Edward Marriott’s dramatic, gripping new book gives you yet another thing to worry about.” —New York Plague. The very word carries an unholy resonance. No other disease can claim its apocalyptic power: it can lie dormant for centuries, only to resurface with nation-killing force. Here, with the high drama of an adventure tale, Edward Marriott unravels the story of this lethal disease: the historic battle to identify its source, the devastating effects of pandemics, and the prospects for new outbreaks. Marriott begins the trail in Hong Kong in the summer of 1894, when a plague diagnosis brought to the island two top scientists—Alexandre Yersin, a maverick Frenchman, and his Japanese rival, Shibasaburo Kitasato. Marriott interweaves the narrative of their fierce competition with vivid scenes of the scourge’s persistence: California in 1900; Surat, India, in 1994; and New York City sometime in the future.A masterly account of medical and human history, Plague is at once an instructive warning and a chilling read.

    Indeed, most are only barely aware of the diseases caused by them, except, perhaps, for mad cow disease. Yet prions are the stuff of a revolutionary science?a science that might lead to cures for some of humankind?s most devastating diseases.Fatal Flaws is a scientific detective story about this elusive protein, starting with the discovery of kuru, a disease unique to New Guinea in the 1950s that baffled scientists and carried with it whispers of cannibalism. Kuru began a scientific stampede to seek out the agent of this mysterious disease?the prion?a misfolded protein whose existence some of the world?s top scientists still find difficult to accept. Today, the subject of prions remains controversial, yet the proteins might promise new treatments for some of the most intractable brain diseases, ones that affect millions around the planet, including Parkinson?s, ALS and Alzheimer?s.In Fatal Flaws, Jay Ingram unties a complicated interweaving of biology, medicine, human tragedy, surprise and disbelief in the world of prions, and he unravels some of history?s most stunning revelations about disease, the brain and infection.

    Touching on such diverse subspecialties as genetics, pharmacology, neurology, sexology, and immunology, Pickover intersperses “obvious” historical milestones--the Hippocratic Oath, general anesthesia, the Human Genome Project--with unexpected and intriguing topics like “truth serum,” the use of cocaine in eye surgery, and face transplants.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    The problem with this version of history? There’s not a shred of evidence to support it.Here anthropologist David Graeber presents a stunning reversal of conventional wisdom. He shows that for more than 5,000 years, since the beginnings of the first agrarian empires, humans have used elaborate credit systems to buy and sell goods—that is, long before the invention of coins or cash. It is in this era, Graeber argues, that we also first encounter a society divided into debtors and creditors. Graeber shows that arguments about debt and debt forgiveness have been at the center of political debates from Italy to China, as well as sparking innumerable insurrections. He also brilliantly demonstrates that the language of the ancient works of law and religion (words like “guilt,” “sin,” and “redemption”) derive in large part from ancient debates about debt, and shape even our most basic ideas of right and wrong. We are still fighting these battles today without knowing it.Debt: The First 5,000 Years is a fascinating chronicle of this little known history—as well as how it has defined human history, and what it means for the credit crisis of the present day and the future of our economy.

    It wiped out one-third of Europe's population, taking some 20 million lives. And yet, most of what we know about it is wrong. The details of the Plague etched in the minds of terrified schoolchildren—the hideous black welts, the high fever, and the awful end by respiratory failure—are more or less accurate. But what the Plague really was and how it made history remain shrouded in a haze of myths.Now, Norman Cantor, the premier historian of the Middle Ages, draws together the most recent scientific discoveries and groundbreaking historical research to pierce the mist and tell the story of the Black Death as a gripping, intimate narrative.

    student, worked on a wartime project in microbiology professor Selman Waksman's lab, searching for an antibiotic to fight infections on the front lines and at home. In his eleventh experiment on a common bacterium found in farmyard soil, Schatz discovered streptomycin, the first effective cure for tuberculosis, one of the world's deadliest diseases.As director of Schatz's research, Waksman took credit for the discovery, belittled Schatz's work, and secretly enriched himself with royalties from the streptomycin patent filed by the pharmaceutical company Merck. In an unprecedented lawsuit, young Schatz sued Waksman, and was awarded the title of "co-discoverer" and a share of the royalties. But two years later, Professor Waksman alone was awarded the Nobel Prize. Schatz disappeared into academic obscurity.For the first time, acclaimed author and journalist Peter Pringle unravels the intrigues behind one of the most important discoveries in the history of medicine. The story unfolds on a tiny college campus in New Jersey, but its repercussions spread worldwide. The streptomycin patent was a breakthrough for the drug companies, overturning patent limits on products of nature and paving the way for today's biotech world. As dozens more antibiotics were found, many from the same family as streptomycin, the drug companies created oligopolies and reaped big profits. Pringle uses firsthand accounts and archives in the United States and Europe to reveal the intensely human story behind the discovery that started a revolution in the treatment of infectious diseases and shaped the future of Big Pharma.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    Belknap's Waterproof Grand Canyon River Guide (All New Color Edition)

    The book continues to help students make sense of a complex world in transition and explains how globalization became part of public discourse. Filled with case studies, this text makes the intricacies of globalization concrete, meaningful, and clear for students and moves them away from simple social evolutionary views, encouraging them to connect social change, development policies, global inequalities and social movements. The book challenges students to see themselves as global citizens whose consumption decisions have real social and ecological implications.

