This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.

    During flow, people typically experience deep enjoyment, creativity, and a total involvement with life. Csikszentmihalyi demonstrates the ways this positive state can be controlled, not just left to chance. Flow: The Psychology of Optimal Experience teaches how, by ordering the information that enters our consciousness, we can discover true happiness, unlock our potential, and greatly improve the quality of our lives.

    We live in an age of winners and losers, where the odds are stacked in favour of the already fortunate. Stalled social mobility and entrenched inequality give the lie to the promise that "you can make it if you try". And the consequence is a brew of anger and frustration that has fuelled populist protest, with the triumph of Brexit and election of Donald Trump.Michael J. Sandel argues that to overcome the polarized politics of our time, we must rethink the attitudes toward success and failure that have accompanied globalisation and rising inequality. Sandel highlights the hubris a meritocracy generates among the winners and the harsh judgement it imposes on those left behind. He offers an alternative way of thinking about success - more attentive to the role of luck in human affairs, more conducive to an ethic of humility, and more hospitable to a politics of the common good.

    Today there is just one. Us. Homo sapiens. How did our species succeed in the battle for dominance? Why did our foraging ancestors come together to create cities and kingdoms? How did we come to believe in gods, nations and human rights; to trust money, books and laws; and to be enslaved by bureaucracy, timetables and consumerism? And what will our world be like in the millennia to come? In Sapiens, Dr Yuval Noah Harari spans the whole of human history, from the very first humans to walk the earth to the radical – and sometimes devastating – breakthroughs of the Cognitive, Agricultural and Scientific Revolutions. Drawing on insights from biology, anthropology, paleontology and economics, he explores how the currents of history have shaped our human societies, the animals and plants around us, and even our personalities. Have we become happier as history has unfolded? Can we ever free our behaviour from the heritage of our ancestors? And what, if anything, can we do to influence the course of the centuries to come? Bold, wide-ranging and provocative, Sapiens challenges everything we thought we knew about being human: our thoughts, our actions, our power ... and our future.

    As a man, Tchaikovsky was defined by and indivisible from his music, which became an outlet for all the shifting moods of his turbulent soul. As Professor Robert Greenberg says, "If Tchaikovsky felt it, it found a way into his music." As an artist—and it is worth recalling that he was the first full-time, formally trained, professional composer in Russian history—Tchaikovsky walked a fine and difficult line between his Romantic penchant for expression and the demands of Classical structure.This delicate balancing act—between heart and head, emotion and reason, release and control, Russian expressive content and German technique—is a key to his music that you find amply illustrated by Professor Greenberg's musical selections and commentary. Course Lecture Titles1. Introduction and Early Life 2. A Career in Music 3. The First Masterworks 4. Maturity 5. Three WomenTatyana, Antonina, and Nadezhda 6. My Great Friend 7. A Free Man 8. The Last Years, or Don't Drink the Water

    And, though the emerging Orthodox Church eventually condemned Gnosticism as heretical, the church formed many of its most central doctrines (such as original sin, the Immaculate Conception, and even the concept of heresy) in response to Gnostic ideas.This fascinating 24-lecture course is a richly detailed guide to the theology, sacred writings, rituals, and outstanding human figures of the Gnostic movements. What we call "Gnosticism" comprised a number of related religious ideologies and movements, all of which sought "gnosis," or immediate, direct, and intimate knowledge of God. The Gnostics had many scriptures, but unlike the holy texts of other religions, Gnostic scriptures were often modified over time. Gnostic cosmology was extraordinarily intricate and multidimensional, but religious myth was simply a means to the ultimate end of gnosis.Follow Gnostic ideology and its vivid impact on Western thought through the centuries, from its role in early religions and its re-emergence in medieval spirituality to its remarkable traces in modern popular culture, from science fiction novels like Blade Runner to Hollywood films like The Matrix. In delving into the paths of gnosis, you'll discover a compelling, alternative current of religious practice in the West, and reveal Gnostic influence resonating in Western spirituality even in the present day.

