The popularity of murder mystery books, TV series, and even board games shows that there is an appetite for death, and the more unusual or macabre the method, the better. With gunshots or stabbings the cause of death is obvious, but poisons are inherently more mysterious. How are some compounds so deadly in such tiny amounts?Agatha Christie used poison to kill her characters more often than any other crime fiction writer. The poison was a central part of the novel, and her choice of deadly substances was far from random; the chemical and physiological characteristics of each poison provide vital clues to the discovery of the murderer. Christie demonstrated her extensive chemical knowledge (much of it gleaned by working in a pharmacy during both world wars) in many of her novels, but this is rarely appreciated by the reader.Written by former research chemist Kathryn Harkup, each chapter takes a different novel and investigates the poison used by the murderer. Fact- and fun-packed, A is for Arsenic looks at why certain chemicals kill, how they interact with the body, and the feasibility of obtaining, administering, and detecting these poisons, both when Christie was writing and today.

    Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep.In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children’s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers’ odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder?This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You’ll never look at your pillow the same way again.

    She had killed someone with a thought, spread untold disease, and ogled the bodies of other children. Only by performing an exhausting series of secret routines could she make up for what she’d done. But no matter how intricate or repetitive, no act of penance was ever enough.Beautifully written and astonishingly intimate, Because We Are Bad recounts a childhood consumed by obsessive compulsive disorder. As a child, Bailey created a second personality inside herself—"I" became "we"—to help manifest compulsions that drove every minute of every day of her young life. Now she writes about the forces beneath her skin, and how they ordered, organized, and urged her forward. Lily charts her journey, from checking on her younger sister dozens of times a night, to "normalizing" herself at school among new friends as she grew older, and finally to her young adult years, learning—indeed, breaking through—to make a way for herself in a big, wide world that refuses to stay in check.Charming and raw, harrowing and redemptive, Because We Are Bad is an illuminating and uplifting look into the mind and soul of an extraordinary young woman, and a startling portrait of OCD that allows us to see and understand this condition as never before.

    Anyone will tell you that! But for all the rosy sentiments surrounding friendship, most people don’t talk much about what it really takes to stay close for the long haul.Now two friends, Aminatou Sow and Ann Friedman, tell the story of their equally messy and life-affirming Big Friendship in this honest and hilarious book that chronicles their first decade in one another’s lives. As the hosts of the hit podcast Call Your Girlfriend, they’ve become known for frank and intimate conversations. In this book, they bring that energy to their own friendship—its joys and its pitfalls. An inspiring and entertaining testament to the power of society’s most underappreciated relationship, Big Friendship will invite you to think about how your own bonds are formed, challenged, and preserved. It is a call to value your friendships in all of their complexity. Actively choose them. And, sometimes, fight for them.

    Odder still, she reveals that she’s suffering from a persistent memory problem. Routinely, she “loses” parts of her day, finding herself in places she doesn’t remember going to or being told about conversations she doesn’t remember having. Her problems are so pervasive that she often feels like an impersonator in her own life; she doesn’t recognize the people who call themselves her friends, and she can’t even remember being intimate with her own husband. Baer recognizes that Karen is on the verge of suicide and, while trying various medications to keep her alive, attempts to discover the root cause of her strange complaints. It’s the work of months, and then years, to gain Karen’s trust and learn the true extent of the trauma buried in her past. What she eventually reveals is nearly beyond belief, a narrative of a childhood spent grappling with unimaginable horror. How has Karen survived with even a tenuous grasp on sanity?Then Baer receives an envelope in the mail. It’s marked with Karen’s return address but contains a letter from a little girl who writes that she’s seven years old and lives inside of Karen. Soon Baer receives letters from others claiming to be parts of Karen. Under hypnosis, these alternate Karen personalities reveal themselves in shocking variety and with undeniable traits—both physical and psychological. One “alter” is a young boy filled with frightening aggression; another an adult male who considers himself Karen’s protector; and a third a sassy flirt who seeks dominance over the others. It’s only by compartmentalizing her pain, guilt, and fear in this fashion—by “switching time” with alternate selves as the situation warrants—that Karen has been able to function since childhood.Realizing that his patient represents an extreme case of multiple personality disorder, Baer faces the daunting task of creating a therapy that will make Karen whole again. Somehow, in fact, he must gain the trust of each of Karen’s seventeen “alters” and convince them of the necessity of their own annihilation.As powerful as Sybil or The Three Faces of Eve, Switching Time is the first complete account of such therapy to be told from the perspective of the treating physician, a stunningly devoted healer who worked selflessly for decades so that Karen could one day live as a single human being.From the Hardcover edition.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    His revolutionary new book shows, for the first time, how the amazing process of neuroplastic healing really works. It describes natural, non-invasive avenues into the brain provided by the forms of energy around us—light, sound, vibration, movement—which pass through our senses and our bodies to awaken the brain’s own healing capacities without producing unpleasant side effects. Doidge explores cases where patients alleviated years of chronic pain or recovered from debilitating strokes or accidents; children on the autistic spectrum or with learning disorders normalizing; symptoms of multiple sclerosis, Parkinson’s disease, and cerebral palsy radically improved, and other near-miracle recoveries. And we learn how to vastly reduce the risk of dementia with simple approaches anyone can use. For centuries it was believed that the brain’s complexity prevented recovery from damage or disease. The Brain’s Way of Healing shows that this very sophistication is the source of a unique kind of healing. As he did so lucidly in The Brain That Changes Itself, Doidge uses stories to present cutting-edge science with practical real-world applications, and principles that everyone can apply to improve their brain’s performance and health.

