Soon it was gone, only to be succeeded by another. And another. Strange, Karinthy thought, it had been years since Budapest had streetcars. Only then did he realize he was suffering from an auditory hallucination of extraordinary intensity. What in fact Karinthy was suffering from was a brain tumor, not cancerous but hardly benign, though it was only much later—after spells of giddiness, fainting fits, friends remarking that his handwriting had altered, and books going blank before his eyes—that he consulted a doctor and embarked on a series of examinations that would lead to brain surgery. Karinthy’s description of his descent into illness and his observations of his symptoms, thoughts, and feelings, as well as of his friends’ and doctors’ varied responses to his predicament, are exact and engrossing and entirely free of self-pity. A Journey Round My Skull is not only an extraordinary piece of medical testimony, but a powerful work of literature—one that dances brilliantly on the edge of extinction.

    While psychedelics of all sorts are demonized in America today, the visionary compounds found in plants are the spiritual sacraments of tribal cultures around the world. From the iboga of the Bwiti in Gabon, to the Mazatecs of Mexico, these plants are sacred because they awaken the mind to other levels of awareness--to a holographic vision of the universe.Breaking Open the Head is a passionate, multilayered, and sometimes rashly personal inquiry into this deep division. On one level, Daniel Pinchbeck tells the story of the encounters between the modern consciousness of the West and these sacramental substances, including such thinkers as Allen Ginsberg, Antonin Artaud, Walter Benjamin, and Terence McKenna, and a new underground of present-day ethnobotanists, chemists, psychonauts, and philosophers. It is also a scrupulous recording of the author's wide-ranging investigation with these outlaw compounds, including a thirty-hour tribal initiation in West Africa; an all-night encounter with the master shamans of the South American rain forest; and a report from a psychedelic utopia in the Black Rock Desert that is the Burning Man Festival.Breaking Open the Head is brave participatory journalism at its best, a vivid account of psychic and intellectual experiences that opened doors in the wall of Western rationalism and completed Daniel Pinchbeck's personal transformation from a jaded Manhattan journalist to shamanic initiate and grateful citizen of the cosmos.

    student, worked on a wartime project in microbiology professor Selman Waksman's lab, searching for an antibiotic to fight infections on the front lines and at home. In his eleventh experiment on a common bacterium found in farmyard soil, Schatz discovered streptomycin, the first effective cure for tuberculosis, one of the world's deadliest diseases.As director of Schatz's research, Waksman took credit for the discovery, belittled Schatz's work, and secretly enriched himself with royalties from the streptomycin patent filed by the pharmaceutical company Merck. In an unprecedented lawsuit, young Schatz sued Waksman, and was awarded the title of "co-discoverer" and a share of the royalties. But two years later, Professor Waksman alone was awarded the Nobel Prize. Schatz disappeared into academic obscurity.For the first time, acclaimed author and journalist Peter Pringle unravels the intrigues behind one of the most important discoveries in the history of medicine. The story unfolds on a tiny college campus in New Jersey, but its repercussions spread worldwide. The streptomycin patent was a breakthrough for the drug companies, overturning patent limits on products of nature and paving the way for today's biotech world. As dozens more antibiotics were found, many from the same family as streptomycin, the drug companies created oligopolies and reaped big profits. Pringle uses firsthand accounts and archives in the United States and Europe to reveal the intensely human story behind the discovery that started a revolution in the treatment of infectious diseases and shaped the future of Big Pharma.

    In the spring of 1940, the aspiring but unknown writer Albert Camus and budding scientist Jacques Monod were quietly pursuing ordinary, separate lives in Paris. After the German invasion and occupation of France, each joined the Resistance to help liberate the country from the Nazis, ascended to prominent, dangerous roles, and were very lucky to survive. After the war and through twists of circumstance, they became friends, and through their passionate determination and rare talent, they emerged as leading voices of modern literature and biology, each receiving the Nobel Prize in their respective fields. Drawing upon a wealth of previously unpublished and unknown material gathered over several years of research, Brave Genius tells the story of how each man endured the most terrible episode of the twentieth century and then blossomed into extraordinarily creative and engaged individuals. It is a story of the transformation of ordinary lives into exceptional lives by extraordinary events--of courage in the face of overwhelming adversity, the flowering of creative genius, deep friendship, and of profound concern for and insight into the human condition.

