These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    That simple act became a national news story because Abby was the director of a Planned Parenthood clinic in Texas who, after participating in her first actual abortion procedure, walked across the road to join the Coalition for Life. "Unplanned" is a heartstopping personal drama of life-and-death encounters, a courtroom battle, and spiritual transformation that speaks hope and compassion into the political controversy that surrounds this issue. Telling Abby’s story from both sides of the abortion clinic property line, this book is a must-read for anyone who cares about the life versus rights debate and helping women who face crisis pregnancies.

    Hit with this devastating barrage, Tig took her grief onstage. Days after receiving her cancer diagnosis, she broke new comedic ground, opening an unvarnished set with the words, “Good evening. Hello. I have cancer. How are you? Hi, how are you? Is everybody having a good time? I have cancer.” Word of the set went viral instantly. This set was ultimately released as Tig’s sophomore album, Live, which sold 100,000 units in just six weeks and was nominated for a Grammy. Now, the wildly popular star takes stock of that no good, very bad year—a difficult yet astonishing period in which tragedy turned into absurdity and despair into joy. An inspired combination of the deadpan silliness of her comedy and the open-hearted vulnerability that has emerged in the wake of that dire time, Untitled is a moving and often hilarious look at this very brave, very funny woman’s journey through the darkness and her thrilling return.

    Before Nic became addicted to crystal meth, he was a charming boy, joyous and funny, a varsity athlete and honor student adored by his two younger siblings. After meth, he was a trembling wraith who lied, stole, and lived on the streets. David Sheff traces the first warning signs: the denial, the three a.m. phone calls—is it Nic? the police? the hospital? His preoccupation with Nic became an addiction in itself. But as a journalist, he instinctively researched every treatment that might save his son. And he refused to give up on Nic.

    . . . It should be difficult to get lost forever": These were the haunting last words legendary adventurer Roman Dial received from his son, before the 27-year old disappeared into the jungles of Costa Rica. This is Dial’s intensely gripping and deeply moving account of his two-year quest to unravel the mystery of his son’s fate.In the predawn hours of July 10, 2014, twenty-seven-year-old Cody Roman Dial, the son of preeminent Alaskan scientist and National Geographic Explorer Roman Dial, walked alone into Corcovado National Park, an untracked rainforest along Costa Rica’s remote Pacific Coast that shelters miners, poachers, and drug smugglers. He carried a light backpack and machete. Before he left, he emailed his father: "I am not sure how long it will take me, but I’m planning on doing 4 days in the jungle and a day to walk out. I’ll be bounded by a trail to the west and the coast everywhere else, so it should be difficult to get lost forever."They were the last words Dial received from his son.The Adventurer’s Son recreates the author’s two-year quest to learn the truth about his child’s disappearance. Immediately after Cody Roman’s planned departure date passed without a word from him, Dial set off for Costa Rica. As he trekked through the dense jungle, interviewing locals and searching for clues—the authorities suspected murder—the desperate father was forced to confront the deepest questions about his own life. Roman had raised his son to be fearless, to seek out adventure amid earth’s wildest places. Was he ultimately responsible for his son’s fate?A harrowing story of drama, adventure, and a father’s love for his son, set in the most beautiful and dangerous reaches of the planet, The Adventurer’s Son is a mystery, the memoir of a father and his son, and an unforgettable story of love and profound loss.The Adventurer’s Son includes 25 color photographs.

    That's all it took to change Stephanie Wittels Wachs' life forever..Her younger brother Harris, a star in the comedy world known for his work on shows like Parks and Recreation, had died of a heroin overdose. How do you make sense of such a tragic end to a life of so much hilarious brilliance?In beautiful, unsentimental, and surprisingly funny prose, Stephanie Wittels Wachs alternates between her brother's struggle with addiction, which she learned about three days before her wedding, and the first year after his death, in all its emotional devastation. This compelling portrait of a comedic genius and a profound exploration of the love between siblings is A Year of Magical Thinking for a new generation of readers.A heartbreaking but hopeful memoir of addiction, grief, and family, Everything is Horrible and Wonderful will make you laugh, cry, and wonder if that possum on the fence is really your brother's spirit animal.

