Where are we? Who are we? Are our emotions, our beliefs, and our hopes and dreams ultimately meaningless out there in the void? Does human purpose and meaning fit into a scientific worldview?In short chapters filled with intriguing historical anecdotes, personal asides, and rigorous exposition, readers learn the difference between how the world works at the quantum level, the cosmic level, and the human level--and then how each connects to the other.  Carroll's presentation of the principles that have guided the scientific revolution from Darwin and Einstein to the origins of life, consciousness, and the universe is dazzlingly unique.Carroll shows how an avalanche of discoveries in the past few hundred years has changed our world and what really matters to us. Our lives are dwarfed like never before by the immensity of space and time, but they are redeemed by our capacity to comprehend it and give it meaning.The Big Picture is an unprecedented scientific worldview, a tour de force that will sit on shelves alongside the works of Stephen Hawking, Carl Sagan, Daniel Dennett, and E. O. Wilson for years to come.

    The result is a wealth of stimulating ideas set among clear explanations drawn from a revelatory decade in biology."—Andrew H. Knoll, author of Life on a Young Planet"Thought-provoking and lucidly written. . . . The Plausibility of Life will help readers understand not just the plausibility of evolution, but its remarkable, inventive powers." —Sean Carroll, author of Endless Forms Most Beautiful: The New Science of Evo Devo“Remarkably lucid and comprehensive, this new theoretical synthesis will . . . shift the grounds for debate in the controversy surrounding organic evolution.”—Booklist (starred review)

    For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change.Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code.Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

    When a new team of hand- picked, investigators, devised a different strategy to crack the genetic code that protected the Unabomber’s anonymity, the first task was to begin blasting away the layers of bureaucratic constraints that had plagued the earlier efforts to retrace the trail of crimes. As the rules broke and the bureaucratic restraints crumbled, the puzzle pieces of earlier bombings that the terrorist left behind were found and the puzzle collapsed around the Unabomber like a deck of cards. This is the story, told in the narrative, by the three FBI Agents who led the chase, of how, they broke the Bureau’s own rules and finally captured the notorious Unabomber who had led the Federal Bureau of Investigation on the longest chase in its century- old history.

    "If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In "Biopunk," Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.

    Drawing on anecdotes from science, economics, history, politics and philosophy, Matt Ridley’s wide-ranging, highly opinionated opus demolishes conventional assumptions that major scientific and social imperatives are dictated by those on high, whether in government, business, academia, or morality. On the contrary, our most important achievements develop from the bottom up. Patterns emerge, trends evolve. Just as skeins of geese form Vs in the sky without meaning to, and termites build mud cathedrals without architects, so brains take shape without brain-makers, learning can happen without teaching and morality changes without a plan.Although we neglect, defy and ignore them, bottom-up trends shape the world. The growth of technology, the sanitation-driven health revolution, the quadrupling of farm yields so that more land can be released for nature—these were largely emergent phenomena, as were the Internet, the mobile phone revolution, and the rise of Asia. Ridley demolishes the arguments for design and effectively makes the case for evolution in the universe, morality, genes, the economy, culture, technology, the mind, personality, population, education, history, government, God, money, and the future.

    Dickson Despommier's visionary book provides a blueprint for securing the world's food supply and at the same time solving one of the gravest environmental crises facing us today."--StingImagine a world where every town has their own local food source, grown in the safest way possible, where no drop of water or particle of light is wasted, and where a simple elevator ride can transport you to nature's grocery store - imagine the world of the vertical farm.When Columbia professor Dickson Despommier set out to solve America's food, water, and energy crises, he didn't just think big - he thought up. Despommier's stroke of genius, the vertical farm, has excited scientists, architects, and politicians around the globe. Now, in this groundbreaking book, Despommier explains how the vertical farm will have an incredible impact on changing the face of this planet for future generations.Despommier takes readers on an incredible journey inside the vertical farm, buildings filled with fruits and vegetables that will provide local food sources for entire cities.Vertical farms will allow us to:- Grow food 24 hours a day, 365 days a year- Protect crops from unpredictable and harmful weather- Re-use water collected from the indoor environment- Provide jobs for residents- Eliminate use of pesticides, fertilizers, or herbicides- Drastically reduce dependence on fossil fuels- Prevent crop loss due to shipping or storage- Stop agricultural runoffVertical farms can be built in abandoned buildings and on deserted lots, transforming our cities into urban landscapes which will provide fresh food grown and harvested just around the corner. Possibly the most important aspect of vertical farms is that they can built by nations with little or no arable land, transforming nations which are currently unable to farm into top food producers. In the tradition of the bestselling The World Without Us, The Vertical Farm is a completely original landmark work destined to become an instant classic

