A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation s disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

    To Jenna Bush Hager, they were her beloved Gampy and Ganny, who taught her about respect, humility, kindness, and living a life of passion and meaning—timeless lessons that continue to guide her.In Midland, Texas, Jenna’s maternal grandparents, Harold and Jenna Welch—Pa and Grammee—a home builder and homemaker, lived a quieter life outside the national spotlight. Yet their influence was no less indelible to their granddaughter. Throughout Jenna’s childhood and adolescence, the Welches taught her the name of every star in the sky, the way a dove uses her voice—teaching her to appreciate the beauty in the smallest things.Now the mother of three young children, Jenna pays homage to her grandparents in this collection of heartwarming, intimate personal essays. Filled with love, laughter, and unforgettable stories, Everything Beautiful in Its Time captures the joyous and bittersweet nature of life itself. Jenna reflects on the single year in which she and her family lost Barbara and George H. W. Bush, and Jenna Welch. With the light, self-deprecating charm of the bestselling Sisters First—cowritten with her twin sister, Barbara—Jenna reveals how they navigated this difficult period with grace, faith, and nostalgic humor, uplifted by their grandparents’ sage advice and incomparable spirits.In this moving book, Jenna remembers the past, cherishes the present, and prepares for the future—providing a wealth of anecdotes and lessons for her own children and all of us. Poignant and humorous, intimate and sincere, Everything Beautiful in Its Time is a warm and wonderful celebration of the enduring power of family and an exploration of the things that truly matter most.

    "A stunning memoir from the astronaut who spent a record-breaking year aboard the International Space Station – a candid account of his remarkable voyage, the journeys that preceded it, and his colorful formative years." Inside book cover comments.

    Schizophrenia is not a single unifying diagnosis, and Esme Weijun Wang writes not just to her fellow members of the "collected schizophrenias" but to those who wish to understand it as well. Opening with the journey toward her diagnosis of schizoaffective disorder, Wang discusses the medical community's own disagreement about labels and procedures for diagnosing those with mental illness, and then follows an arc that examines the manifestations of schizophrenia in her life. In essays that range from using fashion to present as high-functioning to the depths of a rare form of psychosis, and from the failures of the higher education system and the dangers of institutionalisation to the complexity of compounding factors such as PTSD and Lyme disease, Wang's analytical eye, honed as a former lab researcher at Stanford, allows her to balance research with personal narrative. An essay collection of undeniable power, The Collected Schizophrenias dispels misconceptions and provides insight into a condition long misunderstood.

    After the abolition of slavery in 1793, Toussaint Louverture became the leader of the colony's black population, commander of its republican army and eventually its governor. Treacherously captured by Napoleon's invading army a year later and imprisoned, he ended his days as the revolution's most eminent martyr. Louverture confronted the mighty forces of his age - slavery, settler colonialism, imperial domination, racial hierarchy and European cultural supremacy - and bent them to his will.Sudhir Hazareesingh draws on a wealth of archival material, much of it overlooked by previous biographers, to follow every step in Louverture's singular career, to capture his voice and the force of his personality. To a greater extent than any previous biography, Black Spartacus understands Louverture's vision and leadership not solely in the context of events in Europe and imported Enlightenment ideals, but in a world of hybrid slave culture and African and Caribbean influences.

    After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love.

    As the mother of 5 kids -- 6 if you include her husband -- sat in the neurosurgery department in star-covered sweats too whimsical for the seriousness of the situation, all she could think was "Am I going to die?"Thankfully, Jeannie and her family were able to survive their time of crisis, and now she is sharing her deeply personal journey through this miraculous story: the challenging conversations she had with her children; how she came to terms with feeling powerless and ferociously crabby while bedridden and unable to eat for a month; and how she ultimately learned, re-learned and re re-learned to be more present in life.With sincerity and hilarity, Jeannie invites you into her heart (and brain) during this trying time, emphasizing the importance of family, faith and humor as keys to her recovery and leading a more fulfilling life.

    She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.

    As he would later write in the first of a series of award-winning columns for "Vanity Fair," he suddenly found himself being deported "from the country of the well across the stark frontier that marks off the land of malady." Over the next eighteen months, until his death in Houston on December 15, 2011, he wrote constantly and brilliantly on politics and culture, astonishing readers with his capacity for superior work even in extremis.Throughout the course of his ordeal battling esophageal cancer, Hitchens adamantly and bravely refused the solace of religion, preferring to confront death with both eyes open. In this account of his affliction, he describes the torments of illness, discusses its taboos, and explores how disease transforms experience and changes our relationship to the world around us. By turns personal and philosophical, Hitchens embraces the full panoply of human emotions as cancer invades his body and compels him to grapple with the enigma of mortality.

