These beautifully rendered tales illuminate the fundamental pathways of life from birth to death.A woman finds herself daydreaming as she returns home from a business trip; a young man loses his wallet. We learn, too, from more extreme examples: the patient who points an unloaded gun at a police officer, the compulsive liar who convinces his wife he's dying of cancer. The stories invite compassionate understanding, suggesting answers to the questions that compel and disturb us most about love and loss, parents and children, work and change. The resulting journey will spark new ideas about who we are and why we do what we do.

    Clichés around marriage—eternal bliss, domestic harmony, soul mates—leave out the real stuff. After marriage you may still want to sleep with other people. Sometimes your partner will bore the hell out of you. And when stuck paying for your spouse’s mistakes, you might miss being single.In Wedding Toasts I’ll Never Give, Ada Calhoun presents an unflinching but also loving portrait of her own marriage, opening a long-overdue conversation about the institution as it truly is: not the happy ending of a love story or a relic doomed by high divorce rates, but the beginning of a challenging new chapter of which “the first twenty years are the hardest.”Calhoun’s funny, poignant personal essays explore the bedrooms of modern coupledom for a nuanced discussion of infidelity, existential anxiety, and the many other obstacles to staying together. Both realistic and openhearted, Wedding Toasts I’ll Never Give offers a refreshing new way to think about marriage as a brave, tough, creative decision to stay with another person for the rest of your life. “What a burden,” Calhoun calls marriage, “and what a gift.”

    Despite her flapping arms and shaking legs, she continued to speak clearly and was able to finish her speech. It was as if she had suddenly become two people: a calm orator and a shuddering wreck. Then the seizures happened again and again. The Shaking Woman tracks Hustvedt’s search for a diagnosis, one that takes her inside the thought processes of several scientific disciplines, each one of which offers a distinct perspective on her paroxysms but no ready solution. In the process, she finds herself entangled in fundamental questions: What is the relationship between brain and mind? How do we remember? What is the self?During her investigations, Hustvedt joins a discussion group in which neurologists, psychiatrists, psychoanalysts, and brain scientists trade ideas to develop a new field: neuropsychoanalysis. She volunteers as a writing teacher for psychiatric in-patients at the Payne Whitney clinic in New York City and unearths precedents in medical history that illuminate the origins of and shifts in our theories about the mind-body problem. In The Shaking Woman, Hustvedt synthesizes her experience and research into a compelling mystery: Who is the shaking woman? In the end, the story she tells becomes, in the words of George Makari, author of Revolution in Mind, “a brilliant illumination for us all.”

    She moved from New York to San Francisco, where she landed at a big-data startup in the heart of the Silicon Valley bubble: a world of surreal extravagance, dubious success, and fresh-faced entrepreneurs hell-bent on domination, glory, and, of course, progress.Anna arrived amidst a massive cultural shift, as the tech industry rapidly transformed into a locus of wealth and power rivaling Wall Street. But amid the company ski vacations and in-office speakeasies, boyish camaraderie and ride-or-die corporate fealty, a new Silicon Valley began to emerge: one in far over its head, one that enriched itself at the expense of the idyllic future it claimed to be building.Part coming-age-story, part portrait of an already-bygone era, Anna Wiener’s memoir is a rare first-person glimpse into high-flying, reckless startup culture at a time of unchecked ambition, unregulated surveillance, wild fortune, and accelerating political power. With wit, candor, and heart, Anna deftly charts the tech industry’s shift from self-appointed world savior to democracy-endangering liability, alongside a personal narrative of aspiration, ambivalence, and disillusionment.Unsparing and incisive, Uncanny Valley is a cautionary tale, and a revelatory interrogation of a world reckoning with consequences its unwitting designers are only beginning to understand.

