But there is a field of psychology that looks at the bright side, that considers seriously these questions: What makes life most worth living? And how can we pursue a good life? That field is called, not surprisingly, positive psychology. In Pursuing the Good Life, one of the founders of positive psychology, Christopher Peterson, offers one hundred bite-sized reflections exploring the many sides of this exciting new field. With the humor, warmth, and wisdom that has made him an award- winning teacher, Peterson takes readers on a lively tour of the sunny side of the psychological street. What are the roles played by positive emotions and happiness, by strengths of character, by optimism, and by good relationships with others? How can we pursue the good life in families, workplaces, schools, and sports, no matter who we are or where we live? With titles such as "You May Now Kiss the Bride--And Would You Like Fries With That?" and "How Can You Tell If Someone from France is Happy?" Peterson good- humoredly explores these questions and many others, including such diverse topics as the difference between employment and work, the value of doing the right thing, and why books matter, among other subjects. Throughout, Peterson shows that happiness is not simply the result of a fortunate spin of the genetic wheel. There are things that people can learn to do to lead happier lives. Pursuing the Good Life is both an enjoyable read and an invaluable guide to making the good life part of your everyday existence.

    Today, says Dale Purves, the dominant research agenda may have taken us as far as it can--and neuroscientists may be approaching a paradigm shift. In this highly personal book, Purves reveals how we got to this point and offers his notion of where neuroscience may be headed next. Purves guides you through a half-century of the most influential ideas in neuroscience and introduces the extraordinary scientists and physicians who created and tested them. Purves offers a critical assessment of the paths that neuroscience research has taken, their successes and their limitations, and then introduces an alternative approach for thinking about brains. Building on new research on visual perception, he shows why common ideas about brain networks can't be right and uncovers the factors that determine our subjective experience. The resulting insights offer a deeper understanding of what it means to be human. - Why we need a better conception of what brains are trying to do and how they do it Approaches to understanding the brain over the past several decades may be at an impasse - The surprising lessons that can be learned from what we see How complex neural processes owe more to trial-and-error experience than to logical principles - Brains--and the people who think about them Meet some of the extraordinary individuals who've shaped neuroscience - The -ghost in the machine- problem The ideas presented further undermine the concept of free will

    By some estimates, half of the results from these studies can't be replicated elsewhere-the science is simply wrong. Often, research institutes and academia emphasize publishing results over getting the right answers, incentivizing poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence. How are those with breast cancer helped when the cell on which 900 papers are based turns out not to be a breast cancer cell at all? How effective could a new treatment for ALS be when it failed to cure even the mice it was initially tested on? In Rigor Mortis, award-winning science journalist Richard F. Harris reveals these urgent issues with vivid anecdotes, personal stories, and interviews with the nation's top biomedical researchers. We need to fix our dysfunctional biomedical system-now.

    The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    Lorimer Moseley is an evidence based book designed for therapists, patients and students. It answers the most common questions asked by pain sufferers: 'why do I hurt?' and 'what can I do for my pain?' Written in simple language that anyone can understand, it encourages patients to move better and research shows that they will have less pain once they have understood its underlying causes.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep.In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children’s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers’ odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder?This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You’ll never look at your pillow the same way again.

    A man of average income feels he cannot be truly happy unless he owns an expensive luxury car. A dieter has an irresistible craving for ice cream. Desires often come to us unbidden and unwanted, and they can have a dramatic impact, sometimes changing the course of our lives.In On Desire, William B. Irvine takes us on a wide-ranging tour of our impulses, wants, and needs, showing us where these feelings come from and how we can try to rein them in. Spicing his account with engaging observations by writers like Seneca, Tolstoy, and Freud, Irvine considers the teachings of Buddhists, Hindus, the Amish, Shakers, and Catholic saints, as well as those of ancient Greek and Roman and modern European philosophers. Irvine also looks at what modern science can tell us about desire--what happens in the brain when we desire something and how animals evolved particular desires--and he advances a new theory about how desire itself evolved. Irvine also suggests that at the same time that we gained the ability to desire, we were programmed to find some things more desirable than others. Irvine concludes that the best way to attain lasting happiness is not to change the world around us or our place in it, but to change ourselves. If we can convince ourselves to want what we already have, we can dramatically enhance our happiness.Brimming with wisdom and practical advice, On Desire offers a thoughtful approach to controlling unwanted passions and attaining a more meaningful life.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    'A focused snapshot of a brave new world.' - Nature In 2018 the world woke up to gene editing with a storm of controversy over twin girls born in China with genetic changes deliberately introduced by scientists – changes they will pass on to their own offspring. Genetic modification (GM) has been with us for 45 years now, but the new system known as CRISPR or gene editing can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago. But is it ethical to change the genetic material of organisms in a way that might be passed on to future generations? If a person is suffering from a lethal genetic disease, is it unethical to deny them this option? Who controls the application of this technology, when it makes ‘biohacking’ – perhaps of one’s own genome – a real possibility?Nessa Carey’s book is a thrilling and timely snapshot of a cutting-edge technology that will radically alter our futures and the way we prevent disease.

