Phill Juptitus talks about his personal word game habits, and we'll remember the late Humphrey Lyttelton's scurrilous account of Una Stubbs on I'm Sorry I Haven't a Clue.We'll travel deep inside the mind of puzzle-setter Chris Maslanka and visit the Comedy Store in London to experience the lightning reflexes of some top word-athletes. Plus, we'll examine an extraordinary claim—that the fashion for increasingly cryptic crosswords helped to defeat Hitler.Stephen Fry celebrates the fun side of the English language in this exclusive extended edition of a BBC Radio 4 special.

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

    New technologies have revealed secrets locked in prehistoric bones that no one could have previously predicted. We can now work out the color of dinosaurs, the force of their bite, their top speeds, and even how they cared for their young.Remarkable new fossil discoveries—giant sauropod dinosaur skeletons in Patagonia, dinosaurs with feathers in China, and a tiny dinosaur tail in Burmese amber—remain the lifeblood of modern paleobiology. Thanks to advances in technologies and methods, however, there has been a recent revolution in the scope of new information gleaned from such fossil finds.In Dinosaurs Rediscovered, leading paleontologist Michael J. Benton gathers together all the latest paleontological evidence, tracing the transformation of dinosaur study from its roots in antiquated natural history to an indisputably scientific field. Among other things, the book explores how dinosaur remains are found and excavated, and especially how paleontologists read the details of dinosaurs’ lives from their fossils—their colors, their growth, and even whether we will ever be able to bring them back to life. Benton’s account shows that, though extinct, dinosaurs are still very much a part of our world.

      Leonard Mlodinow takes us on a passionate and inspiring tour through the exciting history of human progress and the key events in the development of science. In the process, he presents a fascinating new look at the unique characteristics of our species and our society that helped propel us from stone tools to written language and through the birth of chemistry, biology, and modern physics to today’s technological world.   Along the way he explores the cultural conditions that influenced scientific thought through the ages and the colorful personalities of some of the great philosophers, scientists, and thinkers: Galileo, who preferred painting and poetry to medicine and dropped out of university; Isaac Newton, who stuck needlelike bodkins into his eyes to better understand changes in light and color; and Antoine Lavoisier, who drank nothing but milk for two weeks to examine its effects on his body. Charles Darwin, Albert Einstein, Werner Heisenberg, and many lesser-known but equally brilliant minds also populate these pages, each of their stories showing how much of human achievement can be attributed to the stubborn pursuit of simple questions (why? how?), bravely asked.  The Upright Thinkers is a book for science lovers and for anyone interested in creative thinking and in our ongoing quest to understand our world. At once deeply informed, accessible, and infused with the author’s trademark wit, this insightful work is a stunning tribute to humanity’s intellectual curiosity.  (With black-and-white illustrations throughout.)

    Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities. . . .But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are--our appearance, our height, our penchants--in inconceivably subtle ways." Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors--using a word that once referred to kingdoms and estates--but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

    The universe is all about extremes, and in this engaging and thought-provoking book, astronomer Bryan Gaensler gives a whirlwind tour of the galaxies, with an emphasis on its fastest, hottest, heaviest, brightest, oldest, densest, and even loudest elements. From supernova explosions a billion times brighter than the sun to an asteroid the size of a beach ball, Extreme Cosmos offers a fascinating, fresh, and informed perspective of the remarkable richness of the universe, and the incredible physics that modern astronomy has revealed.

    Drawing from years of teaching modern physics to nonscientists, Wolfson explains in a lively, conversational style the simple principles underlying Einstein's theory.Relativity, Wolfson shows, gave us a new view of space and time, opening the door to questions about their flexible nature: Is the universe finite or infinite? Will it expand forever or eventually collapse in a "big crunch"? Is time travel possible? What goes on inside a black hole? How does gravity really work? These questions at the forefront of twenty-first-century physics are all rooted in the profound and sweeping vision of Albert Einstein's early twentieth-century theory. Wolfson leads his readers on an intellectual journey that culminates in a universe made almost unimaginably rich by the principles that Einstein first discovered.

    There are deep connections between stars and atoms, between the cosmos and the microworld. Just six numbers, imprinted in the "big bang," determine the essential features of our entire physical world. Moreover, cosmic evolution is astonishingly sensitive to the values of these numbers. If any one of them were "untuned," there could be no stars and no life. This realization offers a radically new perspective on our universe, our place in it, and the nature of physical laws.

