Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    It covers the entire scope of mechanical metallurgy, from an understanding of the continuum description of stress and strain, through crystalline and defect mechanisms of flow and fracture, and on to a consideration of major mechanical property tests and the basic metalworking process. It has been updated throughout, SI units have been added, and end-of-chapter study questions are included.

    

    It makes us aware of the world around us and our own self. How all this emerges from a kilogram of brain cells is one of the greatest unanswered questions. In Your Conscious Mind leading brain scientists and New Scientist take you on a journey through the mind to discover what consciousness really is, and what we can learn when it goes awry. Find out if we will ever build conscious machines, what animal consciousness can tell us about being human and explore the enigma of free will. ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

    To love and loathe the fox is a British condition."The fox is our apex predator, our most beautiful and clever killer. We have witnessed its wild touch, watched it slink by bins at night and been chilled by its high-pitched scream. And yet we long to stroke the tumbling cubs outside their tunnel homes and watch the vixen stalk the cornfield.There is something about foxes. They captivate us like no other species.Exploring a long and sometimes complicated relationship, The Wild Life of the Fox captures our love – and sometimes loathing – of this magnificent creature in vivid detail and lyrical prose.

    

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    It is within the realm of possibility that their work may usher in a change in global economics as profound as the Industrial Revolution. As may be expected, press reports dealing with asteroid mining have been numerous, ranging in scope from short and breezy to broad and serious, and in quality from accurate to impressionistic to simply uninformed. There is good reason to be curious about what may be the biggest game-changer in human economic history. And there is good reason to look closely at the underlying science and engineering that form the foundation of this work.

    The world you live in is stranger than fiction... as you read this, you exist in other places at the same time. Do not regret having missed the chance to realize your dreams, for you may just have fulfilled it in another universe.. * Are the trillions of atoms that make you, nothing but vibrations in 10 dimensions?* Is it true that we are all connected with each other?* Can you go into the future to change the present?* Why do scientists and philosophers struggle with the concept of Time?* Can science explain consciousness through physics?* Is our fate driven by the underlying randomness in nature?* Is nature hiding the best-kept secrets which can never be unravelled by humans?The Speed of Time approaches the most complex and esoteric theories of science in lucid, clear and simple language and in the style of a thriller, leaving you wanting more... while addressing questions through the enigmatic theories in Physics such as Quantum Mechanics, Einstein's Theory of Relativity, Time, Chaos, and much more. Just start reading and you will not put it down.

    The Grand Question of Lifes Origins 2. The Historical Setting of Origins Research 3. What Is Life? 4. Is There Life on Mars? 5. Earths Oldest Fossils 6. Fossil Isotopes 7. Molecular Biosignatures 8. Emergence 9. The Miller-Urey Experiment 10. Life from the Bottom of the Sea 11. The Deep, Hot Biosphere 12. Experiments at High Pressure 13. More Experiments Under Pressure 14. Deep Space Dust, Molten Rock, and Zeolite 15. Macromolecules and the Tree of Life 16. Lipids and Membrane Self-Organization 17. Life on Clay, Clay as Life 18. Lifes Curious Handedness 19. Self-Replicating Molecular Systems 20. Günter Wächtershäusers Grand Hypothesis 21. The RNA World 22. The Pre-RNA World 23. Natural Selection and Competition 24. Three Scenarios for the Origin of Life

    Full of advice on how surgeons should use their heads as well as their hands - how to think, plan, and improvise - when, for example, operating on a massively bleeding trauma patient. Starts with general principles, continues with specific injuries to abdomen, chest, neck, and peripheral vessels. Generously illustrated throughout, with drawings produced specifically for this book. For residents, general surgeons with an interest in trauma, and for surgeons operating on badly wounded patients in isolated military, rural, or humanitarian settings. Asher Hirshberg and Kenneth L Mattox are trauma surgeons at the Ben Taub General Hospital, Houston, and professors at the Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA. Kenneth L Maddox is famous as the lead editor of McGraw Hill's classic text, Trauma, now in its fifth edition. This is going to be a GREAT book!

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    It draws on all the latest knowledge from anthropology and archaeology, via genetics and evolution, to psychology and medicine. It tackles issues such as hereditary genes in criminal behaviour and homosexuality.

    Lehninger Principles of Biochemistry, Fourth Edition brings clarity and coherence to an often unwieldy discipline, while incorporating the field's most important recent developments and applications.

    How to approach complex normal and abnormal behaviors through biology. How to integrate disciplines including sociobiology, ethology, neuroscience, and endocrinology to examine behaviors such as aggression, sexual behavior, language use, and mental illness.36 hours lectures