It’s so bound up with our deepest feelings that emotional trauma causes it to change shape.Practising cardiologist Sandeep Jauhar beautifully weaves his own experiences with the defining discoveries of the past to tell the story of our most vital organ. He looks at some of the pioneers who risked their careers and their patients’ lives to better understand the heart. People like Daniel Hale Williams, who performed the world’s first documented heart surgery, and Wilson Greatbatch, who accidentally invented the pacemaker.Amid gripping scenes from the operating theatre, Jauhar interweaves stories about the patients he’s treated with the moving tale of his family’s own history of heart problems, from his grandfather’s sudden death in India – an event that sparked his life-long obsession – to the ominous signs of how he himself might die.He also confronts the limits of medical technology and argues that future progress will be determined more by how we choose to live rather than by any device we invent.

    Now comes a gripping account of the doctors and scientists fighting to protect us, an urgent wake-up call about the future of emerging viruses—from the #1 bestselling author of The Hot Zone, soon to be a National Geographic original miniseries.This time, Ebola started with a two-year-old child who likely had contact with a wild creature and whose entire family quickly fell ill and died. The ensuing global drama activated health professionals in North America, Europe, and Africa in a desperate race against time to contain the viral wildfire. By the end—as the virus mutated into its deadliest form, and spread farther and faster than ever before—30,000 people would be infected, and the dead would be spread across eight countries on three continents.In this taut and suspenseful medical drama, Richard Preston deeply chronicles the outbreak, in which we saw for the first time the specter of Ebola jumping continents, crossing the Atlantic, and infecting people in America. Rich in characters and conflict—physical, emotional, and ethical—Crisis in the Red Zone is an immersion in one of the great public health calamities of our time.Preston writes of doctors and nurses in the field putting their own lives on the line, of government bureaucrats and NGO administrators moving, often fitfully, to try to contain the outbreak, and of pharmaceutical companies racing to develop drugs to combat the virus. He also explores the charged ethical dilemma over who should and did receive the rare doses of an experimental treatment when they became available at the peak of the disaster. Crisis in the Red Zone makes clear that the outbreak of 2013–2014 is a harbinger of further, more severe outbreaks, and of emerging viruses heretofore unimagined—in any country, on any continent. In our ever more interconnected world, with roads and towns cut deep into the jungles of equatorial Africa, viruses both familiar and undiscovered are being unleashed into more densely populated areas than ever before.The more we discover about the virosphere, the more we realize its deadly potential. Crisis in the Red Zone is an exquisitely timely book, a stark warning of viral outbreaks to come.

    But it’s hardly surprising considering how long it’s had to hone its skills. Forty-thousand years ago, our ancestors set off from the cradle of civilization on their journey towards populating the planet. Tuberculosis hitched a lift and came with us, and it’s been there ever since; waiting, watching, and learning. The organism responsible, Mycobacterium tuberculosis, has had plenty of time to adapt to its chosen habitat--human lungs--and has learned through natural selection to be an almost perfect pathogen. Using our own immune cells as a Trojan Horse to aid its spread, it’s come up with clever ways to avoid being killed by antibiotics. But patience has been its biggest lesson--it can enter into a latent state when times are tough, only to come back to life when a host’s immune system is compromised. Today, more than one million people die of the disease every year and around one-third of the world’s population are believed to be infected. That’s more than two billion people. Throw in the compounding problems of drug resistance, the HIV epidemic, and poverty, and it’s clear that tuberculosis remains one of the most serious problems in world medicine. Catching Breath follows the history of TB through the ages, from its time as an infection of hunter-gatherers to the first human villages, which set it up with everything it needed to become the monstrous disease it is today, through to the perils of industrialization and urbanization. It goes on to look at the latest research in fighting the disease, with stories of modern scientific research, interviews with doctors on the TB frontline, and the personal experiences of those affected by the disease.

    Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    In Shapeshifters, physician and writer Gavin Francis considers the inevitable changes all of our bodies undergo -- such as birth, puberty, and death, but also laughter, sleeping, and healing-and those that only some of our bodies will: like getting a tattoo, experiencing psychosis, suffering anorexia, being pregnant, or undergoing a gender transition. In Francis's hands, each event becomes an opportunity to explore the meaning of identity and the natures-biological, psychological, and philosophical-of our selves. True to its own subject, Shapeshifters combines Francis's lyrical imagination and deep knowledge of medicine and the humanities for a life-altering read.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives..

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    Carried along the mighty Mississippi River, it ravaged towns from New Orleans to St. Louis. New York City lost 2,000 lives in one year alone. It even forced the nation's capital to relocate from Philadelphia to Washington, DC. "The American Plague" reveals the true story of yellow fever, recounting Memphis, Tennessee's near-destruction and resurrection from the epidemic-and the four men who changed medical history with their battle against an invisible foe that remains a threat to this very day.

    

    A slip of the hand and life ebbs away.The balance between life and death is so delicate, and the heart surgeon walks that rope between the two. In the operating room there is no time for doubt. It is flesh, blood, rib-retractors and pumping the vital organ with your bare hand to squeeze the life back into it. An off-day can have dire consequences – this job has a steep learning curve, and the cost is measured in human life. Cardiac surgery is not for the faint of heart.Professor Stephen Westaby took chances and pushed the boundaries of heart surgery. He saved hundreds of lives over the course of a thirty-five year career and now, in his astounding memoir, Westaby details some of his most remarkable and poignant cases – such as the baby who had suffered multiple heart attacks by six months old, a woman who lived the nightmare of locked-in syndrome, and a man whose life was powered by a battery for eight years.A powerful, important and incredibly moving book, Fragile Lives offers an exceptional insight into the exhilarating and sometimes tragic world of heart surgery, and how it feels to hold someone’s life in your hands.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    Improper use of antibiotics. Local warfare. Massive refugee migration. Changing social and environmental conditions around the world have fostered the spread of new and potentially devastating viruses and diseases—HIV, Lassa, Ebola, and others. Laurie Garrett takes you on a fifty-year journey through the world's battles with microbes and examines the worldwide conditions that have culminated in recurrent outbreaks of newly discovered diseases, epidemics of diseases migrating to new areas, and mutated old diseases that are no longer curable. She argues that it is not too late to take action to prevent the further onslaught of viruses and microbes, and offers possible solutions for a healthier future.