    He was bound for a New Jersey dueling ground to settle his bitter dispute with Aaron Burr. Hamilton took just two men with him: his “second” for the duel, and Dr. David Hosack.As historian Victoria Johnson reveals in her groundbreaking biography, Hosack was one of the few points the duelists did agree on. Summoned that morning because of his role as the beloved Hamilton family doctor, he was also a close friend of Burr. A brilliant surgeon and a world-class botanist, Hosack—who until now has been lost in the fog of history—was a pioneering thinker who shaped a young nation.Born in New York City, he was educated in Europe and returned to America inspired by his newfound knowledge. He assembled a plant collection so spectacular and diverse that it amazes botanists today, conducted some of the first pharmaceutical research in the United States, and introduced new surgeries to American. His tireless work championing public health and science earned him national fame and praise from the likes of Thomas Jefferson, James Madison, Alexander von Humboldt, and the Marquis de Lafayette.One goal drove Hosack above all others: to build the Republic’s first botanical garden. Despite innumerable obstacles and near-constant resistance, Hosack triumphed when, by 1810, his Elgin Botanic Garden at last crowned twenty acres of Manhattan farmland. “Where others saw real estate and power, Hosack saw the landscape as a pharmacopoeia able to bring medicine into the modern age” (Eric W. Sanderson, author of Mannahatta). Today what remains of America’s first botanical garden lies in the heart of midtown, buried beneath Rockefeller Center.Whether collecting specimens along the banks of the Hudson River, lecturing before a class of rapt medical students, or breaking the fever of a young Philip Hamilton, David Hosack was an American visionary who has been too long forgotten. Alongside other towering figures of the post-Revolutionary generation, he took the reins of a nation. In unearthing the dramatic story of his life, Johnson offers a lush depiction of the man who gave a new voice to the powers and perils of nature.

    Full of extraordinary facts and astonishing stories, The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological make up.A wonderful successor to A Short History of Nearly Everything, this book will have you marvelling at the form you occupy, and celebrating the genius of your existence, time and time again.

    A brilliant visual storyteller, Redniss has hand-designed more than 100 color collages to tell Curie’s story, fascinating in its scientific significance and its sometimes whimsical, sometimes haunting mix of romance and intrigue. Bringing together archival photos, images, and clippings with dazzling line drawings and a compelling narrative, Radioactive is far more than just an art book or a graphic novel: It is a stunning visual biography and a true work of art.

    His fame was such that many Greek medical writings became attributed to him. What they have in common is not dogma but, rather, constructive debate between one another. They also share a concern with meticulous observation and an insistence on physical, not supernatural, causation of illness. The writers were the pioneers of rational medicine; their ideas, dominant for centuries, still reveal to us the ideal of ethical practice, as well as the origins not just of Western medicine but of scientific method.This excellent selection of Hippocratic treatises shows the range of writing and thought. Some are technical works on embryology, surgery or anatomy; others are addressed to a lay audience; all are informed with the spirit of inquiry. G.E.R. Lloyd's authoritative introduction puts them into their contemporary context and assesses their later influence.

    In this Octavo we have assembled scattered secrets for a Supreme Grimoire forRoundworld, the universe in which you're standing. To this end we have taken some inspiration from Pratchett's Discworld, and a lot from Theoretical Physics and Practical Chaos Magic. "The most original, and probably the most important, writer on Magick since Aleister Crowley." -Robert Anton Wilson, author of the Cosmic Trigger trilogy. Peter J. Carroll is one of the founders of the Magical Pact of the Illuminates of Thanateros (IOT) which he led for a decade. He has spent thirty-seven years in research and experiment and is the author of three other books Liber Null & Psychonaut, Liber Kaos: the Psychonomicon, and Psybermagic, and The Apophenion.