    Illuminating, completely engaging—it's essential reading for all since we all know someone whose life, family or friends are touched by the disease that directly afflicts a fifth of Canadians. In her early twenties, while outwardly thriving in her dream job and enjoying warm familial support and a strong social network, award-winning journalist Anna Mehler Paperny found herself trapped by feelings of failure and despair. Her first suicide attempt—ingesting a deadly mix of sleeping pills and antifreeze—landed her in the ICU, followed by weeks of enforced detention that ran the gamut of horrifying, boring, hilarious, and absurd. This was Anna's entry into the labyrinthine psychiatric care system responsible for providing care to millions of Canadians.As she struggled to survive the psych ward and as an outpatient—enduring the "survivor's" shame of facing concerned family, friends, and co-workers; finding (or not) the right therapist, the right meds; staying healthy, insured, and employed—Anna could not help but turn her demanding journalist's eye on her condition and on the system in which she found herself. She set off on a quest to "know her enemy," interviewing leading practitioners in the field across Canada and the US—from psychiatrists to neurological experts, brain-mapping pioneers to heroic family practitioners, and others dabbling in novel hypotheses. She reveals in courageously frank detail her own experiences with the pharmacological pitfalls and side effects of long-term treatment, and offers moving case studies of conversations with others, opening wide a window into how we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

    The critically acclaimed series became America’s most watched—and most talked about—network show, even building on its fan base in the drama’s second season. As Kate Pearson, Chrissy Metz presents a character that has never been seen on television, yet viewers see themselves in her, no matter what they look like or where they come from. Considered a role model just for being her authentic self, Chrissy found herself on magazine covers and talk shows, walking red carpets, and as the subject of endless conversations on social media “I don’t know what you’ve been through to play her,” she is often told by fans, “but it was something.”In This is Me, Chrissy Metz shares her story with a raw honesty that will leave readers both surprised but also inspired. Infused with the same authenticity she brings to her starring role, Chrissy’s This is Me is so much more than your standard Hollywood memoir or collection of personal essays. She embraces the spirit of Shonda Rhimes’ Year of Yes, and shares how she has applied the lessons she learned from both setbacks and successes. A born entertainer, Chrissy finds light in even her darkest moments, and leaves the reader feeling they are spending time with a friend who gets it.Chrissy Metz grew up in a large family, one that always seemed to be moving, and growing. Her father disappeared one day, leaving her mother to work a series of menial jobs and his children to learn to live with the threat of hunger and the electricity being cut off. When her mother remarried, Chrissy hoped for “normal” but instead experienced a form of mental pain that seemed crafted just for her. The boys who showed her attention did so with strings attached as well, and Chrissy accepted it, because for her, love always came with conditions.When she set out for Los Angeles, it was the first time she had been away from her family and from Florida. And for years, she got barely an audition. So how does a woman with the deck stacked against her radiate such love, beauty and joy? This too is at the heart of This is Me. With chapters that alternate from autobiographical to instructional, Chrissy offers practical applications of her hard-won insights in a series of “Bee Mindful” interstitials. There she invites you to embrace gratitude in “Say Thank You” or to be honest with your partner and yourself in “The Shrouded Supreme.” Blending love and experience, Chrissy encourages us all to claim our rightful place in a world that may be trying to knock us down, find our own unique gifts, and pursue our dreams.

    Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.Then, Dr. Alexander’s own brain was attacked by a rare illness. The part of the brain that controls thought and emotion—and in essence makes us human—shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexander’s eyes popped open. He had come back.Alexander’s recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine source of the universe itself.Alexander’s story is not a fantasy. Before he underwent his journey, he could not reconcile his knowledge of neuroscience with any belief in heaven, God, or the soul. Today Alexander is a doctor who believes that true health can be achieved only when we realize that God and the soul are real and that death is not the end of personal existence but only a transition.This story would be remarkable no matter who it happened to. That it happened to Dr. Alexander makes it revolutionary. No scientist or person of faith will be able to ignore it. Reading it will change your life.

