What happened, how it happened, and what it means to you today. A colorful cast of characters whose discoveries were often driven not only by personal tragedy, curiosity, and hard work, but petty bickering, dumb luck, and a healthy dose of humor. For anyone interested in science, medicine, and beyond... Why are you alive right now? Chances are, you owe your life to one of the remarkable medical discoveries in this book. Maybe it was vaccines. Or antibiotics. Or X-rays. Revolutionary medical breakthroughs like these haven’t just changed the way we treat disease, they’ve transformed how we understand ourselves and the world we live in. In Breakthrough!, Jon Queijo tells the hidden stories behind 10 of history’s most amazing medical discoveries. This isn’t dry history: These are life-and-death mysteries uncovered, tales of passionate, often-mocked individuals who stood their ground and were proven right. From germs to genetics, the ancient Hippocrates to the cutting edge, these are stories that have changed the world—and, quite likely, saved your life.

    This book provides the first complete identification guides to the birds of this teeming tropical paradise. It gives descriptions of 820 regional species, illustrated in 88 specially commissioned color plates accompanied by notes detailing distinctive features and habitats. Entries cover nomenclature, plumage, markings, voice, global range, distribution and regional status, habits, and diet. The main text gives practical information on where to find many exotic species, citing major birdwatching locations. Introductory chapters discuss habitats, climate, land-use, and conservation concerns. Professional ornithologists and amateur bird watchers alike will find this the indispensable bird guide for eastern Malaysia and western Indonesia for many years to come. It is also an unrivalled source of information for casual travellers and ecotourists.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    The shocking story of blinded eyes, and the medical school that allowed it.

    In this book, he builds on that theme by showing why this is the luckiest time yet to be alive, giving you the keys to the new kingdom of wellness.Medicine is undergoing rapid change. In the old world, you followed general principles and doctors treated you based on broad, one-size-fits all solutions. In this new golden age, you’ll be able to take full advantage of the latest scientific findings and leverage the power of technology to customize your care. Only those who know how to access and adapt to these breakthroughs—without being distracted by hyped ideas and bad medicine—will benefit. Imagine being able to get fit and lose weight without dieting, train your immune system to fight cancer, edit your DNA to avoid a certain fate, erase the risk of a heart attack, reverse aging, and know exactly which drugs to take to optimize health with zero side effects.That’s the picture of the future that you can enter starting today. Welcome to The Lucky Years.

    Focusing on four specific examples — corn, silkworms, domestic cats, and apples — she traces the histories of species that have been fundamentally altered over the centuries by the whims and needs of people.

    Life remains the only way to make life. Are we still missing a vital ingredient in its creation?      Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences. Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe. Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.

    In college, I ran against Kenyans, and wondered whether endurance genes might have traveled with them from East Africa. At the same time, I began to notice that a training group on my team could consist of five men who run next to one another, stride for stride, day after day, and nonetheless turn out five entirely different runners. How could this be?We all knew a star athlete in high school. The one who made it look so easy. He was the starting quarterback and shortstop; she was the all-state point guard and high-jumper. Naturals. Or were they?The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training?The truth is far messier than a simple dichotomy between nature and nurture. In the decade since the sequencing of the human genome, researchers have slowly begun to uncover how the relationship between biological endowments and a competitor’s training environment affects athleticism. Sports scientists have gradually entered the era of modern genetic research.In this controversial and engaging exploration of athletic success, Sports Illustrated senior writer David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving this great riddle. He investigates the so-called 10,000-hour rule to uncover whether rigorous and consistent practice from a young age is the only route to athletic excellence.Along the way, Epstein dispels many of our perceptions about why top athletes excel. He shows why some skills that we assume are innate, like the bullet-fast reactions of a baseball or cricket batter, are not, and why other characteristics that we assume are entirely voluntary, like an athlete’s will to train, might in fact have important genetic components.This subject necessarily involves digging deep into sensitive topics like race and gender. Epstein explores controversial questions such as:Are black athletes genetically predetermined to dominate both sprinting and distance running, and are their abilities influenced by Africa’s geography?Are there genetic reasons to separate male and female athletes in competition?Should we test the genes of young children to determine if they are destined for stardom?Can genetic testing determine who is at risk of injury, brain damage, or even death on the field?Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

    Each case includes an extended discussion, definition of terms, clinical pearls, and USMLE format review questions. This interactive learning system helps you understand essential concepts instead of memorizing facts.

