For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family’s spoons, tried on their underpants and tested their chamber pots.Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions. Women wore makeup made with mercury and lead. Men rubbed turds on their bald spots. Physicians prescribed mercury enemas, arsenic skin cream, drinks of lead filings, and potions of human fat and skull, fresh from the executioner. The most gorgeous palaces were little better than filthy latrines. Gazing at gorgeous portraits of centuries past, we don’t see what lies beneath the royal robes and the stench of unwashed bodies; the lice feasting on private parts; and worms nesting in the intestines.In The Royal Art of Poison, Eleanor Herman combines her unique access to royal archives with cutting-edge forensic discoveries to tell the true story of Europe’s glittering palaces: one of medical bafflement, poisonous cosmetics, ever-present excrement, festering natural illness, and, sometimes, murder.

    . . brilliantly integrat[es] science, literature, and pop culture into elegant and insightful commentaries on the most interesting and important questions of our time. A delightful read.”—Michael Shermer, author of The Science of Good and Evil“Entertaining and thought-provoking.”—Steven Pinker, author of The Blank SlateIf we are, in part, a product of our genes, can free will exist? Incisive and engaging, this indispensable tour of evolutionary biology runs the gamut of contemporary debates, from science and religion to our place in the universe.David Barash is the author of The Myth of Monogamy and Madame Bovary’s Ovaries. He lives in Redmond, Washington.

    But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.

    But molecules, such as water and sugar, are not alive. So how do our cells--assemblies of otherwise "dead" molecules--come to life, and together constitute a living being? In "Life's Ratchet," physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. The complex molecules of our cells can rightfully be called "molecular machines," or "nanobots"; these machines, unlike any other, work autonomously to create order out of chaos. Tiny electrical motors turn electrical voltage into motion, tiny factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city--an unfathomable, complex collection of molecular worker bees working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. We are essentially giant assemblies of interacting nanoscale machines; machines more amazing than can be found in any science fiction novel. Incredibly, the molecular machines in our cells function without a mysterious "life force," nor do they violate any natural laws. Scientists can now prove that life is not supernatural, and that it can be fully understood in the context of science. Part history, part cutting-edge science, part philosophy, "Life's Ratchet" takes us from ancient Greece to the laboratories of modern nanotechnology to tell the story of our quest for the machinery of life.

    In the great halls of science, dogma holds that Darwin's theory of natural selection explains every branch on the tree of life: which species thrive, which wither away to extinction, and what features each evolves. But can adaptation by natural selection really account for everything we see in nature? Yale University ornithologist Richard Prum--reviving Darwin's own views--thinks not. Deep in tropical jungles around the world are birds with a dizzying array of appearances and mating displays: Club-winged Manakins who sing with their wings, Great Argus Pheasants who dazzle prospective mates with a four-foot-wide cone of feathers covered in golden 3D spheres, Red-capped Manakins who moonwalk. In thirty years of fieldwork, Prum has seen numerous display traits that seem disconnected from, if not outright contrary to, selection for individual survival. To explain this, he dusts off Darwin's long-neglected theory of sexual selection in which the act of choosing a mate for purely aesthetic reasons--for the mere pleasure of it--is an independent engine of evolutionary change. Mate choice can drive ornamental traits from the constraints of adaptive evolution, allowing them to grow ever more elaborate. It also sets the stakes for sexual conflict, in which the sexual autonomy of the female evolves in response to male sexual control. Most crucially, this framework provides important insights into the evolution of human sexuality, particularly the ways in which female preferences have changed male bodies, and even maleness itself, through evolutionary time. The Evolution of Beauty presents a unique scientific vision for how nature's splendor contributes to a more complete understanding of evolution and of ourselves.

    Scientists such as Richard Dawkins, Lawrence Krauss, and Sam Harris tell us that our most intimate actions, thoughts, and values are mere byproducts of thousands of generations of mindless adaptation. We are just one species among multitudes, and therefore no more significant than any other living creature. Now comes Brown University biologist Kenneth R. Miller to make the case that this view betrays a gross misunderstanding of evolution. Natural selection surely explains how our bodies and brains were shaped, but Miller argues that it’s not a social or cultural theory of everything. In The Human Instinct, he rejects the idea that our biological heritage means that human thought, action, and imagination are pre-determined, describing instead the trajectory that ultimately gave us reason, consciousness and free will. A proper understanding of evolution, he says, reveals humankind in its glorious uniqueness—one foot planted firmly among all of the creatures we’ve evolved alongside, and the other in the special place of self-awareness and understanding that we alone occupy in the universe. Equal parts natural science and philosophy, The Human Instinct is a moving and powerful celebration of what it means to be human.

    David Starr Jordan was a taxonomist, a man possessed with bringing order to the natural world. In time, he would be credited with discovering nearly a fifth of the fish known to humans in his day. But the more of the hidden blueprint of life he uncovered, the harder the universe seemed to try to thwart him. His specimen collections were demolished by lightning, by fire, and eventually by the 1906 San Francisco earthquake—which sent more than a thousand of his discoveries, housed in fragile glass jars, plummeting to the floor. In an instant, his life’s work was shattered. Many might have given up, given in to despair. But Jordan? He surveyed the wreckage at his feet, found the first fish he recognized, and confidently began to rebuild his collection. And this time, he introduced one clever innovation that he believed would at last protect his work against the chaos of the world. When NPR reporter Lulu Miller first heard this anecdote in passing, she took Jordan for a fool—a cautionary tale in hubris, or denial. But as her own life slowly unraveled, she began to wonder about him. Perhaps instead he was a model for how to go on when all seemed lost. What she would unearth about his life would transform her understanding of history, morality, and the world beneath her feet. Part biography, part memoir, part scientific adventure, Why Fish Don’t Exist reads like a fable about how to persevere in a world where chaos will always prevail.

