But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    You renders the singular arc of a woman’s life through letters Mary-Louise Parker composes to the men, real and hypothetical, who have informed the person she is today. Beginning with the grandfather she never knew, the letters range from a missive to the beloved priest from her childhood to remembrances of former lovers to an homage to a firefighter she encountered to a heartfelt communication with the uncle of the infant daughter she adopted. Readers will be amazed by the depth and style of these letters, which reveal the complexity and power to be found in relationships both loving and fraught.

    Parents and family members who never thought they could get inside the head of their autistic loved one, at last, have a way to break through to the curious, subtle, and complex life within.Using an alphabet grid to painstakingly construct words, sentences, and thoughts that he is unable to speak out loud, Naoki answers even the most delicate questions that people want to know. Questions such as: “Why do people with autism talk so loudly and weirdly?” “Why do you line up your toy cars and blocks?” “Why don’t you make eye contact when you’re talking?” and “What’s the reason you jump?” (Naoki’s answer: “When I’m jumping, it’s as if my feelings are going upward to the sky.”) With disarming honesty and a generous heart, Naoki shares his unique point of view on not only autism but life itself. His insights—into the mystery of words, the wonders of laughter, and the elusiveness of memory—are so startling, so strange, and so powerful that you will never look at the world the same way again.

    It's odd when I think of the arc of my life, from child to young woman to aging adult. First I was who I was. Then I didn't know who I was. Then I invented someone, and became her. Then I began to like what I'd invented. And finally I was what I was again. It turned out I wasn't alone in that particular progression. As she did in her beloved New York Times columns, and in A Short Guide to a Happy Life, Quindlen says for us here what we may wish we could have said ourselves. Using her past, present, and future to explore what matters most to women at different ages, Quindlen talks aboutMarriage: "A safety net of small white lies can be the bedrock of a successful marriage. You wouldn't believe how cheaply I can do a kitchen renovation."Girlfriends: "Real friends offer both hard truths and soft landings and realize that it's sometimes more important to be nice than to be honest." Our bodies: "I've finally recognized my body for what it is, a personality-delivery system, designed expressly to carry my character from place to place, now and in the years to come. It's like a car, and while I like a red convertible or even a Bentley as well as the next person, what I really need are four tires and an engine."Parenting: "Being a parent is not transactional. We do not get what we give. It is the ultimate pay-it-forward: We are good parents, not so they will be loving enough to stay with us, but so they will be strong enough to leave us." From childhood memories to manic motherhood to middle age, Quindlen uses the events of her own life to illuminate our own. Along with the downsides of age, she says, can come wisdom, a perspective on life that makes it both satisfying and even joyful. So here's to lots of candles, plenty of cake.

    At once shocking, heartbreaking, and inspiring, Wall’s story of subjugation and survival exposes the darkness at the root of this rebel offshoot of the Mormon faith.

    As the creator and star of Mister Rogers’ Neighborhood, he was a champion of compassion, equality, and kindness. Rogers was fiercely devoted to children and to taking their fears, concerns, and questions about the world seriously.The Good Neighbor, the first full-length biography of Fred Rogers, tells the story of this utterly unique and enduring American icon. Drawing on original interviews, oral histories, and archival documents, Maxwell King traces Rogers’s personal, professional, and artistic life through decades of work, including a surprising decision to walk away from the show to make television for adults, only to return to the neighborhood with increasingly sophisticated episodes, written in collaboration with experts on childhood development. An engaging story, rich in detail, The Good Neighbor is the definitive portrait of a beloved figure, cherished by multiple generations.

    “Whenever I came up with a funny bit, whether it happened on a stage, in a conversation, or working it out on my preferred canvas, the big yellow legal pad, I kept it in one of those old school accordion folders,” Seinfeld writes. “So I have everything I thought was worth saving from forty-five years of hacking away at this for all I was worth.” For this book, Jerry Seinfeld has selected his favorite material, organized decade by decade. In page after hilarious page, one brilliantly crafted observation after another, readers will witness the evolution of one of the great comedians of our time and gain new insights into the thrilling but unforgiving art of writing stand-up comedy.

    Includes special bonus material!Sharing never-before-heard stories ranging from their struggles with depression, eating disorders, and addiction, Karen and Georgia irreverently recount their biggest mistakes and deepest fears, reflecting on the formative life events that shaped them into two of the most followed voices in the nation.In Stay Sexy & Don’t Get Murdered, Karen and Georgia focus on the importance of self-advocating and valuing personal safety over being ‘nice’ or ‘helpful.’ They delve into their own pasts, true crime stories, and beyond to discuss meaningful cultural and societal issues with fierce empathy and unapologetic frankness.

    Resettling in America, the couple swore eternal fidelity to each other, but also swore to never, ever, under any circumstances get legally married. (Both were survivors of previous bad divorces. Enough said.) But providence intervened one day in the form of the United States government, which-after unexpectedly detaining Felipe at an American border crossing-gave the couple a choice: they could either get married, or Felipe would never be allowed to enter the country again. Having been effectively sentenced to wed, Gilbert tackled her fears of marriage by delving into this topic completely, trying with all her might to discover through historical research, interviews, and much personal reflection what this stubbornly enduring old institution actually is. Told with Gilbert's trademark wit, intelligence and compassion, Committed attempts to "turn on all the lights" when it comes to matrimony, frankly examining questions of compatibility, infatuation, fidelity, family tradition, social expectations, divorce risks and humbling responsibilities. Gilbert's memoir is ultimately a clear-eyed celebration of love with all the complexity and consequence that real love, in the real world, actually entails.

