A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.

    government faced many difficult decisions, including what to do with the Third Reich’s scientific minds. These were the brains behind the Nazis’ once-indomitable war machine. So began Operation Paperclip, a decades-long, covert project to bring Hitler’s scientists and their families to the United States.Many of these men were accused of war crimes, and others had stood trial at Nuremberg; one was convicted of mass murder and slavery. They were also directly responsible for major advances in rocketry, medical treatments, and the U.S. space program. Was Operation Paperclip a moral outrage, or did it help America win the Cold War?Drawing on exclusive interviews with dozens of Paperclip family members, colleagues, and interrogators, and with access to German archival documents (including previously unseen papers made available by direct descendants of the Third Reich’s ranking members), files obtained through the Freedom of Information Act, and dossiers discovered in government archives and at Harvard University, Annie Jacobsen follows more than a dozen German scientists through their postwar lives and into a startling, complex, nefarious, and jealously guarded government secret of the twentieth century.In this definitive, controversial look at one of America’s most strategic, and disturbing, government programs, Jacobsen shows just how dark government can get in the name of national security.

    The weird turns that followed in this already sensational take are truly astonishing--the Hearst family tried to secure Patty's release by feeding the people of Oakland and San Francisco for free; bank security cameras captured "Tania" wielding a machine gun during a roberry; the LAPD engaged in the largest police shoot-out in American history; the first breaking news event was broadcast live on telelvision stations across the country; and then there was Patty's circuslike trial, filled with theatrical courtroom confrontations and a dramatic last-minute reversal, after which the term "Stockholm syndrome" entered the lexicon. Ultimately, the saga highlighted a decade in which America seemed to be suffering a collective nervous breakdown.

    Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    During the summer before the United States entered World War I, when ocean swimming was just becoming popular and luxurious Jersey Shore resorts were thriving as a chic playland for an opulent yet still innocent era's new leisure class, Americans were abruptly introduced to the terror of sharks. In July 1916 a lone Great White left its usual deep-ocean habitat and headed in the direction of the New Jersey shoreline. There, near the towns of Beach Haven and Spring Lake-and, incredibly, a farming community eleven miles inland-the most ferocious and unpredictable of predators began a deadly rampage: the first shark attacks on swimmers in U.S. history. For Americans celebrating an astoundingly prosperous epoch much like our own, fueled by the wizardry of revolutionary inventions, the arrival of this violent predator symbolized the limits of mankind's power against nature.Interweaving a vivid portrait of the era and meticulously drawn characters with chilling accounts of the shark's five attacks and the frenzied hunt that ensued, Michael Capuzzo has created a nonfiction historical thriller with the texture of Ragtime and the tension of Jaws. From the unnerving inevitability of the first attack on the esteemed son of a prosperous Philadelphia physician to the spine-tingling moment when a farm boy swimming in Matawan Creek feels the sandpaper-like skin of the passing shark, Close to Shore is an undeniably gripping saga.Heightening the drama are stories of the resulting panic in the citizenry, press and politicians, and of colorful personalities such as Herman Oelrichs, a flamboyant millionaire who made a bet that a shark was no match for a man (and set out to prove it); Museum of Natural History ichthyologist John Treadwell Nichols, faced with the challenge of stopping a mythic sea creature about which little was known; and, most memorable, the rogue Great White itself moving through a world that couldn't conceive of either its destructive power or its moral right to destroy.Scrupulously researched and superbly written, Close to Shore brings to life a breathtaking, pivotal moment in American history. Masterfully written and suffused with fascinating period detail and insights into the science and behavior of sharks, Close to Shore recounts a breathtaking, pivotal moment in American history with startling immediacy.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    An epic tale of family, separation, divided loyalties, love, reconciliation, loss, and redemption, Pamela Rotner Sakamoto’s history is a riveting chronicle of U.S.-Japan relations and of the Japanese experience in America.After their father’s death, the Fukuhara children—all born and raised in the Pacific Northwest—moved with their mother to Hiroshima, their parents’ ancestral home. Eager to go back to America, Harry and his sister, Mary, returned there in the late 1930s. Then came Pearl Harbor. Harry and Mary were sent to an internment camp until a call came for Japanese translators, and Harry dutifully volunteered to serve his country. Back in Hiroshima, their brothers, Frank and Pierce, became soldiers in the Imperial Japanese Army.As the war raged on, Harry, one of the finest bilingual interpreters in the United States Army, island-hopped across the Pacific, moving ever closer to the enemy—and to his younger brothers. But before the Fukuharas would have to face one another in battle, the U.S. detonated the atomic bomb over Hiroshima, gravely injuring tens of thousands of civilians, including members of the Fukuhara family.Alternating between American and Japanese perspectives, Midnight in Broad Daylight captures the uncertainty and intensity of those charged with the fighting, as well as the deteriorating home front of Hiroshima—never depicted before in English—and provides a fresh look at the events surrounding the dropping of the first atomic bomb. Intimate and evocative, here is an indelible portrait of a resilient family, a scathing examination of racism and xenophobia, an homage to the tremendous Japanese American contribution to the American war effort, and an invaluable addition to the historical record of this extraordinary time.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    His kidnapping started the longest war in American history, and both sides--the Apaches and the white invaders—blamed him for it. A mixed-blood warrior who moved uneasily between the worlds of the Apaches and the American soldiers, he was never trusted by either but desperately needed by both. He was the only man Geronimo ever feared. He played a pivotal role in this long war for the desert Southwest from its beginning in 1861 until its end in 1890 with his pursuit of the renegade scout, Apache Kid. In this sprawling, monumental work, Paul Hutton unfolds over two decades of the last war for the West through the eyes of the men and women who lived it. This is Mickey Free's story, but also the story of his contemporaries: the great Apache leaders Mangas Coloradas, Cochise, and Victorio; the soldiers Kit Carson, O. O. Howard, George Crook, and Nelson Miles; the scouts and frontiersmen Al Sieber, Tom Horn, Tom Jeffords, and Texas John Slaughter; the great White Mountain scout Alchesay and the Apache female warrior Lozen; the fierce Apache warrior Geronimo; and the Apache Kid. These lives shaped the violent history of the deserts and mountains of the Southwestern borderlands--a bleak and unforgiving world where a people would make a final, bloody stand against an American war machine bent on their destruction.

