In this now-classic study, Michael Bliss unearths a wealth of material, ranging from scientists& unpublished memoirs to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a longstanding controversy dating to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the credit with an additional associate, medical opinion was intensely divided over the allotment of credit for the discovery. Bliss also offers a wealth of new detail on such subjects as the treatment of diabetes before insulin and the life-and-death struggle to manufacture it.Bliss;s excellent account of the insulin story is a rare dissection of the anatomy of scientific discovery, and serves as a model of how rigorous historical method can correct the myths and legends sometimes perpetrated in the scientific literature.

    What she did not count on was how much death would be a part of her work. Almost immediately, Chen found herself wrestling with medicine’s most profound paradox, that a profession premised on caring for the ill also systematically depersonalizes dying. Final Exam follows Chen over the course of her education, training, and practice as she grapples at strikingly close range with the problem of mortality, and struggles to reconcile the lessons of her training with her innate knowledge of shared humanity, and to separate her ideas about healing from her fierce desire to cure.From her first dissection of a cadaver in gross anatomy to the moment she first puts a scalpel to a living person; from the first time she witnesses someone flatlining in the emergency room to the first time she pronounces a patient dead, Chen is struck by her own mortal fears: there was a dying friend she could not call; a young patient’s tortured death she could not forget; even the sense of shared kinship with a corpse she could not cast aside when asked to saw its pelvis in two. Gradually, as she confronts the ways in which her fears have incapacitated her, she begins to reject what she has been taught about suppressing her feelings for her patients, and she begins to carve out a new role for herself as a physician and as human being. Chen’s transfixing and beautiful rumination on how doctors negotiate the ineluctable fact of death becomes, in the end, a brilliant questioning of how we should live.Moving and provocative, motored equally by clinical expertise and extraordinary personal grace, this is a piercing and compassionate journey into the heart of a world that is hidden and yet touches all of our lives. A superb addition to the best medical literature of our time.

    Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes.Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics.Author Dr. Alexandra Levitt is an expert on emerging diseases and other public health threats. Here she shares insider accounts she’s collected that go behind the alarming headlines we’ve seen in the media: mysterious food poisonings, unexplained deaths at a children’s hospital, a strange neurologic disease afflicting slaughterhouse workers, flocks of birds dropping dead out of the sky, and drug-resistant malaria running rampant in a refugee camp. Meet the resourceful investigators—doctors, veterinarians, and research scientists—and discover the truth behind these cases and more.

    student, worked on a wartime project in microbiology professor Selman Waksman's lab, searching for an antibiotic to fight infections on the front lines and at home. In his eleventh experiment on a common bacterium found in farmyard soil, Schatz discovered streptomycin, the first effective cure for tuberculosis, one of the world's deadliest diseases.As director of Schatz's research, Waksman took credit for the discovery, belittled Schatz's work, and secretly enriched himself with royalties from the streptomycin patent filed by the pharmaceutical company Merck. In an unprecedented lawsuit, young Schatz sued Waksman, and was awarded the title of "co-discoverer" and a share of the royalties. But two years later, Professor Waksman alone was awarded the Nobel Prize. Schatz disappeared into academic obscurity.For the first time, acclaimed author and journalist Peter Pringle unravels the intrigues behind one of the most important discoveries in the history of medicine. The story unfolds on a tiny college campus in New Jersey, but its repercussions spread worldwide. The streptomycin patent was a breakthrough for the drug companies, overturning patent limits on products of nature and paving the way for today's biotech world. As dozens more antibiotics were found, many from the same family as streptomycin, the drug companies created oligopolies and reaped big profits. Pringle uses firsthand accounts and archives in the United States and Europe to reveal the intensely human story behind the discovery that started a revolution in the treatment of infectious diseases and shaped the future of Big Pharma.

    With a wealth of detail, "A Journal of the Plague Year" seems almost a firsthand account, taking readers through the neighborhoods, houses, and streets that have drastically changed with the rising death toll. The bustle of business and errands gives way to doors marked with the cross to signify a house of death, as well as the dead-carts transporting those struck down to the mass graves as the dead rise in number to nearly 100,000. As the epidemic progresses and the narrator encounters more stories of isolation and horror, Defoe reveals his masterful balance as both a historical and imaginative writer.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    In 'Bad Science', Ben Goldacre hilariously exposed the tricks that quacks and journalists use to distort science. In 'Bad Pharma', he put the $600 billion global pharmaceutical industry under the microscope. Now the pick of the journalism by one of our wittiest, most indignant and most fearless commentators on the worlds of medicine and science is collected in one volume.

