Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

    In a hospital in Lima, Peru, a student named Daniel Carrión was preparing to infect himself with a dreaded disease . . . He had a small, sharp lancet ready . . . Carrión's friends and teacher from the medical school thought it was a bad idea. They knew Carrión was eager to learn more about this mysterious disease. But were the risks worth it?Science and medicine from the inside out-ten engrossing stories of self-experimentationWho are these "guinea pig scientists"? Searching for clues to some of science's and medicine's bigger (and sometimes stranger) questions, they are all the men and women who devoted their lives to help find the answers. Spanning from the 1770s to the present-and uncovering the science behind digestion, the spread of yellow fever, the development of the first heart catheter, and more-their ten stories are at once scientifically detailed and fascinatingly personal.

    But after his dad’s string of successful books, a tragedy strikes the family and now his dad is completely stuck.If only artistic talent were hereditary. Ethan is stuck on a graphic-novel project of his own at school and won’t own up to the fact that he can’t draw. When one night an ink-blot creation emerges from his father’s sketchbook, the family’s whole world begins to change.Featuring artwork by the beloved, award-winning illustrator Sydney Smith, Inkling is a timeless story that speaks to the creator in us all.

    Every year Nory's father goes away on a fishing boat and returns with the rent money for the English lord who owns their cottage and fields, the English lord bent upon forcing the Irish from their land so he can tumble the cottages and clear the fields for grazing. Times are never easy on Maidin Bay, but this year, a terrible blight attacks the potatoes. No crop means starvation. Twelve-year-old Nory must summon the courage and ingenuity to find food, to find hope, to find a way to help her family survive.From the Hardcover edition.

    It is the powerful story of four African-American female mathematicians at NASA who helped achieve some of the greatest moments in our space program. Now a major motion picture starring Taraji P. Henson, Octavia Spencer, Janelle Monae, Kirsten Dunst, and Kevin Costner.Before John Glenn orbited the earth, or Neil Armstrong walked on the moon, a group of dedicated female mathematicians known as “human computers” used pencils, slide rules, and adding machines to calculate the numbers that would launch rockets, and astronauts, into space.This book brings to life the stories of Dorothy Vaughan, Mary Jackson, Katherine Johnson, and Christine Darden, who lived through the Civil Rights era, the Space Race, the Cold War, and the movement for gender equality, and whose work forever changed the face of NASA and the country.

    Our stories are marbled into their marrow.Drawing upon her years of research and a wealth of remarkable experience, the world-renowned forensic anthropologist Professor Dame Sue Black takes us on a journey of revelation. From skull to feet, via the face, spine, chest, arms, hands, pelvis and legs, she shows that each part of us has a tale to tell. What we eat, where we go, everything we do leaves a trace, a message that waits patiently for months, years, sometimes centuries, until a forensic anthropologist is called upon to decipher it.Some of this information is easily understood, some holds its secrets tight and needs scientific cajoling to be released. But by carefully piecing together the evidence, the facts of a life can be rebuilt. Limb by limb, case by case – some criminal, some historical, some unaccountably bizarre – Sue Black reconstructs with intimate sensitivity and compassion the hidden stories in what we leave behind.

    Frankenstein's machine ever animate a body? Why should vampires drink from veins and not arteries? What body parts are best for zombies to eat? (It's not brains.) This fascinating encyclopedia of monsters delves into the history and science behind eight legendary creatures, from Bigfoot and the kraken to zombies and more. Find out each monster's origin story and the real-world history that informed it, and then explore the science of each creature in fun and surprising ways. Tips and infographics--including monster anatomy, how to survive a vampire attack, and real-life giant creatures of the deep sea--make this a highly visual and fun-to-browse book.-- "Journal"

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Its presence in nature was dismissed as a desperate response to starvation or other life-threatening circumstances, and few spent time studying it. A taboo subject in our culture, the behavior was portrayed mostly through horror movies or tabloids sensationalizing the crimes of real-life flesh-eaters. But the true nature of cannibalism--the role it plays in evolution as well as human history--is even more intriguing (and more normal) than the misconceptions we've come to accept as fact. In Cannibalism: A Perfectly Natural History, zoologist Bill Schutt sets the record straight, debunking common myths and investigating our new understanding of cannibalism's role in biology, anthropology, and history in the most fascinating account yet written on this complex topic. Schutt takes readers from Arizona's Chiricahua Mountains, where he wades through ponds full of tadpoles devouring their siblings, to the Sierra Nevadas, where he joins researchers who are shedding new light on what happened to the Donner Party--the most infamous episode of cannibalism in American history. He even meets with an expert on the preparation and consumption of human placenta (and, yes, it goes well with Chianti). Bringing together the latest cutting-edge science, Schutt answers questions such as why some amphibians consume their mother's skin; why certain insects bite the heads off their partners after sex; why, up until the end of the twentieth century, Europeans regularly ate human body parts as medical curatives; and how cannibalism might be linked to the extinction of the Neanderthals. He takes us into the future as well, investigating whether, as climate change causes famine, disease, and overcrowding, we may see more outbreaks of cannibalism in many more species--including our own.Cannibalism places a perfectly natural occurrence into a vital new context and invites us to explore why it both enthralls and repels us.

