As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    By spinning 28 mathematical tales, Orlin shows us that calculus is simply another language to express the very things we humans grapple with every day -- love, risk, time, and most importantly, change. Divided into two parts, "Moments" and "Eternities," and drawing on everyone from Sherlock Holmes to Mark Twain to David Foster Wallace, Change is the Only Constant unearths connections between calculus, art, literature, and a beloved dog named Elvis. This is not just math for math's sake; it's math for the sake of becoming a wiser and more thoughtful human.

    Beginning with the above questions, she began informally researching every affliction that she encountered in humans to learn whether it happened with animals, too. And usually, it did: dinosaurs suffered from brain cancer, koalas can catch chlamydia, reindeer seek narcotic escape in hallucinogenic mushrooms, stallions self-mutilate, and gorillas experience clinical depression. Natterson-Horowitz and science writer Kathryn Bowers have dubbed this pan-species approach to medicine zoobiquity. Here, they present a revelatory understanding of what animals can teach us about the human body and mind, exploring how animal and human commonality can be used to diagnose, treat, and heal patients of all species.

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    By examining fossils and DNA, Shubin shows us that our hands actually resemble fish fins, our head is organized like that of a long-extinct jawless fish, and major parts of our genome look and function like those of worms and bacteria.Shubin makes us see ourselves and our world in a completely new light. Your Inner Fish is science writing at its finest-enlightening, accessible, and told with irresistible enthusiasm.

    In late 2017, scientists at a Hawaiian observatory glimpsed an object soaring through our inner solar system, moving so quickly that it could only have come from another star. Avi Loeb, Harvard’s top astronomer, showed it was not an asteroid; it was moving too fast along a strange orbit, and left no trail of gas or debris in its wake. There was only one conceivable explanation: the object was a piece of advanced technology created by a distant alien civilization.   In Extraterrestrial, Loeb takes readers inside the thrilling story of the first interstellar visitor to be spotted in our solar system. He outlines his controversial theory and its profound implications: for science, for religion, and for the future of our species and our planet. A mind-bending journey through the furthest reaches of science, space-time, and the human imagination, Extraterrestrial challenges readers to aim for the stars—and to think critically about what’s out there, no matter how strange it seems.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    This discovery dramatically reshaped how humans understood their place in the cosmos, and once and for all laid to rest the idea that the Milky Way galaxy was alone in the universe. Six years later, continuing research by Hubble and others forced Albert Einstein to renounce his own cosmic model and finally accept the astonishing fact that the universe was not immobile but instead expanding. The fascinating story of these interwoven discoveries includes battles of will, clever insights, and wrong turns made by the early investigators in this great twentieth-century pursuit. It is a story of science in the making that shows how these discoveries were not the work of a lone genius but the combined efforts of many talented scientists and researchers toiling away behind the scenes. The intriguing characters include Henrietta Leavitt, who discovered the means to measure the vast dimensions of the cosmos . . . Vesto Slipher, the first and unheralded discoverer of the universe’s expansion . . . Georges Lemaître, the Jesuit priest who correctly interpreted Einstein’s theories in relation to the universe . . . Milton Humason, who, with only an eighth-grade education, became a world-renowned expert on galaxy motions . . . and Harlow Shapley, Hubble’s nemesis, whose flawed vision of the universe delayed the discovery of its true nature and startling size for more than a decade.Here is a watershed moment in the history of astronomy, brought about by the exceptional combination of human curiosity, intelligence, and enterprise, and vividly told by acclaimed science writer Marcia Bartusiak.

    These great beasts, or “megafauna,” lived on every habitable continent and on many islands. With a handful of exceptions, all are now gone.What caused the disappearance of these prehistoric behemoths? No one event can be pinpointed as a specific cause, but several factors may have played a role. Paleomammalogist Ross D. E. MacPhee explores them all, examining the leading extinction theories, weighing the evidence, and presenting his own conclusions. He shows how theories of human overhunting and catastrophic climate change fail to account for critical features of these extinctions, and how new thinking is needed to elucidate these mysterious losses.Along the way, we learn how time is determined in earth history; how DNA is used to explain the genomics and phylogenetic history of megafauna—and how synthetic biology and genetic engineering may be able to reintroduce these giants of the past. Until then, gorgeous four-color illustrations by Peter Schouten re-create these megabeasts here in vivid detail.

