Personal, poignant, and meticulously precise, these stories evoke Chekhov, Maugham, and William Carlos Williams, admitting readers to the beating heart of medicine. Internal Medicine is an account of what it means to be a doctor, to be mortal, and to be human.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    She is also a superbly gifted writer–witty, insightful, at once deeply humane and refreshingly wry. In Another Day in the Frontal Lobe, Dr. Firlik draws on this rare combination to create a neurosurgeon’s Kitchen Confidential–a unique insider’s memoir of a fascinating profession.Neurosurgeons are renowned for their big egos and aggressive self-confidence, and Dr. Firlik confirms that timidity is indeed rare in the field. “They’re the kids who never lost at musical chairs,” she writes. A brain surgeon is not only a highly trained scientist and clinician but also a mechanic who of necessity develops an intimate, hands-on familiarity with the gray matter inside our skulls. It’s the balance between cutting-edge medical technology and manual dexterity, between instinct and expertise, that Firlik finds so appealing–and so difficult to master. Firlik recounts how her background as a surgeon’s daughter with a strong stomach and a keen interest in the brain led her to this rarefied specialty, and she describes her challenging, atypical trek from medical student to fully qualified surgeon. Among Firlik’s more memorable cases: a young roofer who walked into the hospital with a three-inch-long barbed nail driven into his forehead, the result of an accident with his partner’s nail gun, and a sweet little seven-year-old boy whose untreated earache had become a raging, potentially fatal infection of the brain lining. From OR theatrics to thorny ethical questions, from the surprisingly primitive tools in a neurosurgeon’s kit to glimpses of future techniques like the “brain lift,” Firlik cracks open medicine’s most prestigious and secretive specialty. Candid, smart, clear-eyed, and unfailingly engaging, Another Day in the Frontal Lobe is a mesmerizing behind-the-scenes glimpse into a world of incredible competition and incalculable rewards.From the Hardcover edition.

    But in this groundbreaking book, prize-winning historian Edith Sheffer exposes that Asperger was not only involved in the racial policies of Hitler’s Third Reich, he was complicit in the murder of children.As the Nazi regime slaughtered millions across Europe during World War Two, it sorted people according to race, religion, behavior, and physical condition for either treatment or elimination. Nazi psychiatrists targeted children with different kinds of minds—especially those thought to lack social skills—claiming the Reich had no place for them. Asperger and his colleagues endeavored to mold certain "autistic" children into productive citizens, while transferring others they deemed untreatable to Spiegelgrund, one of the Reich’s deadliest child-killing centers.In the first comprehensive history of the links between autism and Nazism, Sheffer uncovers how a diagnosis common today emerged from the atrocities of the Third Reich. With vivid storytelling and wide-ranging research, Asperger’s Children will move readers to rethink how societies assess, label, and treat those diagnosed with disabilities.

    He also harbored a terrifying secret: his attraction to men. As Strub explored the capital’s political and social circles, he discovered a parallel world where powerful men lived double lives shrouded in shame. When the AIDS epidemic hit in the early 1980s, Strub was living in New York and soon found himself attending “more funerals than birthday parties.” Scared and angry, he turned to radical activism to combat discrimination and demand research. Strub takes you through his own diagnosis and inside ACT UP, the organization that transformed a stigmatized cause into one of the defining political movements of our time. From the New York of Studio 54 and Andy Warhol’s Factory to the intersection of politics and burgeoning LGBT and AIDS movements, Strub’s story crackles with history. He recounts his role in shocking AIDS demonstrations at St. Patrick’s Cathedral as well as at the home of US Sen­ator Jesse Helms. With an astonishing cast of characters, including Tennessee Williams, Gore Vidal, Keith Haring, Bill Clinton, and Yoko Ono, this is a vivid portrait of a tumultuous era: “A page-turner…[with] the suspense and horror of Paul Monette’s memoir Borrowed Time and the drama of Larry Kramer’s play The Normal Heart….What a lot of action—and life—there is in this gripping book” (The Washington Post).

    From its inception as a "Poor House" dispensing free medical care to indigents, Chicago's Cook County Hospital has been both a renowned teaching hospital and the healthcare provider of last resort for the city's uninsured. COUNTY covers more than thirty years of its history, beginning in the late 1970s when the author began his internship, to the "Final Rounds" when the enormous iconic Victorian hospital building was replaced and hundreds of former trainees gathered to bid it an emotional farewell.Ansell writes of the hundreds of doctors who went through the rigorous training process with him, sharing his vision of saving the world and of resurrecting a hospital on the verge of closing. Radical Medicine is about people, from Ansell’s mentors, including the legendary Quentin Young, to the multitude of patients whom he and County’s medical staff labored to diagnose and heal. It is a story about politics, from contentious union strikes to battles against “patient dumping”, and public health, depicting the AIDS crisis and the opening of County’s HIV/AIDS clinic, the first in the city.Finally, it is about a young man’s medical education in urban America, a coming-of-age story set against a backdrop of race, segregation and poverty.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    There have been other books on Dr Morell's cocktail of treatments for Hitler and Goering's reliance on drugs, but Ohler's book is the first to show how the entire Nazi regime was permeated with drugs - cocaine, heroin, morphine and methamphetamines, the last of these crucial to troops' resilience and partly explaining German victory in 1940. Ohler is explicit that drugs cannot explain Third Reich ideology, but their promiscuous use impaired and confused decision-making, with drastic effects on Hitler and his entourage, who, as the war turned against Germany, took refuge in ever more poorly understood cocktails of stimulants. This chemical euphoria changes how we should think about the Nazi high command and its ability to understand the situation it found itself in by 1944-45. As such Blitzed will force a wider reinterpretation of several key events during the Second World War.

    Even as a reporter, Sheila Hamilton missed the signs as her husband David's mental illness unfolded before her. By the time she had pieced together the puzzle, it was too late. Her once brilliant and passionate partner was dead within six weeks of a diagnosis of bipolar disorder, leaving his wife and nine-year-old daughter without so much as a note to explain his actions, a plan to help them recover from their profound grief, or a solution for the hundreds of thousands of dollars in debt that they would inherit from him.All the Things We Never Knew takes readers on a breathtaking journey, from David and Sheila's early romance through the last three months of their life together and into the year after his death. It details their unsettling spiral from ordinary life into the world of mental illness, examines the fragile line between reality and madness, and reveals the true power of love and forgiveness.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.