As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    She could barely find the strength to get off the sofa, let alone piece her life back together. Until one day she did something she had never done of her own free will – she pulled on a pair of trainers and went for a run.That first attempt didn’t last very long. But to her surprise, she was back out there the next day. And the day after that. She began to set herself achievable goals – to run 5k in under 30 minutes, to walk to work every day for a week, to attempt 10 push-ups in a row. Before she knew it, her mood was lifting for the first time in years.In Jog On, Bella explains with hilarious and unfiltered honesty how she used running to battle crippling anxiety and depression, without having to sacrifice her main loves: booze, cigarettes and ice cream. With the help of a supporting cast of doctors, psychologists, sportspeople and friends, she shares a wealth of inspirational stories, research and tips that show how exercise often can be the best medicine. This funny, moving and motivational book will encourage you to say ‘jog on’ to your problems and get your life back on track – no matter how small those first steps may be.

    Army, Luis Montalván never backed down from a challenge during his two tours of duty in Iraq. After returning home from combat, however, his physical wounds and crippling post-traumatic stress disorder began to take their toll. He wondered if he would ever recover.Then Luis met Tuesday, a sensitive golden retriever trained to assist the disabled. Tuesday had lived among prisoners and at a home for troubled boys, and he found it difficult to trust in or connect with a human being--until Luis.Until Tuesday is the story of how two wounded warriors, who had given so much and suffered the consequences, found salvation in each other. It is a story about war and peace, injury and recovery, psychological wounds and spiritual restoration. But more than that, it is a story about the love between a man and dog, and how, together, they healed each other's souls.

    It is also armed with nuclear weapons. Between 150,000 and 200,000 people are being held in its political prison camps, which have existed twice as long as Stalin's Soviet gulags and twelve times as long as the Nazi concentration camps. Very few born and raised in these camps have escaped. But Shin Donghyuk did.In Escape from Camp 14, acclaimed journalist Blaine Harden tells the story of Shin Dong-hyuk and through the lens of Shin's life unlocks the secrets of the world's most repressive totalitarian state. Shin knew nothing of civilized existence-he saw his mother as a competitor for food, guards raised him to be a snitch, and he witnessed the execution of his own family. Through Harden's harrowing narrative of Shin's life and remarkable escape, he offers an unequaled inside account of one of the world's darkest nations and a riveting tale of endurance, courage, and survival.

    The Muppets made Jim Henson a household name, but they were only part of his remarkable story.This extraordinary biography--written with the generous cooperation of the Henson family--covers the full arc of Henson's all-too-brief life: from his childhood in Leland, Mississippi, through the years of burgeoning fame in Washington D.C., New York, and London, to the decade of international celebrity that preceded his untimely death at age fifty-three. Drawing on hundreds of hours of new interviews with Jim Henson's family, friends, and closest collaborators, as well as unprecedented access to private family and company archives--including never-before-seen interviews, business documents, and Henson's private letters--Brian Jay Jones explores the creation of the Muppets, Henson's contributions to Sesame Street and Saturday Night Live, and his nearly ten year campaign to bring The Muppet Show to television. Jones provides the imaginative context for Henson's non-Muppet projects, including the richly imagined worlds of The Dark Crystal and Labyrinth-as well as fascinating misfires like Henson's dream of opening an inflatable psychedelic nightclub or of staging an elaborate, all-puppet Broadway show.An uncommonly intimate portrait, Jim Henson captures all the facets of this American original: the master craftsman who revolutionized the presentation of puppets on television, the savvy businessman whose deal making prowess won him a reputation as "the new Walt Disney," and the creative team leader whose collaborative ethos earned him the undying loyalty of everyone who worked for him. Here also is insight into Henson's intensely private personal life: his Christian Science upbringing; his love of fast cars, high-stakes gambling, and expensive art; and his weakness for women. Though an optimist by nature, Henson was haunted by the notion that he would not have time to do all the things he wanted to do in life-a fear that his heartbreaking final hours would prove all too well-founded.An up-close look at the charmed life of a legend, Jim Henson gives the full measure to a man whose joyful genius transcended age, language, geography, and culture-and continues to beguile audiences worldwide.

    Throughout her life Justice Ginsburg has been (and continues to be) a prolific writer and public speaker. This book’s sampling is selected by Justice Ginsburg and her authorized biographers Mary Hartnett and Wendy W. Williams. Justice Ginsburg has written an introduction to the book, and Hartnett and Williams introduce each chapter, giving biographical context and quotes gleaned from hundreds of interviews they have conducted. This is a fascinating glimpse into the life of one of America’s most influential women.

    It never prevented her from entering beauty pageants or playing soccer or making the honor role.On an unremarkable day in middle school, while attempting to console a friend, Paige disclosed her HIV-positive status—and within hours the bullying began. She was called "PAIDS," first in whispers, then out in the open. Her soccer coach joked that she was an asset because opposing team members would be too afraid to touch her. Her guidance counselor told her to stop all the “drama,” and her principal said she couldn’t protect her. One night, desperate for escape, Paige swallowed fifteen sleeping pills—one for each year of her life to date. That could have been the end of her story. Instead, it was only the beginning. The gripping first-person account of Paige’s life will pull in even the most reluctant readers of nonfiction, and her call to action to choose compassion over cruelty will stay with them long after they turn the last page.