    But in 1924, Congress instituted a system of ethnic quotas so stringent that it choked off large-scale immigration for decades, sharply curtailing arrivals from southern and eastern Europe and outright banning those from nearly all of Asia.In a riveting narrative filled with a fascinating cast of characters, from the indefatigable congressman Emanuel Celler and senator Herbert Lehman to the bull-headed Nevada senator Pat McCarran, Jia Lynn Yang recounts how lawmakers, activists, and presidents from Truman through LBJ worked relentlessly to abolish the 1924 law. Through a world war, a refugee crisis after the Holocaust, and a McCarthyist fever, a coalition of lawmakers and activists descended from Jewish, Irish, and Japanese immigrants fought to establish a new principle of equality in the American immigration system. Their crowning achievement, the 1965 Immigration and Nationality Act, proved to be one of the most transformative laws in the country’s history, opening the door to nonwhite migration at levels never seen before—and changing America in ways that those who debated it could hardly have imagined.Framed movingly by her own family’s story of immigration to America, Yang’s One Mighty and Irresistible Tide is a deeply researched and illuminating work of history, one that shows how Americans have strived and struggled to live up to the ideal of a home for the "huddled masses," as promised in Emma Lazarus’s famous poem.

    Having grown up worse than poor in South Dakota and reinvented herself as the most prominent woman reporter in America, "Hick," as she's known to her friends and admirers, is not quite instantly charmed by the idealistic, patrician Eleanor. But then, as her connection with the future first lady deepens into intimacy, what begins as a powerful passion matures into a lasting love, and a life that Hick never expected to have.She moves into the White House, where her status as "first friend" is an open secret, as are FDR's own lovers. After she takes a job in the Roosevelt administration, promoting and protecting both Roosevelts, she comes to know Franklin not only as a great president but as a complicated rival and an irresistible friend, capable of changing lives even after his death. Through it all, even as Hick's bond with Eleanor is tested by forces both extraordinary and common, and as she grows as a woman and a writer, she never loses sight of the love of her life.From Washington, D.C. to Hyde Park, from a little white house on Long Island to an apartment on Manhattan's Washington Square, Amy Bloom's new novel moves elegantly through fascinating places and times, written in compelling prose and with emotional depth, wit, and acuity.

    Overnight, these women were transformed from military spouses into American royalty. They had tea with Jackie Kennedy, appeared on the cover of Life magazine, and quickly grew into fashion icons.Annie Glenn, with her picture-perfect marriage, was the envy of the other wives; JFK made it clear that platinum-blonde Rene Carpenter was his favorite; and licensed pilot Trudy Cooper arrived with a secret that needed to stay hidden from NASA. Together with the other wives they formed the Astronaut Wives Club, providing one another with support and friendship, coffee and cocktails.As their celebrity rose-and as divorce and tragedy began to touch their lives-the wives continued to rally together, forming bonds that would withstand the test of time, and they have stayed friends for over half a century. THE ASTRONAUT WIVES CLUB tells the story of the women who stood beside some of the biggest heroes in American history.

    The American experiment rests on three ideas—“these truths,” Jefferson called them—political equality, natural rights, and the sovereignty of the people. But has the nation, and democracy itself, delivered on that promise?These Truths tells this uniquely American story, beginning in 1492, asking whether the course of events over more than five centuries has proven the nation’s truths, or belied them. To answer that question, Lepore wrestles with the state of American politics, the legacy of slavery, the persistence of inequality, and the nature of technological change. “A nation born in contradiction… will fight, forever, over the meaning of its history,” Lepore writes, but engaging in that struggle by studying the past is part of the work of citizenship. With These Truths, Lepore has produced a book that will shape our view of American history for decades to come.

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.