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    She takes us by her side down hospital corridors to visit the wards and meet her unforgettable patients.In the neonatal unit, premature babies fight for their lives, hovering at the very edge of survival, like tiny Emmanuel, wrapped up in a sandwich bag. On the cancer wards, the nurses administer chemotherapy and, long after the medicine stops working, something more important--which Watson learns to recognize when her own father is dying of cancer. In the pediatric intensive care unit, the nurses wash the hair of a little girl to remove the smell of smoke from the house fire. The emergency room is overcrowded as ever, with waves of alcohol and drug addicted patients as well as patients like Betty, a widow suffering chest pain, frail and alone. And the stories of the geriatric ward--Gladys and older patients like her--show the plight of the most vulnerable members of our society.

    Bad arguments, fallacious reasoning, misleading language, and built-in cognitive biases are all traps that keep us from rational decision making-to say nothing of advertisers and politicians who want to convince us with half-truths and empty rhetoric. The Philosopher's Toolkit: How to Be the Most Rational Person in Any Room offers the skills to do just that. Taught by award-winning Professor Patrick Grim of the State University of New York at Stony Brook, this applied philosophy course arms you against the perils of bad thinking and supplies you with an arsenal of strategies to help you be more creative, logical, inventive, realistic, and rational in all aspects of your daily life, from the office to the voting booth.

    In Projections, he combines his groundbreaking access to the brain's inner circuitry with a deep empathy for his patients to examine what mental illness reveals about the mind and the origin of human feelings--how the broken can illuminate the unbroken. An internationally acclaimed professor of bioengineering and psychiatry at Stanford, Deisseroth's true passion is clinical psychiatry, and it is the stories of his patients that form the backbone of Projections. Through these case studies, he tells the larger story of how we can understand the physical and biological origins of human emotion in the brain. As such, he describes vividly how humans experience feelings both in the simple and ancient circuits of our brains and in the poignant moments of suffering in our daily lives. The stories of Deisseroth's patients are rich with humanity and shine an unprecedented light on the self and the ways in which it breaks down. A young woman with an eating disorder reveals how the mind can rebel against the brain's most primitive drives of hunger and thirst; while an older gentleman, smothered into silence by depression and dementia, illuminates how humans evolved to feel joy and its absence; and a lonely Uyghur woman far from home teaches the importance of rich social bonds. An illuminating and essential work, Projections transforms the way we understand the brain as a biological and as an emotional object.A groundbreaking tour of the human mind that illuminates the biological nature of our inner worlds and emotions, through gripping, moving—and, at times, harrowing—clinical stories“[A] scintillating and moving analysis of the human brain and emotions.”—Nature“Beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience.”—Robert Lefkowitz, Nobel Laureate

    In fact, your body is actually endowed with many self-defense measures to hold on to fat. For example, fat can use stem cells to regenerate; increase our appetite if it feels threatened; and use bacteria, genetics, and viruses to expand itself. The secret to losing twenty pounds? You have to work with your fat, not against it. Tara explains how your fat influences your appetite and willpower, how it defends itself when attacked, and why it grows back so quickly. The Secret Life of Fat brings cutting-edge research together with historical perspectives to reveal fat’s true identity: an endocrine organ that, in the right amount, is critical to our health. Fat triggers puberty, enables our reproductive and immune systems, and even affects brain size.Although we spend $60 billion annually fighting fat, our efforts are often misinformed and misdirected. Tara expertly illustrates the complex role that genetics, hormones, diet, exercise, and history play in our weight, and The Secret Life of Fat sets you on the path to beat the bulge once and for all.

    Every aircraft is equipped with an almost indestructible black box. When there is an accident, the box is opened, the data is analyzed, and the reason for the accident excavated. This ensures that procedures are adapted so that the same mistake doesn’t happen again. With this method, the industry has created an astonishing safety record.For pilots working in a safety-critical industry, getting it wrong can have deadly consequences. But most of us have a relationship with failure that impedes progress, halts innovation, and damages our lives. We don’t acknowledge it or learn from it —though we often think we do.Moving from anthropology to psychology and from history to complexity theory, Matthew Syed explains why even when we think we have 20/20 hindsight, our vision’s still fuzzy. He offers a radical new idea: that the most important determinant of success in any field, whether sports, business, or life, is an acknowledgment of failure and a willingness to engage with it. This is how we learn, progress and excel. This approach explains everything from biological evolution and the efficiency of markets to the success of the Mercedes F1 team and the mindset of David Beckham.Using a cornucopia of interviews, gripping stories, and sharp-edged science, Syed explores the intimate relationship between failure and success, and shows why we need to transport black box thinking into our own lives. If we wish to unleash our potential, we must diagnose and break free of our failures. Part manifesto for change, part intellectual adventure, this groundbreaking book reveals how to do both.

