Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Scientists around the world are currently monitoring the sixth extinction, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. This time around, the cataclysm is us. In prose that is at once frank, entertaining, and deeply informed, The New Yorker writer Elizabeth Kolbert tells us why and how human beings have altered life on the planet in a way no species has before. Interweaving research in half a dozen disciplines, descriptions of the fascinating species that have already been lost, and the history of extinction as a concept, Kolbert provides a moving and comprehensive account of the disappearances occurring before our very eyes. She shows that the sixth extinction is likely to be mankind's most lasting legacy, compelling us to rethink the fundamental question of what it means to be human.

    

    Though his path to the heavens was riddled with setbacks and injury, Leland persevered to reach the stars.While training with NASA, Melvin suffered a severe injury that left him deaf. Leland was relegated to earthbound assignments, but chose to remain and support his astronaut family. His loyalty paid off. Recovering partial hearing, he earned his eligibility for space travel. He served as mission specialist for two flights aboard the shuttle Atlantis, working on the International Space Station.In this uplifting memoir, the former NASA astronaut and professional athlete offers an examination of the intersecting role of community, determination, and grace that align to shape our opportunities and outcomes. Chasing Space is not the story of one man, but the story of many men, women, scientists, and mentors who helped him defy the odds and live out an uncommon destiny.As a chemist, athlete, engineer and space traveler, Leland’s life story is a study in the science of achievement. His personal insights illuminate how grit and grace, are the keys to overcoming adversity and rising to success.

    That day--chosen completely at random--turned out to be Sunday, December 28, 1986, by any conventional measure a most ordinary day. Weingarten spent the next six years proving that there is no such thing.That Sunday between Christmas and New Year's turned out to be filled with comedy, tragedy, implausible irony, cosmic comeuppances, kindness, cruelty, heroism, cowardice, genius, idiocy, prejudice, selflessness, coincidence, and startling moments of human connection, along with evocative foreshadowing of momentous events yet to come. Lives were lost. Lives were saved. Lives were altered in overwhelming ways. Many of these events never made it into the news; they were private dramas in the lives of private people. They were utterly compelling.One Day asks and answers the question of whether there is even such a thing as "ordinary" when we are talking about how we all lurch and stumble our way through the daily, daunting challenge of being human.

    In this far-reaching narrative, Weisman explains how our massive infrastructure would collapse and finally vanish without human presence; which everyday items may become immortalized as fossils; how copper pipes and wiring would be crushed into mere seams of reddish rock; why some of our earliest buildings might be the last architecture left; and how plastic, bronze sculpture, radio waves, and some man-made molecules may be our most lasting gifts to the universe.The World Without Us reveals how, just days after humans disappear, floods in New York's subways would start eroding the city's foundations, and how, as the world's cities crumble, asphalt jungles would give way to real ones. It describes the distinct ways that organic and chemically treated farms would revert to wild, how billions more birds would flourish, and how cockroaches in unheated cities would perish without us. Drawing on the expertise of engineers, atmospheric scientists, art conservators, zoologists, oil refiners, marine biologists, astrophysicists, religious leaders from rabbis to the Dalai Lama, and paleontologists—who describe a prehuman world inhabited by megafauna like giant sloths that stood taller than mammoths—Weisman illustrates what the planet might be like today, if not for us.From places already devoid of humans (a last fragment of primeval European forest; the Korean DMZ; Chernobyl), Weisman reveals Earth's tremendous capacity for self-healing. As he shows which human devastations are indelible, and which examples of our highest art and culture would endure longest, Weisman's narrative ultimately drives toward a radical but persuasive solution that needn't depend on our demise. It is narrative nonfiction at its finest, and in posing an irresistible concept with both gravity and a highly readable touch, it looks deeply at our effects on the planet in a way that no other book has.

    Join author Douglas Adams and zoologist Mark Carwardine as they take off around the world in search of exotic, endangered creatures.

    But what would it look like to study the whole of history, from the big bang through the present day -- and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence?These were the questions David Christian set out to answer when he created the field of "Big History," the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as "history." By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together -- from the creation of the planet to the advent of agriculture, nuclear war, and beyond.With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.

    A few years ago, Mark Adams made a strange discovery: Everything we know about the lost city of Atlantis comes from the work of one man, the Greek philosopher Plato. Then he made a second, stranger discovery: Amateur explorers are still actively searching for this sunken city all around the world, based entirely on the clues Plato left behind. Exposed to the Atlantis obsession, Adams decides to track down these people and determine why they believe it’s possible to find the world’s most famous lost city and whether any of their theories could prove or disprove its existence. He visits scientists who use cutting-edge technology to find legendary civilizations once thought to be fictional. He examines the numerical and musical codes hidden in Plato’s writings, and with the help of some charismatic sleuths traces their roots back to Pythagoras, the sixth-century BC mathematician. He learns how ancient societies transmitted accounts of cataclysmic events—and how one might dig out the “kernel of truth” in Plato’s original tale.Meet Me in Atlantis is Adams’s enthralling account of his quest to solve one of history’s greatest mysteries; a travelogue that takes readers to fascinating locations to meet irresistible characters; and a deep, often humorous look at the human longing to rediscover a lost world.

