These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    In her book Self-Inflicted Wounds, comedian, actress, and cohost of CBS’s daytime hit show The Talk, Aisha Tyler recounts a series of epic mistakes and hilarious stories of crushing personal humiliation, and the personal insights and authentic wisdom she gathered along the way. The essays in Self-Inflicted Wounds are refreshingly and sometimes brutally honest, surprising, and laugh-out-loud funny, vividly translating the brand of humor Tyler has cultivated through her successful standup career, as well as the strong voice and unique point of view she expresses on her taste-making comedy podcast Girl on Guy. Riotous, revealing, and wonderfully relatable, Aisha Tyler’s Self-Inflicted Wounds: Heartwarming Tales of Epic Humiliation is about the power of calamity to shape life, learning, and success.

    Now, in a darkly funny and bracing memoir, Valenti explores the toll that sexism takes from the every day to the existential. Sex Object explores the painful, funny, embarrassing, and sometimes illegal moments that shaped Valenti’s adolescence and young adulthood in New York City, revealing a much shakier inner life than the confident persona she has cultivated as one of the most recognizable feminists of her generation. In the tradition of writers like Joan Didion and Mary Karr, this literary memoir is sure to shock those already familiar with Valenti’s work and enthrall those who are just finding it.

    Pink, author of Drive and A Whole New MindA psychiatrist’s stories of his most bizarre cases, The Naked Lady Who Stood on Her Head by Gary Small, M.D., and Gigi Vorgan—co-authors of The Memory Bible—offers a fascinating and highly entertaining look into the peculiarities of the human mind. In the vein of The Man Who Mistook His Wife for a Hat, Awakenings, and the other bestselling works of Oliver Sacks, The Naked Lady Who Stood on Her Head surprises, enthralls, and illuminates as it focuses on medical mysteries that would stump and amaze the brilliant brains on House, M.D.

    Despite her flapping arms and shaking legs, she continued to speak clearly and was able to finish her speech. It was as if she had suddenly become two people: a calm orator and a shuddering wreck. Then the seizures happened again and again. The Shaking Woman tracks Hustvedt’s search for a diagnosis, one that takes her inside the thought processes of several scientific disciplines, each one of which offers a distinct perspective on her paroxysms but no ready solution. In the process, she finds herself entangled in fundamental questions: What is the relationship between brain and mind? How do we remember? What is the self?During her investigations, Hustvedt joins a discussion group in which neurologists, psychiatrists, psychoanalysts, and brain scientists trade ideas to develop a new field: neuropsychoanalysis. She volunteers as a writing teacher for psychiatric in-patients at the Payne Whitney clinic in New York City and unearths precedents in medical history that illuminate the origins of and shifts in our theories about the mind-body problem. In The Shaking Woman, Hustvedt synthesizes her experience and research into a compelling mystery: Who is the shaking woman? In the end, the story she tells becomes, in the words of George Makari, author of Revolution in Mind, “a brilliant illumination for us all.”

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    Richly textured with bits of her own childhood and married life with her husband, John Gregory Dunne, and daughter, Quintana Roo, this book by Joan Didion examines her thoughts, fears, and doubts regarding having children, illness, and growing old.  Blue Nights opens on July 26, 2010, as Didion thinks back to Quintana’s wedding in New York seven years before. Today would be her wedding anniversary. This fact triggers vivid snapshots of Quintana’s childhood—in Malibu, in Brentwood, at school in Holmby Hills. Reflecting on her daughter but also on her role as a parent, Didion asks the candid questions any parent might about how she feels she failed either because cues were not taken or perhaps displaced. “How could I have missed what was clearly there to be seen?” Finally, perhaps we all remain unknown to each other. Seamlessly woven in are incidents Didion sees as underscoring her own age, something she finds hard to acknowledge, much less accept.  Blue Nights—the long, light evening hours that signal the summer solstice, “the opposite of the dying of the brightness, but also its warning”—like The Year of Magical Thinking before it, is an iconic book of incisive and electric honesty, haunting and profoundly moving.

    Eye-opening and utterly gripping, Koren Zailckas’s story is that of thousands of girls like her who are not alcoholics yet but who routinely use booze as a shortcut to courage and a stand-in for good judgment.With one stiff sip of Southern Comfort at the age of fourteen, Zailckas is initiated into the world of drinking. From then on, she will drink faithfully, fanatically. In high school, her experimentation will lead to a stomach pumping. In college, her excess will give way to a pattern of self-poisoning that will grow more destructive each year. At age twenty-two, Zailckas will wake up in an unfamiliar apartment in New York City, elbow her friend who is passed out next to her, and ask, "Where are we?" Smashed is a sober look at how she got there and, after years of blackouts and smashups, what it took for her to realize she had to stop drinking. Smashed is an astonishing literary debut destined to become a classic.