    They say you can’t go home again. But when her father is diagnosed with aggressive lung cancer and her mother with atypical Alzheimer’s, New York-based actress Kate Mulgrew returns to her hometown in Iowa to spend time with her parents and care for them in the time they have left.The months Kate spends with her parents in Dubuque—by turns turbulent, tragic, and joyful—lead her to reflect on each of their lives and how they shaped her own. Those ruminations are transformed when, in the wake of their deaths, Kate uncovers long-kept secrets that challenge her understanding of the unconventional Irish Catholic household in which she was raised.Breathtaking and powerful, laced with the author’s irreverent wit, How to Forget is a considered portrait of a mother and a father, an emotionally powerful memoir that demonstrates how love fuses children and parents, and an honest examination of family, memory, and indelible loss.

    Brought up in Washington, DC, in an abusive family, she went to Harvard, where she met her husband. They stayed together through medical school until two months before she was scheduled to join the staff of a hospital in central Philadelphia, when he told her he couldn't move with her. Her marriage at an end, Harper began her new life in a new city, in a new job, as a newly single woman.In the ensuing years, as Harper learned to become an effective ER physician, bringing insight and empathy to every patient encounter, she came to understand that each of us is broken—physically, emotionally, psychically. How we recognize those breaks, how we try to mend them, and where we go from there are all crucial parts of the healing process.The Beauty in Breaking is the poignant true story of Harper's journey toward self-healing. Each of the patients Harper writes about taught her something important about recuperation and recovery. How to let go of fear even when the future is murky. How to tell the truth when it's simpler to overlook it. How to understand that compassion isn't the same as justice. As she shines a light on the systemic disenfranchisement of the patients she treats as they struggle to maintain their health and dignity, Harper comes to understand the importance of allowing ourselves to make peace with the past as we draw support from the present. In this hopeful, moving, and beautiful book, she passes along the precious, necessary lessons that she has learned as a daughter, a woman, and a physician.

    She was repeatedly hospitalized in excruciating pain, but the doctors insisted it was a urinary tract infection and sent her home with antibiotics. Unable to get out of bed, much less attend class, Norman dropped out of college and embarked on what would become a years-long journey to discover what was wrong with her. It wasn't until she took matters into her own hands--securing a job in a hospital and educating herself over lunchtime reading in the medical library--that she found an accurate diagnosis of endometriosis.In Ask Me About My Uterus, Norman describes what it was like to have her pain dismissed, to be told it was all in her head, only to be taken seriously when she was accompanied by a boyfriend who confirmed that her sexual performance was, indeed, compromised. Putting her own trials into a broader historical, sociocultural, and political context, Norman shows that women's bodies have long been the battleground of a never-ending war for power, control, medical knowledge, and truth. It's time to refute the belief that being a woman is a preexisting condition.

    The colorful characters she meets while delivering babies all over London--from the plucky, warm-hearted nuns with whom she lives to the woman with twenty-four children who can't speak English to the prostitutes and dockers of the city's seedier side--illuminate a fascinating time in history. Beautifully written and utterly moving, The Midwife will touch the hearts of anyone who is, and everyone who has, a mother.

    The childhood illness that left her bedridden for a year, which she was not expected to survive. A teenage yearning to escape that nearly ended in disaster. An encounter with a disturbed man on a remote path. And, most terrifying of all, an ongoing, daily struggle to protect her daughter--for whom this book was written--from a condition that leaves her unimaginably vulnerable to life's myriad dangers.Seventeen discrete encounters with Maggie at different ages, in different locations, reveal a whole life in a series of tense, visceral snapshots. In taut prose that vibrates with electricity and restrained emotion, O'Farrell captures the perils running just beneath the surface, and illuminates the preciousness, beauty, and mysteries of life itself.