This best-selling text gives students a solid understanding of organic chemistry by stressing how fundamental reaction mechanisms function and reactions occur. With the addition of handwritten solutions, new cutting-edge molecular illustrations, updated spectroscopy coverage, seamless integration of molecular modeling exercises, and state-of-the-art multimedia tools, the 7th edition of Organic Chemistry clearly offers the most up-to-date approach to the study of organic chemistry.

    R has traditionally been difficult for non-statisticians to learn, and most R books assume far too much knowledge to be of help. R for Everyone is the solution. Drawing on his unsurpassed experience teaching new users, professional data scientist Jared P. Lander has written the perfect tutorial for anyone new to statistical programming and modeling. Organized to make learning easy and intuitive, this guide focuses on the 20 percent of R functionality you'll need to accomplish 80 percent of modern data tasks. Lander's self-contained chapters start with the absolute basics, offering extensive hands-on practice and sample code. You'll download and install R; navigate and use the R environment; master basic program control, data import, and manipulation; and walk through several essential tests. Then, building on this foundation, you'll construct several complete models, both linear and nonlinear, and use some data mining techniques. By the time you're done, you won't just know how to write R programs, you'll be ready to tackle the statistical problems you care about most. COVERAGE INCLUDES - Exploring R, RStudio, and R packages - Using R for math: variable types, vectors, calling functions, and more - Exploiting data structures, including data.frames, matrices, and lists - Creating attractive, intuitive statistical graphics - Writing user-defined functions - Controlling program flow with if, ifelse, and complex checks - Improving program efficiency with group manipulations - Combining and reshaping multiple datasets - Manipulating strings using R's facilities and regular expressions - Creating normal, binomial, and Poisson probability distributions - Programming basic statistics: mean, standard deviation, and t-tests - Building linear, generalized linear, and nonlinear models - Assessing the quality of models and variable selection - Preventing overfitting, using the Elastic Net and Bayesian methods - Analyzing univariate and multivariate time series data - Grouping data via K-means and hierarchical clustering - Preparing reports, slideshows, and web pages with knitr - Building reusable R packages with devtools and Rcpp - Getting involved with the R global community

    We wouldn’t have unraveled DNA or discovered Neptune or figured out how to put 5,000 songs in your pocket. Though many of us were scared away from this essential, engrossing subject in high school and college, Steven Strogatz’s brilliantly creative, down‑to‑earth history shows that calculus is not about complexity; it’s about simplicity. It harnesses an unreal number—infinity—to tackle real‑world problems, breaking them down into easier ones and then reassembling the answers into solutions that feel miraculous. Infinite Powers recounts how calculus tantalized and thrilled its inventors, starting with its first glimmers in ancient Greece and bringing us right up to the discovery of gravitational waves (a phenomenon predicted by calculus). Strogatz reveals how this form of math rose to the challenges of each age: how to determine the area of a circle with only sand and a stick; how to explain why Mars goes “backwards” sometimes; how to make electricity with magnets; how to ensure your rocket doesn’t miss the moon; how to turn the tide in the fight against AIDS. As Strogatz proves, calculus is truly the language of the universe. By unveiling the principles of that language, Infinite Powers makes us marvel at the world anew.

    Newborn babies typically wake every two to three hours, and there’s nothing bleary-eyed, exhausted parents want more than a night of uninterrupted sleep. But while there’s plenty of advice out there, there is nothing that’s based on the latest cutting-edge research about sleep—until now. In How Babies Sleep, Sofia Axelrod, PhD—neuroscientist, sleep consultant, and mother of two—introduces the first baby sleep method that is truly rooted in the science of sleep. After having her first child, Axelrod realized that the typical baby sleep advice conflicted with the actual science of sleep, inlcuding the findings from her mentor’s Nobel Prize–winning sleep lab. She developed her transformative method based on the latest discoveries about our body’s circadian clock and how it is disturbed by light and other external stimuli. After seeing incredible results with her own babies, she has since counseled countless families in her groundbreaking method—which works with babies’ needs and helps little ones learn to self-soothe, fall asleep more easily, and stay asleep through the night. You’ll discover helpful tips that work, and learn: why using a red lightbulb (instead of a regular one) in the nursery at night can minimize wakings; why the age-old advice “don’t wake a sleeping baby” isn’t true; how to create a healthy routine; how to sleep train gently with minimal crying (under two minutes); and so much more in this revolutionary and effective book that will help both you and your baby enjoy a peaceful night’s sleep.

