It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    Through the eyes of her naive and inexperienced younger self, Byron shares remarkable stories inspired by the people she had the privilege to treat. Gripping, poignant, and full of daring black humor, this book reveals the frightening and challenging induction all mental health staff face and highlights their incredible commitment to their patients. It shares the tales of ordinary people with an amazing resilience to life's challenges.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    And more often than we realize, that face is wearing lipstick. Autism in Heels , an intimate memoir, reveals the woman inside one of autism's most prominent figures, Jennifer O'Toole. At the age of thirty-five, Jennifer was diagnosed with Asperger's syndrome, and for the first time in her life, things made sense. Now, Jennifer exposes the constant struggle between carefully crafted persona and authentic existence, editing the autism script with wit, candor, passion, and power. Her journey is one of reverse-self-discovery not only as an Aspie but--more importantly--as a thoroughly modern woman.Beyond being a memoir, Autism in Heels is a love letter to all women. It's a conversation starter. A game changer. And a firsthand account of what it is to walk in Jennifer's shoes (especially those iconic red stilettos).Whether it's bad perms or body image, sexuality or self-esteem, Jennifer's is as much a human journey as one on the spectrum. Because autism "looks a bit different in pink," most girls and women who fit the profile are not identified, facing years of avoidable anxiety, eating disorders, volatile relationships, self-harm, and stunted independence. Jennifer has been there, too. Autism in Heels takes that message to the mainstream.From her own struggles and self-discovery, she has built an empire of empowerment, inspiring women the world over to realize they aren't mistakes. They are misunderstood miracles.

    But doctors’ emotional responses to the life-and-death dramas of everyday practice have a profound impact on medical care. And while much has been written about the minds and methods of the medical professionals who save our lives, precious little has been said about their emotions. In What Doctors Feel, Dr. Danielle Ofri has taken on the task of dissecting the hidden emotional responses of doctors, and how these directly influence patients.How do the stresses of medical life—from paperwork to grueling hours to lawsuits to facing death—affect the medical care that doctors can offer their patients? Digging deep into the lives of doctors, Ofri examines the daunting range of emotions—shame, anger, empathy, frustration, hope, pride, occasionally despair, and sometimes even love—that permeate the contemporary doctor-patient connection. Drawing on scientific studies, including some surprising research, Dr. Danielle Ofri offers up an unflinching look at the impact of emotions on health care.With her renowned eye for dramatic detail, Dr. Ofri takes us into the swirling heart of patient care, telling stories of caregivers caught up and occasionally torn down by the whirlwind life of doctoring. She admits to the humiliation of an error that nearly killed one of her patients and her forever fear of making another. She mourns when a beloved patient is denied a heart transplant. She tells the riveting stories of an intern traumatized when she is forced to let a newborn die in her arms, and of a doctor whose daily glass of wine to handle the frustrations of the ER escalates into a destructive addiction. But doctors don’t only feel fear, grief, and frustration. Ofri also reveals that doctors tell bad jokes about “toxic sock syndrome,” cope through gallows humor, find hope in impossible situations, and surrender to ecstatic happiness when they triumph over illness.  The stories here reveal the undeniable truth that emotions have a distinct effect on how doctors care for their patients. For both clinicians and patients, understanding what doctors feel can make all the difference in giving and getting the best medical care.

    Reiss explains how the episodes are created, and provides an inside look at the show’s writers, animators, actors and celebrity guests. He answers a range of questions from Simpsons fans and die-hards, and reminisces about the making of perennially favorite episodes.In his freewheeling, irreverent comic style, Reiss reflects on his lifetime inside The Simpsons—a personal highlights reel of his achievements, observations, and favorite stories. Springfield Confidential exposes why Matt Groening decided to make all of the characters yellow; dishes on what it’s like to be crammed in a room full of funny writers sixty hours a week; and tells what Reiss learned after traveling to seventy-one countries where The Simpsons is watched (ironic note: there’s no electricity in many of these places); and even reveals where Springfield is located! He features unique interviews with Judd Apatow, who also provided the foreword, and Conan O'Brien, as well as with Simpsons legends Al Jean, Nancy Cartwright, Dan Castellaneta, and more.Like Cary Elwes’ As You Wish, Jennifer Keishin Armstrong’s Seinfeldia, and Chris Smith’s The Daily Show: An Oral History, Springfield Confidential is a funny, informational, and exclusive look at one of the most beloved programs in all of television land.

    By the age of twenty-three, he was on his first tour of America, facing an astonished audience in his tight silver hotpants, bare legs and a T-shirt with ROCK AND ROLL emblazoned across it in sequins. Elton John had arrived and the music world would never be the same again.His life has been full of drama, from the early rejection of his work with song-writing partner Bernie Taupin to spinning out of control as a chart-topping superstar; from half-heartedly trying to drown himself in his LA swimming pool to disco-dancing with the Queen; from friendships with John Lennon, Freddie Mercury and George Michael to setting up his AIDS Foundation. All the while, Elton was hiding a drug addiction that would grip him for over a decade.In Me Elton also writes about getting clean and changing his life, about finding love with David Furnish and becoming a father.

    She also had a dream that one day she would be a comedian on TV.She has seen both these dreams come true.At last, Tina Fey's story can be told. From her youthful days as a vicious nerd to her tour of duty on Saturday Night Live; from her passionately halfhearted pursuit of physical beauty to her life as a mother eating things off the floor; from her one-sided college romance to her nearly fatal honeymoon—from the beginning of this paragraph to this final sentence.Tina Fey reveals all, and proves what we've all suspected: you're no one until someone calls you bossy.

