The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Fuzzy brown molds mischievously turn forgotten peaches to slime in the kitchen fruit bowl. And in thousands of other ways, members of the kingdom Fungi do their part to make life on Earth the miracle that it is. In this lively book, George Hudler leads us on a tour of an often-overlooked group of organisms, which differ radically from both animals and plants. Along the way the author stops to ponder the marvels of nature and the impact of mere microbes on the evolution of civilization. Nature's ultimate recyclers not only save us from drowning in a sea of organic waste, but also provide us with food, drink, and a wide array of valuable medicines and industrial chemicals.Some fungi make deadly poisons and psychedelic drugs that have interesting histories in and of themselves, and Hudler weaves tales of those into his scientific account of the nature of the fungi. The role of fungi in the Irish potato famine, in the Salem Witch Trials, in the philosophical writings of Greek scholars, and in the creation of ginger snaps are just a few of the many great moments in history to grace these pages.Hudler moves so easily from discussing human history to exploring scientific knowledge, all with a sense of humor and enthusiasm, that one can well understand why he is an award-winning teacher both at Cornell University as well as nationally. Few, for instance, who read his invitation to get out of your chair and take a short walk will ever again look without curiosity and admiration at the rotten part of the world around them. Magical Mushrooms, Mischievous Molds is full of information that will satisfy history buffs, science enthusiasts, and anyone interested in nature's miracles. Everyone in Hudler's audience will develop a new appreciation of the debt they owe to the molds for such common products as penicillin, wine, and bread.

    Emoto demonstrates how water's unique role in transporting the natural vibration of these words can help you welcome change and live a more positive and happy life. Dr. Emoto also explores the significance of words and language, their origins, and their impact on water. He introduces and explains the key concept of resonance -- the vehicle through which life-force energy is transmitted. From this knowledge, he draws out lessons that we can apply to our lives to reap the benefits of positive resonance, including more harmonious relationships, restored health, and improved communications. This thoughtful book includes new and extraordinary water-crystal photographs that provide convincing reasons for all of us to choose positive words and strive for perfect resonance for a more healthy, peaceful, and happy life.

    This thorough revision provides a survey by groups, emphasizing adaptive morphology and physiology, while covering anatomical ground plans and basic developmental patterns. New co-author Richard Fox brings to the revision his expertise as an ecologist, offering a good balance to Ruppert's background as a functional morphologist. Rich illustrations and extensive citations make the book extremely valuable as a teaching tool and reference source.

    We have long been told to breakfast like kings and dine like paupers. In the wake of his own type 2 diabetes diagnosis, Professor Terence Kealey was given the same advice. He soon noticed that his glucose levels were unusually high after eating in the morning, but if he fasted until lunchtime they fell. Professor Kealey began to question how much evidence there was to support the advice he’d been given, and whether there might be an advantage to not eating breakfast after all.Breakfast is a Dangerous Meal asks:What is the reliable scientific and medical evidence for eating breakfast?Who should consider intermittent fasting by removing breakfast from their daily routine?From weight loss to reduced blood pressure, what are the potential benefits of missing breakfast?

    Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses —deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak.Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.” Warren Andiman, MD is professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health.

    It makes us aware of the world around us and our own self. How all this emerges from a kilogram of brain cells is one of the greatest unanswered questions. In Your Conscious Mind leading brain scientists and New Scientist take you on a journey through the mind to discover what consciousness really is, and what we can learn when it goes awry. Find out if we will ever build conscious machines, what animal consciousness can tell us about being human and explore the enigma of free will. ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

    And we all have stories.The bite attacks that Pamela Nagami, M.D., has chosen to write about in Bitten take place in big cities, small towns, and remote villages around the world and throughout history, locales as familiar as New York or Hollywood, or exotic as Africa, the Middle East, or Indonesia. They include a six-year-old girl who descended into weeks of extreme lassitude from a tick bite; a diabetic in the West Indies who awoke to find a rat eating two of his toes; a California man who developed "flesh-eating strep" following a penile bite; and more.With reports from medical journals, case histories, colleagues, and her own twenty-five-year career as a practicing physician and infectious diseases specialist, Pamela Nagami offers readers intrigued by infection, disease, and mesmerized by creatures in the wild a compulsively readable narrative that is entertaining, sometimes disturbing, and always engrossing.

    In his hallmark friendly style, he explores the universal impact of being the right size. By examining stories ranging from Alice in Wonderland to Gulliver's Travels, he shows that humans have always been fascinated by things big and small. Why then does size always reside on the fringes of science and never on the center stage? Why do biologists and others ponder size only when studying something else--running speed, life span, or metabolism? Why Size Matters, a pioneering book of big ideas in a compact size, gives size its due by presenting a profound yet lucid overview of what we know about its role in the living world. Bonner argues that size really does matter--that it is the supreme and universal determinant of what any organism can be and do. For example, because tiny creatures are subject primarily to forces of cohesion and larger beasts to gravity, a fly can easily walk up a wall, something we humans cannot even begin to imagine doing.Bonner introduces us to size through the giants and dwarfs of human, animal, and plant history and then explores questions including the physics of size as it affects biology, the evolution of size over geological time, and the role of size in the function and longevity of living things.As this elegantly written book shows, size affects life in its every aspect. It is a universal frame from which nothing escapes.

    Drugs, transplants, and surgery don’t work for 90 percent of our aches and pains and, while we are grateful for life-saving developments, we know that most come with risks that we ignore at our peril.Long hailed as one of the founding fathers of mind-body medicine, Larry Dossey directs our attention to simple sources of healing that have been available for centuries—treasures often hidden in plain sight—from the power of optimism and of tears to speed recovery to the surprising usefulness of dirt and bugs in curing disease and infection to the benefits of doing nothing.Exploring the medical research that validates these simple remedies, Dossey encourages us to align ourselves with the wisdom of nature and allow true healing to take place. The Extraordinary Healing Power of Ordinary Things can transform our view of what health is all about, whether our concern is cancer or the common cold.From the Hardcover edition.

    The Fast-5 rule is simple -- eat within five consecutive hours. The book is about how to get started, what to expect, and how to deal with the challenges of eating in a way that's not the social norm, but saves time, saves money, and is one of the most easily sustained choices for getting to and maintaining a healthy weight.

    

    “Forget everything you think you know about genes, talent, and intelligence,” he writes. “In recent years, a mountain of scientific evidence has emerged suggesting a completely new paradigm: not talent scarcity, but latent talent abundance.” Integrating cutting-edge research from a wide swath of disciplines—cognitive science, genetics, biology, child development—Shenk offers a highly optimistic new view of human potential. The problem isn't our inadequate genetic assets, but our inability, so far, to tap into what we already have. IQ testing and widespread acceptance of “innate” abilities have created an unnecessarily pessimistic view of humanity—and fostered much misdirected public policy, especially in education. The truth is much more exciting. Genes are not a “blueprint” that bless some with greatness and doom most of us to mediocrity or worse. Rather our individual destinies are a product of the complex interplay between genes and outside stimuli-a dynamic that we, as people and as parents, can influence. This is a revolutionary and optimistic message. We are not prisoners of our DNA. We all have the potential for greatness.