    Bad art is from no one to no one. Am I happy? Damned if I know, but give me a few minutes and I’ll tell you whether you are. Thank heaven I don’t have my friends’ problems. But sometimes I notice an expression on one of their faces that I recognize as secret gratitude. I read sad stories to inoculate myself against grief. I watch action movies to identify with the quick-witted heroes. Both the same fantasy: I’ll escape the worst of it.—from 300 ArgumentsA “Proustian minimalist on the order of Lydia Davis” (Kirkus Reviews), Sarah Manguso is one of the finest literary artists at work today. To read her work is to witness acrobatic acts of compression in the service of extraordinary psychological and spiritual insight.300 Arguments, a foray into the frontier of contemporary nonfiction writing, is at first glance a group of unrelated aphorisms. But, as in the work of David Markson, the pieces reveal themselves as a masterful arrangement that steadily gathers power. Manguso’s arguments about desire, ambition, relationships, and failure are pithy, unsentimental, and defiant, and they add up to an unexpected and renegade wisdom literature.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    For Fadiman, as for many passionate readers, the books she loves have become chapters in her own life story. Writing with remarkable grace, she revives the tradition of the well-crafted personal essay, moving easily from anecdotes about Coleridge and Orwell to tales of her own pathologically literary family. As someone who played at blocks with her father's 22-volume set of Trollope ("My Ancestral Castles") and who only really considered herself married when she and her husband had merged collections ("Marrying Libraries"), she is exquisitely well equipped to expand upon the art of inscriptions, the perverse pleasures of compulsive proof-reading, the allure of long words, and the satisfactions of reading out loud. There is even a foray into pure literary gluttony: Charles Lamb liked buttered muffin crumbs between the leaves, and Fadiman knows of more than one reader who literally consumes page corners. Perfectly balanced between humor and erudition, Ex Libris establishes Fadiman as one of our finest contemporary essayists.

    Includes special bonus material!Sharing never-before-heard stories ranging from their struggles with depression, eating disorders, and addiction, Karen and Georgia irreverently recount their biggest mistakes and deepest fears, reflecting on the formative life events that shaped them into two of the most followed voices in the nation.In Stay Sexy & Don’t Get Murdered, Karen and Georgia focus on the importance of self-advocating and valuing personal safety over being ‘nice’ or ‘helpful.’ They delve into their own pasts, true crime stories, and beyond to discuss meaningful cultural and societal issues with fierce empathy and unapologetic frankness.

    So begins Spinster, a revelatory and slyly erudite look at the pleasures and possibilities of remaining single. Using her own experiences as a starting point, journalist and cultural critic Kate Bolick invites us into her carefully considered, passionately lived life, weaving together the past and present to examine why­ she - along with over 100 million American women, whose ranks keep growing - remains unmarried. This unprecedented demographic shift, Bolick explains, is the logical outcome of hundreds of years of change that has neither been fully understood, nor appreciated. Spinster introduces a cast of pioneering women from the last century whose genius, tenacity, and flair for drama have emboldened Bolick to fashion her life on her own terms: columnist Neith Boyce, essayist Maeve Brennan, social visionary Charlotte Perkins Gilman, poet Edna St. Vincent Millay, and novelist Edith Wharton. By animating their unconventional ideas and choices, Bolick shows us that contemporary debates about settling down, and having it all, are timeless - the crucible upon which all thoughtful women have tried for centuries to forge a good life. Intellectually substantial and deeply personal, Spinster is both an unreservedly inquisitive memoir and a broader cultural exploration that asks us to acknowledge the opportunities within ourselves to live authentically. Bolick offers us a way back into our own lives - a chance to see those splendid years when we were young and unencumbered, or middle-aged and finally left to our own devices, for what they really are: unbounded and our own to savor.

