But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    While it's clear that women and girls are vital voices and agents of change for this planet, they are too often missing from the proverbial table. More than a problem of bias, it's a dynamic that sets us up for failure. To change everything, we need everyone.All We Can Save illuminates the expertise and insights of dozens of diverse women leading on climate in the United States--scientists, journalists, farmers, lawyers, teachers, activists, innovators, wonks, and designers, across generations, geographies, and race--and aims to advance a more representative, nuanced, and solution-oriented public conversation on the climate crisis. These women offer a spectrum of ideas and insights for how we can rapidly, radically reshape society.Intermixing essays with poetry and art, this book is both a balm and a guide for knowing and holding what has been done to the world, while bolstering our resolve never to give up on one another or our collective future. We must summon truth, courage, and solutions to turn away from the brink and toward life-giving possibility. Curated by two climate leaders, the book is a collection and celebration of visionaries who are leading us on a path toward all we can save. With essays and poems by: Emily Atkin • Xiye Bastida • Ellen Bass • Colette Pichon Battle • Jainey K. Bavishi • Janine Benyus • adrienne maree brown • Régine Clément • Abigail Dillen • Camille T. Dungy • Rhiana Gunn-Wright • Joy Harjo • Katharine Hayhoe • Mary Annaïse Heglar • Jane Hirshfield • Mary Anne Hitt • Ailish Hopper • Tara Houska, Zhaabowekwe • Emily N. Johnston • Joan Naviyuk Kane • Naomi Klein • Kate Knuth • Ada Limón • Louise Maher-Johnson • Kate Marvel • Gina McCarthy • Anne Haven McDonnell • Sarah Miller • Sherri Mitchell, Weh’na Ha’mu Kwasset • Susanne C. Moser • Lynna Odel • Sharon Olds • Mary Oliver • Kate Orff • Jacqui Patterson • Leah Penniman • Catherine Pierce • Marge Piercy • Kendra Pierre-Louis • Varshini Prakash • Janisse Ray • Christine E. Nieves Rodriguez • Favianna Rodriguez • Cameron Russell • Ash Sanders • Judith D. Schwartz • Patricia Smith • Emily Stengel • Sarah Stillman • Leah Cardamore Stokes • Amanda Sturgeon • Maggie Thomas • Heather McTeer Toney • Alexandria Villaseñor • Alice Walker • Amy Westervelt • Jane Zelikova

    We will always have exactly as much water on Earth as we have ever had. Water cannot be destroyed, and it can always be made clean enough for drinking again. In fact, water can be made so clean that it actually becomes toxic. As Charles Fishman brings vibrantly to life in this delightful narrative excursion, water runs our world in a host of awe-inspiring ways, which is both the promise and the peril of our unexplored connections to it. Taking listeners from the wet moons of Saturn to the water-obsessed hotels of Las Vegas, and from a rice farm in the Australian outback to a glimpse into giant vats of soup at Campbell's largest factory, he reveals that our relationship to water is conflicted and irrational, neglected and mismanaged. Whether we will face a water scarcity crisis has little to do with water and everything to do with how we think about water-how we use it, connect with it, and understand it.Portraying and explaining both the dangers-in 2008, Atlanta came just ninety days from running completely out of drinking water-and the opportunities, such as advances in rainwater harvesting and businesses that are making huge breakthroughs in water productivity, The Big Thirst will forever change the way we think about water, our crucial relationship to it, and the creativity we can bring to ensuring we always have plenty of it.

    Johnson takes us to those times when the world seemed filled with mysterious forces, when scientists were dazzled by light, by electricity, and by the beating of the hearts they laid bare on the dissecting table. We see Galileo singing to mark time as he measures the pull of gravity, and Newton carefully inserting a needle behind his eye to learn how light causes vibrations in the retina. William Harvey ties a tourniquet around his arm and watches his arteries throb above and his veins bulge below, proving that blood circulates. Luigi Galvani sparks electrical currents in dissected frog legs, wondering at the twitching muscle fibers, and Ivan Pavlov makes his now-famous dogs salivate at ascending chord progressions.For all of them, diligence was rewarded. In an instant, confusion was swept aside and something new about nature leaped into view. In bringing us these stories, Johnson restores some of the romance to science, reminding us of the existential excitement of a single soul staring down the unknown.

    The average young person in the UK will spend 10,000 hours gaming by the age of twenty-one. What's causing this mass exodus? According to world-renowned game designer Jane McGonigal the answer is simple: videogames are fulfilling genuine human needs. Drawing on positive psychology, cognitive science and sociology, Reality is Broken shows how game designers have hit on core truths about what makes us happy, and utilized these discoveries to astonishing effect in virtual environments. But why, McGonigal asks, should we use the power of games for escapist entertainment alone? In this groundbreaking exploration of the power and future of gaming, she reveals how gamers have become expert problem solvers and collaborators, and shows how we can use the lessons of game design to socially positive ends, be it in our own lives, our communities or our businesses. Written for gamers and non-gamers alike, Reality is Broken sends a clear and provocative message: the future will belong to those who can understand, design and play games.

