Like something from a science fiction novel, doctors carefully injected viruses bearing healing genes into the DNA of Corey's eyes a few days later, Corey could see, his sight restored by gene therapy.THE FOREVER FIX is the first book to tell the fascinating story of gene therapy: how it works, the science behind it, how patients (mostly children) have been helped and harmed, and how scientists learned from each trial to get one step closer to its immense promise, the promise of a "forever fix," - a cure that, by fixing problems at their genetic root, does not need further surgery or medication.Told through the voices of the children and families who have been the inspiration, experimental subjects, and successes of genetic science, THE FOREVER FIX is compelling and engaging narrative science that tells explores the future of medicine as well as the families and scientists who are breaking new ground every day."

     From the Aztec plumed serpent to the Christian dove to Plato's vision of the human soul growing wings, religion and philosophy use birds to represent our aspirational selves. Winged creatures appear in mythology and folk tales, and in literature by writers as diverse as Ovid, Thoreau, and T. S. Eliot. They've been omens, allegories, and guides; they've been worshipped, eaten, and feared. Birds figure tellingly in the work of such nature writers as Gilbert White and Peter Matthiessen, and are synonymous with the science of Darwin.Gibson spent years collecting this gorgeously illustrated celebration of centuries of human response to the delights of the feathered tribes. The Bedside Book of Birds is for everyone who is intrigued by the artistic forms that humanity creates to represent its soul.

    At just two years old, Nic experienced a searing pain that signaled the awakening of a new and deadly disease, one that would hurl Nic and his family up against the limits of modern medicine. For years, through false starts and failed cures, Nic holds on to life, buoyed up by his mother’s fierce drive to get him the care he needs. But when even the world’s experts are stumped by Nic’s illness, his doctors come up with a radical, long-shot plan: a step into the unknown. The next major scientific frontier, following the completion of the Human Genome Project, was to figure out how to use our new knowledge to save lives—to bring genomic or personalized medicine into reality. It’s a quest that is undertaken by researchers around the world. But it is only when geneticist Howard Jacob hears about young Nic that the finish line finally comes into sight: It’s no longer a race to make history. It’s a race to save this boy’s life. One in a Billion is an unforgettable tale of the lives that converged to launch a medical revolution. As pioneering geneticist Mary-Claire King pronounced upon learning Nic’s story: “It was as if one had heard about Case Zero of AIDS and the cure, all at once.”

    Supersized life spans are going to radically alter society, and present an unprecedented opportunity to change our approach not only to old age but to all of life’s stages. The ramifications are just beginning to dawn on us.... yet in the meantime, we keep thinking about, and planning for, life as it used to be lived. In A Long Bright Future, longevity and aging expert Laura Carstensen guides us into the new possibilities offered by a longer life. She debunks the myths and misconceptions about aging that stop us from adequately preparing for the future both as individuals and as a society: that growing older is associated with loneliness and unhappiness, and that only the genetically blessed live well and long. She then focuses on other important components of a long life, including finances, health, social relationships, Medicare and Social Security, challenging our preconceived notions of “old age” every step of the way.

    Memetics is the science of memes, the invisible but very real DNA of human society.

    LikeWhen does a bee go through metamorphosis?Why does a queen bee sometimes leave her hive?And where does all this honey come from, anyway?!But Nyuki’s biggest question is, “What is this inner voice I hear, and why does it tell me to go forth to adventure?Follow Nyuki on a lifelong journey as she annoys her sisters, avoids predators, and learns to trust her inner voice as she masters the way of the hive.And if you still have questions at the end, the back of the book uncovers even more mysteries about the lives of these incredible insects!

    Spanning 486 miles from the Denver suburbs to Durango, the trail passes through six national forests and six wilderness areas, traverses five major river systems, and crosses eight mountain ranges. The ninth edition of The Colorado Trail has all the information a day hiker, thru-hiker, mountain biker, or equestrian needs to plan and complete a trip on the trail. New to this edition are five chapters on the 80-mile Collegiate West trail addition. Maps and written descriptions for all twenty-eight segments of the Colorado Trail have also been updated throughout the guide. Each chapter provides essential logistical information for Colorado Trail hikers: trailhead directions; road access points; detailed trail descriptions including distance and elevation gain; color maps and elevation profiles; and information on water sources, campsite locations, and resupply towns. Additional town maps and mountain bike detour maps (around Wilderness Areas) have been included throughout the book. An extensive introduction includes information on planning, supplying, safety, equipment, navigation, mountain biking, horseback riding, regulations, and backcountry ethics—plus chapters on the heritage of The Colorado Trail, natural history, and geology. At the back of the book you will find useful contact information and an index.

