The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    But concern over what Louis Brandeis called the "curse of bigness" can no longer remain the province of specialist lawyers and economists, for it has spilled over into policy and politics, even threatening democracy itself. History suggests that tolerance of inequality and failing to control excessive corporate power may prompt the rise of populism, nationalism, extremist politicians, and fascist regimes. In short, as Wu warns, we are in grave danger of repeating the signature errors of the twentieth century.In The Curse of Bigness, Columbia professor Tim Wu tells of how figures like Brandeis and Theodore Roosevelt first confronted the democratic threats posed by the great trusts of the Gilded Age--but the lessons of the Progressive Era were forgotten in the last 40 years. He calls for recovering the lost tenets of the trustbusting age as part of a broader revival of American progressive ideas as we confront the fallout of persistent and extreme economic inequality.

    Vollmann, S.E. Hinton, Dave Eggers, Myla Goldberg, Rick Moody, and Alexander Payne.  Inspired by the Depression-era WPA guides and awarded an “A” grade by Entertainment Weekly, these delightful essays on the American character deliver “the full plumage of American life, in all its riotous glory” (The New Yorker).

    Sixteen-year-old Padma sparked and burned. Fourteen-year-old Lalli was an incorrigible romantic.They grew up in Katra Sadatganj, an eye-blink of a village in western Uttar Pradesh crammed into less than one square mile of land. It was out in the fields, in the middle of mango season, that the rumors started.Then one night in the summer of 2014 the girls went missing; and hours later they were found hanging in the orchard. Who they were, and what had happened to them, was already less important than what their disappearance meant to the people left behind.In the ensuing months, the investigation into their deaths would implode everything that their small community held to be true, and instigate a national conversation about sex and violence. Slipping deftly behind political maneuvering, caste systems and codes of honor in a village in northern India, The Good Girls returns to the scene of Padma and Lalli's short lives and shameful deaths, and dares to ask: what is the human cost of shame?

    What led to this swing? Is it possible to trace the path to this point? Is there a way back to the just, secular, inclusive vision of our Constitution-makers?This country has long been an outlier in its South Asian neighbourhood, with its inclusive Constitution and functioning democracy. The growth of Hindutva, in some sense, brings India in line with the other polities here. In Our Hindu Rashtra, writer and activist Aakar Patel peels back layer after layer of cause and effect through independent India’s history to understand how Hindutva came to gain such a hold on the country. He examines what it means for India that its laws and judiciary have been permeated by prejudice and bigotry, what the breach of fundamental rights portends in these circumstances, and what the all-round institutional collapse signifies for the future of Indians.Most importantly, Patel asks and answers that most important of questions: what possibilities exist for a return? Thought-provoking and pulling no punches, this book is an essential read for anyone who wishes to understand the nature of politics in India and, indeed, South Asia.

    It has crippled the country’s economy for a long time to come. In this book, Arun Kumar, the country’s leading authority on the black economy, tells us why Modi’s gambit failed. He shows us the way in which the problem can be rooted out, provided the government has the political will and determination to act.Today, the black economy is estimated to be 62 per cent of GDP—or about `93 lakh crore ($1.4 trillion). Corrupt businessmen, corrupt politicians, and corrupt members of the executive (bureaucrats, police and the judiciary) are responsible for controlling the black economy and enabling its growth. If the black economy were to be dismantled and turned into a part of the ‘white’ economy, the country’s rate of growth would be 12 per cent. If it had not grown the way it has since the 1970s, India’s per capita income today would be approximately `7 lakh per annum ($11,000) and India would become the second largest economy in the world. If the black economy were taxed at current rates, it would generate `37 lakh crore in additional taxes and the union budget would show a surplus of `31 lakh crore instead of a deficit.The failure of successive governments to tackle the problem effectively has been the single biggest obstacle to eradicating poverty. It is the cause of both widespread policy failure and the inability of the nation to improve its living conditions rapidly.

    A Vintage Original.Hope Jahren is an award-winning geobiologist, a brilliant writer, and one of the seven billion people with whom we share this earth. The Story of More is her impassioned open letter to humanity as we stand at the crossroads of survival and extinction. Jahren celebrates the long history of our enterprising spirit--which has tamed wild crops, cured diseases, and sent us to the moon--but also shows how that spirit has created excesses that are quickly warming our planet to dangerous levels. In short, highly readable chapters, she takes us through the science behind the key inventions--from electric power to large-scale farming and automobiles--that, even as they help us, release untenable amounts of carbon dioxide. She explains the current and projected consequences of greenhouse gases--from superstorms to rising sea levels--and the science-based tools that could help us fight back. At once an explainer on the mechanisms of warming and a capsule history of human development, The Story of More illuminates the link between our consumption habits and our endangered earth, showing us how we can use less and share more. It is the essential pocket primer on climate change that will leave an indelible impact on everyone who reads it.