    This is a book about the incentives that shape us, and about how hard it is to see ourselves clearly in a culture that revolves around the self. In each essay, Jia writes about the cultural prisms that have shaped her: the rise of the nightmare social internet; the American scammer as millennial hero; the literary heroine’s journey from brave to blank to bitter; the mandate that everything, including our bodies, should always be getting more efficient and beautiful until we die.

    In Broken, Jenny brings readers along on her mental and physical health journey, offering heartbreaking and hilarious anecdotes along the way.With people experiencing anxiety and depression now more than ever, Jenny humanizes what we all face in an all-too-real way, reassuring us that we’re not alone and making us laugh while doing it. From the business ideas that she wants to pitch to Shark Tank to the reason why Jenny can never go back to the post office, Broken leaves nothing to the imagination in the most satisfying way. And of course, Jenny’s long-suffering husband Victor―the Ricky to Jenny’s Lucille Ball―is present throughout.A treat for Jenny Lawson’s already existing fans, and destined to convert new ones, Broken is a beacon of hope and a wellspring of laughter when we all need it most.

    Why then was she driving through Chicago fantasizing about her own death? Why was she envisioning putting an end to the isolation and sadness that still plagued her in spite of her achievements?Enter Dr. Rosen, a therapist who calmly assures her that if she joins one of his psychotherapy groups, he can transform her life. All she has to do is show up and be honest. About everything—her eating habits, childhood, sexual history, etc. Christie is skeptical, insisting that that she is defective, beyond cure. But Dr. Rosen issues a nine-word prescription that will change everything: “You don’t need a cure, you need a witness.So begins her entry into the strange, terrifying, and ultimately life-changing world of group therapy. Christie is initially put off by Dr. Rosen’s outlandish directives, but as her defenses break down and she comes to trust Dr. Rosen and to depend on the sessions and the prescribed nightly phone calls with various group members, she begins to understand what it means to connect.Group is a deliciously addictive read, and with Christie as our guide—skeptical of her own capacity for connection and intimacy, but hopeful in spite of herself—we are given a front row seat to the daring, exhilarating, painful, and hilarious journey that is group therapy—an under-explored process that breaks you down, and then reassembles you so that all the pieces finally fit.

    Reprinted here for the first time is Franzen's controversial l996 investigation of the fate of the American novel in what became known as "the Harper's essay," as well as his award-winning narrative of his father's struggle with Alzheimer's disease, and a rueful account of his brief tenure as an Oprah Winfrey author.