    South Asians, who are predominantly Indians and Pakistanis, make up one-third of the world's population and have the highest prevalence of heart disease and diabetes. Dr. Ronesh Sinha, an internal medicine specialist in Silicon Valley, CA, recipient of the 2013 Silicon Valley Business Journal Health Care hero award, and TEDx speaker, specializes in helping patients of South Asian heritage moderate heart disease risk factors and obesity trends with a comprehensive lifestyle modification approach that has delivered exceptional results.Dr. Sinha's The South Asian Health Solution is the first book to provide an ancestral health-based wellness plan culturally tailored for South Asians. In particular, South Asians living outside of India in countries such as the United States, England, and Canada, show an even greater disease risk due to their immersion into western dietary and lifestyle habits.The book covers some of the following topics: South Asian-specific risk factors and how to accurately interpret cholesterol and body composition readings; Key lifestyle changes for weight loss and disease prevention; Three common cultural myths that lead to unhealthy habits; How to effectively manage sleep, stress and fatigue; And specific tips for women, children, and seniors.The South Asian Health Solution explains complex medical circumstances and terminology in an easy to understand voice, allowing the reader to grasp the how's and why's of dietary and lifestyle modification to prevent disease. The book dispenses practical dietary and medical advice, based on proven techniques used in the author's South Asian consult practice and company wellness programs, that recognizes and respects unique South Asian cultural challenges and barriers that can often hinder progress. Each chapter features a detailed case study of one of Dr. Sinha's actual patients (names changed), lending authenticity and real-life application to the material covered, and ends with a checklist for patients, healthcare providers, and even companies looking to keep their South Asian employees healthy.

    She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

    Rochman takes an authoritative look at the latest hot-button issues in the world of pre- and postnatal testing and tells the stories of women and men struggling to understand the variety of tests and grappling with their results—revelations that are sometimes joyous, sometimes heartbreaking, and often profound.Propelled by human narratives and meticulously reported, The Gene Machine introduces us to scientists working to unlock the secrets of the human genome; gene counselors and spiritual advisers helping parents manage this complex new reality; and, of course, parents themselves, including the author, who glimpse the genetic futures of their children. The Gene Machine is both a scientific road map and a meditation on our power to shape the future, one that gets to the very core of what it means to be human.

     A powerful true story revealing a remarkable relationship between a dying son - and a mother that refuses to let him go. At the age of 10, Deryn was diagnosed with Leukaemia. Then 18 months later he developed another rare form of cancer called Langerhan’s cell sarcoma. Only five other people in the world have it. He is the youngest of them all and the only person in the world known to be fighting it alongside another cancer, making him one in seven billion. Told there was no hope of survival, after four years of intensive treatment, exhausted by his fight and with just days left to live, Deryn planned his own funeral. But, Deryn’s desperate mother, Callie would not let him give in. Battling medical errors, impossible odds and years of hardship as the cancer consumed his body and their world, they looked for more answers. After making some startling discoveries and taking massive chances - something began to change… Would their lives as a family ever be the same again?

    That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    For five years in his mid-twenties, he sailed on the BEAGLE around the world, exploring jungles, climbing mountains, trekking across deserts. With every new landfall, he had new adventures: he rode through bandit country, was thrown into jail by revolutionaries, took part in an armed raid with marines, survived two earthquakes, hunted and fished. He suffered the terrible cold and rain of Tierra del Fuego, the merciless heat of the Australian outback and the inner pangs of heartbreak. He also made the discoveries that finally led him to formulate his theory of Natural Selection as the driving force of evolution. The five-year voyage of the BEAGLE was the basis for all Darwin's later work; but it also turned him from a friendly idler into the greatest scientist of his century. Kevin Jackson is a writer, broadcaster and film-maker. His most recent book is Constellation of Genius: 1922 and All That Jazz (Farrar Strauss Giroux, 2013). He lives in Cambridge, England.