    From the start, the drug's manufacturer aggressively marketed its patented time-release formula as a breakthrough in the effort to reduce prescription drug abuse. It wasn't long, however, before thrill-seeking teenagers shattered that illusion of safety; by simply crushing an "Oxy," they were able to tap into a high so seductive it would come to dominate their lives. Some patients, seeking relief from pain, also found themselves drawn to the drug's dark side. Pain Killer takes readers on a journey of discovery that begins with the true story of Lindsay, a high-school cheerleader in Virginia who gets hooked on Oxys, and expands outward to explore the critical issues of legitimate pain management, prescription drug abuse, and how the misuse of science by the drug industry threatens the public good. With the fast-rising abuse of prescription drugs by young people ringing alarm bells within government, the how and why behind the OxyContin disaster is a gripping read not only for parents, but also for medical professionals, community leaders, business executives, and all those concerned with this crisis. The dangers described in Pain Killer also reverberate far beyond the threat from a single drug at a particular moment in time. The focus of our government's war on drugs has clearly misled many of us into thinking that only illegal drugs smuggled from beyond our borders can be abused. As Meier tells the dramatic story, some of the most deadly substances are produced and sold legally right here at home.THE EXTRAORDINARY AND TRUE STORY OF OXYCONTIN EQUAL PARTS crime thriller, medical detective story, and business exposé, Pain Killer takes a hard-hitting look at how a powerful drug touted as the salvation for millions triggered a national tragedy. At its inception, the legal narcotic OxyContin was seen as a pharmaceutical dream, a "wonder" drug that would herald a sea change in medical care while reaping vast profits for its maker. It did do that; but it also unleashed a public health crisis that cut a swath of despair and crime through unsuspecting small towns, suburbs, and cities across the country. As reports of OxyContin overdoses made front-page and network news, doctors, narcotics agents, regulators, industry executives, and lawmakers raced in, scrambling to slow the damage. Behind it all stood one of America's wealthiest families, and a drug company whose relentless promotion helped fuel the problem Written by award-winning journalist Barry Meier, whose special report in the New York Times triggered national interest in OxyContin, Pain Killer chronicles the rise of the multibillion dollar pain management industry and lays bare its excesses and abuses.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    He traced the ownership of individual copies through the hands of saints, heretics, scalawags, and bibliomaniacs. He was called as the expert witness in the theft of one copy, witnessed the dramatic auction of another, and proves conclusively that "De revolutionibus" was as inspirational as it was revolutionary. Part biography of a book, part scientific exploration, part bibliographic detective story, "The Book Nobody Read" recolors the history of cosmology and offers new appreciation of the enduring power of an extraordinary book and its ideas.

    The Red Goddess takes you through a tale of sex, drugs and violence.This is an ecstatic journey through the unheard history of BABALON from Revelations, back through the Ishtar Gate and forward into a living modern magickal current.This is an explicit and challenging vision of a very modern goddess coming into power.This is more than a history, it is a passionate account of living magick and the transcendent power of Love.The Red Goddess answers the fundamental questions:Who is BABALON?Why should we care?Where did She come from and where is She going?Does Revelations have anything to tell us?Is there a hidden western tradition of sacred sex?The epic sweep of the text takes us from Babylon to Jerusalem to Rome, and onwards to Apocalypse.It looks at the angelic work of renaissance mage John Dee.It delivers a devastating exegisis on the excesses of Aleister Crowley, and unlocks the secrets of Waratah Blossoms.It explains the immolation of the Californian antichrist-superstar Jack Parsons and his relationship with Scientology founder L.Ron Hubbard.There is also a full supporting cast of Solomon, Simon Magus, St John the Divine, Earl Bothwell, the Templars, Mary, the Magdalene and countless others.This is the missing history of the Holy Whore.Thirteen essays conclude the book on subjects including: roses, mirror magick, BDSM, aphrodisiac drugs, the information age, love vs lust, and the meaning of apocalypse.Those working with Ishtar, Inanna, Lilith, Kali, Sekhmet, Bast, Freya, Pomba Gira, Erzulie, witchcraft, tibetan tantra, sacred sex and transgression will find much here to intrigue and inspire them.The Red Goddess is suitable for anyone with blood in their veins, regardless of tradition, background or experience.It is a Love story.

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    R. R. Tolkien and C. S. LewisThe First World War laid waste to a continent and permanently altered the political and religious landscape of the West. For a generation of men and women, it brought the end of innocence—and the end of faith. Yet for J. R. R. Tolkien and C. S. Lewis, the Great War deepened their spiritual quest. Both men served as soldiers on the Western Front, survived the trenches, and used the experience of that conflict to ignite their Christian imagination. Had there been no Great War, there would have been no Hobbit, no Lord of the Rings, no Narnia, and perhaps no conversion to Christianity by C. S. Lewis.Unlike a generation of young writers who lost faith in the God of the Bible, Tolkien and Lewis produced epic stories infused with the themes of guilt and grace, sorrow and consolation. Giving an unabashedly Christian vision of hope in a world tortured by doubt and disillusionment, the two writers created works that changed the course of literature and shaped the faith of millions. This is the first book to explore their work in light of the spiritual crisis sparked by the conflict.