    Legendary marine scientist Sylvia Earle portrays a planet teetering on the brink of irreversible environmental crisis.In recent decades we’ve learned more about the ocean than in all previous human history combined. But, even as our knowledge has exploded, so too has our power to upset the delicate balance of this complex organism. Modern overexploitation has driven many species to the verge of extinction, from tiny but indispensable biota to magnificent creatures like tuna, swordfish, and great whales. Since the mid-20th century about half our coral reefs have died or suffered sharp decline; hundreds of oxygen-deprived "dead zones" blight our coastal waters; and toxic pollutants afflict every level of the food chain.Fortunately, there is reason for hope, but what we do—or fail to do—in the next ten years may well resonate for the next ten thousand. The ultimate goal, Earle argues passionately and persuasively, is to find responsible, renewable strategies that safeguard the natural systems that sustain us. The first step is to understand and act upon the wise message of this accessible, insightful, and compelling book.

    This compact volume contains:An easy-to-use field guide for identifying 1,000 of the region's wildflowers, trees, mushrooms, mosses, fishes, amphibians, reptiles, birds, butterflies, mammals, and much more; A complete overview of New England's natural history, covering geology, wildlife habitats, ecology, fossils, rocks and minerals, clouds and weather patterns and night sky;An extensive sampling of the area's best parks, preserves, beaches, forests, islands, and wildlife sanctuaries, with detailed descriptions and visitor information for 50 sites and notes on dozens of others.The guide is packed with visual information -- the 1,500 full-color images include more than 1,300 photographs, 14 maps, and 16 night-sky charts, as well as 150 drawings explaining everything from geological processes to the basic features of different plants and animals. For everyone who lives or spends time in Connecticut, Maine, Massachusetts, Rhode Island, New Hampshire, or Vermont, there can be no finer guide to the area's natural surroundings than the National Audubon Society Field Guide to New England.

    It starts with those basic steps and soon becomes the adventure of a lifetime. Now, in the Running Room's Book on Running, veteran runner/author John Stanton offers expert advice to help you get the most from your running. This wonderfully illustrated book answers all your questions about running, including:- Getting started and keeping it fun- Building a program that works with your lifestyle- Picking the right gear- Running form, posture and breathing- Heart rate training made clear- Types of running—what to do and how to do it- Nutrition for the runner- Strength and cross-training—easy to manage exercise routines- Women's issues related to running and running during pregnancy- Avoiding and dealing with injuries- Mental preperation and the psychology of running- Tips for race day

    

    Sometimes grizzlies kill people, and in exceptionally rare cases they even eat them. Those incidents are the focus of this book because that's what makes bears so interesting, such a huge part of our culture and our collective imagination.

    that the science is settled. Author Lawrence Solomon an internationally renowned environmentalist shows these men have faced a vicious campaign of intimidation by those who, like Al Gore, seek to pervert science and silence dissent to advance their own political agenda. Some have been intimidated into silence. Others have seen their funding denied and their labs shut down as a result of political pressure. But the testimony of their work remains too powerful to deny. Extensively footnoted including URLs to crucial scientific papers (and lively e-mails detailing the inside politics of global warming) and lavishly illustrated with charts and graphs, The Deniers will do more than spark controversy. The Deniers is destined to become the most reliable and provocative sourcebook on the real global warming debate.

    With two whip-like tentacles, eight arms studded with toothed suckers, and two lidless eyes the size of dinner plates, Architeurthis has inspired myths and movies, nightmares and religious conversions. Yet it has never been studied while alive.Marin biologist, explorer, and artist Richard Ellis delves into myth, literature, and science to bring readers face-to-face with this remarkable creature as it terrifies sailors ad fishermen throughout history and battles for its life against the great sperm whale. Ellis continues his exploration into the modern era, when scientists rush to study a rare carcass, and the giant squid is a staple on the big screen.Interweaving his narrative with a wralth of illustrations and photographs, Ellis gives us the first scientific and cultural history of the only living creature that can still truly be called a sea monster.

    The book emphasizes a general introduction to probability theory and provides a detailed discussion of specific designs and analyses that are typically encountered in ecology and environmental science. Appropriate for use as either a stand-alone or supplementary text for upper-division undergraduate or graduate courses in ecological and environmental statistics, ecology, environmental science, environmental studies, or experimental design, the Primer also serves as a resource for environmental professionals who need to use and interpret statistics daily but have little or no formal training in the subject.