Best of
Genetics

2019

A Short History of Humanity: A New History of Old Europe


Johannes Krause - 2019
    Krause is a pioneer in the revolutionary new science of archaeogenetics, archaeology augmented by revolutionary DNA sequencing technology, which has allowed scientists to uncover a new version of human history reaching back more than 100,000 years. Using this technology to re-examine human bones from the distant past, Krause has been able to map not only the genetic profiles of the dead, but also their ancient journeys.In this concise narrative he tells us their long-forgotten stories of migration and intersection. It's well known that many human populations carry genetic material from Neanderthals; but, as Krause and his colleagues discovered, we also share DNA with a newly uncovered human form, the Denisovans. We know now that a wave of farmers from Anatolia migrated into Europe 8,000 years ago, essentially displacing the dark-skinned, blue-eyed hunter-gatherers who preceded them. The farmer DNA is one of the core genetic components of contemporary Europeans and European Americans. Though the first people to cross into North and South America have long been assumed to be primarily of East Asian descent, we now know that they also share DNA with contemporary Europeans and European Americans. Genetics has an unfortunate history of smuggling in racist ideologies, but our most cutting-edge science tells us that genetic categories in no way reflect national borders.Krause vividly introduces us to prehistoric cultures such as the Aurignacians, innovative artisans who carved animals, people, and even flutes from bird bones more than 40,000 years ago; the Varna, who buried their loved ones with gold long before the Pharaohs of Egypt; and the Gravettians, big-game hunters who were Europe's most successful early settlers until they perished in the ice age. This informed retelling of the human epic confirms that immigration and genetic mingling have always defined our species and that who we are is a question of culture not genetics.

Hacking Darwin: Genetic Engineering and the Future of Humanity


Jamie Metzl - 2019
    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

Cancer and the New Biology of Water


Thomas Cowan - 2019
    The research establishment was trumpeting the discovery of oncogenes, the genes that supposedly cause cancer. As soon as we identified them and treated cancer patients accordingly, cancer would become a thing of the past.Fifty years later it’s clear that the War on Cancer has failed—despite what the cancer industry wants us to believe. New diagnoses have continued to climb; one in three people in the United States can now expect to battle cancer during their lifetime. For the majority of common cancers, the search for oncogenes has not changed the treatment: We’re still treating with the same old triad of removing (surgery), burning out (radiation), or poisoning (chemotherapy).In Cancer and the New Biology of Water, Thomas Cowan, MD, argues that this failure was inevitable because the oncogene theory is incorrect—or at least incomplete—and based on a flawed concept of biology in which DNA controls our cellular function and therefore our health. Instead, Dr. Cowan tells us, the somatic mutations seen in cancer cells are the result of a cellular deterioration that has little to do with oncogenes, DNA, or even the nucleus. The root cause is metabolic dysfunction that deteriorates the structured water that forms the basis of cytoplasmic—and therefore, cellular—health.Despite mainstream medicine’s failure to bring an end to suffering or deliver on its promises, it remains illegal for physicians to prescribe anything other than the “standard of care” for their cancer patients—no matter how dangerous and ineffective that standard may be—and despite the fact that gentler, more effective, and more promising treatments exist. While Dr. Cowan acknowledges that all of these treatments need more research, Cancer and the New Biology of Water is an impassioned plea from a long-time physician that these promising treatments merit our attention and research dollars and that patients have the right to information, options, and medical freedom in matters of their own life and death.

Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are


Bill Sullivan - 2019
    The foods we enjoy, the people we love, the emotions we feel, and the beliefs we hold can all be traced back to our DNA, germs, and environment. This witty, colloquial book is popular science at its best, describing in everyday language how genetics, epigenetics, microbiology, and psychology work together to influence our personality and actions. Mixing cutting-edge research and relatable humor, Pleased to Meet Me is filled with fascinating insights that shine a light on who we really are--and how we might become our best selves.