    Along the way, she meets biologists who are trying to preserve the world's rarest fish, which lives in a single tiny pool in the middle of the Mojave; engineers who are turning carbon emissions to stone in Iceland; Australian researchers who are trying to develop a super coral that can survive on a hotter globe; and physicists who are contemplating shooting tiny diamonds into the stratosphere to cool the earth.One way to look at human civilization, says Kolbert, is as a ten-thousand-year exercise in defying nature. In The Sixth Extinction, she explored the ways in which our capacity for destruction has reshaped the natural world. Now she examines how the very sorts of interventions that have imperiled our planet are increasingly seen as the only hope for its salvation.

    But when Feynman said he didn’t understand quantum mechanics, he didn’t mean that he couldn’t do it – he meant that’s all he could do. He didn’t understand what the maths was saying: what quantum mechanics tells us about reality.Over the past decade or so, the enigma of quantum mechanics has come into sharper focus. We now realise that quantum mechanics is less about particles and waves, uncertainty and fuzziness, than a theory about information: about what can be known and how.This is more disturbing than our bad habit of describing the quantum world as ‘things behaving weirdly’ suggests. It calls into question the meanings and limits of space and time, cause and effect, and knowledge itself.The quantum world isn’t a different world: it is our world, and if anything deserves to be called ‘weird’, it’s us. This exhilarating book is about what quantum maths really means – and what it doesn’t mean.

    But which one? And how?Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.

    John Brockman brings together the world’s best-known physicists and science writers—including Brian Greene, Walter Isaacson, Nobel Prize-winners Murray Gell-Mann and Frank Wilczek, and Brian Cox—to explain the universe in all wondrous splendor.In Universe, today’s most influential science writers explain the science behind our evolving understanding of the universe and everything in it, including the cutting edge research and discoveries that are shaping our knowledge.Lee Smolin reveals how math and cosmology are helping us create a theory of the whole universe Brian Cox offers new dimensions on the Large Hadron and the existence of a Higgs-Boson particle Neil Turok analyzes the fundamental laws of nature, what came before the big bang, and the possibility of a unified theory.Seth Lloyd investigates the impact of computational revolutions and the informational revolution Lawrence Krauss provides fresh insight into gravity, dark matter, and the energy of empty space Brian Greene and Walter Isaacson illuminate the genius who revolutionized modern science: Albert Einstein and much more.Explore the Universe with some of today’s greatest minds: what it is, how it came into being, and what may happen next.

    In the quantum realm, objects can be in two places at once. It's a place where time travel is not only possible, but necessary. It's a place where cause and effect can happen in reverse and observing something changes its state. From parallel universes to antimatter, quantum mechanics has revealed that when you get right down to it, the laws of nature are insane. The scientist J. B. S. Haldane once said, 'Reality is not only stranger than we imagine . . . it's stranger than we can imagine.' Never is this more true than with quantum mechanics; our best, most recent attempt to make sense of the fundamental laws of nature.Fundamental is a comprehensive beginner's guide to quantum mechanics, explaining not only the weirdness of the subject but the experiments that proved it to be true. Using a humorous and light-hearted approach, Fundamental tells the story of how the most brilliant minds in science grappled with seemingly impossible ideas and gave us everything from microchips to particle accelerators. Fundamental gives clear explanations of all the quantum phenomena known to modern science, without requiring an understanding of complex mathematics; tells the eccentric stories of the scientists who made these shattering discoveries and what they used them for; explains how quantum field theory (a topic not covered in detail by any other popular-science book) gave rise to particle physics and why the Higgs boson isn't the end of the story.

    Here is a delightfully entertaining and enlightening look at the unique sex lives of humans.

    Among the estimated one hundred billion solar systems in the known universe, evolving life is surely abundant. That evolution is a process of becoming in each case. Since Newton, we have turned to physics to assess reality. Butphysics alone cannot tell us where we came from, how we arrived, and why our world has evolved past the point of unicellular organisms to an extremely complex biosphere.Building on concepts from his work as a complex systems researcher at the Santa Fe Institute, Kauffman focuses in particular on the idea of cells constructing themselves and introduces concepts such as constraint closure. Living systems are defined by the concept of organization which has notbeen focused on in enough in previous works. Cells are autopoetic systems that build themselves: they literally construct their own constraints on the release of energy into a few degrees of freedom that constitutes the very thermodynamic work by which they build their own self creating constraints.Living cells are machines that construct and assemble their own working parts. The emergence of such systems-the origin of life problem-was probably a spontaneous phase transition to self-reproduction in complex enough prebiotic systems. The resulting protocells were capable of Darwin's heritablevariation, hence open-ended evolution by natural selection. Evolution propagates this burgeoning organization. Evolving living creatures, by existing, create new niches into which yet further new creatures can emerge. If life is abundant in the universe, this self-constructing, propagating, exploding diversity takes us beyond physics to biospheres everywhere.