Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    She paints rainbow-colored rooftops, striped pears, birds in hats, teacups, cats, and more—all drawn to bring joy to anyone who views them. When the weather is rainy and gray, Sevig paints herself some sunshine. When she feels sad, she paints something colorful to cheer herself up; when anxious, something soothing and repetitive; when overwhelmed, she makes a series of small decisions about what to put on the page and begins to feel empowered.In Striped Pears and Polka Dots, Sevig invites readers into her cozy, sunny world of snail mail, patterned socks and knitted sweaters, ice cream and flaky croissants, and dachshunds in sweaters. This perfect gift book will inspire readers to look around and notice all the little happy-makers that surround them in their daily lives.

    But that’s hard to do when you, your boss or your team are still trying to replicate the way you work at the office, enduring an endless series of video calls while pretending that yes, everyone is wearing pants.Remote, Inc. shows you a new approach, based on the mindset and habits of people who flourish while working outside the office some or all of the time.  These are the folks who manage to get even more done at home, even though you know they’ve got kids or dogs underfoot and somehow fit in a daily run at lunchtime. Their secret? They think like a “business of one.” That’s how productivity experts Robert C. Pozen and Alexandra Samuel describe the mindset that lets people thrive when they’re working remotely, whether working from home full-time or spending a few days each week in the office. You can follow their lead by embracing the work habits and independence of an entrepreneur – while also tapping into the benefits of collegiality and online collaboration.Remote, Inc. maps out the principles that drive this entrepreneurial approach, and translates them into the specific habits and tools that make remote work productive and enjoyable. It shows you how to:Focus on goals and results instead of the 9-to-5 scheduleWow your managers by treating them like valued clientsBeat information overload with a system that prioritizes the most important emails and messages   Make online meetings purposeful, focused and engaging Learn to love your colleagues again by building great relationships through online collaborationPlan for success in a world in which many professionals will work remotelyJust as important as making you a professional powerhouse, Remote Inc. will help you find a balance between work from home, and life at home.

    A man who against expedition orders drove his tractor to the South Pole; a man honoured around the world for his pioneering climbs yet who collapsed on more than one occasion on a mountain, and a man who gave so much to Nepal yet lost his family to its mountains.The author, Michael Gill, was a close friend of Hillary’s for nearly 50 years, accompanying him on many expeditions and becoming heavily involved in Hillary’s aid work building schools and hospitals in the Himalaya. During the writing of this book, Gill was granted access to a large archive of private papers and photos that were deposited in the Auckland museum after Hillary’s death in 2008. Building on this unpublished material, as well as his extensive personal experience, Michael Gill profiles a man whose life was shaped by both triumph and tragedy.Gill describes the uncertainties of the first 33 years of Hillary’s life, during which time he served in the New Zealand air force during the Second World War, as well as the background to the first ascent of Mount Everest in 1953, when Hillary and Tenzing Norgay became the first climbers to reach the summit – a feat that brought the pair instant worldwide fame. He reveals the loving relationship Hillary had with his wife Louise, in part through their touching letters to each other. Her importance to him during their 22 years of marriage only underlines the horror of her death, along with that of their youngest daughter, Belinda, in a plane crash in 1975. Hillary eventually pulled out of his subsequent depression to continue his life’s work in the Himalaya.Affectionate, but scrupulously fair, in Edmund Hillary – A Biography Michael Gill has gone further than anyone before to reveal the humanity of this remarkable man.

    Willingham on educational neuroscience? Written for busy teachers, trainers, managers and students, this dip-in dip-out guide makes theories of learning accessible and practical. It explores over 100 classic and contemporary learning theorists in an easy-to-use, bite-sized format with clear relevant illustrations on how each theory will benefit your teaching and learning.Each model or theory is explained in less than 350 words, many with accompanying diagrams, and the 'how to use it' sections, in less than 500 words. Every entry includes:Do it steps in order to apply the theory or modelReflection points & challenges to develop your understanding of how to apply itAnalogies & metaphors from which understanding and meaning can be drawnTips for the classroomFurther reading if you want to explore a theory in greater depth. More titles by Bob Bates: Educational Leadership Simplified A Quick Guide to Special Needs and Disabilities

    O'RourkeP. J. O'Rourke says we've worked ourselves into a state of anger and perplexity, and it's no surprise because perplexed and angry are what Americans have been since the Roanoke Colony got lost. This astute and entertaining look at the state of these United States includes essays on everything from our fraught history ("Oh Beautiful for . . . Pilgrim Feet?") to the political effects of social media, ("Whose Bright Idea Was It to Make Sure that Every Idiot in the World Is in Touch with Every Other Idiot?"). A plan is advanced to reform federal poverty programs, "Just Give Them the Money." And a rant is made against the "Internet of Things" because your juicer is sending fake news to your Fitbit about what's in your refrigerator.Included is a quiz to determine whether you're a "Coastal" or a "Heartlander" (you know organic, fair-traded, locavore, and gluten-free, but do you know hay from straw?), an impassioned plea to license politicians (we license beauticians!), and much more. This is P. J. at his finest.