    In this far-reaching narrative, Weisman explains how our massive infrastructure would collapse and finally vanish without human presence; which everyday items may become immortalized as fossils; how copper pipes and wiring would be crushed into mere seams of reddish rock; why some of our earliest buildings might be the last architecture left; and how plastic, bronze sculpture, radio waves, and some man-made molecules may be our most lasting gifts to the universe.The World Without Us reveals how, just days after humans disappear, floods in New York's subways would start eroding the city's foundations, and how, as the world's cities crumble, asphalt jungles would give way to real ones. It describes the distinct ways that organic and chemically treated farms would revert to wild, how billions more birds would flourish, and how cockroaches in unheated cities would perish without us. Drawing on the expertise of engineers, atmospheric scientists, art conservators, zoologists, oil refiners, marine biologists, astrophysicists, religious leaders from rabbis to the Dalai Lama, and paleontologists—who describe a prehuman world inhabited by megafauna like giant sloths that stood taller than mammoths—Weisman illustrates what the planet might be like today, if not for us.From places already devoid of humans (a last fragment of primeval European forest; the Korean DMZ; Chernobyl), Weisman reveals Earth's tremendous capacity for self-healing. As he shows which human devastations are indelible, and which examples of our highest art and culture would endure longest, Weisman's narrative ultimately drives toward a radical but persuasive solution that needn't depend on our demise. It is narrative nonfiction at its finest, and in posing an irresistible concept with both gravity and a highly readable touch, it looks deeply at our effects on the planet in a way that no other book has.

    Nearly a half-century after Neil Armstrong walked on the moon, these Space Barons-most notably Elon Musk and Jeff Bezos, along with Richard Branson and Paul Allen-are using Silicon Valley-style innovation to dramatically lower the cost of space travel, and send humans even further than NASA has gone. These entrepreneurs have founded some of the biggest brands in the world-Amazon, Microsoft, Virgin, Tesla, PayPal-and upended industry after industry. Now they are pursuing the biggest disruption of all: space. Based on years of reporting and exclusive interviews with all four billionaires, this authoritative account is a dramatic tale of risk and high adventure, the birth of a new Space Age, fueled by some of the world's richest men as they struggle to end governments' monopoly on the cosmos. The Space Barons is also a story of rivalry-hard-charging startups warring with established contractors, and the personal clashes of the leaders of this new space movement, particularly Musk and Bezos, as they aim for the moon and Mars and beyond.

    To its adherents, it is an elegant statement about learning from experience. To its opponents, it is subjectivity run amok.In the first-ever account of Bayes' rule for general readers, Sharon Bertsch McGrayne explores this controversial theorem and the human obsessions surrounding it. She traces its discovery by an amateur mathematician in the 1740s through its development into roughly its modern form by French scientist Pierre Simon Laplace. She reveals why respected statisticians rendered it professionally taboo for 150 years—at the same time that practitioners relied on it to solve crises involving great uncertainty and scanty information (Alan Turing's role in breaking Germany's Enigma code during World War II), and explains how the advent of off-the-shelf computer technology in the 1980s proved to be a game-changer. Today, Bayes' rule is used everywhere from DNA de-coding to Homeland Security.Drawing on primary source material and interviews with statisticians and other scientists, The Theory That Would Not Die is the riveting account of how a seemingly simple theorem ignited one of the greatest controversies of all time.

