In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    This is the funny, poignant story of their two decades together.On Valentine's Day 1985, biologist Stacey O'Brien first met a four-day-old baby barn owl -- a fateful encounter that would turn into an astonishing 19-year saga. With nerve damage in one wing, the owlet's ability to fly was forever compromised, and he had no hope of surviving on his own in the wild. O'Brien, a young assistant in the owl laboratory at Caltech, was immediately smitten, promising to care for the helpless owlet and give him a permanent home. Wesley the Owl is the funny, poignant story of their dramatic two decades together. With both a tender heart and a scientist's eye, O'Brien studied Wesley's strange habits intensively and first-hand -- and provided a mice-only diet that required her to buy the rodents in bulk (28,000 over the owl's lifetime). As Wesley grew, she snapped photos of him at every stage like any proud parent, recording his life from a helpless ball of fuzz to a playful, clumsy adolescent to a gorgeous, gold-and-white, macho adult owl with a heart-shaped face and an outsize personality that belied his 18-inch stature. Stacey and Wesley's bond deepened as she discovered Wesley's individual personality, subtle emotions, and playful nature that could also turn fiercely loyal and protective -- though she could have done without Wesley's driving away her would-be human suitors! O'Brien also brings us inside the prestigious research community, a kind of scientific Hogwarts where resident owls sometimes flew freely from office to office and eccentric, brilliant scientists were extraordinarily committed to studying and helping animals; all of them were changed by the animal they loved. As O'Brien gets close to Wesley, she makes important discoveries about owl behavior, intelligence, and communication, coining the term "The Way of the Owl" to describe his inclinations: he did not tolerate lies, held her to her promises, and provided unconditional love, though he was not beyond an occasional sulk. When O'Brien develops her own life-threatening illness, the biologist who saved the life of a helpless baby bird is herself rescued from death by the insistent love and courage of this wild animal. Enhanced by wonderful photos, Wesley the Owl is a thoroughly engaging, heartwarming, often funny story of a complex, emotional, non-human being capable of reason, play, and, most important, love and loyalty. It is sure to be cherished by animal lovers everywhere.

    And certainly no one wants to overeat for years, become overweight, and end up with a high risk of diabetes or heart disease--yet two thirds of Americans do precisely that. Even though we know better, we often eat too much. Why does our behavior betray our own intentions to be lean and healthy? The problem, argues obesity and neuroscience researcher Stephan J. Guyenet, is not necessarily a lack of willpower or an incorrect understanding of what to eat. Rather, our appetites and food choices are led astray by ancient, instinctive brain circuits that play by the rules of a survival game that no longer exists. And these circuits don’t care about how you look in a bathing suit next summer.To make the case, The Hungry Brain takes readers on an eye-opening journey through cutting-edge neuroscience that has never before been available to a general audience. The Hungry Brain delivers profound insights into why the brain undermines our weight goals and transforms these insights into practical guidelines for eating well and staying slim. Along the way, it explores how the human brain works, revealing how this mysterious organ makes us who we are.

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    Their circumstances offer a grounding counterpoint to his own misfortunes: the shock of New York City after 9/11, the evacuation of New Orleans during Hurricane Katrina, and the day his heart nearly stopped for good.

    In late 2004, leading Western scientists joined the Dalai Lama at his home in Dharamsala, India, to address this very question–and in the process brought about a revolution in our understanding of the human mind. In this fascinating and far-reaching book, Wall Street Journal science writer Sharon Begley reports on how cutting-edge science and the ancient wisdom of Buddhism have come together to show how we all have the power to literally change our brains by changing our minds. These findings hold exciting implications for personal transformation.For decades, the conventional wisdom of neuroscience held that the hardware of the brain is fixed and immutable–that we are stuck with what we were born with. As Begley shows, however, recent pioneering experiments in neuroplasticity, a new science that investigates whether and how the brain can undergo wholesale change, reveal that the brain is capable not only of altering its structure but also of generating new neurons, even into old age. The brain can adapt, heal, renew itself after trauma, and compensate for disability. Begley documents how this fundamental paradigm shift is transforming both our understanding of the human mind and our approach to deep-seated emotional, cognitive, and behavioral problems. These breakthroughs show that it is possible to reset our happiness meter, regain the use of limbs disabled by stroke, train the mind to break cycles of depression and OCD, and reverse age-related changes in the brain. They also suggest that it is possible to teach and learn compassion, a key step in the Dalai Lama’s quest for a more peaceful world. But as we learn from studies performed on Buddhist monks, an important component in changing the brain is to tap the power of mind and, in particular, focused attention. This is the classic Buddhist practice of mindfulness, a technique that has become popular in the West and that is immediately available to everyone. With her extraordinary gift for making science accessible, meaningful, and compelling, Sharon Begley illuminates a profound shift in our understanding of how the brain and the mind interact. This tremendously hopeful book takes us to the leading edge of a revolution in what it means to be human.