    The government's financewatchdog- the Comptroller and Auditor General (CAG) - found the government had pickedfavourites and avoided open and competitive bidding which would have generatedfar more revenue for a cash-starved state. The CAG concluded that India hadlost ` 1.861akh crore (over $ 30 billion) in theprocess, all of which went to the private companies. It was the biggestrecorded seam in the history of India. The Central Bureau of Investigation (CBI),India's premier investigation agency, then filed an FIR against the top officerin the coal ministry-Secretary PC Parakh and industrialist Kumar MangalamBirla. Parakh had by then earned a fine reputation for ability and integrity inover three decades. as a civil servant. His stint as the top bureaucrat in thecoal ministry was his last posting in a sterling career. The FIR outraged thecivil services and corporate India and was widely condemned by theintelligentsia of the country. The book isn't just about the coal seam. It isalso about working with some of the biggest Indian politicians, starting withchief ministers of Andhra Pradesh. It is about life in the coal ministry withMamata Banerjee, Shibu Soren and Dr. Manmohan Singh, who was also the PrimeMinister. It is about the lessons learnt before Parakh met any of thesedignitaries. It is an account that startles with never-before revealed information. About the Author PC

    Today, they lead to Beijing.'When The Silk Roads was published in 2015, it became an instant classic. A major reassessment of world history, it compelled us to look at the past from a different perspective. The New Silk Roads brings this story up to date, addressing the present and future of a world that is changing dramatically.Following the Silk Roads eastwards, from Europe through to China, by way of Russia and the Middle East, The New Silk Roads provides a timely reminder that we live in a world that is profoundly interconnected. In an age of Brexit and Trump, the themes of isolation and fragmentation permeating the Western world stand in sharp contrast to events along the Silk Roads since 2015, where ties have been strengthened and mutual cooperation established.With brilliant insight, Peter Frankopan takes a fresh look at the network of relationships being formed along the length and breadth of the Silk Roads today, assessing the global reverberations of these continual shifts in the centre of power - all too often absent from headlines in the West. This important - and ultimately hopeful - book asks us to reassess who we are and where we are in the world, illuminating the themes on which all our lives and livelihood depend.

    It allegedly involved sexual exploitation, forced castrations, private militias, illegal trade in arms and opium, and land grab on an untold scale-until the self-styled godman was convicted for one of his many crimes in August 2017. The book opens with an anonymous letter which led to the first-ever journalistic investigation, in 2007-Tehelka's Operation Jhootha Sauda-into the reported criminal activities at the Dera. In the years that followed, the author continued to document the lonely battles for justice against the influential godman who had the might of the Dera's machinery and manpower behind him. This book is as much about the grit and determination of ordinary citizens fighting power systems as it is about the difficulty of investigating crimes committed by the rich and powerful in India today.

    Board of Education. Thomas Sowell takes a tough, factual look at what has actually happened over these decades -- as distinguished from the hopes with which they began or the rhetoric with which they continue, Who has gained and who has lost? Which of the assumptions behind the civil rights revolution have stood the test of time and which have proven to be mistaken or even catastrophic to those who were supposed to be helped?

    It is rare that a historian of the Left has managed to retain as much credibility while refusing to let his academic mantle change his beautiful writing style from being anything but direct, forthright, and accessible. Whether his subject is war, race, politics, economic justice, or history itself, each of his works serves as a reminder that to embrace one's subjectivity can mean embracing one's humanity, that heart and mind can speak with one voice. Here, in six sections, is the historian's own choice of his shorter essays on some of the most critical problems facing America throughout its history, and today.

    Journey through timeto visit the baths and palaces of the first cities of Harappa, the stupas ofAshoka and the flamboyant courts of the great Mughals, rich in art, cultureand architecture. Learn how the revolution of 1857 really started, and marchalongside Gandhi on his quest for an India free from British rule. Plus,discover more about each period through fun and easy ‘To do’ activities.Told in simple, lucid prose, and interspersed with beautiful illustrations,A Children’s History of India makes learning history a fun and engagingexperience for readers of all ages.

    I am what you may call a "defector" from the USSR, and I have a message for you: I love you very much. I love all of you-- liberals and conservatives, "decadent capitalists" and "oppressed masses," blacks and whites and browns and yellows, rednecks and intellectuals. For me you are the people who created a unique nation, country and society in the history of mankind,-- by no means a perfect one, but, let's face it-- the most free, affluent and just in today's world.I am not alone in this love. People all over the Earth, whether they praise America or bitterly criticize her, look upon you as the only hope for mankind's survival and the last stronghold of freedom. Some may not think in these idealistic terms, but they certainly enjoy the fruits of your civilization, often forgetting to be grateful for them. Millions of people in the so-called "socialist camp" or in the "Third World" literally owe their lives to America.

    It has seared the psyche of four plus generations of this subcontinent. Why did this partition take place at all? Who was/is responsible - Jinnah? The Congress party? Or the British? Jaswant Singh attempts to find an answer, his answer, for there can perhaps not be a definitive answer, yet the author searches. Jinnah's political journey began as 'an ambassador of Hindu-Muslim Unity' (Gopal Krishna Gokhale), yet ended with his becoming the 'sole spokesman' of Muslims in India; the creator of Pakistan, The Quaid-e-Azam: How and why did this transformation take place?No Indian or Pakistani politician/Member of Parliament has ventured an analytical, political biography of Quaid-e-Azam Mohammad Ali Jinnah, about whom views necessarily get divided as being either Hagiographical or additional demonology. The book attempts an objective evaluation. Jaswant Singh's experience as a minister responsible for the conduct of India's foreign policy, managing the country's defence (concurrently), had been uniformly challenging (Lahore Peace process; betrayed at Kargil; Kandahar; the Agra Peace Summit; the attack on Jammu and Kashmir Assembly and the Indian Parliament; coercive diplomacy of 2002; the peace overtures reinitiated in April 2003).He asks where and when did this questionable thesis of 'Muslims as a separate nation' first originate and lead the Indian sub-continent to? And where did it drag Pakistan to? Why then a Bangladesh? Also what now of Pakistan? Where is it headed? This book is special; it stands apart, for it is authored by a practitioner of policy, an innovator of policies in search of definitive answers. Those burning 'whys' of the last sixty-two years, which bedevil us still. Jaswant Singh believes that for the return of lasting peace in South Asia there is no alternative but to first understand what made it 'abandon' us in the first place. Until we do that, a minimum, a must, we will never be able to persuade peace to return.