    Tirelessly trekking across miles of the Thames’ muddy shores, where others only see the detritus of city life, Maiklem unearths evidence of England’s captivating, if sometimes murky, history—with some objects dating back to 43 AD, when London was but an outpost of the Roman Empire. From medieval mail worn by warriors on English battlefields to nineteenth-century glass marbles mass-produced for the nation’s first soda bottles, Maiklem deduces the historical significance of these artifacts with the quirky enthusiasm and sharp-sightedness of a twenty-first century Sherlock Holmes.Seamlessly interweaving reflections from her own life with meditations on the art of wandering, Maiklem ultimately delivers—for Anglophiles and history lovers alike—a memorable treatise on the objects we leave in our wake, and the stories they can reveal if only we take a moment to look.

    In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past. Journeying to far-flung Siberian locales in search of ice age bones and delving into her own research--as well as those of fellow experts such as Svante Paabo, George Church, and Craig Venter--Shapiro considers de-extinction's practical benefits and ethical challenges. Would de-extinction change the way we live? Is this really cloning? What are the costs and risks? And what is the ultimate goal?Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms. But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem.Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.

    It produced a cloud of roiling debris that blackened the sky for months as well as other geologic disasters--and triggered the demise of Tyrannosaurus rex. We know what happened largely because Walter Alvarez--synthesizing the findings of experts from a variety of scientific fields--has written a gripping story of the decades-long search for the cause of the dinosaurs' extinction. Painstakingly assembling clues from the Italian Apennines and the depths of the Pacific and presenting them with the excitement of a great novel, T. rex and the Crater of Doom is a book of undeniable importance and irresistible appeal by a major figure in contemporary science. " Engaging and witty. Read Alvarez for and excellent account of how scientists pose questions and seek to solve them." --Scientific American " First-rate...Alvarez provides the up-close tale of the comet or asteroid that wiped out the dinosaurs." --San Francisco Chronicle

    Croix. He went to America to pursue his education. Along the way he became one of the American Revolution’s most dashing—and unlikely—heroes. Adored by Washington, hated by Jefferson, Hamilton was a lightning rod: the most controversial leader of the American Revolution.She was the well-to-do daughter of one of New York’s most exalted families—feisty, adventurous, and loyal to a fault. When she met Alexander, she fell head over heels. She pursued him despite his illegitimacy, and loved him despite his infidelity. In 1816 (two centuries ago), she shamed Congress into supporting his seven orphaned children. Elizabeth Schuyler Hamilton started New York’s first orphanage. The only “founding mother” to truly embrace public service, she raised 160 children in addition to her own.With its flawless writing, brilliantly drawn characters, and epic scope, The Hamilton Affair will take its place among the greatest novels of American history.

    While most of these discoveries live quietly in museum collections, there are a few that have become world-renowned celebrity personas—ambassadors of science that speak to public audiences. In Seven Skeletons, historian of science Lydia Pyne explores how seven such famous fossils of our ancestors have the social cachet they enjoy today.Drawing from archives, museums, and interviews, Pyne builds a cultural history for each celebrity fossil—from its discovery to its afterlife in museum exhibits to its legacy in popular culture. These seven include the three-foot tall “hobbit” from Flores, the Neanderthal of La Chapelle, the Taung Child, the Piltdown Man hoax, Peking Man, Australopithecus sediba, and Lucy—each embraced and celebrated by generations, and vivid examples of how discoveries of how our ancestors have been received, remembered, and immortalized. With wit and insight, Pyne brings to life each fossil, and how it is described, put on display, and shared among scientific communities and the broader public. This fascinating, endlessly entertaining book puts the impact of paleoanthropology into new context, a reminder of how our past as a species continues to affect, in astounding ways, our present culture and imagination.

    It offers a glimpse into the minds of a vast range of different peoples: early hunter-gatherers and farmers, ancient Egyptians, traditional Chinese sages, the founders of Christianity, trail-blazers of the Scientific Revolution, and those who constructed our modern consumer society.Taking the reader on an archaeological exploration of the mind, the author, an entrepreneur and sustainability leader, uses recent findings in cognitive science and systems theory to reveal the hidden layers of values that form today's cultural norms. Uprooting the tired clichés of the science-religion debate, he shows how medieval Christian rationalism acted as an incubator for scientific thought, which in turn shaped our modern vision of the conquest of nature. The author probes our current crisis of unsustainability and argues that it is not an inevitable result of human nature, but is culturally driven: a product of particular mental patterns that could conceivably be reshaped. By shining a light on our possible futures, the book foresees a coming struggle between two contrasting views of humanity: one driving to a technological endgame of artificially enhanced humans, the other enabling a sustainable future arising from our intrinsic connectedness with each other and the natural world. This struggle, it concludes, is one in which each of us will play a role through the meaning we choose to forge from the lives we lead.

    In his gripping and controversial new work, New York Times bestselling author Steven Pinker shows that despite the ceaseless news about war, crime, and terrorism, violence has actually been in decline over long stretches of history. Exploding myths about humankind's inherent violence and the curse of modernity, this ambitious book continues Pinker's exploration of the essence of human nature, mixing psychology and history to provide a remarkable picture of an increasingly enlightened world.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In