    Now this classic book has been fully updated and revised with leading-edge practices--and hundreds of new code samples--illustrating the art and science of software construction. Capturing the body of knowledge available from research, academia, and everyday commercial practice, McConnell synthesizes the most effective techniques and must-know principles into clear, pragmatic guidance. No matter what your experience level, development environment, or project size, this book will inform and stimulate your thinking--and help you build the highest quality code. Discover the timeless techniques and strategies that help you: Design for minimum complexity and maximum creativity Reap the benefits of collaborative development Apply defensive programming techniques to reduce and flush out errors Exploit opportunities to refactor--or evolve--code, and do it safely Use construction practices that are right-weight for your project Debug problems quickly and effectively Resolve critical construction issues early and correctly Build quality into the beginning, middle, and end of your project

    Following a career-threatening injury in 2018, Ross was forced to reassess his training and take the next steps in a lifelong journey of redefining what the human body is capable of. In Blueprint , Ross shares the cutting-edge training program that empowered him to rebuild his body from surgery and a doctor’s gloomy prognosis in just 365 days to complete a world record swim. Whether it’s climbing a mountain, swimming the English Channel, or a gruelling triathlon, Blueprint  will teach you the tried and tested principles of sports science that have been used for decades by Olympians, explorers and adventurers at the limits of peak physical endurance.Blueprint is Ross Edgley's complete training journey that shows you how to:• Divide a 365-day training plan into seasons (winter, spring, summer and autumn)• Rebuild your body using evolutionary medicine• Build a superhuman work capacity with forgotten Spartan-style training• Gain bulletproof resilience through Soviet-inspired strength training• Boost your aerobic base with Olympian techniques. Blueprint applies the exact same principles that enabled Ross to complete extreme feats such as the World's Longest Sea Swim, World's Longest Rope Climb, World's Heaviest Triathlon and World's Strongest Marathon.Ross is your elite guide to achieving the impossible in the gym and beyond. Featuring almost 30 tailored workouts for different phases of training, packed with digestible sports science to help you optimise your workouts, and interspersed with Ross' own daring adventures across the world, Blueprint is the ultimate guide to optimising your time and training to make the impossible possible.

    With the "You Don’t Know JS" book series, you’ll get a more complete understanding of JavaScript, including trickier parts of the language that many experienced JavaScript programmers simply avoid.The series’ first book, Up & Going, provides the necessary background for those of you with limited programming experience. By learning the basic building blocks of programming, as well as JavaScript’s core mechanisms, you’ll be prepared to dive into the other, more in-depth books in the series—and be well on your way toward true JavaScript.With this book you will: Learn the essential programming building blocks, including operators, types, variables, conditionals, loops, and functions Become familiar with JavaScript's core mechanisms such as values, function closures, this, and prototypes Get an overview of other books in the series—and learn why it’s important to understand all parts of JavaScript

     At any given moment, somewhere in the world someone struggles with the same software design problems you have. You know you don't want to reinvent the wheel (or worse, a flat tire), so you look to Design Patterns--the lessons learned by those who've faced the same problems. With Design Patterns, you get to take advantage of the best practices and experience of others, so that you can spend your time on...something else. Something more challenging. Something more complex. Something more fun. You want to learn about the patterns that matter--why to use them, when to use them, how to use them (and when NOT to use them). But you don't just want to see how patterns look in a book, you want to know how they look "in the wild". In their native environment. In other words, in real world applications. You also want to learn how patterns are used in the Java API, and how to exploit Java's built-in pattern support in your own code. You want to learn the real OO design principles and why everything your boss told you about inheritance might be wrong (and what to do instead). You want to learn how those principles will help the next time you're up a creek without a design pattern. Most importantly, you want to learn the "secret language" of Design Patterns so that you can hold your own with your co-worker (and impress cocktail party guests) when he casually mentions his stunningly clever use of Command, Facade, Proxy, and Factory in between sips of a martini. You'll easily counter with your deep understanding of why Singleton isn't as simple as it sounds, how the Factory is so often misunderstood, or on the real relationship between Decorator, Facade and Adapter. With Head First Design Patterns, you'll avoid the embarrassment of thinking Decorator is something from the "Trading Spaces" show. Best of all, in a way that won't put you to sleep! We think your time is too important (and too short) to spend it struggling with academic texts. If you've read a Head First book, you know what to expect--a visually rich format designed for the way your brain works. Using the latest research in neurobiology, cognitive science, and learning theory, Head First Design Patterns will load patterns into your brain in a way that sticks. In a way that lets you put them to work immediately. In a way that makes you better at solving software design problems, and better at speaking the language of patterns with others on your team.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    Based on extensive research and over 140 exclusive interviews with key movers and shakers from gaming's past, Replay tells the sensational story of how the creative vision of game designers gave rise to one of the world's most popular and dynamic art forms.