    Then she met Aaron, a charismatic art director and her kindred spirit. They made mix tapes (and pancakes) into the wee hours of the morning. They finished each other’s sentences. They just knew. When Aaron was diagnosed with a rare brain cancer, they refused to let it limit their love. They got engaged on Aaron’s hospital bed and married after his first surgery. They had a baby when he was on chemo. They shared an amazing summer filled with happiness and laughter. A few months later, Aaron died in Nora’s arms in another hospital bed. His wildly creative obituary, which they wrote together, touched the world.Now, Nora shares hysterical, moving, and painfully honest stories about her journey with Aaron. It’s Okay to Laugh explores universal themes of love, marriage, work, (single) motherhood, and depression through her refreshingly frank viewpoint. A love letter to life, in all of its messy glory, and what it’s like to still be kickin', It’s Okay to Laugh is like a long chat with a close friend over a cup of coffee (or chardonnay).

    Jon Benjamin--the lead voice behind Archer and Bob's Burgers--helps us all feel a little better about our own failures by sharing his own in a hilarious memoir-ish chronicle of failure.Most people would consider H. Jon Benjamin a comedy show business success. But he'd like to remind everyone that as great as success can be, failure is also an option. And maybe the best option. In this book, he tells stories from his own life, from his early days ("wherein I'm unable to deliver a sizzling fajita") to his romantic life ("how I failed to quantify a threesome") to family ("wherein a trip to P.F. Chang's fractures a family") to career ("how I failed at launching a kid's show").As Jon himself says, breaking down one's natural ability to succeed is not an easy task, but also not an insurmountable one. Society as we know it is, sadly, failure averse. But more acceptance of failure, as Jon sees it, will go a long way to making this world a different place . . . a kinder, gentler place, where gardens are overgrown and most people stay home with their pets. A vision of failure, but also a vision of freedom.With stories, examples of artistic and literary failure, and a powerful can't-do attitude, Failure Is an Option is the book the world doesn't need right now but will get regardless.

    In this remarkable symphony of essays adapted and expanded from his ground-breaking, critically acclaimed podcast, John Green reviews different facets of the human-centered planet - from the QWERTY keyboard and Halley's Comet to Penguins of Madagascar - on a five-star scale.Complex and rich with detail, the Anthropocene's reviews have been praised as 'observations that double as exercises in memoiristic empathy', with over 10 million lifetime downloads. John Green's gift for storytelling shines throughout this artfully curated collection about the shared human experience; it includes beloved essays along with six all-new pieces exclusive to the book.

    Like many others on the autism spectrum, 20-something stand-up comic Michael McCreary has been told by more than a few well-meaning folks that he doesn't "look" autistic. But, as he's quick to point out in this memoir, autism "looks" different for just about everyone with Autism Spectrum Disorder (ASD). Diagnosed with ASD at age five, McCreary got hit with the performance bug not much later. During a difficult time in junior high, he started journaling, eventually turning his pain e into something empowering--and funny. He scored his first stand-up gig at age 14, and hasn't looked back. An #OwnVoices memoir breaks down what it's like to live with autism for readers on and off the spectrum.

    He chronicles the torture of finding a job before the internet when you had to talk on the phone all the time, and fantasizes, as we all do, about who to tell off when he finally wins an Oscar. As Gary himself says, "These are essays from my childhood and young adulthood about things that still annoy me."Original, brazen, and laugh out loud funny, Do You Mind if I Cancel? is something not to be missed.

    Now I’m letting my guard down.” —Hillary Rodham Clinton, from the introduction of What HappenedFor the first time, Hillary Rodham Clinton reveals what she was thinking and feeling during one of the most controversial and unpredictable presidential elections in history. Now free from the constraints of running, Hillary takes you inside the intense personal experience of becoming the first woman nominated for president by a major party in an election marked by rage, sexism, exhilarating highs and infuriating lows, stranger-than-fiction twists, Russian interference, and an opponent who broke all the rules. This is her most personal memoir yet. In these pages, she describes what it was like to run against Donald Trump, the mistakes she made, how she has coped with a shocking and devastating loss, and how she found the strength to pick herself back up afterward. With humor and candor, she tells readers what it took to get back on her feet—the rituals, relationships, and reading that got her through, and what the experience has taught her about life. She speaks about the challenges of being a strong woman in the public eye, the criticism over her voice, age, and appearance, and the double standard confronting women in politics. She lays out how the 2016 election was marked by an unprecedented assault on our democracy by a foreign adversary. By analyzing the evidence and connecting the dots, Hillary shows just how dangerous the forces are that shaped the outcome, and why Americans need to understand them to protect our values and our democracy in the future. The election of 2016 was unprecedented and historic. What Happened is the story of that campaign and its aftermath—both a deeply intimate account and a cautionary tale for the nation.

    She has left her job as a receptionist at a veterinary clinic, has published successful books and is courted by Hollywood, left Chicago, and moved into a house with a garden that requires repairs and know-how with her wife and two step-children in a small white, Republican town in Michigan where she now hosts book clubs. This is the bourgeois life of dreams. She goes on bad dates with new friends, spends weeks in Los Angeles taking meetings with "skinny, luminous peoples" while being a "cheese fry-eating slightly damp Midwest person," "with neck pain and no cartilage in [her] knees," and hides Entenmann's cookies under her bed and unopened bills under her pillow.Into the gross --Girls gone mild --Hung up! --Late-1900s time capsule --Love and marriage --Are you familiar with my work? --Hysterical! --Lesbian bed death --Body negativity --Country crock --A guide to simple home repairs --We almost got a fucking dog --Detachment parenting --Season 1, episode 1 --Hollywood summer --$$$ --Hello, 911? --An extremely specific guide to publishing a book