    Brought up in Washington, DC, in an abusive family, she went to Harvard, where she met her husband. They stayed together through medical school until two months before she was scheduled to join the staff of a hospital in central Philadelphia, when he told her he couldn't move with her. Her marriage at an end, Harper began her new life in a new city, in a new job, as a newly single woman.In the ensuing years, as Harper learned to become an effective ER physician, bringing insight and empathy to every patient encounter, she came to understand that each of us is broken—physically, emotionally, psychically. How we recognize those breaks, how we try to mend them, and where we go from there are all crucial parts of the healing process.The Beauty in Breaking is the poignant true story of Harper's journey toward self-healing. Each of the patients Harper writes about taught her something important about recuperation and recovery. How to let go of fear even when the future is murky. How to tell the truth when it's simpler to overlook it. How to understand that compassion isn't the same as justice. As she shines a light on the systemic disenfranchisement of the patients she treats as they struggle to maintain their health and dignity, Harper comes to understand the importance of allowing ourselves to make peace with the past as we draw support from the present. In this hopeful, moving, and beautiful book, she passes along the precious, necessary lessons that she has learned as a daughter, a woman, and a physician.

    She was repeatedly hospitalized in excruciating pain, but the doctors insisted it was a urinary tract infection and sent her home with antibiotics. Unable to get out of bed, much less attend class, Norman dropped out of college and embarked on what would become a years-long journey to discover what was wrong with her. It wasn't until she took matters into her own hands--securing a job in a hospital and educating herself over lunchtime reading in the medical library--that she found an accurate diagnosis of endometriosis.In Ask Me About My Uterus, Norman describes what it was like to have her pain dismissed, to be told it was all in her head, only to be taken seriously when she was accompanied by a boyfriend who confirmed that her sexual performance was, indeed, compromised. Putting her own trials into a broader historical, sociocultural, and political context, Norman shows that women's bodies have long been the battleground of a never-ending war for power, control, medical knowledge, and truth. It's time to refute the belief that being a woman is a preexisting condition.

    While she may have left her home in Alabama, married a New Yorker, forgotten how to drive, and abandoned the puffy headbands of her youth, Helen Ellis is clinging to her Southern accent like mayonnaise to white bread, and offering readers a hilarious, completely singular view on womanhood for both sides of the Mason-Dixon.Making a marriage magically tidy --Topeka three-way --How to stay happily married --Free to be...you and me (and childfree) --Room of one's own (that's full of gay men) --Other woman's Burberry coat --Peggy Sue got marijuana --What every girl should learn from ABC's The bachelor --Ghost experience --Party foul --Today was a good day --Straighten up and fly right. --Halloween people --Tonight we're gonna party like it's 1979 --How to be the best guest --When to write a thank-you note --An Emily Post for the apocalypse --How I watch pornography like a lady --Dumb boobs --Young ladies, listen to me --Seven things I'm doing instead of a neck lift --Serious women --That kind of woman

    Five years after he married Kristen, the love of his life, they learn that he has Asperger syndrome. The diagnosis explains David’s ever-growing list of quirks and compulsions, his lifelong propensity to quack and otherwise melt down in social exchanges, and his clinical-strength inflexibility. But it doesn’t make him any easier to live with.Determined to change, David sets out to understand Asperger syndrome and learn to be a better husband—no easy task for a guy whose inability to express himself rivals his two-year-old daughter's, who thinks his responsibility for laundry extends no further than throwing things in (or at) the hamper, and whose autism-spectrum condition makes seeing his wife's point of view a near impossibility.Nevertheless, David devotes himself to improving his marriage with an endearing yet hilarious zeal that involves excessive note-taking, performance reviews, and most of all, the Journal of Best Practices: a collection of hundreds of maxims and hard-won epiphanies that result from self-reflection both comic and painful. They include "Don’t change the radio station when she's singing along," "Apologies do not count when you shout them," and "Be her friend, first and always." Guided by the Journal of Best Practices, David transforms himself over the course of two years from the world’s most trying husband to the husband who tries the hardest, the husband he’d always meant to be.Filled with humor and surprising wisdom, The Journal of Best Practices is a candid story of ruthless self-improvement, a unique window into living with an autism-spectrum condition, and proof that a true heart can conquer all.

    Then while living in Cambridge in her early 40s, “an age when the view from the hill can be clear and poignant both,” Caldwell adopts a rambunctious puppy named Clementine. On one of their bucolic walks, she meets Caroline and her dog, Lucille, and both women’s lives change forever.Though they are more different than alike, these two fiercely private, independent women quickly relax into a friendship more profound than either of them expected, a friendship that will thrive on their shared secrets, including parallel struggles with alcoholism and loneliness. They grow increasingly inseparable until, in 2003, Caroline is diagnosed with Stage IV lung cancer. Caldwell writes: “It’s an old, old story: I had a friend and we shared everything, and then she died and so we shared that, too.”     In her signature exquisite prose, Caldwell mines the deepest levels of devotion and grief in this wise and affecting account about losing her best friend. Let’s Take the Long Way Home is also a celebration of life and all the little moments worth cherishing—and affirms why Gail Caldwell is rightly praised as one of our bravest and most honest literary voices.