté never judges. His book is a powerful call-to-arms, both for the decriminalization of drugs and for a more sympathetic and informed view of addiction. As Maté observes, "Those whom we dismiss as 'junkies' are not creatures from a different world, only men and women mired at the extreme end of a continuum on which, here or there, all of us might well locate ourselves." In the Realm of Hungry Ghosts begins by introducing us to many of Dr. Maté's most dire patients who steal, cheat, sell sex, and otherwise harm themselves for their next hit. Maté looks to the root causes of addiction, applying a clinical and psychological view to the physical manifestation and offering some enlightening answers for why people inflict such catastrophe on themselves.Finally, he takes aim at the hugely ineffectual, largely U.S.-led War on Drugs (and its worldwide followers), challenging the wisdom of fighting drugs instead of aiding the addicts, and showing how controversial measures such as safe injection sites are measurably more successful at reducing drug-related crime and the spread of disease than anything most major governments have going. It's not easy reading, but we ignore his arguments at our peril. When it comes to combating the drug trade and the ravages of addiction, society can use all the help it can get. --Kim Hughes

    Politicians and marketers present shoddy evidence for dubious claims all the time. But smart people make mistakes too, and when it comes to statistics, plenty of otherwise great scientists--yes, even those published in peer-reviewed journals--are doing statistics wrong."Statistics Done Wrong" comes to the rescue with cautionary tales of all-too-common statistical fallacies. It'll help you see where and why researchers often go wrong and teach you the best practices for avoiding their mistakes.In this book, you'll learn: - Why "statistically significant" doesn't necessarily imply practical significance- Ideas behind hypothesis testing and regression analysis, and common misinterpretations of those ideas- How and how not to ask questions, design experiments, and work with data- Why many studies have too little data to detect what they're looking for-and, surprisingly, why this means published results are often overestimates- Why false positives are much more common than "significant at the 5% level" would suggestBy walking through colorful examples of statistics gone awry, the book offers approachable lessons on proper methodology, and each chapter ends with pro tips for practicing scientists and statisticians. No matter what your level of experience, "Statistics Done Wrong" will teach you how to be a better analyst, data scientist, or researcher.

    Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book.

    Since the publication of the First Edition over thirty years ago, Div, Grad, Curl, and All That has been widely renowned for its clear and concise coverage of vector calculus, helping science and engineering students gain a thorough understanding of gradient, curl, and Laplacian operators without required knowledge of advanced mathematics.

    Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

    BONUS! FREE DIGITAL ACCESS One-year subscription to DrugGuide.com, Davis's Drug Guide Online, powered by Unbound Medicine. You'll have access to over 1,100 monographs from your desktop, laptop, or any mobile device with a web browser. LIFE-SAVING GUIDANCE... AT A GLANCE Red tab for high alert medications, plus in-depth high alert and patient safety coverage Red, capitalized letters for life-threatening side effects Drug-drug, drug-food, drug-natural product interactions Pedi, Geri, OB, and Lactation cautions IV Administration subheads NEW! REMS (Risk Evaluation and Mitigation Strategies) icon Pharmacogenomic content Canadian-specific Much more! LEARNING, CARE PLANNING, AND PATIENT EDUCATION TOOLS Online at DavisPlus Interactive flash cards MORE! Audio podcasts Video clips Animations Schematic brain illustrations Much more!

    But if code isn't clean, it can bring a development organization to its knees. Every year, countless hours and significant resources are lost because of poorly written code. But it doesn't have to be that way. Noted software expert Robert C. Martin presents a revolutionary paradigm with Clean Code: A Handbook of Agile Software Craftsmanship . Martin has teamed up with his colleagues from Object Mentor to distill their best agile practice of cleaning code on the fly into a book that will instill within you the values of a software craftsman and make you a better programmer but only if you work at it. What kind of work will you be doing? You'll be reading code - lots of code. And you will be challenged to think about what's right about that code, and what's wrong with it. More importantly, you will be challenged to reassess your professional values and your commitment to your craft. Clean Code is divided into three parts. The first describes the principles, patterns, and practices of writing clean code. The second part consists of several case studies of increasing complexity. Each case study is an exercise in cleaning up code - of transforming a code base that has some problems into one that is sound and efficient. The third part is the payoff: a single chapter containing a list of heuristics and "smells" gathered while creating the case studies. The result is a knowledge base that describes the way we think when we write, read, and clean code. Readers will come away from this book understanding ‣ How to tell the difference between good and bad code‣ How to write good code and how to transform bad code into good code‣ How to create good names, good functions, good objects, and good classes‣ How to format code for maximum readability ‣ How to implement complete error handling without obscuring code logic ‣ How to unit test and practice test-driven development This book is a must for any developer, software engineer, project manager, team lead, or systems analyst with an interest in producing better code.