    She takes us by her side down hospital corridors to visit the wards and meet her unforgettable patients.In the neonatal unit, premature babies fight for their lives, hovering at the very edge of survival, like tiny Emmanuel, wrapped up in a sandwich bag. On the cancer wards, the nurses administer chemotherapy and, long after the medicine stops working, something more important--which Watson learns to recognize when her own father is dying of cancer. In the pediatric intensive care unit, the nurses wash the hair of a little girl to remove the smell of smoke from the house fire. The emergency room is overcrowded as ever, with waves of alcohol and drug addicted patients as well as patients like Betty, a widow suffering chest pain, frail and alone. And the stories of the geriatric ward--Gladys and older patients like her--show the plight of the most vulnerable members of our society.

    Now: actress, single working mother of teenage rock star, and weight-loss inspiration to millions. We all knew and loved Valerie Bertinelli years ago when she played girl-next-door cutie Barbara Cooper in the hit TV show "One Day at a Time," and then starred in numerous TV movies. From wholesome primetime in America's living rooms, Valerie moved to late nights with the hardest-partying band of the decadent eighties when she became, at twenty, wife to rock guitarist Eddie Van Halen. Losing It is Valerie's frank account of her life backstage and in the spotlight. Here are the ups and downs of teen stardom, of her complicated marriage to a brilliant, tormented musical genius, and of her very public struggle with her weight.

    He often came across as a man possessed, holding forth on culture and politics while mixing in personal revelations – all with mercurial, tongue-twisting intensity as he inhabited and shed one character after another with lightning speed.But as Dave Itzkoff shows in this revelatory biography, Williams’s comic brilliance masked a deep well of conflicting emotions and self-doubt, which he drew upon in his comedy and in celebrated films like Dead Poets Society; Good Morning, Vietnam; The Fisher King; Aladdin; and Mrs. Doubtfire, where he showcased his limitless gift for improvisation to bring to life a wide range of characters. And in Good Will Hunting he gave an intense and controlled performance that revealed the true range of his talent.Itzkoff also shows how Williams struggled mightily with addiction and depression – topics he discussed openly while performing and during interviews – and with a debilitating condition at the end of his life that affected him in ways his fans never knew. Drawing on more than a hundred original interviews with family, friends, and colleagues, as well as extensive archival research, Robin is a fresh and original look at a man whose work touched so many lives.

    When the bird refuses to leave Tom's side, the young teacher has no choice but to take it with him and look after it. This is their story.

    Kear's biggest concern is choosing a major--until she walks into a doctor's office in midtown Manhattan and gets a life-changing diagnosis. She is going blind, courtesy of an eye disease called retinitis pigmentosa, and has only a decade or so before Lights Out. Instead of making preparations as the doctor suggests, Kear decides to carpe diem and make the most of the vision she has left. She joins circus school, tears through boyfriends, travels the world, and through all these hi-jinks, she keeps her vision loss a secret.When Kear becomes a mother, just a few years shy of her vision's expiration date, she amends her carpe diem strategy, giving up recklessness in order to relish every moment with her kids. Her secret, though, is harder to surrender - and as her vision deteriorates, harder to keep hidden. As her world grows blurred, one thing becomes clear: no matter how hard she fights, she won't win the battle against blindness. But if she comes clean with her secret, and comes to terms with the loss, she can still win her happy ending.Told with humor and irreverence, Now I See You is an uplifting story about refusing to cower at life's curveballs, about the power of love to triumph over fear. But, at its core, it's a story about acceptance: facing the truths that just won't go away, and facing yourself, broken parts and all.

    National bestseller "Medicine Men" follows the beloved #1 bestselling "Heart in the Right Place". This is a collection of the most memorable moments from more than a dozen rural physicians who each practiced medicine for more than 50 years in the Southern Appalachian Mountains from 1930-2012. Hilarious, heroic, true stories of miracle cures, ghost dogs, and much madcap medical mayhem. Unimaginably funny and touching situations where men with nerves of steel and hearts of gold get stuck between a rock and a hard place in the Smoky Mountains. These men are saints who walk among us and Jourdan's father is one of them. Jourdan's work is often compared to James Herriot and Bill Bryson. This story collection is like "All Creatures Great and Small" but with people instead of animals or vingnettes from country doctors who took "A Walk in the Woods".Jourdan's first book is on hundreds of lists of best books of the year, best book club books, and funniest books. "Heart in the Right Place" was chosen as Family Circle magazine's first ever Book of the Month, won the Elle magazine Reader's Prize, named a Wall Street Journal Nonfiction Bestseller and ranked #1 on Amazon in Biography, Memoir, Science, and Medicine.