    Our ancestors crossed the Alps in animal skins and colonized the New World in loin cloths. They evaded predators and built civilizations with just their raw brainpower and inner grit. But things have changed and now comfort is king. Today we live in the thrall of constant climate control and exercise only when our office schedules permit. The technologies that we use to make us comfortable are so all-encompassing that they sever the biological link to a changing environment. Now we hate the cold and the heat. We suffer from autoimmune diseases. And many of us are chronically overweight. Most of us don't even realize that natural variation—sweating and shivering—is actually good for us. What Doesn't Kill Us uncovers how just about anyone can reclaim a measure of our species' evolutionary strength by tapping into the things that feel uncomfortable. When we slightly reimagine how our body fits into the world, we can condition ourselves to find resilience in unfamiliar environments. The feeling that something is missing from our daily routines is growing and has spawned a movement. Every year, millions of people forgo traditional gyms and push the limits of human endurance by doing boot camp style workouts in raw conditions. These extreme athletes train in CrossFit boxes, compete in Tough Mudders and challenge themselves in Spartan races. They are connecting with their environment and, whether they realize it or not, are changing their bodies. No one exemplifies this better than Dutch fitness guru Wim Hof, whose remarkable ability to control his body temperature in extreme cold has sparked a whirlwind of scientific study. Because of him, scientists in the United States and Europe are just beginning to understand how cold adaptation might help combat autoimmune diseases and chronic pains and, in some cases, even reverse diabetes. Award winning investigative journalist, Scott Carney dives into the fundamental philosophy at the root of this movement in three interlocking narratives. His own journey culminates in a record bending 28-hour climb up to the snowy peak of Mt. Kilimanjaro wearing nothing but a pair of running shorts and sneakers.

    These three Great Untruths are part of a larger philosophy that sees young people as fragile creatures who must be protected and supervised by adults. But despite the good intentions of the adults who impart them, the Great Untruths are harming kids by teaching them the opposite of ancient wisdom and the opposite of modern psychological findings on grit, growth, and antifragility. The result is rising rates of depression and anxiety, along with endless stories of college campuses torn apart by moralistic divisions and mutual recriminations. This is a book about how we got here. First Amendment expert Greg Lukianoff and social psychologist Jonathan Haidt take us on a tour of the social trends stretching back to the 1980s that have produced the confusion and conflict on campus today, including the loss of unsupervised play time and the birth of social media, all during a time of rising political polarization. This is a book about how to fix the mess. The culture of “safety” and its intolerance of opposing viewpoints has left many young people anxious and unprepared for adult life, with devastating consequences for them, for their parents, for the companies that will soon hire them, and for a democracy that is already pushed to the brink of violence over its growing political divisions. Lukianoff and Haidt offer a comprehensive set of reforms that will strengthen young people and institutions, allowing us all to reap the benefits of diversity, including viewpoint diversity. This is a book for anyone who is confused by what’s happening on college campuses today, or has children, or is concerned about the growing inability of Americans to live and work and cooperate across party lines.

    Humanity's last survivors escaped earth's ruins to find a new home. But when they find it, can their desperation overcome its dangers?WHO WILL INHERIT THIS NEW EARTH?The last remnants of the human race left a dying Earth, desperate to find a new home among the stars. Following in the footsteps of their ancestors, they discover the greatest treasure of the past age—a world terraformed and prepared for human life.But all is not right in this new Eden. In the long years since the planet was abandoned, the work of its architects has borne disastrous fruit. The planet is not waiting for them, pristine and unoccupied. New masters have turned it from a refuge into mankind's worst nightmare.Now two civilizations are on a collision course, both testing the boundaries of what they will do to survive. As the fate of humanity hangs in the balance, who are the true heirs of this new Earth?