    A community betrayed ... The whistle-blower priest who paid the ultimate price Glen Walsh and Steven Alward were childhood friends in their tight-knit working-class community in Shortland, on the outskirts of Newcastle, New South Wales. Both proud altar boys at the local Catholic church, they went on to attend the city's Catholic boys' highs schools: Glen to Marist Brothers and Steven to St Pius X. Both did well: Steven became a journalist; Glen a priest. But when Glen discovered another priest was sexually abusing boys, he reported the offending to police, breaking Canon Law and his vows to the Catholic 'brotherhood' in the process. Just weeks before he was due to give evidence at a key trial against the highest cleric to ever be charged with covering up child abuse, Father Glen Walsh was dead. Two months later, his friend Steven also died, only weeks before he was to marry the love of his life. Ensuing investigations revealed that at least 60 men in the region had taken their own lives. Why? What had happened, and why were so many from the three Catholic high schools in the area?By six-time Walkley Award-winning investigative reporter Suzanne Smith, The Altar Boys is the powerful expose of widespread and organised clerical abuse of children in an Australian city, and how the cover-up in the Catholic Church in Australia extended from parish priests to every echelon of the organisation. Focusing on two childhood friends, their families and community, this gripping and explosive story is backed by secret documents, diary notes and witness accounts, and details a deliberate church strategy of using psychological warfare against witnesses in key trials involving paedophile priests.

    Robert J. Darling organizes President Bush's trip to Florida on Sept. 10, 2001, he believes the next couple of days will be quiet. He has no idea that a war is about to begin. The next day, after terrorists crash airliners into the World Trade Center towers and the Pentagon, Maj. Darling rushes to the president's underground chamber at the White House. There, he takes on the task of liaison between the vice president, national security advisor and the Pentagon. He works directly with the National Command Authority, and he's in the room when Vice President Cheney orders two fighter jets to get airborne in order to shoot down United Flight 93. Throughout the attacks, Maj. Darling witnesses the unprecedented actions that leaders are taking to defend America. As Vice President Cheney, Secretary of State Condoleezza Rice, and others make decisions at a lightning pace with little or no deliberation, he's there to lend his support. Follow Darling's story as he becomes a Marine Corps aviator and rises through the ranks to play an incredible role in responding to a crisis that changed the world in 9-11-01: The White House: Twenty-Four Hours inside the President's Bunker.

    This is perhaps the first time we have such a complete firsthand account in which nothing is kept back and there is no departmental “diplomacy.” The author is a nuclear power specialist who worked for a time at the Chernobyl AES and knows it well, just as he is personally acquainted with all the principal participants in the events. By virtue of his official position, he has attended many of the crucial conferences concerning nuclear power plant construction. Immediately after the accident, Medvedev was sent to Chernobyl and had an opportunity to learn a great deal while the trail was still fresh and to see things with his own eyes. He presents many technical details indispensable to understanding the mechanism whereby the accident occurred, he exposes the secrets of bureaucratic relations, he tells about the oversights of scientists and designers, about the disastrous overbearing pressure in the command system, about the violations of glasnost before the accident and in the emergency situation following it that have caused enormous harm. The chronicle of events at Chernobyl in the tragic days of April and May 1986 takes up the central place in the story. The author portrays the behavior and role of numerous participants in the drama, of real living people with their shortcomings and virtues, their doubts, their weaknesses, their illusions, and their heroism alongside the nuclear monster that had gone out of control. It is not possible to read about this without the deepest emotion. We knew about the exploits of the firemen. The author tells about the heroism of the electricians, the turbine specialists, the operators, and other workers at the station who prevented the accident from taking on greater proportions.

    It presents a profound and challenging investigation into the nature of human reason, its knowledge and its illusions. Reason, Kant argues, is the seat of certain concepts that precede experience and make it possible, but we are not therefore entitled to draw conclusions about the natural world from these concepts. The Critique brings together the two opposing schools of philosophy: rationalism, which grounds all our knowledge in reason, and empiricism, which traces all our knowledge to experience. Kant's transcendental idealism indicates a third way that goes far beyond these alternatives.

    To some, nuclear deterrence appeared as utter madness, and was in fact commonly referred to as M.A.D. The concept of Mutually Assured Destruction provoked protests and marches, and the architect of M.A.D, General Curtis LeMay, became a symbol of madness himself.