Genetics and the Aryan debate: "Early Indians" Tony Joseph's Latest Assault


Shrikant G. Talageri - 2019
    Throughout its history, debate was based on three academic disciplines: Linguistics, Archeology and Textual/ Inscriptional data. However, the weight of the evidence in these three fields is now increasingly confirms the rival theory, the OIT or “Out Of India theory” which sees India as the original homeland of these languages. So the proponents of the AIT have recently abandoned these three fields and have started falling back on a totally new field of study: Genetics The spokesperson for the AIT since the last few years is one Tony Joseph, through his articles in The Hindu. Tony Joseph has now written a full-fledged volume titled – “Early Indians” (262 pp), published by Juggernaut books, New Delhi 2018. Since the book is the subject of a full-fledged systemic and intense media campaign, this present work analyses the whole “genetic” case for the AIT as per this book by Tony Joseph and demonstrates how Genetics is irrelevant to the problem of the ancient history of Indo-European languages. The writer, Shrikant G. Talageri, is the foremost proponent of the OIT or “Out Of India theory” through his many articles and blogs on the subject, primarily his three published books on the subject: The Aryan Invasion Theory and Indian Nationalism(1993), Rigveda - A Historical Analysis(2000), and The Rigveda And The Avesta - The Final Evidence(2008).

Fables and Futures: Biotechnology, Disability, and the Stories We Tell Ourselves (The MIT Press)


George Estreich - 2019
    That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities—especially when their voices are all but absent from the conversation?This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich—an award-winning poet and memoirist, and the father of a young woman with Down syndrome—delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on “three-parent IVF,” a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented.In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.

Individualism and the Western Liberal Tradition: Evolutionary Origins, History, and Prospects for the Future


Kevin B. MacDonald - 2019
    The prehistoric invasion of the Indo-Europeans had a transformative influence on Western Europe, inaugurating a prolonged period of what is labeled "aristocratic individualism" resulting form variants of Indo-European genetic and cultural influence. However, beginning in the seventeenth century and gradually becoming dominant was a new culture labeled "egalitarian individualism" which was influenced by preexisting egalitarian tendencies of northwest Europeans. Egalitarian individualism ushered in the modern world but may well carry the seeds of its own destruction.

The CRISPR Generation: The Story of the World's First Gene-Edited Babies


Kiran Musunuru - 2019
     In November 2018, Dr. He Jiankui of Shenzhen, China, announced via YouTube that he had created the world's first gene-edited babies. It soon became clear that this was not a historic scientific achievement, but rather a historic ethical fiasco, a deeply flawed experiment on unborn human beings. What made it possible for a rogue scientist with no medical training to covertly and recklessly alter the genes of babies? What does the future hold now that the first members of the CRISPR generation have been born? In The CRISPR Generation, Dr. Kiran Musunuru takes the reader through an insider's view of the history of the gene-editing field, key discoveries about how gene editing can be used to prevent and treat diseases like AIDS and heart attacks, a full account of the events surrounding Dr. He's revelation to the world, a dissection of Dr. He's scientific and ethical lapses, and a look ahead to the consequences of gene editing for humankind, both good and bad. Gene-editing technology has the potential to cause untold damage if taken up by the wrong hands and used irresponsibly. But it also promises to be a boon for the health of patients otherwise destined for disease and suffering.

Biochemistry and Molecular Biology - How Life Works


Kevin Ahern - 2019
    Unfortunately, the details of biochemistry often cause students to get lost, and consequently, they don’t get to see the big picture. Without connections to real life, the details simply become things to memorize for tests—and are soon forgotten.These lectures were designed to help everyone learn and enjoy biochemistry using explanations of real-world biochemistry problems as tools to understand the subject—while still introducing college-level biochemistry and not dumbing it down. And without any need for memorization, you won’t spend your time memorizing facts, giving much more time to listen to explanations and think through the concepts.Biochemistry combines biology—the science of life—and chemistry, the science of molecules. Biochemistry, then, is the molecular basis of life. Every single thing that makes people alive is due to biological molecules and their interactions.