    Starting with its energized, work-obsessed royal families, the Dukes and the Reynoldses, and their embattled successors like the eccentric autocrat George Washington Hill and the feisty Joseph F. Cullman, the book vividly portrays the cigarrettemakers generations of entrepreneurial geniuses. Their problematic achievement was based on cunning business strategies and marketing dazzle, deft political power plays, and a relentless, often devious attack on antismoking forces in science, public health, and government. Enabling the whole process to unfold was the weirdly symbiotic relationship of an industry geared at any cost to sell, sell, sell cigarettes, and an American public habituated to ignore all health warnings and buy, buy, buy.At the center of this epic is the continuing drama of the Philip Morris Company and the crafty men at its helm. The youngest, once smallest entry in the business, it remained an underdog until the marketing brainstorm that transformed the Marlboro brand from little more than a woman’s fashion accessory to the ultimate emblem of hairy-chested machismo (and made it America’s – and the world’s – #1 smoke). Remarkably, the company’s global prosperity mounted steadily even as the news about cigarettes and health grew more dire by the year.Caught up in the Philip Morris story is the whole sweep of America’s cigarette history, from the glory days of rampant hucksterism – when smokers would “walk a mile for a Camel,” Winston tasted “good like a cigarette should,” and most of the nation could decipher “L.S. / M.F.T” – to the bombshell 1964 Surgeon General’s Report that definitively indicted smoking as a killer, to the age of the massive mergers that spawned RJR Nabisco and Philip Morris-Kraft General Foods.Here we learn how the leaf that was the New World’s most passionately devoured gift to the Old grew into humankind’s most dangerous consumer product, employing a vast rural corps of laborers, fattening tax revenues, and propagating a ring of fiercely competitive corporate superpowers; how tobacco’s peerless public-relations spinners applied their techniques to becloud the overwhelming evidence of the cigarette’s lethal and addictive nature; and finally, how the besieged industry and the aroused public-health forces nationwide collided over whether to outlaw the butt habit altogether or bring it into ever more withering social disdain and under ever tighter government control.

    When a highly lethal strain of avian flu broke out in Asia in recent years and raced westward, the Washington Post’s Alan Sipress chased the emerging threat as it infiltrated remote jungle villages, mountain redoubts, and teeming cities. He tracked the virus across nine countries, watching its secrets repeatedly elude the world’s brightest scientists and most intrepid disease hunters. Savage and mercurial, this novel influenza strain—H5N1—has been called the kissing cousin of the Spanish flu and, with just a few genetic tweaks, could kill millions of people. None of us is immune.The Fatal Strain is a fast-moving account that weaves cultural, political, and scientific strands into a tale of inevitable epidemic. In his vivid portrayal of the struggle between man and microbe, Sipress chronicles the accelerating number of near misses and explores the cruel dynamic that has often made Asia the fountainhead of killer flu strains. Even more than modern medicine, it is chicken smugglers, fighting cock breeders, and witch doctors who could determine the evolution of this viral menace by allowing it to breed and speeding it on its way.The ease of international travel and the delicate balance of today’s global economy have left the world vulnerable to pandemic in a way the victims of 1918 could never imagine. But it is human failings that may pose the greatest peril. Political bosses in country after country have covered up outbreaks. Ancient customs, like trading in live poultry and the ritual release of birds to earn religious merit, have failed to adapt to the microbial threat. The world’s wealthy countries have left poorer, frontline countries without affordable vaccines or other weapons for confronting the disease, fostering a sense of grievance that endangers us all.The chilling truth is that we don’t have command over the H5N1 virus. It continues to spread, thwarting efforts to uproot it. And as it does, the viral dice continue to roll, threatening to produce a pandemic strain that is both deadly and can spread as easily as the common cold. Swine flu has reminded us that flu epidemics happen. Sipress reminds us something far worse could be brewing.

    Conventional wisdom may be wrong. In this controversial book, the eminent biologist Paul W. Ewald offers some startling arguments:-Germs appear to be at the root of heart disease, Alzheimer’s, schizophrenia, many forms of cancer, and other chronic diseases.-The greatest threats to our health come not from sensational killers such as Ebola, West Nile virus, and super-virulent strains of influenza, but from agents that are already here causing long-term infections, which eventually lead to debilitation and death. -The medical establishment has largely ignored the evidence that implicates these germs, to the detriment of our public health.-New evolutionary theories are available, which explain how germs function and offer opportunities for controlling these modern plagues — if we are willing to listen to them.Plague Time is an eye-opening exploration of the revolutionary new understanding of disease that may set the course of medical research for the twenty-first century.

    But we should--even those of us who take care of our business in pristine, sanitary conditions. For it's not only in developing countries that human waste is a major public health threat: population growth is taxing even the most advanced sewage systems, and the disease spread by waste kills more people worldwide every year than any other single cause of death. Even in America, 1.95 million people have no access to an indoor toilet. Yet the subject remains unmentionable."The Big Necessity "takes aim at the taboo, revealing everything that matters about how people do--and don't--deal with their own waste. Moving from the deep underground sewers of Paris, London, and New York--an infrastructure disaster waiting to happen--to an Indian slum where ten toilets are shared by 60,000 people, Rose George stops along the way to explore the potential saviors: China's five million biogas digesters, which produce energy from waste; the heroes of third world sanitation movements; the inventor of the humble Car Loo; and the U.S. Army's personal lasers used by soldiers to zap their feces in the field.With razor-sharp wit and crusading urgency, mixing levity with gravity, Rose George has turned the subject we like to avoid into a cause with the most serious of consequences.

    By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.Of all diseases, the 1918 flu was by far the worst that has ever afflicted humankind; not even the Black Death of the Middle Ages comes close in terms of the number of lives it took. No war, no natural disaster, no famine has claimed so many. In the space of eighteen months in 1918-1919, about 500 million people--one-third of the global population at the time--came down with influenza. The exact total of lives lost will never be known, but the best estimate is between 50 and 100 million. In this powerful book, filled with black and white photographs, nonfiction master Albert Marrin examines the history, science, and impact of this great scourge--and the possibility for another worldwide pandemic today.