But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    But molecules, such as water and sugar, are not alive. So how do our cells--assemblies of otherwise "dead" molecules--come to life, and together constitute a living being? In "Life's Ratchet," physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. The complex molecules of our cells can rightfully be called "molecular machines," or "nanobots"; these machines, unlike any other, work autonomously to create order out of chaos. Tiny electrical motors turn electrical voltage into motion, tiny factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city--an unfathomable, complex collection of molecular worker bees working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. We are essentially giant assemblies of interacting nanoscale machines; machines more amazing than can be found in any science fiction novel. Incredibly, the molecular machines in our cells function without a mysterious "life force," nor do they violate any natural laws. Scientists can now prove that life is not supernatural, and that it can be fully understood in the context of science. Part history, part cutting-edge science, part philosophy, "Life's Ratchet" takes us from ancient Greece to the laboratories of modern nanotechnology to tell the story of our quest for the machinery of life.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    But how has the earth itself determined our destiny? Our planet wobbles, driving changes in climate that forced the transition from nomadism to farming. Mountainous terrain led to the development of democracy in Greece. Atmospheric circulation patterns later on shaped the progression of global exploration, colonization, and trade. Even today, voting behavior in the south-east United States ultimately follows the underlying pattern of 75 million-year-old sediments from an ancient sea. Everywhere is the deep imprint of the planetary on the human.From the cultivation of the first crops to the founding of modern states, Origins reveals the breathtaking impact of the earth beneath our feet on the shape of our human civilizations.

    From liberty to democracy to community, the terms and concepts originated by political philosophers are ingrained in our global consciousness. Yet many of us have an incomplete picture of how these ideas developed and, quite possibly, a skewed perception of their intentions and implications.This highly relevant course sheds light on the labyrinth of Western political and social theory, as well as its influence on modern history. Guided by an award-winning professor of philosophy and author, these eye-opening lectures reveal how political philosophers, in responding to the societal problems and changing conditions of their day in revolutionary ways, created virtual blueprints of action for leaders. You'll gain not only the tools to comprehend the omnipresent language of politics, but a thorough understanding of the wellspring of thought that has emerged over centuries of political philosophy and the intellectual origins of major historical movements and events.Throughout, questions of democracy, freedom, and distributive justice are addressed, and revolutionary figures who have left an indelible mark on history - from Niccolo Machiavelli to Ayn Rand - are encountered.By the conclusion of lecture 36, you will have the context necessary to appreciate the evolution of a myriad of political ideas, including hot-button topics of today such as libertarianism, neoconservatism, feminism, and environmentalism.

    It’s difficult to imagine a nation whose history is more compelling for Americans than that of Russia.Before the collapse of the Soviet Union, this was the nation against which we measured our own nation’s values and power and with whom war, if it ever came, could spell unimaginable catastrophe for our planet.Yet many Americans have never had the opportunity to study Russia in any kind of depth and to see how the forces of history came together so ironically to shape a future so very different from the dreams of most ordinary Russian people, eager to see their nation embrace Western values of progress, human rights, and justice.

    It's ever-present. Without it, you would die in minutes. And it has an epic story to tell.In Caesar's Last Breath, New York Times bestselling author Sam Kean takes us on a journey through the periodic table, around the globe, and across time to tell the story of the air we breathe, which, it turns out, is also the story of earth and our existence on it.With every breath, you literally inhale the history of the world. On the ides of March, 44 BC, Julius Caesar died of stab wounds on the Senate floor, but the story of his last breath is still unfolding; in fact, you're probably inhaling some of it now. Of the sextillions of molecules entering or leaving your lungs at this moment, some might well bear traces of Cleopatra's perfumes, German mustard gas, particles exhaled by dinosaurs or emitted by atomic bombs, even remnants of stardust from the universe's creation.Tracing the origins and ingredients of our atmosphere, Kean reveals how the alchemy of air reshaped our continents, steered human progress, powered revolutions, and continues to influence everything we do. Along the way, we'll swim with radioactive pigs, witness the most important chemical reactions humans have discovered, and join the crowd at the Moulin Rouge for some of the crudest performance art of all time. Lively, witty, and filled with the astounding science of ordinary life, Caesar's Last Breath illuminates the science stories swirling around us every second.

    The consequences of losing beavers were profound: streams eroded, wetlands dried up, and species from salmon to swans lost vital habitat. Today, a growing coalition of “Beaver Believers”―including scientists, ranchers, and passionate citizens―recognizes that ecosystems with beavers are far healthier, for humans and non-humans alike, than those without them. From the Nevada deserts to the Scottish highlands, Believers are now hard at work restoring these industrious rodents to their former haunts. Eager is a powerful story about one of the world’s most influential species, how North America was colonized, how our landscapes have changed over the centuries, and how beavers can help us fight drought, flooding, wildfire, extinction, and the ravages of climate change. Ultimately, it’s about how we can learn to coexist, harmoniously and even beneficially, with our fellow travelers on this planet.

    We find animals and plants where we do because, over time, the continents have moved, separating and uniting in a long, slow dance; because sea levels have risen, cutting off one bit of land from another; because new and barren volcanic islands have risen up from the sea; and because animals and plants vary greatly in their ability to travel, and separation causes the formation of new species. This is the story of how life has responded to, and has in turn altered, the ever-changing Earth. And it includes many fascinating tales--of pygmy mammoths and elephant birds and of radical ideas by bold young scientists.