    And in so doing, he offers something for everyone, no matter which strand draws you in.”—The New York Times Book ReviewIn November 2014, thirteen members of the Biden family gathered on Nantucket for Thanksgiving, a tradition they had been celebrating for the past forty years; it was the one constant in what had become a hectic, scrutinized, and overscheduled life. The Thanksgiving holiday was a much-needed respite, a time to connect, a time to reflect on what the year had brought, and what the future might hold. But this year felt different from all those that had come before. Joe and Jill Biden’s eldest son, Beau, had been diagnosed with a malignant brain tumor fifteen months earlier, and his survival was uncertain. “Promise me, Dad,” Beau had told his father. “Give me your word that no matter what happens, you’re going to be all right.” Joe Biden gave him his word.Promise Me Dad chronicles the year that followed, which would be the most momentous and challenging in Joe Biden’s extraordinary life and career. As vice president, Biden traveled more than a hundred thousand miles that year, across the world, dealing with crises in Ukraine, Central America, and Iraq. When a call came from New York, or Capitol Hill, or Kyiv, or Baghdad—“Joe, I need your help”—he responded. For twelve months, while Beau fought for and then lost his life, the vice president balanced the twin imperatives of living up to his responsibilities to his country and his responsibilities to his family. And never far away was the insistent and urgent question of whether he should seek the presidency in 2016.The year brought real triumph and accomplishment, and wrenching pain. But even in the worst times, Biden was able to lean on the strength of his long, deep bonds with his family, on his faith, and on his deepening friendship with the man in the Oval Office, Barack Obama.Writing with poignancy and immediacy, Joe Biden allows readers to feel the urgency of each moment, to experience the days when he felt unable to move forward as well as the days when he felt like he could not afford to stop.This is a book written not just by the president, but by a father, grandfather, friend, and husband. Promise Me Dad is a story of how family and friendships sustain us and how hope, purpose, and action can guide us through the pain of personal loss into the light of a new future.

    A tough broad who could have stepped straight out of Stephen Sondheim’s repertoire, she has spent nearly forty years as the legendary personal shopper at Bergdorf Goodman, where she works with socialites, stars, and ordinary women off the street. She has helped many find their true selves through clothes, frank advice, and her own brand of wisdom. She is trusted by the most discriminating persons—including Hollywood’s top stylists—to tell them what looks best. But Halbreich’s personal transformation from a cosseted young girl to a fearless truth teller is the greatest makeover of her career.A Chicago native, Halbreich moved to Manhattan at twenty after marrying the dashing Sonny Halbreich, a true character right out of Damon Runyon who liked the nightlife of New York in the fifties. On the surface, they were a great match, but looks can be deceiving; an unfaithful Sonny was emotionally distant while Halbreich became increasingly anguished. After two decades, the fraying marriage finally came undone. Bereft without Sonny and her identity as his wife, she hit rock bottom.After she began the frightening process of reclaiming herself and started therapy, Halbreich was offered a lifeline in the form of a job at the legendary luxury store Bergdorf Goodman. Soon, she was asked to run the store’s first personal shopping service. It was a perfect fit.Meticulous, impeccable, hardworking, elegant, and—most of all—delightfully funny, Halbreich has never been afraid to tell it to her clients straight. She won’t sell something just to sell it. If an outfit or shoe or purse is too expensive, she’ll dissuade you from buying it. As Halbreich says, “There are two things nobody wants to face: their closet and their mirror.” She helps women do both, every day.

    "Startlingly candid".--People. Includes never-before-seen photographs.

    Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.

    He has run over mountains, across Death Valley, and to the South Pole-and is probably the first person to eat an entire pizza while running. With an insight, candor, and humor rarely seen in sports memoirs (and written without the aid of a ghostwriter or cowriter), Ultramarathon Man has inspired tens of thousands of people-nonrunners and runners alike-to push themselves beyond their comfort zones and be reminded of what it feels like to be truly alive, says Sam Fussell, author of Muscle.Ultramarathon Man answers the questions Karnazes is continually asked:- Why do you do it?- How do you do it?- Are you insane?And in the new paperback edition, Karnazes answers the two questions he was most asked on his book tour:- What, exactly, do you eat?- How do you train to stay in such good shape?

    In 1969, her father, Robert Nichols, moved to Sellerstown, North Carolina, to serve as a pastor. There he found a small community eager to welcome him--with one exception. Glaring at him from pew number seven was a man obsessed with controlling the church. Determined to get rid of anyone who stood in his way, he unleashed a plan of terror that was more devastating and violent than the Nichols family could have ever imagined. Refusing to be driven away by acts of intimidation, Rebecca's father stood his ground until one night when an armed man walked into the family's kitchen . . . And Rebecca's life was shattered. If anyone had a reason to harbor hatred and seek personal revenge, it would be Rebecca. Yet The Devil in Pew Number Seven tells a different story. It is the amazing true saga of relentless persecution, one family's faith and courage in the face of it, and a daughter whose parents taught her the power of forgiveness.

    A Slip of the Keyboard brings together for the first time the finest examples of Pratchett's non fiction writing, both serious and surreal: from musings on mushrooms to what it means to be a writer (and why banana daiquiris are so important); from memories of Granny Pratchett to speculation about Gandalf's love life, and passionate defences of the causes dear to him.With all the humour and humanity that have made his novels so enduringly popular, this collection brings Pratchett out from behind the scenes of the Discworld to speak for himself - man and boy, bibliophile and computer geek, champion of hats, orang-utans and Dignity in Dying.