It had to be found. But projects as big as CERN’s Large Hadron Collider don’t happen without incredible risks – and occasional skullduggery. In the definitive account of this landmark event, Caltech physicist and acclaimed science writer Sean Carroll reveals the insights, rivalry, and wonder that fuelled the Higgs discovery, and takes us on a riveting and irresistible ride to the very edge of physics today.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Chapters cover cancer, infection, immune disorders, genetics, and disorders of each body system, highlighting pathophysiologic processes, resulting signs and symptoms, diagnostic test findings, and current treatments. Reader-friendly features include illustrations, checklists, and full-color miniguides illustrating the pathophysiology of specific disorders.This edition has new full-color miniguides on cancer pathophysiology and neuropathology. A new Focus on Genetics feature identifies gene-related discoveries and their implications for treatment or diagnosis. Review questions and answers follow current NCLEX-RN® requirements and alternate-format questions are included.

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    Why does music evoke such powerful moods? The answers are at last be- coming clear, thanks to revolutionary neuroscience and the emerging field of evolutionary psychology. Both a cutting-edge study and a tribute to the beauty of music itself, This Is Your Brain on Music unravels a host of mysteries that affect everything from pop culture to our understanding of human nature, including: • Are our musical preferences shaped in utero? • Is there a cutoff point for acquiring new tastes in music? • What do PET scans and MRIs reveal about the brain’s response to music? • Is musical pleasure different from other kinds of pleasure?This Is Your Brain on Music explores cultures in which singing is considered an essential human function, patients who have a rare disorder that prevents them from making sense of music, and scientists studying why two people may not have the same definition of pitch. At every turn, this provocative work unlocks deep secrets about how nature and nurture forge a uniquely human obsession.

    With a logical, body-systems organization and engaging terminology exercises throughout, it's your key to communicating confidently and effectively with other health care professionals.Systematic approach to terminology prepares you to recognize and define new words as you encounter them and build the medical vocabulary you'll need in the health care setting.Pronunciation key provides quick access to frequently referenced material.Complimentary and Alternative Medicine terms boxes highlight words and phrases associated with this increasingly popular discipline.Case studies encourage critical thinking and demonstrate how to apply the information you've learned.Terminology flash cards, included with every book, give you valuable review and self-assessment tools you can take anywhere for study on the go.Evolve resources enhance your learning and reinforcement opportunities with additional exercises, a Spanish/English glossary, and the Body Spectrum Electronic Anatomy Coloring Book.Medical Terminology Online, available at an additional charge, gives you access to a complete online course for the most advanced learning and understanding.New terms and abbreviations familiarize you with the latest terminology in use in health care.New images and illustrations visually acquaint you with pathologic information and procedures you'll encounter in the clinical setting.Enhanced chapter features highlight important concepts and provide guidance for more effective learning and study.CD references within the text direct you to expanded learning opportunities on the companion CD.More than 20 new medical records let you practice medical terminology using the forms you'll encounter in the clinical setting.New icons make it easy to distinguish a variety of helpful boxes and reference the material you need quickly.Answers to review exercises help you gauge your strengths and weaknesses and configure the most effective study plan for you.Website boxes refer you to valuable content you can access online for further learning.Revised pharmacy appendix helps you easily reference key pharmaceutical terms.The vastly updated companion CD provides fun alternatives for reinforcing what you've learned with new learning games, including Medical Millionaire and Termbusters.Enhanced audio companion, available on CD or as iTerms downloads for portable media players, helps you perfect your pronunciation skills and confidently use the terms you've learned in practice.

    Your life, your thoughts, your diseases, and your health are all the function of cells.But what do you really know about what goes on inside you?The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant.The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world.Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover:A deeper understanding of how cells work and the basic nature of life on earth.Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research.The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells.The ability to make better decisions about health and to debunk the misinformation that comes in daily via media.Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.

    He asks: How do we "read" other people?What is the neurochemistry behind love and sex?What does it mean that the brain is teeming with powerful chemicals closely related to recreational drugs?Why does music move us to tears?Where do breakthrough ideas come from? Johnson answers these and many more questions arising from the events of our everyday lives. You do not have to be a neuroscientist to wonder, for example, why do you smile? And why do you sometimes smile inappropriately, even if you don't want to? How do others read your inappropriate smile? How does such interplay occur neurochemically, and what, if anything, can you do about it? Fascinating and rewarding, Mind Wide Open speaks to brain buffs, self-obsessed neurotics, barstool psychologists, mystified parents, grumpy spouses, exasperated managers, and anyone who enjoys speculating and gossiping about the motivations and behaviors of other human beings. Steven Johnson shows us the transformative power of understanding brain science and offers new modes of introspection and tools for better parenting, better relationships, and better living.

    From the research biologist who stung himself with every conceivable insect to the world's most murderous mammals, this book explores oft-ignored but alluring facets of biology, anatomy, space exploration, nature, and more. Featuring interviews with leading researchers in the field and a large dose of wit, the author reveals the most intriguing real-world applications of science in all their glory.

    But evolutionary biologists also point out many examples of contingency, cases where the tiniest change--a random mutation or an ancient butterfly sneeze--caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary freaks? And what does that say about life on other planets?Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be.Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.

    The 10,000 Year Explosion: How Civilization Accelerated Human Evolution

    Mankind's battle to stay alive and healthy for as long as possible is our oldest, most universal struggle. With his characteristic wit and vastly informed historical scope, Roy Porter examines the war fought between disease and doctors on the battleground of the flesh from ancient times to the present. He explores the many ingenious ways in which we have attempted to overcome disease through the ages: the changing role of doctors, from ancient healers, apothecaries, and blood-letters to today's professionals; the array of drugs, from Ayurvedic remedies to the launch of Viagra; the advances in surgery, from amputations performed by barbers without anesthetic to today's sophisticated transplants; and the transformation of hospitals from Christian places of convalescence to modern medical powerhouses. Cleverly illustrated with historic line drawings, the chronic ailments of humanity provide vivid anecdotes for Porter's enlightening story of medicine's efforts to prevail over a formidable and ever-changing adversary.

    The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.

    J. Simpson case, popular interest in forensic science has exploded: CBS's CSI has 16 to 26 million viewers every week, and Patricia Cornwell's novels featuring a medical examiner sleuth routinely top bestseller lists, to cite just a few examples. Now, everyone can get the lowdown on the science behind crime scene investigations. Using lots of fascinating case studies, forensics expert Dr. D. P. Lyle clues people in on everything from determining cause and time of death to fingerprints, fibers, blood, ballistics, forensic computing, and forensic psychology. With its clear, entertaining explanations of forensic procedures and techniques, this book will be an indispensable reference for mystery fans and true crime aficionados everywhere-and even includes advice for people interested in forensic science careers. D. P. Lyle, MD (Laguna Hills, CA), is a practicing cardiologist who is also a forensics expert and mystery writer. He runs a Web site that answers writers' questions about forensics, dplylemd.com, and is the author of Murder and Mayhem: A Doctor Answers Medical and Forensic Questions for Writers, as well as several mystery novels. John Pless, MD, is Professor Emeritus of Pathology at Indiana University School of Medicine and former President of the National Association of Medical Examiners.

    Gazzaniga has been called the “father of cognitive neuroscience.” In his remarkable book, Who’s in Charge?, he makes a powerful and provocative argument that counters the common wisdom that our lives are wholly determined by physical processes we cannot control. His well-reasoned case against the idea that we live in a “determined” world is fascinating and liberating, solidifying his place among the likes of Oliver Sacks, Antonio Damasio, V.S. Ramachandran, and other bestselling science authors exploring the mysteries of the human brain