    A long-buried personal sadness is enfolding her—and her career is stalled—when she stumbles upon an unusual group of immigrants living in rural California. She follows them on their annual return to the remote Azorean islands in the Atlantic Ocean, where bulls run down village streets, volcanoes are active, and the people celebrate festas to ease their saudade, a longing so deep that the Portuguese word for it can’t be fully translated.Years later, California is in a terrible drought, the wildfires seem to never end, and Diana finds herself still dreaming of those islands and the chuva—a rain so soft you don’t notice when it begins or ends.With her troublesome Labrador retriever, Murphy, in tow, Diana returns to the islands of her dreams only to discover that there are still things she longs for—and one of them may be a most unexpected love.

    We’re judged by social media’s faceless masses, pressured into maintaining a Pinterest-perfect home, and expected to base our self-worth on retweets, faves, likes, and followers. Our collective FOMO, and the disparity between the ideal and reality, is leading us to spend more and feel worse. No wonder we’re getting twitchy. Save for an Independence Day–style alien invasion, how do we begin to escape from the stressors that make up our days?Jen Lancaster is here to take a hard look at our elevating anxieties, and with self-deprecating wit and levelheaded wisdom, she charts a path out of the quagmire that keeps us frightened of the future and ashamed of our imperfectly perfect human lives. Take a deep breath, and her advice, and you just might get through a holiday dinner without wanting to disown your uncle.

    Now she brings her vast experience, good cheer, and finely sharpened pencils to help the rest of us in a boisterous language book as full of life as it is of practical advice.Between You & Me features Norris's laugh-out-loud descriptions of some of the most common and vexing problems in spelling, punctuation, and usage—comma faults, danglers, "who" vs. "whom," "that" vs. "which," compound words, gender-neutral language—and her clear explanations of how to handle them. Down-to-earth and always open-minded, she draws on examples from Charles Dickens, Emily Dickinson, Henry James, and the Lord's Prayer, as well as from The Honeymooners, The Simpsons, David Foster Wallace, and Gillian Flynn. She takes us to see a copy of Noah Webster's groundbreaking Blue-Back Speller, on a quest to find out who put the hyphen in Moby-Dick, on a pilgrimage to the world's only pencil-sharpener museum, and inside the hallowed halls of The New Yorker and her work with such celebrated writers as Pauline Kael, Philip Roth, and George Saunders.Readers—and writers—will find in Norris neither a scold nor a softie but a wise and witty new friend in love with language and alive to the glories of its use in America, even in the age of autocorrect and spell-check. As Norris writes, "The dictionary is a wonderful thing, but you can't let it push you around."

    This is a gripping medical narrative that brings readers into the complex world of newborn intensive care, where brilliant but imperfect doctors do all they can to coax life into their tiny, injured patients.

    At the age of 29, Diana Hill fell under a London train. In 7 seconds the tall, glamorous businesswoman went from busy woman of the world with everything to live for to double-leg amputee, her life in ruins. Then it got worse. A few days after her accident, as she lay in hospital, traumatised and heavily sedated, she learnt via a newspaper article that the railway’s Transport Police were to interview “The Fall Girl”, as the Press had labelled her, with a view to prosecution. She had boarded a moving train, they said, and trespassed onto their railway line. Her fight for justice took 5 years and was, she declares with no hesitation, a more harrowing experience than having both of her legs ‘stolen’ from her. As any young, single woman would be, Diana was shocked to the core by the sudden, catastrophic change in her body image. What man would ever love her now? The issues surrounding sexuality and disability are explored here with stark honesty as she recalls her complicated love life, the High Court dramas, and the rawness of her pain amidst a turmoil of emotion, all told with tremendous humour, charm and heart. For Diana loves to tell stories. Especially true ones. A brutally honest, heartwarming memoir that shocks and delights in equal measure – when you're not crying for her you're laughing with her: "A computer is a thing that can be disabled, not a person." Diana Morgan-Hill

    Each piece compels readers to rethink not only how they have arrived at their own personal beliefs but also the extent to which they share them with others. Featuring a well-known list of contributors--including Isabel Allende, Colin Powell, Gloria Steinem, William F. Buckley Jr., Penn Jillette, Bill Gates, and John Updike--the collection also contains essays by a Brooklyn lawyer; a part-time hospital clerk from Rehoboth, Massachusetts; a woman who sells Yellow Pages advertising in Fort Worth, Texas; and a man who serves on the state of Rhode Island's parole board. The result is a stirring and provocative trip inside the minds and hearts of a diverse group of people whose beliefs--and the incredibly varied ways in which they choose to express them--reveal the American spirit at its best.

    On a hot July night on Cape Cod when Adrienne was fourteen, her mother, Malabar, woke her at midnight with five simple words that would set the course of both of their lives for years to come: Ben Souther just kissed me.    Adrienne instantly became her mother’s confidante and helpmate, blossoming in the sudden light of her attention, and from then on, Malabar came to rely on her daughter to help orchestrate what would become an epic affair with her husband’s closest friend. The affair would have calamitous consequences for everyone involved, impacting Adrienne’s life in profound ways, driving her into a precarious marriage of her own, and then into a deep depression. Only years later will she find the strength to embrace her life—and her mother—on her own terms.  Wild Game is a brilliant, timeless memoir about how the people close to us can break our hearts simply because they have access to them, and the lies we tell in order to justify the choices we make. It’s a remarkable story of resilience, a reminder that we need not be the parents our parents were to us.