    Award-winning comedian and popular-science writer Helen Keen uncovers the astounding science behind the mystical, blood-soaked world of Game of Thrones, answering questions like: Is it possible to crush a person's head with your bare hands? What really happens when royal families interbreed? Does Cersei have Borderline Personality Disorder? What curious medical disorder does Hodor suffer from? And more. Join Keen as she investigates wildfire, ice walls, face transplants, and every wild feature of Westeros and beyond, revealing a magical world that may be closer to our own than we think. The Science of Game of Thrones is the ultimate guide to the epic series as well as the perfect gift for science-lovers and fans. So pour yourself a bowl of brown, climb on your beast of burden, and prepare yourself to see the Seven Kingdoms as you have never seen them before.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    In a lab filled with curiosities--beakers, microscopes, Bunsen burners, and hundreds upon hundreds of books--sat an investigator who would go on to crack at least two thousand cases in his forty-year career. Known as the "American Sherlock Holmes," Edward Oscar Heinrich was one of America's greatest--and first--forensic scientists, with an uncanny knack for finding clues, establishing evidence, and deducing answers with a skill that seemed almost supernatural.Heinrich was one of the nation's first expert witnesses, working in a time when the turmoil of Prohibition led to sensationalized crime reporting and only a small, systematic study of evidence. However with his brilliance, and commanding presence in both the courtroom and at crime scenes, Heinrich spearheaded the invention of a myriad of new forensic tools that police still use today, including blood spatter analysis, ballistics, lie-detector tests, and the use of fingerprints as courtroom evidence. His work, though not without its serious--some would say fatal--flaws, changed the course of American criminal investigation.Based on years of research and thousands of never-before-published primary source materials, American Sherlock captures the life of the man who pioneered the science our legal system now relies upon--as well as the limits of those techniques and the very human experts who wield them.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    On July 5, 2011, nearly three years after her initial arrest, Casey Anthony walked away, virtually scot-free, from one of the most sensational murder trials of all time. She'd been accused of killing her daughter, Caylee, but the trial only left behind more questions: Was she actually innocent? What really happened to Caylee? Was this what justice really looked like?In Imperfect Justice, prosecutor Jeff Ashton, one of the principal players in the case's drama, sheds light on those questions and much more, telling the behind-the-scenes story of the investigation, the trial, and the now-infamous verdict. Providing an inside account of the case, Ashton, a career prosecutor for the state of Florida, goes where the press and pundits have only speculated, detailing what really happened during the investigation, showing how the prosecution built their case, and explaining how a woman so shrouded in suspicion was proclaimed innocent.Moving beyond the simple explanations, Ashton offers an in-depth look at the complex figure of Casey Anthony, a woman whose lies he spent three years trying to understand. And yet this focus on Casey came with its own risks; here he details how this widespread fixation on Casey—both in the media and in the trial—may have undermined the case itself. As everyone got caught up in the quest to understand the supposed villain, somehow the victim, Caylee, was all but forgotten—not just to the public, but more important, to the jury.Complete with never-before-revealed information about the case and the accused, Ashton examines what the prosecution got right, what they got wrong, and why he remains completely convinced of Casey Anthony's guilt.

    In Dataclysm, Christian Rudder uses it to show us who we truly are.   For centuries, we’ve relied on polling or small-scale lab experiments to study human behavior. Today, a new approach is possible. As we live more of our lives online, researchers can finally observe us directly, in vast numbers, and without filters. Data scientists have become the new demographers.   In this daring and original book, Rudder explains how Facebook "likes" can predict, with surprising accuracy, a person’s sexual orientation and even intelligence; how attractive women receive exponentially more interview requests; and why you must have haters to be hot. He charts the rise and fall of America’s most reviled word through Google Search and examines the new dynamics of collaborative rage on Twitter. He shows how people express themselves, both privately and publicly. What is the least Asian thing you can say? Do people bathe more in Vermont or New Jersey? What do black women think about Simon & Garfunkel? (Hint: they don’t think about Simon & Garfunkel.) Rudder also traces human migration over time, showing how groups of people move from certain small towns to the same big cities across the globe. And he grapples with the challenge of maintaining privacy in a world where these explorations are possible.   Visually arresting and full of wit and insight, Dataclysm is a new way of seeing ourselves—a brilliant alchemy, in which math is made human and numbers become the narrative of our time.