    And we know that another global disaster is eventually headed our way. Can we survive it? How?As a species, Homo sapiens is at a crossroads. Study of our planet’s turbulent past suggests that we are overdue for a catastrophic disaster, whether caused by nature or by human interference.It’s a frightening prospect, as each of the Earth’s past major disasters—from meteor strikes to bombardment by cosmic radiation—resulted in a mass extinction, where more than 75 percent of the planet’s species died out. But in Scatter, Adapt, and Remember, Annalee Newitz, science journalist and editor of the science Web site io9.com explains that although global disaster is all but inevitable, our chances of long-term species survival are better than ever. Life on Earth has come close to annihilation—humans have, more than once, narrowly avoided extinction just during the last million years—but every single time a few creatures survived, evolving to adapt to the harshest of conditions.      This brilliantly speculative work of popular science focuses on humanity’s long history of dodging the bullet, as well as on new threats that we may face in years to come. Most important, it explores how scientific breakthroughs today will help us avoid disasters tomorrow. From simulating tsunamis to studying central Turkey’s ancient underground cities; from cultivating cyanobacteria for “living cities” to designing space elevators to make space colonies cost-effective; from using math to stop pandemics to studying the remarkable survival strategies of gray whales, scientists and researchers the world over are discovering the keys to long-term resilience and learning how humans can choose life over death.     Newitz’s remarkable and fascinating journey through the science of mass extinctions is a powerful argument about human ingenuity and our ability to change. In a world populated by doomsday preppers and media commentators obsessively forecasting our demise, Scatter, Adapt, and Remember is a compelling voice of hope. It leads us away from apocalyptic thinking into a future where we live to build a better world—on this planet and perhaps on others. Readers of this book will be equipped scientifically, intellectually, and emotionally to face whatever the future holds.

    Voted #1 BEST BOOK (2000 & 2001) by the Association of Pet Dog Trainers?the largest and most influential worldwide association of professional pet dog trainers. The Culture Clash is utterly unique, fascinating to the extreme, and literally overflowing with information so new that it virtually redefines the state of the art in dog behavior and training. The Culture Clash depicts dogs as they really are?stripped of their Hollywood fluff, with their loveable "can I eat it, chew it, urinate on it, what's in it for me" philosophy. The author's tremendous affection for dogs shines through at all times, as does her keen insight into the dog's mind. Relentlessly she champions the dog's point of view, always showing concern for their education and well-being.

    She has more friends, fewer worries, and way more fun. So Dave decides to figure out how Lucy manages to stay so happy, to see if he can make his own life happier by doing the things she does (except for drinking from the toilet). He reconnects with old friends and tries to make new ones—which turns out to be a struggle, because Lucy likes people a lot more than he does. And he gets back in touch with two ridiculous but fun groups from his past: the Lawn Rangers, a group of guys who march in parades pushing lawnmowers and twirling brooms (alcohol is involved), and the Rock Bottom Remainders, the world’s oldest and least-talented all-author band. With each new lesson, Dave riffs hilariously on dogs, people, and life in general, while also pondering Deep Questions, such as when it’s okay to lie. (Answer: when scallops are involved.) Lessons from Lucy shows readers a new side to Dave Barry that’s “touching and sentimental, but there’s still a laugh on every page” (Sacramento Bee). The master humorist has written a witty and affable guide to joyous living at any age.