    We often overlook the historical link between mathematics and technological advances, says Stewart—but this connection is integral to any complete understanding of human history.Equations are modeled on the patterns we find in the world around us, says Stewart, and it is through equations that we are able to make sense of, and in turn influence, our world. Stewart locates the origins of each equation he presents—from Pythagoras's Theorem to Newton's Law of Gravity to Einstein's Theory of Relativity—within a particular historical moment, elucidating the development of mathematical and philosophical thought necessary for each equation's discovery. None of these equations emerged in a vacuum, Stewart shows; each drew, in some way, on past equations and the thinking of the day. In turn, all of these equations paved the way for major developments in mathematics, science, philosophy, and technology. Without logarithms (invented in the early 17th century by John Napier and improved by Henry Briggs), scientists would not have been able to calculate the movement of the planets, and mathematicians would not have been able to develop fractal geometry. The Wave Equation is one of the most important equations in physics, and is crucial for engineers studying the vibrations in vehicles and the response of buildings to earthquakes. And the equation at the heart of Information Theory, devised by Claude Shannon, is the basis of digital communication today.An approachable and informative guide to the equations upon which nearly every aspect of scientific and mathematical understanding depends, In Pursuit of the Unknown is also a reminder that equations have profoundly influenced our thinking and continue to make possible many of the advances that we take for granted.

    Significant numbers of poorly designed programs have been created by less-experienced developers, resulting in applications that are inefficient and hard to maintain and extend. Increasingly, software system professionals are discovering just how difficult it is to work with these inherited, non-optimal applications. For several years, expert-level object programmers have employed a growing collection of techniques to improve the structural integrity and performance of such existing software programs. Referred to as refactoring, these practices have remained in the domain of experts because no attempt has been made to transcribe the lore into a form that all developers could use... until now. In Refactoring: Improving the Design of Existing Software, renowned object technology mentor Martin Fowler breaks new ground, demystifying these master practices and demonstrating how software practitioners can realize the significant benefits of this new process.

    Here, from author Jay Williams, is the moving story of the man behind the Renaissance myth.

    The vision behind Clojure is of a radically simple language framework holding together a sophisticated collection of programming features. Learning Clojure involves much more than just learning the mechanics of the language. To really get Clojure you need to understand the ideas underlying this structure of framework and features. You need this book: an accessible introduction to Clojure that focuses on the ideas behind the language as well as the practical details of writing code.

    And this may sound weirdly obvious, but every single one of those pieces of software was written by a programmer. Programmers are thus among the most quietly influential people on the planet. As we live in a world made of software, they're the architects. The decisions they make guide our behavior. When they make something newly easy to do, we do a lot more of it. If they make it hard or impossible to do something, we do less of it.If we want to understand how today's world works, we ought to understand something about coders. Who exactly are the people that are building today's world? What makes them tick? What type of personality is drawn to writing software? And perhaps most interestingly -- what does it do to them?One of the first pieces of coding a newbie learns is the program to make the computer say "Hello, world!" Like that piece of code, Clive Thompson's book is a delightful place to begin to understand this vocation, which is both a profession and a way of life, and which essentially didn't exist little more than a generation ago, but now is considered just about the only safe bet we can make about what the future holds. Thompson takes us close to some of the great coders of our time, and unpacks the surprising history of the field, beginning with the first great coders, who were women. Ironically, if we're going to traffic in stereotypes, women are arguably "naturally" better at coding than men, but they were written out of the history, and shoved out of the seats, for reasons that are illuminating. Now programming is indeed, if not a pure brotopia, at least an awfully homogenous community, which attracts people from a very narrow band of backgrounds and personality types. As Thompson learns, the consequences of that are significant - not least being a fetish for disruption at scale that doesn't leave much time for pondering larger moral issues of collateral damage. At the same time, coding is a marvelous new art form that has improved the world in innumerable ways, and Thompson reckons deeply, as no one before him has, with what great coding in fact looks like, who creates it, and where they come from. To get as close to his subject has he can, he picks up the thread of his own long-abandoned coding practice, and tries his mightiest to up his game, with some surprising results.More and more, any serious engagement with the world demands an engagement with code and its consequences, and to understand code, we must understand coders. In that regard, Clive Thompson's Hello, World! is a marvelous and delightful master class.