    There was the location: an impoverished, nuclear waste-riddled area of the American Midwest. There was her mother, a woman who speaks almost entirely in strange koans and warnings of impending danger. Above all, there was her gun-toting, guitar-riffing, frequently semi-naked father, who underwent a religious conversion on a submarine and discovered a loophole which saw him approved for the Catholic priesthood by the future Pope Benedict XVI - despite already having a wife and children.When the expense of a medical procedure forces the 30-year-old Patricia to move back in with her parents, husband in tow, she must learn to live again with her family's simmering madness, and to reckon with the dark side of a childhood spent in the bosom of the Catholic Church. Told with the comic sensibility of a brasher, bluer Waugh or Wodehouse, this is at the same time a lyrical and affecting story of how, having ventured into the underworld, we can emerge with our levity and our sense of justice intact.

    While an illness keeps her bedridden, Bailey watches a wild snail that has taken up residence on her nightstand. As a result, she discovers the solace and sense of wonder that this mysterious creature brings and comes to a greater understanding of her own confined place in the world. Intrigued by the snail’s molluscan anatomy, cryptic defenses, clear decision making, hydraulic locomotion, and mysterious courtship activities, Bailey becomes an astute and amused observer, providing a candid and engaging look into the curious life of this underappreciated small animal.  Told with wit and grace, The Sound of a Wild Snail Eating is a remarkable journey of survival and resilience, showing us how a small part of the natural world illuminates our own human existence and provides an appreciation of what it means to be fully alive.

    Mara Altman's volatile and apprehensive relationship with her body has led her to wonder about a lot of stuff over the years. Like, who decided that women shouldn't have body hair? And how sweaty is too sweaty? Also, why is breast cleavage sexy but camel toe revolting? Isn't it all just cleavage? These questions and others like them have led to the comforting and sometimes smelly revelations that constitute Gross Anatomy, an essay collection about what it's like to operate the bags of meat we call our bodies.Divided into two sections, "The Top Half" and "The Bottom Half," with cartoons scattered throughout, Altman's book takes the reader on a wild and relatable journey from head to toe—as she attempts to strike up a peace accord with our grody bits.With a combination of personal anecdotes and fascinating research, Gross Anatomy holds up a magnifying glass to our beliefs, practices, biases, and body parts and shows us the naked truth: that there is greatness in our grossness.

    Cultural critic and bestselling author Roxane Gay has edited a collection of essays that explore what it means to live in a world where women are frequently belittled and harassed due to their gender, and offers a call to arms insisting that "not that bad" must no longer be good enough.

    One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose office she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but. As Gottlieb explores the inner chambers of her patients' lives -- a self-absorbed Hollywood producer, a young newlywed diagnosed with a terminal illness, a senior citizen threatening to end her life on her birthday if nothing gets better, and a twenty-something who can't stop hooking up with the wrong guys -- she finds that the questions they are struggling with are the very ones she is now bringing to Wendell. With startling wisdom and humor, Gottlieb invites us into her world as both clinician and patient, examining the truths and fictions we tell ourselves and others as we teeter on the tightrope between love and desire, meaning and mortality, guilt and redemption, terror and courage, hope and change.Maybe You Should Talk to Someone is revolutionary in its candor, offering a deeply personal yet universal tour of our hearts and minds and providing the rarest of gifts: a boldly revealing portrait of what it means to be human, and a disarmingly funny and illuminating account of our own mysterious lives and our power to transform them.

    Shameful to talk about and often misunderstood, loneliness is everywhere, from the most major of metropolises to the smallest of towns.In Seek You, Kristen Radtke's wide-ranging exploration of our inner lives and public selves, Radtke digs into the ways in which we attempt to feel closer to one another, and the distance that remains. Through the lenses of gender and violence, technology and art, Radtke ushers us through a history of loneliness and longing, and shares what feels impossible to share.Ranging from the invention of the laugh-track to the rise of Instagram, the bootstrap-pulling cowboy to the brutal experiments of Harry Harlow, Radtke investigates why we engage with each other, and what we risk when we turn away. With her distinctive, emotionally charged drawings and deeply empathetic prose, Kristen Radtke masterfully shines a light on some of our most vulnerable and sublime moments, and asks how we might keep the spaces between us from splitting entirely.