    They spread rapidly, even in such seemingly harmless places as high school locker rooms, where they infect young athletes. Throughout the world, many more people are dying from these infections. Astoundingly, as antibiotic resistant infections are skyrocketing in incidence—creating a critical need for new antibiotics—research and development of new antibiotics has ground to a screeching halt!In Rising Plague, Dr. Brad Spellberg—an infectious diseases specialist and member of a national task force charged with attacking antibiotic resistant infections—tells the story of this potentially grave public health crisis. The author shares true and very moving patient stories to emphasize the terrible frustration he and his colleagues have experienced while attempting to treat untreatable infections, not to mention the heart-break and tragedy that many of these patients’ families had to endure. Dr. Spellberg corrects the nearly universal misperception that physician misuse of antibiotics and "dirty hospitals" are responsible for causing antibiotic-resistant infections. He explains the true causes of antibiotic resistance and of the virtual collapse of antibiotic research and development. Most important, he advocates ways to reverse this dire trend and instead bolster the production of desperately needed new and effective antibiotics. He also warns against complacency induced by the decades-old assumption that some miracle drug will always be available to ensure the continuation of our "antibiotic era." If we do nothing, we run the risk of inviting a bleak future when infectious diseases will once again reign supreme. Then many of the medical breakthroughs that we now take for granted—from routine surgery and organ transplants to intensive care and battlefield medicine—might all be threatened.This crucial and timely book is lucidly written in terms that everyone can understand. It issues a call to action, explaining how, through a strong and concerted effort, we can all help prevent this nightmare scenario from happening. By following this courageous doctor’s recommendations, we can assure that magic bullets will be there for our families and us in the future.

    This book contains student-friendly Study Tips, Clinical View boxes, and progressive question sets to motivate students to internalize and apply what they've learned.

    The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern tobacco plantations to the dense immigrant neighborhoods of northern cities to far-flung villages on the edges of the nascent American empire. In Pox, award-winning historian Michael Willrich offers a gripping chronicle of how the nation's continentwide fight against smallpox launched one of the most important civil liberties struggles of the twentieth century.At the dawn of the activist Progressive era and during a moment of great optimism about modern medicine, the government responded to the deadly epidemic by calling for universal compulsory vaccination. To enforce the law, public health authorities relied on quarantines, pesthouses, and "virus squads"-corps of doctors and club-wielding police. Though these measures eventually contained the disease, they also sparked a wave of popular resistance among Americans who perceived them as a threat to their health and to their rights.At the time, anti-vaccinationists were often dismissed as misguided cranks, but Willrich argues that they belonged to a wider legacy of American dissent that attended the rise of an increasingly powerful government. While a well-organized anti-vaccination movement sprang up during these years, many Americans resisted in subtler ways-by concealing sick family members or forging immunization certificates. Pox introduces us to memorable characters on both sides of the debate, from Henning Jacobson, a Swedish Lutheran minister whose battle against vaccination went all the way to the Supreme Court, to C. P. Wertenbaker, a federal surgeon who saw himself as a medical missionary combating a deadly-and preventable-disease.As Willrich suggests, many of the questions first raised by the Progressive-era antivaccination movement are still with us: How far should the government go to protect us from peril? What happens when the interests of public health collide with religious beliefs and personal conscience? In Pox, Willrich delivers a riveting tale about the clash of modern medicine, civil liberties, and government power at the turn of the last century that resonates powerfully today.

    Five actual journal articles are reproduced in the appendix as examples of the different research designs.

    Includes timelines, boxed features on significant medical breakthroughs, fascinating case histories, anecdotes and medical curiosities. Contains 150 color photographs.

    With it you can prime yourself with the key concepts of statistics before getting involved in the associated calculations. Using words and diagrams instead of figures, formulae and equations, Derek Rowntree makes statistics accessible to those who are non-mathematicians. And just to get you into the spirit of things. Rowntree has included questions in his argument; answer them as you go and you will be able to tell how far you have mastered the subject.

    The novel approach taken here banishes determinants to the end of the book and focuses on the central goal of linear algebra: understanding the structure of linear operators on vector spaces. The author has taken unusual care to motivate concepts and to simplify proofs. For example, the book presents - without having defined determinants - a clean proof that every linear operator on a finite-dimensional complex vector space (or an odd-dimensional real vector space) has an eigenvalue. A variety of interesting exercises in each chapter helps students understand and manipulate the objects of linear algebra. This second edition includes a new section on orthogonal projections and minimization problems. The sections on self-adjoint operators, normal operators, and the spectral theorem have been rewritten. New examples and new exercises have been added, several proofs have been simplified, and hundreds of minor improvements have been made throughout the text.

    Drawing on newly available papers of Jonas Salk, Albert Sabin and other key players, Oshinsky paints a suspenseful portrait of the race for the cure, weaving a dramatic tale centered on the furious rivalry between Salk and Sabin. He also tells the story of Isabel Morgan, perhaps the most talented of all polio researchers, who might have beaten Salk to the prize if she had not retired to raise a family.Oshinsky offers an insightful look at the National Foundation for Infantile Paralysis, which was founded in the 1930s by FDR and Basil O'Connor, it revolutionized fundraising and the perception of disease in America. Oshinsky also shows how the polio experience revolutionized the way in which the government licensed and tested new drugs before allowing them on the market, and the way in which the legal system dealt with manufacturers' liability for unsafe products. Finally, and perhaps most tellingly, Oshinsky reveals that polio was never the raging epidemic portrayed by the media, but in truth a relatively uncommon disease. But in baby-booming America--increasingly suburban, family-oriented, and hygiene-obsessed--the specter of polio, like the specter of the atomic bomb, soon became a cloud of terror over daily life.Both a gripping scientific suspense story and a provocative social and cultural history, Polio opens a fresh window onto postwar America.