    Whether you're new to camping or a seasoned pro, hit the road with Stephanie and Jeremy, hosts of the popular The RV Atlas podcast, as they show you the different ways that camping can lead to a happier, healthier family. From hiking with infants to navigating RV camping in state parks and camping in national parks—these outdoor lovers have tried it all, and See You at the Campground is a beautifully illustrated camping book for adults packed with personal anecdotes, packing lists, site recommendations, and recipes that will help you create a one-of-a-kind vacation on a family-friendly budget.Tips include: Reasons camping vacations are better Buying an RV Trip planning tips Road trip tips Campground etiquette Camping with family and friends National park adventuresThe perfect resource for parents—and a great gift for campers at any level—this is the ultimate family vacation book to bring the family closer every time you set up camp—whether it's in a cabin, tent, or RV.

    After days of treatment for recurring infection, it becomes obvious that her arm must be amputated. Dr. Ajay Seth, the son of immigrant parents from India and a local orthopaedic surgeon in private practice, performs his first-ever amputation procedure. In the months that follow, divine intervention, combined with Melissa’s determination and Dr. Seth’s disciplined commitment and dedication to his patients, brings about the opportunity for a medical breakthrough that will potentially transform the lives of amputees around the world.Rewired is the inspirational, miraculous story of Dr. Seth’s revolutionary surgery that allows Melissa to not just move a prosthetic arm simply by thinking, but to actually feel with the prosthetic hand, just as she would with her natural arm. This resulted in what others have recognized as the world’s most advanced amputee, all done from Dr. Seth’s private practice in a community hospital, using a local staff, and with no special training or extensive research funding.

    The world would be a better place if we were as tough-minded in how we donate money as in how we make it."—Nicholas Kristof, New York Times "Bold, fresh, inspired, reasoned, optimistic."—Walter M. Bortz II, MD, Huffington Post Blog Peter Singer’s books and ideas have been disturbing our complacency ever since the appearance of Animal Liberation. Now he directs our attention to a new movement in which his own ideas have played a crucial role: effective altruism. Effective altruism is built upon the simple but profound idea that living a fully ethical life involves doing the "most good you can do." Such a life requires an unsentimental view of charitable giving: to be a worthy recipient of our support, an organization must be able to demonstrate that it will do more good with our money or our time than other options open to us. Singer introduces us to an array of remarkable people who are restructuring their lives in accordance with these ideas, and shows how living altruistically often leads to greater personal fulfillment than living for oneself.The Most Good You Can Do develops the challenges Singer has made, in the New York Times and Washington Post, to those who donate to the arts, and to charities focused on helping our fellow citizens, rather than those for whom we can do the most good. Effective altruists are extending our knowledge of the possibilities of living less selfishly, and of allowing reason, rather than emotion, to determine how we live. The Most Good You Can Do offers new hope for our ability to tackle the world’s most pressing problems.

    Combining vibrant storytelling, vivid portraiture, and thematic analysis, Lemann shows why this experiment did not turn out as planned. It did create a new elite, but it also generated conflict and tension—and America's best educated, most privileged people are now leaders without followers.Drawing on unprecedented access to the Educational Testing Service's archives, Lemann maintains that America's meritocracy is neither natural nor inevitable, and that it does not apportion opportunity equally or fairly. His important study not only asks profound moral and political questions about the past and future of our society but also carries implications for current social and educational policy. As Brent Staples noted in his New York Times editorial column: "Mount Holyoke College in Massachusetts announced that prospective students would no longer be required to submit SAT scores with their applications. . . . Holyoke's president, Joanne Creighton, was personally convinced by reading Nicholas Lemann's book, The Big Test, which documents how the SAT became a tool for class segregation."All students of education, sociology, and recent U.S. history—especially those focused on testing, theories of learning, social stratification, or policymaking—will find this book fascinating and alarming.