    Our Big Bang, our distant future, parallel worlds, the sub-atomic and intergalactic - none of them are what they seem. But there is a way to understand this immense strangeness - mathematics. Seeking an answer to the fundamental puzzle of why our universe seems so mathematical, Tegmark proposes a radical idea: that our physical world not only is described by mathematics, but that it is mathematics. This may offer answers to our deepest questions: How large is reality? What is everything made of? Why is our universe the way it is?Table of ContentsPreface 1 What Is Reality? Not What It Seems • What’s the Ultimate Question? • The Journey Begins Part One: Zooming Out 2 Our Place in Space Cosmic Questions • How Big Is Space? • The Size of Earth • Distance to the Moon • Distance to the Sun and the Planets • Distance to the Stars • Distance to the Galaxies • What Is Space? 3 Our Place in TimeWhere Did Our Solar System Come From? • Where Did theGalaxies Come From? • Where Did the Mysterious MicrowavesCome From? • Where Did the Atoms Come From? 4 Our Universe by NumbersWanted: Precision Cosmology • Precision Microwave-Background Fluctuations • Precision Galaxy Clustering • The Ultimate Map of Our Universe • Where Did Our Big Bang Come From? 5 Our Cosmic Origins What’s Wrong with Our Big Bang? • How Inflation Works • The Gift That Keeps on Giving • Eternal Inflation 6 Welcome to the Multiverse The Level I Multiverse • The Level II Multiverse • Multiverse Halftime Roundup Part Two: Zooming In 7 Cosmic Legos Atomic Legos • Nuclear Legos • Particle-Physics Legos • Mathematical Legos • Photon Legos • Above the Law? • Quanta and Rainbows • Making Waves • Quantum Weirdness • The Collapse of Consensus • The Weirdness Can’t Be Confined • Quantum Confusion 8 The Level III Multiverse The Level III Multiverse • The Illusion of Randomness • Quantum Censorship • The Joys of Getting Scooped • Why Your Brain Isn’t a Quantum Computer • Subject, Object and Environment • Quantum Suicide • Quantum Immortality? • Multiverses Unified • Shifting Views: Many Worlds or Many Words? Part Three: Stepping Back 9 Internal Reality, External Reality and Consensus Reality External Reality and Internal Reality • The Truth, the Whole Truth and Nothing but the Truth • Consensus Reality • Physics: Linking External to Consensus Reality 10 Physical Reality and Mathematical Reality Math, Math Everywhere! • The Mathematical Universe Hypothesis • What Is a Mathematical Structure? 11 Is Time an Illusion? How Can Physical Reality Be Mathematical? • What Are You? • Where Are You? (And What Do You Perceive?) • When Are You? 12 The Level IV Multiverse Why I Believe in the Level IV Multiverse • Exploring the Level IV Multiverse: What’s Out There? • Implications of the Level IV Multiverse • Are We Living in a Simulation? • Relation Between the MUH, the Level IV Multiverse and Other Hypotheses •Testing the Level IV Multiverse 13 Life, Our Universe and Everything How Big Is Our Physical Reality? • The Future of Physics • The Future of Our Universe—How Will It End? • The Future of Life •The Future of You—Are You Insignificant? Acknowledgments Suggestions for Further Reading Index

    In the great halls of science, dogma holds that Darwin's theory of natural selection explains every branch on the tree of life: which species thrive, which wither away to extinction, and what features each evolves. But can adaptation by natural selection really account for everything we see in nature? Yale University ornithologist Richard Prum--reviving Darwin's own views--thinks not. Deep in tropical jungles around the world are birds with a dizzying array of appearances and mating displays: Club-winged Manakins who sing with their wings, Great Argus Pheasants who dazzle prospective mates with a four-foot-wide cone of feathers covered in golden 3D spheres, Red-capped Manakins who moonwalk. In thirty years of fieldwork, Prum has seen numerous display traits that seem disconnected from, if not outright contrary to, selection for individual survival. To explain this, he dusts off Darwin's long-neglected theory of sexual selection in which the act of choosing a mate for purely aesthetic reasons--for the mere pleasure of it--is an independent engine of evolutionary change. Mate choice can drive ornamental traits from the constraints of adaptive evolution, allowing them to grow ever more elaborate. It also sets the stakes for sexual conflict, in which the sexual autonomy of the female evolves in response to male sexual control. Most crucially, this framework provides important insights into the evolution of human sexuality, particularly the ways in which female preferences have changed male bodies, and even maleness itself, through evolutionary time. The Evolution of Beauty presents a unique scientific vision for how nature's splendor contributes to a more complete understanding of evolution and of ourselves.

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.