    Bronowski's exciting, illustrated investigation offers a perspective not just on science, but on civilization itself. Lower than the angelsForewordThe harvest of the seasons The grain in the stoneThe hidden structure The music of the spheresThe starry messanger The majestic clockworkThe drive for power The ladder of creation World within world Knowledge or certainty Generation upon generationThe long childhoodBibliographyIndex

    

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely--technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future--is now within reach.In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage.  As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars.  We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage.  By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

    More than one million students have completed courses developed by the Motorcycle Safety Foundation, and this book is the culmination of what that leading rider training organization has learned about teaching students of all ages and experience. It is the perfect refresher for anyone who has taken an MSF course and will be an eye-opener for those who have not yet discovered them. In a clear, engaging style with detailed diagrams and extensive full-color photographs and illustrations, the book covers rider attitude, proper dress, performance, maintenance and troubleshooting, as well as basic and advanced street skills. Included are tips on how to stop quickly when necessary; avoid traffic hazards; apply evasive maneuvers; countersteer for better control; travel skillfully in a group; identify and fix mechanical problems; ride more smoothly at high and low speeds; maintain momentum in off-highway riding; and much more. A remarkable source of riding wisdom, the first edition has been a best-seller and the definitive reference for the sport. This new second edition features the latest insights from the new, updated MSF curriculum, plus all new photos and graphics that make its valuable lessons easy to follow.

    This ebook documents the most egregious – and most hilarious – offenders from the moment Superman flew onto the Atari 2600 in 1978 all the way through 1992, when Konami's classic X-Men sucked in quarter after quarter in arcades. NEARLY 80 SUPERHERO GAMES Some you've played. Some you haven't. And quite a few you never even knew existed in the first place. Some high-/lowlights: Purple Dark Knight vs. Green Joker in Batman: The Video Game (NES) Proven instances of "slapping a license" on an already-developed game Games that stripped Wolverine and He-Man of their most iconic weaponry A questionable transportation method for the Man of Steel in Superman (NES) A Transformers game from the creator of Pitfall! The strangest comic book license ever to hit the Sega Genesis The most unnecessary tie-in to a superhero animated series of all time The Danger Mouse Trilogy That one lonely Thundercats game ANSWERS TO BURNING QUESTIONS YOU DIDN'T EVEN KNOW TO ASK Who is "the Princess Peach of superhero games"? Who was the first Marvel character to be featured in three games? And what's the single gaming appearance he's had since 1985? Which super-character is most consistently misrepresented in games? What common superhero gaming feature was pioneered by LJN's otherwise absolutely horrible X-Men NES game? Which hero's primary gaming nemesis is someone he still has yet to even meet in the comics? What do an NES game and a major restaurant chain agree is Wolverine's favorite food? Why is Carnage getting naked on my SNES?! GAMING PLATFORMS YOU LOVED...OR DIDN'T KNOW EXISTED Atari 2600 | Intellivision | Commodore 64 | Nintendo Entertainment System | Game Boy | Super NES | Sega Master System | Genesis | Game Gear | Lynx | ZX Spectrum | MSX | PC-DOS | MORE! YOUR FAVORITE HEROES (AND SOME YOU'VE NEVER HEARD OF) From Marvel! Spider-Man | Wolverine and the X-Men | Hulk | Captain America, Iron Man, Hawkeye, Vision, and a bunch of other Avengers | Punisher | Human Torch and the Thing from the Fantastic Four | Silver Surfer | Howard the Duck From DC! Superman | Batman | Flash | Swamp Thing From Other Comic Publishers! Conan | Flash Gordon | Judge Dredd | Ex-Mutants From Toy Lines and Cartoons! Transformers | Teenage Mutant Ninja Turtles | He-Man and the Masters of the Universe | Bartman and Radioactive Man from The Simpsons | G.I.

    They distill more than 20 years of research and first-hand accounts from the most biodiverse ecosystems on Earth into straightforward principles and guidance for confronting our culture of hyper-novelty.For evolutionary biologists Heather Heying and Bret Weinstein, the cause of our woes is clear: the modern world is out of sync with our ancient brains and bodies. We evolved to live in clans, but today most people don't even know their neighbors' names. Differences between the sexes once served a necessary evolutionary purpose, but today many dismiss the concept of biological sex as offensive. The cognitive dissonance spawned by trying to live in a society we're not built for is killing us.

    Gregory Stock, an expert on the implications of recent advances in reproductive biology, has glimpsed the inevitable future of biomedical engineering. Within decades, Stock asserts, technological advances will bring meaningful changes to our offspring; this scientific revolution promises to fundamentally alter the human species. With recent findings presented in a new afterword, Stock's provocative assessment cuts through the debate to envision an age of radical biotechnological advancement and unprecedented human choice.