    The intriguing cast of characters includes Mary Anning, a working-class woman who became one of the most successful fossil collectors of all time; Thomas Hawkins, another amateur collector who "improved upon" fossils in order to increase their market value; the eccentric William Buckland, discoverer of the world's first dinosaur (Megalosaurus), and Richard Owen, an expert anatomist, who synthesized the discoveries of the age and ultimately coined the word "dinosaur" in 1842. Christopher McGowan takes us back to a time when the new sciences of geology and paleontology were as young and vibrant as genetic engineering is today. Through heated public debates on everything from the age of the earth to the notion of extinction, the Dragon Seekers initiated the shift from a biblical to a scientific interpretation of the remote past. In this way, they laid the intellectual groundwork for Darwin's revolutionary ideas, and launched a global obsession with the Age of Reptiles that continues even today.

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    Obsessive and inspired efforts by scientists to solve mysteries and save lives. From The Hot Zone to The Demon in the Freezer and beyond, Richard Preston’s bestselling works have mesmerized readers everywhere by showing them strange worlds of nature they never dreamed of.Panic in Level 4 is a grand tour through the eerie and unforgettable universe of Richard Preston, filled with incredible characters and mysteries that refuse to leave one’s mind. Here are dramatic true stories from this acclaimed and award-winning author, including:• The phenomenon of “self-cannibals,” who suffer from a rare genetic condition caused by one wrong letter in their DNA that forces them to compulsively chew their own flesh–and why everyone may have a touch of this disease.• The search for the unknown host of Ebola virus, an organism hidden somewhere in African rain forests, where the disease finds its way into the human species, causing outbreaks of unparalleled horror.• The brilliant Russian brothers–“one mathematician divided between two bodies”–who built a supercomputer in their apartment from mail-order parts in an attempt to find hidden order in the number pi (π).In fascinating, intimate, and exhilarating detail, Richard Preston portrays the frightening forces and constructive discoveries that are currently roiling and reordering our world, once again proving himself a master of the nonfiction narrative and, as noted in The Washington Post, “a science writer with an uncommon gift for turning complex biology into riveting page-turners.”From the Hardcover edition.

    Disease. Starvation. Cannibals. From the ancient wayfarers to modern astronauts, world explorers have blazed trails fraught with danger. Yet, as History's Greatest Voyages of Exploration vividly demonstrates, exploration continues to be one of humanity's deepest impulses.Across 24 lectures that unveil the process by which we came to know the far reaches of our planet, you'll witness the awe-inspiring and surprisingly interconnected tale of global exploration. An award-winning history professor from the University of Tennessee, Knoxville, revolutionizes how you view the world as he introduces you to some of the greatest and most influential explorers ever known-successful as well as unsuccessful, admirable as well as flawed. You'll be spellbound as you learn of the treacherous, at times fatal, expeditions into the unknown these adventurers embarked upon, whether to the frozen Poles, Asia, Europe, the Americas, Africa, the ocean's depths, or the final frontier of space.Through it all, you consider what drove these intrepid individuals, from proselytizing and pilgrimage to the lure of wealth, conquest, fame, and new lands, as evidenced by the Vikings' arrival in North America; Marco Polo's journey along the Silk Road to China; Christopher Columbus' "Enterprise of the Indies"; the conquistadors' ravages in Latin America; and the tiny kingdom of Portugal's triumphant circumnavigation of Africa to seize control of trade in the Indian Ocean.In every lesson, you'll follow these fascinating figures - including several remarkable women - as they venture into uncharted territory and put themselves, and often their crews, in dire peril. With Professor Liulevicius' uniquely global approach, you also get a meaningful portrait of the travels of non-Westerners, as well as the perspectives of discovered people.

    James Cleaves II seek to answer the most crucial question in science: How did life begin? They trace the trials and triumphs of the iconoclastic scientists who have sought to solve the mystery, from Darwin’s theory of evolution to Crick and Watson’s unveiling of DNA. This fascinating exploration not only examines the origin-of-life question, but also interrogates the very nature of scientific discovery and objectivity.

    With black and white illustrations. "Here is a new collection of Gould's unexpected connections between evolution and all manner of subjects, literature high among them. Gathered from his monthly column in "Natural History" magazine, these articles should delight, surprise, and inform his vast readership, as have his six prior volumes of essays. Somehow the light bulb pops on every month as his deadline approaches, some glowing fact pulled out of memory--often a line from Shakespeare or Tennyson--that illumines a generality Gould wishes to discuss. "Nature, red in tooth and claw" (Lord Alfred's line) induces dilations on the extent science can inform moral matters (not much, Gould believes); a remembrance of the infamous Wansee protocol prompts Gould's denunciation of the genocidal looting of evolutionary theory and, by extension, its vulnerability to ignoramuses in general. These two examples of the Gouldian essay method, fortunately, don't foreshadow a gloomy parade of topics: Gould can as easily alight at the fun house where mass culture absorbs ideas about evolution through movies of monsters run amok from Frankenstein to Jurassic Park. In other essays, he plunges directly into matters of evolutionary interpretation but customarily employs a literary twist: who else but Gould could link Edgar Allan Poe with his own area of professional eminence, the paleontology of snails? A discovery awaits in every essay--in every haystack--which solidifies Gould as one of the most eloquent science popularizers writing today."--"Booklist"