    Suppose, instead of thinking about organisms using genes to reproduce themselves, as we had since Mendel's work was rediscovered, we turn it around and imagine that "our" genes build and maintain us in order to make more genes. That simple reversal seems to answer many puzzlers which had stumped scientists for years, and we haven't thought of evolution in the same way since. Drawing fascinating examples from every field of biology, he paved the way for a serious re-evaluation of evolution. He also introduced the concept of self-reproducing ideas, or memes, which (seemingly) use humans exclusively for their propagation. If we are puppets, he says, at least we can try to understand our strings.

     If you've been on social media lately, or turned on your TV, you may have noticed a lot of dumb ideas floating around."We know when history will repeat and when it won't.""We can tell the difference between evidence and coincidences.""The simplest explanation is usually true."Wrong, wrong, and dangerous!If we're not careful, loserthink would have us believe that every Trump supporter is a bigoted racist, addicts should be responsible for fixing the opioid epidemic, and that your relationship fell apart simply because you chewed with your mouth open.Even the smartest people can slip into loserthink's seductive grasp. This book will teach you how to spot and avoid it--and will give you scripts to respond when hollow arguments are being brandished against you, whether by well-intentioned friends, strangers on the internet, or political pundits. You'll also learn how to spot the underlying causes of loserthink, like the inability to get ego out of your decisions, thinking with words instead of reasons, failing to imagine alternative explanations, and making too much of coincidences.Your bubble of reality doesn't have to be a prison. This book will show you how to break free--and, what's more, to be among the most perceptive and respected thinkers in every conversation.

    Inspired by her own feline's instinct to hunt and supported by her studies abroad, Thomas examines the life actions, as well as the similarities and differences of these majestic creatures. Lions, tigers, pumas and housecats: Her observations shed light on their social lives, thought processes, eating habits, and communication techniques, and reveal how they survive and coexist with each other and with humans.

    Lieberman traces the field from its birth as a mystic pseudo-science through its adolescence as a cult of "shrinks" to its late blooming maturity — beginning after World War II — as a science-driven profession that saves lives. With fascinating case studies and portraits of the luminaries of the field — from Sigmund Freud to Eric Kandel — Shrinks is a gripping and illuminating read, and an urgent call-to-arms to dispel the stigma of mental illnesses by treating them as diseases rather than unfortunate states of mind.“A lucid popular history...At once skeptical and triumphalist. It shows just how far psychiatry has come.” —Julia M. Klein, Boston Globe

    But the very existence of consciousness raises profound questions: Why would any collection of matter in the universe be conscious? How are we able to think about this? And why should we?In this wonderfully accessible book, Annaka Harris guides us through the evolving definitions, philosophies, and scientific findings that probe our limited understanding of consciousness. Where does it reside, and what gives rise to it? Could it be an illusion, or a universal property of all matter? As we try to understand consciousness, we must grapple with how to define it and, in the age of artificial intelligence, who or what might possess it. Conscious offers lively and challenging arguments that alter our ideas about consciousness—allowing us to think freely about it for ourselves, if indeed we can.

    . . on addiction.”—Ezra Klein, New York Times.“Accessible and enjoyable. The Craving Mind brilliantly combines the latest science with universal real-life experiences—from falling in love to spending too much time with our phones.”—Arianna Huffington We are all vulnerable to addiction. Whether it’s a compulsion to constantly check social media, binge eating, smoking, excessive drinking, or any other behaviors, we may find ourselves uncontrollably repeating. Why are bad habits so hard to overcome? Is there a key to conquering the cravings we know are unhealthy for us?   This book provides groundbreaking answers to the most important questions about addiction. Dr. Judson Brewer, a psychiatrist and neuroscientist who has studied the science of addictions for twenty years, reveals how we can tap into the very processes that encourage addictive behaviors in order to step out of them. He describes the mechanisms of habit and addiction formation, then explains how the practice of mindfulness can interrupt these habits. Weaving together patient stories, his own experience with mindfulness practice, and current scientific findings from his own lab and others, Dr. Brewer offers a path for moving beyond our cravings, reducing stress, and ultimately living a fuller life.