    With elegance and wit, this exhilarating history alights at the pivotal points of cultural transformation. The motivating question throughout: How does history help us understand the vast changes we are now experiencing in the landscape of knowledge?Beginning in Alexandria and its great center of Hellenistic learning and imperial power, we then see the monastery in the wilderness of a collapsed civilization, the rambunctious universities of the late medieval cities, and the thick social networks of the Enlightenment republic of letters. The development of science and the laboratory as a dominant knowledge institution brings us to the present, seeking patterns in the new digital networks of knowledge.Full of memorable characters, this fresh history succeeds in restoring the strangeness and the significance of the past.

    But as amazing as these abilities are, they are not mysterious. Our brains constantly process a huge amount of information below our awareness, and what these gifted individuals have in common is that through practice, injury, an innate brain disorder, or even more unusual circumstances, they have managed to gain a degree of conscious access to this potent processing power. The Superhuman Mind takes us inside the lives and brains of geniuses, savants, virtuosos, and a wide variety of ordinary people who have acquired truly extraordinary talents, one way or another. Delving into the neurological underpinnings of these abilities, the authors even reveal how we can acquire some of them ourselves—from perfect pitch and lightning fast math skills to supercharged creativity. The Superhuman Mind is a book full of the fascinating science readers look for from the likes of Oliver Sacks, combined with the exhilarating promise of Moonwalking with Einstein.

    Within forty-eight hours of his victory, the essay "Autocracy: Rules for Survival" had gone viral, and Gessen's coverage of his norm-smashing presidency became essential reading for a citizenry struggling to wrap their heads around the unimaginable. Thanks to the special perspective that is the legacy of a Soviet childhood and two decades covering the resurgence of totalitarianism in Russia, Gessen has a sixth sense for signs of autocracy--and the unique cross-cultural fluency to delineate its emergence to Americans. This incisive book provides an indispensable overview of the calamitous trajectory of the past few years. Gessen not only highlights the corrosion of the media, the judiciary, and the cultural norms we hoped would save us but also tells us the story of how a short few years have changed us, from a people who saw ourselves as a nation of immigrants to a populace haggling over a border wall, heirs to a degraded sense of truth, meaning, and possibility. Surviving Autocracy is an inventory of ravages but also a beacon to recovery--or to enduring, and resisting, an ongoing assault.

    To figure out why this is happening and how to put an end to it, child psychologist Dr. Charlotte Peterson has been spending six months every five years living in indigenous villages and observing their parenting practices. What she's found is that the people of peaceful cultures, particularly the Tibetan, Bhutanese, and Balinese people, know something we Westerners, despite our modernity, don't, and their children are happier, healthier, and more balanced because of it.What Dr. Peterson has found is that the children in these cultures are raised with a high degree of cherishing and empathy. Attachments are promoted by intensive nurturing of infants and gentle, clear limit-setting with toddlers that teaches self-control and builds self-esteem. The result, as Dr. Peterson has found after visiting these places again and again, is children who are trusting, enjoyable, and kind, —not “spoiled,” as we might imagine.The Mindful Parent brings together Dr. Peterson's village interviews, observations, research, and over thirty-five years of work as a psychologist to teach modern parents how to raise healthier, more well-balanced, and kinder children. It includes creative ideas from parents who are currently adopting these practices and balancing other aspects of their personal, career, and financial responsibilities to assure their children get the support they need to thrive.

    But what few people have grasped yet is how quickly this is happening, how extensive brain changes can be, and how much control each of us has over the process.In Bliss Brain, famed researcher Dawson Church digs deep into leading-edge science, and finds stunning evidence of rapid and radical brain change. In just eight weeks of practice, 12 minutes a day, using the right techniques, we can produce measurable changes in our brains. These make us calmer, happier, and more resilient.When we cultivate these pleasurable states over time, they become traits. We don't just feel more blissful as a temporary state; the changes are literally hard-wired into our brains, becoming stable and enduring personality traits.The startling conclusions of Church's research show that neural remodeling goes much farther than scientists have previously understood, with stress circuits shriveling over time. Simultaneously, "The Enlightenment Circuit"-associated with happiness, compassion, productivity, creativity, and resilience-expands.During deep meditation, Church shows how "the 7 neurochemicals of ecstasy" are released in our brains. These include anandamide, a neurotransmitter that's been named "the bliss molecule" because it mimics the effects of THC, the active ingredient in cannabis. It boosts serotonin and dopamine; the first is an analog of psilocybin, the second of cocaine. He shows how cultivating these elevated emotional states literally produces a self-induced high.