These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Then, in 2005, astronomer Mike Brown made the discovery of a lifetime: a tenth planet, Eris, slightly bigger than Pluto. But instead of its resulting in one more planet being added to our solar system, Brown’s find ignited a firestorm of controversy that riled the usually sedate world of astronomy and launched him into the public eye. The debate culminated in the demotion of Pluto from real planet to the newly coined category of “dwarf” planet. Suddenly Brown was receiving hate mail from schoolchildren and being bombarded by TV reporters—all because of the discovery he had spent years searching for and a lifetime dreaming about.Filled with both humor and drama, How I Killed Pluto and Why It Had It Coming is Mike Brown’s engaging first-person account of the most tumultuous year in modern astronomy—which he inadvertently caused. As it guides readers through important scientific concepts and inspires us to think more deeply about our place in the cosmos, it is also an entertaining and enlightening personal story: While Brown sought to expand our understanding of the vast nature of space, his own life was changed in the most immediate, human ways by love, birth, and death. A heartfelt and personal perspective on the demotion of everyone’s favorite farflung planet, How I Killed Pluto and Why It Had It Coming is the book for anyone, young or old, who has ever dreamed of exploring the universe—and who among us hasn’t?

    The pages take the reader on a wild narrative ride through the world of squid science and adventure, along the way addressing some riddles about what intelligence is, and what monsters lie in the deep. In addition to squid, both giant and otherwise, Kraken examines other equally enthralling cephalopods, including the octopus and the cuttlefish, and explores their otherworldly abilities, such as camouflage and bioluminescence. Accessible and entertaining, Kraken is also the first substantial volume on the subject in more than a decade and a must for fans of popular science.

    Illustrated.

    But natural selection has given us a suite of beneficial social features, including our capacity for love, friendship, cooperation, and learning. Beneath all of our inventions -- our tools, farms, machines, cities, nations -- we carry with us innate proclivities to make a good society.In Blueprint, Nicholas A. Christakis introduces the compelling idea that our genes affect not only our bodies and behaviors, but also the ways in which we make societies, ones that are surprisingly similar worldwide.With many vivid examples -- including diverse historical and contemporary cultures, communities formed in the wake of shipwrecks, commune dwellers seeking utopia, online groups thrown together by design or involving artificially intelligent bots, and even the tender and complex social arrangements of elephants and dolphins that so resemble our own -- Christakis shows that, despite a human history replete with violence, we cannot escape our social blueprint for goodness.In a world of increasing political and economic polarization, it's tempting to ignore the positive role of our evolutionary past. But by exploring the ancient roots of goodness in civilization, Blueprint shows that our genes have shaped societies for our welfare and that, in a feedback loop stretching back many thousands of years, societies are still shaping our genes today.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    To the right listener, they tell us all about themselves: where they came from, how they lived, how they died - and who killed them. Forensic scientists can unlock the mysteries of the past and help justice to be done using the messages left by a corpse, a crime scene or the faintest of human traces. Forensics uncovers the secrets of forensic medicine, drawing on interviews with top-level professionals, ground-breaking research and Val McDermid's own experience to lay bare the secrets of this fascinating science. And, along the way, she wonders at how maggots collected from a corpse can help determine time of death, how a DNA trace a millionth the size of a grain of salt can be used to convict a killer and how a team of young Argentine scientists led by a maverick American anthropologist uncovered the victims of a genocide.In her crime novels, Val McDermid has been solving complex crimes and confronting unimaginable evil for years. Now, she's looking at the people who do it for real, and real crime scenes. It's a journey that will take her to war zones, fire scenes and autopsy suites, and bring her into contact with extraordinary bravery and wickedness, as she traces the history of forensics from its earliest beginnings to the cutting-edge science of the modern day.

    Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences.In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility.A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

    With a new preface about the significance of the discovery of the Higgs particle, A Universe from Nothing uses Krauss’s characteristic wry humor and wonderfully clear explanations to take us back to the beginning of the beginning, presenting the most recent evidence for how our universe evolved—and the implications for how it’s going to end. Provocative, challenging, and delightfully readable, this is a game-changing look at the most basic underpinning of existence and a powerful antidote to outmoded philosophical, religious, and scientific thinking.

    In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past. Journeying to far-flung Siberian locales in search of ice age bones and delving into her own research--as well as those of fellow experts such as Svante Paabo, George Church, and Craig Venter--Shapiro considers de-extinction's practical benefits and ethical challenges. Would de-extinction change the way we live? Is this really cloning? What are the costs and risks? And what is the ultimate goal?Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms. But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem.Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.

    Today there is just one. Us. Homo sapiens. How did our species succeed in the battle for dominance? Why did our foraging ancestors come together to create cities and kingdoms? How did we come to believe in gods, nations and human rights; to trust money, books and laws; and to be enslaved by bureaucracy, timetables and consumerism? And what will our world be like in the millennia to come? In Sapiens, Dr Yuval Noah Harari spans the whole of human history, from the very first humans to walk the earth to the radical – and sometimes devastating – breakthroughs of the Cognitive, Agricultural and Scientific Revolutions. Drawing on insights from biology, anthropology, paleontology and economics, he explores how the currents of history have shaped our human societies, the animals and plants around us, and even our personalities. Have we become happier as history has unfolded? Can we ever free our behaviour from the heritage of our ancestors? And what, if anything, can we do to influence the course of the centuries to come? Bold, wide-ranging and provocative, Sapiens challenges everything we thought we knew about being human: our thoughts, our actions, our power ... and our future.

    Like Jared Diamond's Guns, Germs and Steel, Mapping Human History is a groundbreaking synthesis of science and history. Drawing on a wide range of sources, including the latest genetic research, linguistic evidence, and archaeological findings, Olson reveals the surprising unity among modern humans and "demonstrates just how naive some of our ideas about our human ancestry have been" (Discover).Olson offers a genealogy of all humanity, explaining, for instance, why everyone can claim Julius Caesar and Confucius as forebears. Olson also provides startling new perspectives on the invention of agriculture, the peopling of the Americas, the origins of language, the history of the Jews, and more. An engaging and lucid account, Mapping Human History will forever change how we think about ourselves and our relations with others.

    But evolutionary biologists also point out many examples of contingency, cases where the tiniest change--a random mutation or an ancient butterfly sneeze--caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary freaks? And what does that say about life on other planets?Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be.Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.

    William Maples can deduce the age, gender, and ethnicity of a murder victim, the manner in which the person was dispatched, and, ultimately, the identity of the killer.  In Dead Men Do Tell Tales, Dr. Maples revisits his strangest, most interesting, and most horrific investigations, from the baffling cases of conquistador Francisco Pizarro and Vietnam MIAs to the mysterious deaths of President Zachary Taylor and the family of Czar Nicholas II.

    You experience it passing every day when you watch clocks tick, bread toast, and children grow. But most physicists see things differently, from Newton to Einstein to today’s quantum theorists. For them, time isn’t real. You may think you experience time passing, but they say it’s just an illusion.Lee Smolin, author of the controversial bestseller The Trouble with Physics, argues this limited notion of time is holding physics back. It’s time for a major revolution in scientific thought. The reality of time could be the key to the next big breakthrough in theoretical physics.What if the laws of physics themselves were not timeless? What if they could evolve? Time Reborn offers a radical new approach to cosmology that embraces the reality of time and opens up a whole new universe of possibilties. There are few ideas that, like our notion of time, shape our thinking about literally everything, with major implications for physics and beyond—from climate change to the economic crisis. Smolin explains in lively and lucid prose how the true nature of time impacts our world.