    Little do they know the plant's toxic cattle feed is turning cows into flesh-craving monsters...ZOMBIES!!! The boys decide to launch a stealth investigation into the plant's dangerous practices, unknowingly discovering a greedy corporation's plot to look the other way as tainted meat is sold to thousands all over the country. With no grownups left they can trust, Rabi and his friends will have to grab their bats to protect themselves (and a few of their enemies) if they want to stay alive...and maybe even save the world. In this inventive, fast-paced novel that strikes a pitch-perfect tone for reluctant readers, National Book Award finalist and Printz Award-winning author Paolo Bacigalupi effectively uses humour and high-intensity action to take on hard-hitting themes - from food safety to racism and immigration - and creates a zany, grand-slam adventure that will get kids thinking about where their food comes from.

    In the chaos of what happens next, shots are fired and four students are killed. To this day, there is still argument of what happened and why.Told in multiple voices from a number of vantage points -- protestor, Guardsman, townie, student.

    The launch of the Challenger is just weeks away, and Cash, Fitch, and Bird Nelson Thomas are three siblings in seventh grade together in Park, Delaware.Cash loves basketball, Dr. J, and a girl named Penny; he's also in danger of failing seventh grade for a second time. Fitch spends every afternoon playing Major Havoc at the arcade and wrestles with an explosive temper that he doesn't understand. And Bird, his twelve-year-old twin, dreams of being NASA's first female shuttle commander, but feels like she's disappearing.The Nelson Thomas siblings exist in their own orbits, circling a tense, crowded, and unpredictable household, dreaming of escape, dreaming of the future, dreaming of space. They have little in common except an enthusiastic science teacher named Ms. Salonga—a failed applicant to the Teacher in Space program—who encourages her students to live vicariously through the launch. Cash and Fitch take a passive interest, but Bird builds her dreams around it.When the fated day arrives, it changes everything.

    Jonathan B. Tucker traces the history of the smallpox virus from its first recorded outbreak around 3700 B.C. through its use as the first biological warfare agent in human history, and draws some decisively important lessons for the future. In a timely debate, Tucker addresses the ever-growing concerns about the proliferation of the deadly smallpox virus and its use by terrorist organizations. Explaining how the eradication of the disease in the late 1970s encouraged military research and production of the virus, he exposes the failure of the Russian government to secure its remaining cold-war stockpiles, and evaluates the past and present measures undertaken by the United States to counter the existing dangers of a smallpox attack. Ultimately, he passionately argues for the strengthening of the existing legal ban on the development and possession of biological weapons. Impeccably researched, Scourge is as arresting as it is indispensable, and as William Beatty in Booklist raves, Tucker has a sense of ... history that helps him make the story of smallpox as disease and ... weapon fascinating and frightening. Scourge has been acclaimed as a concise, suspenseful and scientifically accurate narrative. -- The New York Times Book Review Tucker's fascinating, revealing book affords the reader a sobering look at this new type of warfare.... -- Chris Patsilelis, Houston Chronicle -- [Tucker] reports the debate evenhandedly and with telling detail. -- David Brown, The Washington Post Book World

    Her father is a known criminal who once used Ashley to help him elude justice, and in his attempt to escape, a life was taken. He now sits in federal prison, but still casts a shadow over Ashley's life. In the meantime, Ashley has bounced from foster home to foster home and represents a real challenge to the social workers who try to help her--not because she's inherently bad, but because trouble always seems to find her.Ashley's latest set of presumably short-term foster parents are Kitch and Yuka Nolan. Like Ashley, Kitch happens to be an artist. Yuka, on the other hand, is a geneticist working for a very high-level tech company, one that's contracted out to work for the government and the military. And it's Yuka's latest top secret project that has her very concerned. Developed for the military, it's a set of body paints that, when applied to the wearer, grant them a wide range of special powers. Fearful that this invention will be misused, Yuka sneaks the set of paints home, substituting a dummy suitcase with an ordinary set of paints in their place.From here, signals get crossed. Ashley comes home from school one day with her new friend Luke and, thinking that the Nolans have purchased a surprise gift for her upcoming birthday, finds the set of paints. Being an artist, Ashley naturally assumes these are for her. It isn't long before she realizes that she's stumbled upon something much bigger and a lot more dangerous. Although she uses her newly discovered powers for good, it's not long before the military becomes wise to what happened to their secret weapon. And this spells big trouble not only for Ashley, but for her newfound family and friends as well.

    For seventh-grader Mila, it starts with some boys giving her an unwanted hug on the school blacktop. A few days later, at recess, one of the boys (and fellow trumpet player) Callum tells Mila it’s his birthday, and asks her for a “birthday hug.” He’s just being friendly, isn’t he? And how can she say no? But Callum’s hug lasts a few seconds too long, and feels…weird. According to her friend, Zara, Mila is being immature and overreacting. Doesn’t she know what flirting looks like? But the boys don’t leave Mila alone. On the bus. In the halls. During band practice—the one place Mila could always escape. It doesn’t feel like flirting—so what is it? Thanks to a chance meeting, Mila begins to find solace in a new place: karate class. Slowly, with the help of a fellow classmate, Mila learns how to stand her ground and how to respect others—and herself. From the author of Everything I Know About You, Halfway Normal, and Star-Crossed comes this timely story of a middle school girl standing up and finding her voice.”