    Starting once again with fossils, he turns his gaze skyward, showing us how the entirety of the universe’s fourteen-billion-year history can be seen in our bodies. As he moves from our very molecular composition (a result of stellar events at the origin of our solar system) through the workings of our eyes, Shubin makes clear how the evolution of the cosmos has profoundly marked our own bodies. Fully illustrated with black and white drawings.

    Our 1940s heroes are the brilliant mathematician Lawrence Waterhouse, crypt analyst extraordinaire, and gung-ho, morphine-addicted marine Bobby Shaftoe. They're part of Detachment 2702, an Allied group trying to break Axis communication codes while simultaneously preventing the enemy from figuring out that their codes have been broken. Their job boils down to layer upon layer of deception. Dr. Alan Turing is also a member of 2702, and he explains the unit's strange workings to Waterhouse. "When we want to sink a convoy, we send out an observation plane first... Of course, to observe is not its real duty—we already know exactly where the convoy is. Its real duty is to be observed... Then, when we come round and sink them, the Germans will not find it suspicious."All of this secrecy resonates in the present-day story line, in which the grandchildren of the WWII heroes—inimitable programming geek Randy Waterhouse and the lovely and powerful Amy Shaftoe—team up to help create an offshore data haven in Southeast Asia and maybe uncover some gold once destined for Nazi coffers. To top off the paranoiac tone of the book, the mysterious Enoch Root, key member of Detachment 2702 and the Societas Eruditorum, pops up with an unbreakable encryption scheme left over from WWII to befuddle the 1990s protagonists with conspiratorial ties.

    Through encrypted channels, he then receives documents revealing how the president of Argentina has sequestered millions of dollars of state money for private use. This is just the beginning. Obermayer and fellow Suddeutsche journalist Frederik Obermaier find themselves immersed in the secret world where complex networks of letterbox companies help the super-rich to hide their money. Faced with the contents of the largest data leak in history, they activate an international network of journalists to follow every possible line of inquiry. Operating in the strictest secrecy for over a year, they uncover cases involving European prime ministers and international dictators, emirs and kings, celebrities and aristocrats. The real-life thriller behind the story of the century, The Panama Papers is an intense, unputdownable account that proves, once and for all, that there exists a small elite living by a different set of rules and blows their secret world wide open.

    Just over fifteen years later, he had transformed himself into the charismatic CEO of a company worth $47 billion--at least on paper. With his long hair and feel-good mantras, the 6-foot-five Neumann, who grew up in part on a kibbutz, looked the part of a messianic Silicon Valley entrepreneur. The vision he offered was mesmerizing: a radical reimagining of work space for a new generation, with its fluid jobs and lax office culture. He called it WeWork. Though the company was merely subleasing amenity-filled office space to freelancers and small startups, Neumann marketed it like a revolutionary product--and investors swooned.As billions of funding dollars poured in, Neumann's ambitions grew limitless. WeWork wasn't just an office space provider, he boasted. It would build schools, create WeWork cities, even colonize Mars. Could he, Neumann wondered from the ice bath he'd installed in his office, become the first trillionaire or a world leader? In pursuit of its founder's grandiose vision, the company spent money faster than it could bring it in. From his private jet, sometimes clouded with marijuana smoke, the CEO scoured the globe for more capital. In late 2019, just weeks before WeWork's highly publicized IPO, a Hail Mary effort to raise cash, everything fell apart. Neumann was ousted from his company--but still was poised to walk away a billionaire.Calling to mind the recent demise of Theranos and the hubris of the dotcom era bust, WeWork's extraordinary rise and staggering implosion were fueled by disparate characters in a financial system blind to its risks, from a Japanese billionaire with designs on becoming the Warren Buffet of tech, to leaders at JPMorgan and Goldman Sachs who seemed intoxicated by a Silicon Valley culture where sensible business models lost out to youthful CEOs who promised disruption. Why did some of the biggest names in banking and venture capital buy the hype? And what does the future hold for Silicon Valley unicorns? Wall Street Journal reporters Eliot Brown and Maureen Farrell explore these questions in this definitive account of WeWork's unraveling.

     NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY CHICAGO TRIBUNE AND THE DALLAS MORNING NEWS - "A deft blend of nostalgia, humor and devastating insights."--PeopleRemember all those ingrained habits, cherished ideas, beloved objects, and stubborn preferences from the pre-Internet age? They're gone.To some of those things we can say good riddance. But many we miss terribly. Whatever our emotional response to this departed realm, we are faced with the fact that nearly every aspect of modern life now takes place in filtered, isolated corners of cyberspace--a space that has slowly subsumed our physical habitats, replacing or transforming the office, our local library, a favorite bar, the movie theater, and the coffee shop where people met one another's gaze from across the room. Even as we've gained the ability to gather without leaving our house, many of the fundamentally human experiences that have sustained us have disappeared.In one hundred glimpses of that pre-Internet world, Pamela Paul, editor of The New York Times Book Review, presents a captivating record, enlivened with illustrations, of the world before cyberspace--from voicemails to blind dates to punctuation to civility. There are the small losses: postcards, the blessings of an adolescence largely spared of documentation, the Rolodex, and the genuine surprises at high school reunions. But there are larger repercussions, too: weaker memories, the inability to entertain oneself, and the utter demolition of privacy.100 Things We've Lost to the Internet is at once an evocative swan song for a disappearing era and, perhaps, a guide to reclaiming just a little bit more of the world IRL.

    Each page offers simple activities that help you understand the roles of your “happy chemicals”—serotonin, dopamine, oxytocin, and endorphin. You’ll also learn how to build new habits by rerouting the electricity in your brain to flow down a new pathway, making it even easier to trigger these happy chemicals and increase feelings of satisfaction when you need them most. Filled with dozens of exercises that will help you reprogram your brain, Habits of a Happy Brain shows you how to live a happier, healthier life!

    This level of belief rivals that of belief in God. American Cosmic examines the mechanisms at work behind the thriving belief system in extraterrestrial life, a system that is changing and even supplanting traditional religions.Over the course of a six-year ethnographic study, D.W. Pasulka interviewed successful and influential scientists, professionals, and Silicon Valley entrepreneurs who believe in extraterrestrial intelligence, thereby disproving the common misconception that only fringe members of society believe in UFOs. She argues that widespread belief in aliens is due to a number of factors including their ubiquity in modern media like The X-Files, which can influence memory, and the believability lent to that media by the search for planets that might support life. American Cosmic explores the intriguing question of how people interpret unexplainable experiences, and argues that the media is replacing religion as a cultural authority that offers believers answers about non-human intelligent life.

    With this book, discover how to get the best sound for your money, how to identify the weak links in your system and upgrade where it will do the most good, how to set up and tweak your system for maximum performance, and how to become a more perceptive and appreciative listener. Just a few of the secrets you will learn cover high-end sound on a budget, how to do it cheap and still do it right; five system set-up mistakes and how to avoid them; how to make your speakers sound up to 50% better, at no cost; how to choose and set up a computer-based music system; how to find the one speaker in 50 worth owning; and why all 100-watt amplifiers don't sound the same. Since the first edition's publication in 1994, The Complete Guide to High-End Audio has been considered the essential reference on high-quality music reproduction, with more than 150,000 copies sold in five languages.

    In Turing’s Cathedral, George Dyson focuses on a small group of men and women, led by John von Neumann at the Institute for Advanced Study in Princeton, New Jersey, who built one of the first computers to realize Alan Turing’s vision of a Universal Machine. Their work would break the distinction between numbers that mean things and numbers that do things—and our universe would never be the same. Using five kilobytes of memory (the amount allocated to displaying the cursor on a computer desktop of today), they achieved unprecedented success in both weather prediction and nuclear weapons design, while tackling, in their spare time, problems ranging from the evolution of viruses to the evolution of stars. Dyson’s account, both historic and prophetic, sheds important new light on how the digital universe exploded in the aftermath of World War II. The proliferation of both codes and machines was paralleled by two historic developments: the decoding of self-replicating sequences in biology and the invention of the hydrogen bomb. It’s no coincidence that the most destructive and the most constructive of human inventions appeared at exactly the same time.  How did code take over the world? In retracing how Alan Turing’s one-dimensional model became John von Neumann’s two-dimensional implementation, Turing’s Cathedral offers a series of provocative suggestions as to where the digital universe, now fully three-dimensional, may be heading next.

    In First You Build a Cloud, K. C. Cole provides cogent explanations through animated prose, metaphors, and anecdotes, allowing us to comprehend the nuances of physics-gravity and light, color and shape, quarks and quasars, particles and stars, force and strength. We also come to see how the physical world is so deeply intertwined with the ways in which we think about culture, poetry, and philosophy. Cole, one of our preeminent science writers, serves as a guide into the world of such legendary scientific minds as Richard Feynman, Victor Weisskopf, brothers Frank Oppenheimer and J. Robert Oppenheimer, Philip Morrison, Vera Kistiakowsky, and Stephen Jay Gould.