    Based in the latest research in neuroscience, this audiobook offers dozens of little things you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life.Depression doesn't happen all at once. It starts gradually and builds momentum over time. If you go through a difficult experience, you may stop taking care of yourself. You may stop exercising and eating healthy, which will end up making you feel even worse as time goes on. You are caught in a downward spiral, but you may feel too tired, too overwhelmed, and too scared to try and pull yourself back up. The good news is that just one small step can be a step in the right direction.In The Upward Spiral, neuroscientist Alex Korb demystifies the neurological processes in the brain that cause depression and offers effective ways to get better "one little step at a time". In the book, you'll discover that there isn't "one big solution" that will solve your depression. Instead, there are dozens of small, practical things you can do to alleviate your symptoms and start healing. Some are as simple as relaxing certain muscles to reduce feelings of anxiety, while others involve making small efforts toward more positive social interactions. Small steps in the right direction can have profound effects giving you the power to literally "reshape" your brain.Like most people, you probably didn't wake up one day and find yourself completely depressed. Instead, it probably happened over time, as a series of reactions to difficult situations and negative thinking. But if you are ready to reverse the trajectory of your depression and find lasting happiness, this book will show you how.

    Incorporating the latest advances in brain scanning and neuroscience, Dutton demonstrates that the brilliant neurosurgeon who lacks empathy has more in common with a Ted Bundy who kills for pleasure than we may wish to admit, and that a mugger in a dimly lit parking lot may well, in fact, have the same nerveless poise as a titan of industry.Dutton argues that there are indeed “functional psychopaths” among us—different from their murderous counterparts—who use their detached, unflinching, and charismatic personalities to succeed in mainstream society, and that shockingly, in some fields, the more “psychopathic” people are, the more likely they are to succeed. Dutton deconstructs this often misunderstood diagnosis through bold on-the-ground reporting and original scientific research as he mingles with the criminally insane in a high-security ward, shares a drink with one of the world’s most successful con artists, and undergoes transcranial magnetic stimulation to discover firsthand exactly how it feels to see through the eyes of a psychopath.As Dutton develops his theory that we all possess psychopathic tendencies, he puts forward the argument that society as a whole is more psychopathic than ever: after all, psychopaths tend to be fearless, confident, charming, ruthless, and focused—qualities that are tailor-made for success in the twenty-first century. Provocative at every turn, The Wisdom of Psychopaths is a riveting adventure that reveals that it’s our much-maligned dark side that often conceals the trump cards of success.

    But behind her seemingly flawless façade lay a dangerous secret—for the better part of her life Cheney had been battling debilitating bipolar disorder and concealing a pharmacy's worth of prescriptions meant to stabilize her moods and make her "normal."In bursts of prose that mirror the devastating highs and extreme lows of her illness, Cheney describes her roller-coaster life with shocking honesty—from glamorous parties to a night in jail; from flying fourteen kites off the edge of a cliff in a thunderstorm to crying beneath her office desk; from electroshock therapy to a suicide attempt fueled by tequila and prescription painkillers.With Manic, Cheney gives voice to the unarticulated madness she endured. The clinical terms used to describe her illness were so inadequate that she chose to focus instead on her own experience, in her words, "on what bipolar disorder felt like inside my own body." Here the events unfold episodically, from mood to mood, the way she lived and remembers life. In this way the reader is able to viscerally experience the incredible speeding highs of mania and the crushing blows of depression, just as Cheney did. Manic does not simply explain bipolar disorder—it takes us in its grasp and does not let go.In the tradition of Darkness Visible and An Unquiet Mind, Manic is Girl, Interrupted with the girl all grown up. This harrowing yet hopeful book is more than just a searing insider's account of what it's really like to live with bipolar disorder. It is a testament to the sharp beauty of a life lived in extremes.

    In this riveting work of true crime, he spotlights four of the most diabolical criminals he’s confronted, interviewed and learned from. Going deep into each man’s life and crimes, he outlines the factors that led them to murder and how he used his interrogation skills to expose their means, motives, and true evil. Like the hit Netflix show, The Killer Across the Table is centered around Douglas’ unique interrogation and profiling process. With his longtime collaborator Mark Olshaker, Douglas recounts the chilling encounters with these four killers as he experienced them—revealing for the first time his profile methods in detail. Going step by step through his interviews, Douglas explains how he connects each killer’s crimes to the specific conversation, and contrasts these encounters with those of other deadly criminals to show what he learns from each one. In the process, he returns to other famous cases, killers and interviews that have shaped his career, describing how the knowledge he gained from those exchanges helped prepare him for these.A glimpse into the mind of a man who has pierced the heart of human darkness, The Killer Across the Table unlocks the ultimate mystery of depravity and the techniques and approaches that have countered evil in the name of justice.