    In my case, blinking my left eyelid is my only means of communication.’In December 1995, Jean-Dominique Bauby, editor-in-chief of French ‘Elle’ and the father of two young children, suffered a massive stroke and found himself paralysed and speechless, but entirely conscious, trapped by what doctors call ‘locked-in syndrome’. Using his only functioning muscle – his left eyelid – he began dictating this remarkable story, painstakingly spelling it out letter by letter.His book offers a haunting, harrowing look inside the cruel prison of locked-in syndrome, but it is also a triumph of the human spirit.

    These black-and-white and vibrantly colored images, many resembling abstract art, are employed daily by scientists around the world, but most have never before been seen by the general public. Each chapter addresses a different set of techniques for studying the brain as revealed through the images, and each is introduced by a leading scientist in that field of study. Author Carl Schoonover’s captions provide detailed explanations of each image as well as the major insights gained by scientists over the course of the past 20 years. Accessible to a wide audience, this book reveals the elegant methods applied to study the mind, giving readers a peek at its innermost workings, helping us to understand them, and offering clues about what may lie ahead. Praise for Portraits of the Mind: "An odyssey through the brain, illuminated by a rainbow" --New York Times "Stunning images" --Scientific American "The collection of images in the new book Portraits of the Mind is truly impressive . . . The mix of history, science and art is terrific." -Wired.com "History, science, and art come together to provide a unique perspective on what's going on upstairs." --New Yorker.com "No knowledge of the source or subject matter of these images is necessary; the book is justified by their beauty alone." --Science "A remarkable new book"- -Discover.com "John Keats's insistence that truth is beauty is exemplified by Carl Schoonover's wonderful book Portraits of the Mind. Since one cannot understand the present without examining the past, this book offers a delightful and instructive way of accomplishing just that. I enthusiastically recommend this beautiful book both to students of brain science and to lovers of art." -Eric R. Kandel, MD, Nobel Prize in Physiology or Medicine, 2000; University Professor at Columbia; Fred Kavli Professor and Director, Kavli Institute for Brain Science; Senior Investigator at the Howard Hughes Medical Institute; and author of In Search of Memory: The Emergence of a New Science of Mind "Portraits of the Mind achieves a rare combination of beauty and knowledge. Its images of the brain are mesmerizing, from medieval engravings to modern visualizations as gorgeously abstract as anything by Rothko or de Kooning. And in explaining the nature of these images, this book also delivers an enlightening, up-to-date history of neuroscience." -Carl Zimmer, author of Soul Made Flesh: The Discovery of the Brain-and How It Changed the World and The Mind's Eye Goes Blind: Fifteen Journeys Through the Brain "Portraits of the Mind is a remarkable book that combines beautifully reproduced illustrations of the nervous system as it has been visualized over the centuries, as well as lively and authoritative commentaries by some of today's leading neuroscientists. It will be enjoyed by professionals and general readers alike." --Dale Purves, MD, Professor of Neurobiology, Psychology and Neuroscience; and Philosophy at Duke University

    Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    Armed with the extraordinary new discoveries about our genes, Ridley turns his attention to the nature versus nurture debate to bring the first popular account of the roots of human behaviour. What makes us who we are?In February 2001 it was announced that the genome contains not 100,000 genes as originally expected but only 30,000. This startling revision led some scientists to conclude that there are simply not enough human genes to account for all the different ways people behave: we must be made by nurture, not nature.Matt Ridley argues that the emerging truth is far more interesting than this myth. Nurture depends on genes, too, and genes need nurture. Genes not only predetermine the broad structure of the brain; they also absorb formative experiences, react to social cues and even run memory. They are consequences as well as causes of the will.Published fifty years after the discovery of the double helix of DNA, Nature via Nurture chronicles a new revolution in our understanding of genes. Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. Nature via Nurture is an enthralling, up-to-the-minute account of how genes build brains to absorb experience.